Mutagenetix > Incidental Mutation

Incidental Mutation 'R1594:Kmt2c'

175551

Institutional Source

Beutler Lab

Gene Symbol

Kmt2c

Ensembl Gene

ENSMUSG00000038056

Gene Name

lysine (K)-specific methyltransferase 2C

Synonyms

Mll3, E330008K23Rik, HALR

MMRRC Submission

039631-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R1594 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

25271798-25498783 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 25314878 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Serine at position 2078 (N2078S)

Ref Sequence

ENSEMBL: ENSMUSP00000043874 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000045291] [ENSMUST00000173073]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000045291
AA Change: N2078S

PolyPhen 2 Score 0.010 (Sensitivity: 0.96; Specificity: 0.77)

SMART Domains

Protein: ENSMUSP00000043874
Gene: ENSMUSG00000038056
AA Change: N2078S

Domain	Start	End	E-Value	Type
low complexity region	9	32	N/A	INTRINSIC
AT_hook	34	46	9.68e-1	SMART
low complexity region	73	87	N/A	INTRINSIC
PHD	283	330	2.56e-2	SMART
C1	329	384	5.45e-1	SMART
PHD	342	388	4.19e-7	SMART
RING	343	387	1.45e-1	SMART
PHD	389	435	4.77e-11	SMART
RING	390	434	1.46e0	SMART
PHD	465	517	8.25e-6	SMART
low complexity region	776	789	N/A	INTRINSIC
AT_hook	898	910	1.41e2	SMART
PHD	953	1002	2.89e-10	SMART
RING	954	1001	4.74e0	SMART
C1	994	1045	8.38e-2	SMART
PHD	1003	1049	1.05e-12	SMART
PHD	1080	1131	2.08e-2	SMART
low complexity region	1189	1201	N/A	INTRINSIC
low complexity region	1337	1348	N/A	INTRINSIC
low complexity region	1394	1406	N/A	INTRINSIC
low complexity region	1431	1442	N/A	INTRINSIC
low complexity region	1520	1539	N/A	INTRINSIC
low complexity region	1557	1570	N/A	INTRINSIC
HMG	1639	1703	2.64e-3	SMART
low complexity region	1708	1724	N/A	INTRINSIC
coiled coil region	1745	1789	N/A	INTRINSIC
low complexity region	1847	1860	N/A	INTRINSIC
low complexity region	1864	1891	N/A	INTRINSIC
internal_repeat_3	1893	2084	1.27e-14	PROSPERO
internal_repeat_3	2123	2306	1.27e-14	PROSPERO
low complexity region	2336	2348	N/A	INTRINSIC
low complexity region	2375	2394	N/A	INTRINSIC
low complexity region	2427	2440	N/A	INTRINSIC
low complexity region	2516	2527	N/A	INTRINSIC
low complexity region	2696	2720	N/A	INTRINSIC
low complexity region	2723	2742	N/A	INTRINSIC
low complexity region	2930	2943	N/A	INTRINSIC
coiled coil region	3048	3075	N/A	INTRINSIC
low complexity region	3156	3165	N/A	INTRINSIC
low complexity region	3173	3195	N/A	INTRINSIC
coiled coil region	3226	3270	N/A	INTRINSIC
low complexity region	3277	3290	N/A	INTRINSIC
coiled coil region	3389	3427	N/A	INTRINSIC
low complexity region	3460	3486	N/A	INTRINSIC
low complexity region	3597	3611	N/A	INTRINSIC
low complexity region	3649	3667	N/A	INTRINSIC
low complexity region	3769	3783	N/A	INTRINSIC
low complexity region	3822	3827	N/A	INTRINSIC
low complexity region	3860	3869	N/A	INTRINSIC
low complexity region	3887	3904	N/A	INTRINSIC
low complexity region	3994	4009	N/A	INTRINSIC
low complexity region	4015	4038	N/A	INTRINSIC
low complexity region	4293	4309	N/A	INTRINSIC
low complexity region	4412	4419	N/A	INTRINSIC
PHD	4454	4500	2.94e-2	SMART
RING	4455	4499	8.1e0	SMART
FYRN	4554	4597	1.18e-21	SMART
FYRC	4603	4690	4.54e-32	SMART
SET	4764	4886	3.17e-34	SMART
PostSET	4888	4904	1.82e-6	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000173073

SMART Domains

Protein: ENSMUSP00000134442
Gene: ENSMUSG00000038056

Domain	Start	End	E-Value	Type
low complexity region	9	32	N/A	INTRINSIC
AT_hook	34	46	9.68e-1	SMART
low complexity region	73	87	N/A	INTRINSIC
PHD	283	330	2.56e-2	SMART
C1	329	384	5.45e-1	SMART
PHD	342	388	4.19e-7	SMART
RING	343	387	1.45e-1	SMART
PHD	389	435	4.77e-11	SMART
RING	390	434	1.46e0	SMART
PHD	465	517	8.25e-6	SMART
low complexity region	776	789	N/A	INTRINSIC
AT_hook	858	870	1.41e2	SMART
PHD	913	962	2.89e-10	SMART
RING	914	961	4.74e0	SMART
C1	954	1005	8.38e-2	SMART
PHD	963	1009	1.05e-12	SMART
PHD	1040	1091	2.08e-2	SMART
low complexity region	1149	1161	N/A	INTRINSIC
low complexity region	1297	1308	N/A	INTRINSIC
low complexity region	1354	1366	N/A	INTRINSIC
low complexity region	1445	1464	N/A	INTRINSIC
low complexity region	1482	1495	N/A	INTRINSIC
HMG	1564	1628	2.64e-3	SMART
low complexity region	1633	1649	N/A	INTRINSIC
coiled coil region	1670	1714	N/A	INTRINSIC

