Mutagenetix > Incidental Mutations

Incidental Mutation 'R1568:Olfr1466'

175456

Institutional Source

Beutler Lab

Gene Symbol

Olfr1466

Ensembl Gene

ENSMUSG00000096485

Gene Name

olfactory receptor 1466

Synonyms

MOR202-12, GA_x6K02T2RE5P-3672907-3673839

MMRRC Submission

039607-MU

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.097) question?

Stock #

R1568 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

13338862-13343572 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

C to A at 13342175 bp

Zygosity

Heterozygous

Amino Acid Change

Proline to Glutamine at position 139 (P139Q)

Ref Sequence

ENSEMBL: ENSMUSP00000147188 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000075868] [ENSMUST00000207124]

Predicted Effect

probably benign
Transcript: ENSMUST00000075868
AA Change: P139Q

PolyPhen 2 Score 0.142 (Sensitivity: 0.92; Specificity: 0.86)

SMART Domains

Protein: ENSMUSP00000075265
Gene: ENSMUSG00000096485
AA Change: P139Q

Domain	Start	End	E-Value	Type
Pfam:7tm_4	32	310	4.1e-49	PFAM
Pfam:7TM_GPCR_Srsx	36	306	1.9e-6	PFAM
Pfam:7tm_1	42	291	7e-19	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000207124
AA Change: P139Q

PolyPhen 2 Score 0.142 (Sensitivity: 0.92; Specificity: 0.86)

Coding Region Coverage

1x: 99.1%
3x: 98.2%
10x: 95.8%
20x: 90.9%

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 61 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
0610010F05Rik	T	C	11: 23,589,971	K48E	probably damaging	Het
4931408C20Rik	T	C	1: 26,685,869	T77A	probably benign	Het
Adam18	T	G	8: 24,647,783		probably null	Het
Adgb	A	T	10: 10,442,665	Y138*	probably null	Het
Adra1d	T	C	2: 131,546,172	R488G	possibly damaging	Het
Ahnak	G	A	19: 9,002,375	G341E	probably damaging	Het
Ankmy1	T	C	1: 92,881,116	D690G	probably damaging	Het
Arhgef38	C	T	3: 133,132,464	E21K	probably damaging	Het
Atp8b2	T	C	3: 89,949,848	M402V	probably damaging	Het
Atp8b4	G	T	2: 126,325,394	H1062N	probably benign	Het
Bdnf	A	G	2: 109,723,794	H131R	probably damaging	Het
Cblb	C	T	16: 52,135,829	T265M	probably damaging	Het
Cenpe	T	A	3: 135,239,758	M1011K	probably benign	Het
Clca2	A	T	3: 145,075,649	Y711*	probably null	Het
Clca4a	A	G	3: 144,952,929	Y842H	probably benign	Het
Clspn	T	A	4: 126,581,517	M1021K	probably benign	Het
Cpne8	G	T	15: 90,619,642	R107S	probably damaging	Het
D6Ertd527e	C	G	6: 87,111,524	T223S	unknown	Het
Dna2	C	T	10: 62,949,187	R28W	probably benign	Het
Dnah5	T	A	15: 28,409,177	N3580K	probably damaging	Het
Dsp	T	C	13: 38,175,147	I298T	probably damaging	Het
Dync2h1	T	C	9: 7,157,553	K858R	probably null	Het
Fasn	A	T	11: 120,813,249	V1448E	possibly damaging	Het
Ghdc	A	G	11: 100,768,505	I322T	probably benign	Het
Gins2	T	C	8: 120,582,200	D105G	probably damaging	Het
Insr	A	T	8: 3,165,576	D975E	probably benign	Het
Klrc3	T	C	6: 129,639,547	D169G	probably benign	Het
Krt76	T	A	15: 101,885,008	S532C	unknown	Het
Lamp3	A	T	16: 19,673,525	M323K	probably damaging	Het
Lgmn	T	C	12: 102,394,609	I423M	possibly damaging	Het
Lpgat1	A	T	1: 191,776,426	T359S	possibly damaging	Het
Lrguk	T	A	6: 34,086,438	I466N	probably damaging	Het
Magi3	A	C	3: 104,089,527	M234R	probably benign	Het
Myh14	G	A	7: 44,611,698	R1042*	probably null	Het
Nfia	T	G	4: 98,111,224	Y378D	possibly damaging	Het
Npffr1	T	A	10: 61,626,233	S383T	possibly damaging	Het
Olfr1308	C	A	2: 111,960,240	V278F	probably benign	Het
Olfr1410	T	C	1: 92,607,954	L39P	probably damaging	Het
Olfr658	T	A	7: 104,644,770	I199F	probably benign	Het
Osr1	G	A	12: 9,579,798		probably null	Het
Pde4b	A	C	4: 102,597,699	R375S	probably damaging	Het
Pde8a	A	G	7: 81,292,263	E150G	probably damaging	Het
Pkhd1l1	A	T	15: 44,545,501		probably null	Het
Ppp3ca	A	G	3: 136,928,544	T422A	probably benign	Het
Proser1	T	C	3: 53,477,759	V354A	possibly damaging	Het
Rgs20	G	T	1: 5,020,827	R127S	probably benign	Het
Sec22a	T	C	16: 35,347,628	D171G	probably benign	Het
Secisbp2	A	G	13: 51,673,107	E417G	possibly damaging	Het
Serpinb6b	T	C	13: 32,974,912	L32S	probably damaging	Het
Sf3b1	C	G	1: 55,019,395	E12Q	possibly damaging	Het
Slc39a10	A	T	1: 46,826,215	S487T	probably benign	Het
Slc6a1	G	T	6: 114,307,770	G263V	probably damaging	Het
Spag6	A	G	2: 18,733,114	D265G	probably benign	Het
Sybu	G	T	15: 44,718,832	S132*	probably null	Het
Virma	T	C	4: 11,528,776	S1288P	probably damaging	Het
Vmn1r229	T	A	17: 20,814,805	V104D	probably damaging	Het
Vmn1r238	T	C	18: 3,123,358	T19A	probably benign	Het
Vmn2r86	C	T	10: 130,453,141	V164I	probably benign	Het
Wfdc13	G	T	2: 164,686,934	A64S	probably damaging	Het
Zfp873	C	A	10: 82,060,279	H318Q	probably damaging	Het
Zyg11a	A	G	4: 108,183,646		probably null	Het

