Incidental Mutation 'R1594:Mgst3'
ID 175539
Institutional Source Beutler Lab
Gene Symbol Mgst3
Ensembl Gene ENSMUSG00000026688
Gene Name microsomal glutathione S-transferase 3
Synonyms 2010306B17Rik, GST-III, 2700004G04Rik, 2010012L10Rik
MMRRC Submission 039631-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R1594 (G1)
Quality Score 225
Status Validated
Chromosome 1
Chromosomal Location 167199535-167221410 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 167201379 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Phenylalanine at position 102 (Y102F)
Ref Sequence ENSEMBL: ENSMUSP00000028005 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000028005]
AlphaFold Q9CPU4
Predicted Effect probably damaging
Transcript: ENSMUST00000028005
AA Change: Y102F

PolyPhen 2 Score 0.985 (Sensitivity: 0.74; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000028005
Gene: ENSMUSG00000026688
AA Change: Y102F

DomainStartEndE-ValueType
Pfam:MAPEG 11 134 8.9e-28 PFAM
Meta Mutation Damage Score 0.0766 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.3%
  • 10x: 96.0%
  • 20x: 91.7%
Validation Efficiency 100% (55/55)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) protein family. Members of this family are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes an enzyme which catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. This enzyme also demonstrates glutathione-dependent peroxidase activity towards lipid hydroperoxides.[provided by RefSeq, May 2011]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acap2 G A 16: 30,946,205 (GRCm39) A264V probably benign Het
Adam17 A G 12: 21,390,471 (GRCm39) probably null Het
Adcy10 A G 1: 165,352,602 (GRCm39) N479D probably benign Het
C2cd2l A G 9: 44,228,070 (GRCm39) S84P probably damaging Het
Capn13 A G 17: 73,658,474 (GRCm39) V198A probably benign Het
Cblc G A 7: 19,526,471 (GRCm39) S206F probably damaging Het
Ccdc7b A T 8: 129,904,838 (GRCm39) T159S possibly damaging Het
Clpx A G 9: 65,231,552 (GRCm39) T546A probably damaging Het
Col18a1 A G 10: 76,948,870 (GRCm39) V214A possibly damaging Het
Csgalnact1 A T 8: 68,811,284 (GRCm39) V462E probably damaging Het
Cts6 G A 13: 61,346,181 (GRCm39) T202I probably damaging Het
Cwf19l2 A G 9: 3,430,973 (GRCm39) Y435C probably benign Het
D630003M21Rik T A 2: 158,053,550 (GRCm39) Q646L probably damaging Het
E2f2 A G 4: 135,914,141 (GRCm39) Q297R possibly damaging Het
Eef1d T C 15: 75,768,195 (GRCm39) E189G probably damaging Het
Fam114a2 A C 11: 57,404,066 (GRCm39) probably null Het
Fam24b A C 7: 130,928,025 (GRCm39) Y55D probably benign Het
Gimap6 T C 6: 48,679,125 (GRCm39) T304A probably benign Het
Gm11232 T C 4: 71,675,572 (GRCm39) E63G possibly damaging Het
Hbs1l A G 10: 21,227,922 (GRCm39) M152V probably benign Het
Herc3 C A 6: 58,864,569 (GRCm39) probably benign Het
Hmx2 A G 7: 131,157,231 (GRCm39) D115G probably benign Het
Igsf3 C A 3: 101,358,393 (GRCm39) Y761* probably null Het
Kbtbd13 A G 9: 65,298,901 (GRCm39) W12R probably benign Het
Kif2c C A 4: 117,035,385 (GRCm39) R21L probably benign Het
Kmt2c T C 5: 25,519,876 (GRCm39) N2078S probably benign Het
Mov10 G T 3: 104,702,727 (GRCm39) T946N probably damaging Het
Nbeal1 T A 1: 60,344,450 (GRCm39) I2317N possibly damaging Het
Nid2 T A 14: 19,831,329 (GRCm39) I741N probably benign Het
Nlrp9a G A 7: 26,269,932 (GRCm39) W786* probably null Het
Or8g20 A C 9: 39,396,042 (GRCm39) I166S probably benign Het
Or9a7 T C 6: 40,521,281 (GRCm39) I211V probably benign Het
Pi4ka G T 16: 17,191,283 (GRCm39) probably benign Het
Plcb4 A G 2: 135,812,310 (GRCm39) probably benign Het
Psg16 A G 7: 16,827,748 (GRCm39) T144A probably damaging Het
Sec24b A G 3: 129,785,000 (GRCm39) V1002A probably benign Het
Shank1 A T 7: 43,976,647 (GRCm39) K582* probably null Het
Slc22a7 T C 17: 46,748,957 (GRCm39) D120G possibly damaging Het
Slco6c1 T A 1: 96,990,163 (GRCm39) T676S probably benign Het
Sulf2 A G 2: 165,926,367 (GRCm39) probably benign Het
Tgm1 T C 14: 55,946,976 (GRCm39) D344G probably damaging Het
Tle4 C T 19: 14,430,970 (GRCm39) W604* probably null Het
Tmco3 T C 8: 13,342,052 (GRCm39) S109P probably damaging Het
Unc13d T G 11: 115,959,538 (GRCm39) D647A probably benign Het
Usp19 T C 9: 108,375,721 (GRCm39) V887A probably damaging Het
Vmn2r49 A T 7: 9,710,550 (GRCm39) D727E probably damaging Het
Ypel1 A G 16: 16,899,985 (GRCm39) H72R probably damaging Het
Zfp407 A G 18: 84,227,456 (GRCm39) V2051A probably benign Het
Zfp438 A G 18: 5,213,515 (GRCm39) L481P possibly damaging Het
Zfp850 C A 7: 27,688,816 (GRCm39) R464L probably benign Het
Zfp985 T C 4: 147,667,537 (GRCm39) V135A probably benign Het
Other mutations in Mgst3
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0744:Mgst3 UTSW 1 167,201,374 (GRCm39) missense probably damaging 1.00
R1283:Mgst3 UTSW 1 167,205,865 (GRCm39) missense possibly damaging 0.74
R2267:Mgst3 UTSW 1 167,201,368 (GRCm39) missense probably benign 0.23
R3885:Mgst3 UTSW 1 167,200,131 (GRCm39) missense probably benign 0.00
R4659:Mgst3 UTSW 1 167,204,848 (GRCm39) missense probably damaging 1.00
R6139:Mgst3 UTSW 1 167,205,874 (GRCm39) missense possibly damaging 0.95
R8778:Mgst3 UTSW 1 167,203,032 (GRCm39) missense probably benign 0.00
R9251:Mgst3 UTSW 1 167,205,860 (GRCm39) critical splice donor site probably null
R9374:Mgst3 UTSW 1 167,205,871 (GRCm39) missense probably damaging 1.00
R9551:Mgst3 UTSW 1 167,205,871 (GRCm39) missense probably damaging 1.00
R9552:Mgst3 UTSW 1 167,205,871 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ACAATATTTAAAATTTGGCTGGGCGGTG -3'
(R):5'- GACTGAGACGAATAACCCCATGATTTCC -3'

Sequencing Primer
(F):5'- agttccagggcagccag -3'
(R):5'- AATAACCCCATGATTTCCTAACTCTG -3'
Posted On 2014-04-24