Other mutations in Olfr1466

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02442:Olfr1466	APN	19	13342120	missense	probably benign	0.13
IGL02568:Olfr1466	APN	19	13342219	missense	probably benign	0.08
IGL03073:Olfr1466	APN	19	13342022	missense	probably benign	0.00
R0943:Olfr1466	UTSW	19	13341793	missense	probably benign	0.00
R1301:Olfr1466	UTSW	19	13341847	missense	probably benign	0.05
R1355:Olfr1466	UTSW	19	13342518	nonsense	probably null
R1524:Olfr1466	UTSW	19	13342122	nonsense	probably null
R1993:Olfr1466	UTSW	19	13341814	missense	possibly damaging	0.65
R2031:Olfr1466	UTSW	19	13342406	missense	probably benign	0.18
R3693:Olfr1466	UTSW	19	13342529	missense	possibly damaging	0.73
R3694:Olfr1466	UTSW	19	13342529	missense	possibly damaging	0.73
R3853:Olfr1466	UTSW	19	13342498	missense	possibly damaging	0.55
R5313:Olfr1466	UTSW	19	13342065	missense	probably benign	0.07
R5467:Olfr1466	UTSW	19	13342157	missense	probably damaging	1.00
R6060:Olfr1466	UTSW	19	13342133	missense	probably benign	0.08
R7125:Olfr1466	UTSW	19	13341739	critical splice acceptor site	probably null
R7591:Olfr1466	UTSW	19	13342255	missense	probably benign	0.28
Z1177:Olfr1466	UTSW	19	13342255	missense	probably benign	0.28

Predicted Primers

PCR Primer
(F):5'- TCTTCAGCGGTCACACCAAAAGTC -3'
(R):5'- CTGAACTCCTGCTTCTGAGTGCATC -3'

Sequencing Primer
(F):5'- GCAGCCTTTGCTACTGTTGA -3'
(R):5'- CTGGCTTGATAAATAAGTACCAGTTC -3'

Posted On

2014-04-24