Meta Mutation Damage Score

0.0588

Coding Region Coverage

1x: 99.1%
3x: 98.3%
10x: 96.0%
20x: 91.7%

Validation Efficiency

100% (55/55)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the myeloid/lymphoid or mixed-lineage leukemia (MLL) family and encodes a nuclear protein with an AT hook DNA-binding domain, a DHHC-type zinc finger, six PHD-type zinc fingers, a SET domain, a post-SET domain and a RING-type zinc finger. This protein is a member of the ASC-2/NCOA6 complex (ASCOM), which possesses histone methylation activity and is involved in transcriptional coactivation. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-out allele display partial embryonic lethality, delayed eyelid opening, postnatal growth retardation, impaired fertility in both sexes, and decreased proliferation of cultured mouse embryonic fibroblasts. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 51 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acap2	G	A	16: 31,127,387 (GRCm38)	A264V	probably benign	Het
Adam17	A	G	12: 21,340,470 (GRCm38)		probably null	Het
Adcy10	A	G	1: 165,525,033 (GRCm38)	N479D	probably benign	Het
C2cd2l	A	G	9: 44,316,773 (GRCm38)	S84P	probably damaging	Het
Capn13	A	G	17: 73,351,479 (GRCm38)	V198A	probably benign	Het
Cblc	G	A	7: 19,792,546 (GRCm38)	S206F	probably damaging	Het
Ccdc7b	A	T	8: 129,178,357 (GRCm38)	T159S	possibly damaging	Het
Clpx	A	G	9: 65,324,270 (GRCm38)	T546A	probably damaging	Het
Col18a1	A	G	10: 77,113,036 (GRCm38)	V214A	possibly damaging	Het
Csgalnact1	A	T	8: 68,358,632 (GRCm38)	V462E	probably damaging	Het
Cts6	G	A	13: 61,198,367 (GRCm38)	T202I	probably damaging	Het
Cwf19l2	A	G	9: 3,430,973 (GRCm38)	Y435C	probably benign	Het
D630003M21Rik	T	A	2: 158,211,630 (GRCm38)	Q646L	probably damaging	Het
E2f2	A	G	4: 136,186,830 (GRCm38)	Q297R	possibly damaging	Het
Eef1d	T	C	15: 75,896,346 (GRCm38)	E189G	probably damaging	Het
Fam114a2	A	C	11: 57,513,240 (GRCm38)		probably null	Het
Fam24b	A	C	7: 131,326,296 (GRCm38)	Y55D	probably benign	Het
Gimap6	T	C	6: 48,702,191 (GRCm38)	T304A	probably benign	Het
Gm11232	T	C	4: 71,757,335 (GRCm38)	E63G	possibly damaging	Het
Hbs1l	A	G	10: 21,352,023 (GRCm38)	M152V	probably benign	Het
Herc3	C	A	6: 58,887,584 (GRCm38)		probably benign	Het
Hmx2	A	G	7: 131,555,502 (GRCm38)	D115G	probably benign	Het
Igsf3	C	A	3: 101,451,077 (GRCm38)	Y761*	probably null	Het
Kbtbd13	A	G	9: 65,391,619 (GRCm38)	W12R	probably benign	Het
Kif2c	C	A	4: 117,178,188 (GRCm38)	R21L	probably benign	Het
Mgst3	T	A	1: 167,373,810 (GRCm38)	Y102F	probably damaging	Het
Mov10	G	T	3: 104,795,411 (GRCm38)	T946N	probably damaging	Het
Nbeal1	T	A	1: 60,305,291 (GRCm38)	I2317N	possibly damaging	Het
Nid2	T	A	14: 19,781,261 (GRCm38)	I741N	probably benign	Het
Nlrp9a	G	A	7: 26,570,507 (GRCm38)	W786*	probably null	Het
Olfr44	A	C	9: 39,484,746 (GRCm38)	I166S	probably benign	Het
Olfr461	T	C	6: 40,544,347 (GRCm38)	I211V	probably benign	Het
Pi4ka	G	T	16: 17,373,419 (GRCm38)		probably benign	Het
Plcb4	A	G	2: 135,970,390 (GRCm38)		probably benign	Het
Psg16	A	G	7: 17,093,823 (GRCm38)	T144A	probably damaging	Het
Sec24b	A	G	3: 129,991,351 (GRCm38)	V1002A	probably benign	Het
Shank1	A	T	7: 44,327,223 (GRCm38)	K582*	probably null	Het
Slc22a7	T	C	17: 46,438,031 (GRCm38)	D120G	possibly damaging	Het
Slco6c1	T	A	1: 97,062,438 (GRCm38)	T676S	probably benign	Het
Sulf2	A	G	2: 166,084,447 (GRCm38)		probably benign	Het
Tgm1	T	C	14: 55,709,519 (GRCm38)	D344G	probably damaging	Het
Tle4	C	T	19: 14,453,606 (GRCm38)	W604*	probably null	Het
Tmco3	T	C	8: 13,292,052 (GRCm38)	S109P	probably damaging	Het
Unc13d	T	G	11: 116,068,712 (GRCm38)	D647A	probably benign	Het
Usp19	T	C	9: 108,498,522 (GRCm38)	V887A	probably damaging	Het
Vmn2r49	A	T	7: 9,976,623 (GRCm38)	D727E	probably damaging	Het
Ypel1	A	G	16: 17,082,121 (GRCm38)	H72R	probably damaging	Het
Zfp407	A	G	18: 84,209,331 (GRCm38)	V2051A	probably benign	Het
Zfp438	A	G	18: 5,213,515 (GRCm38)	L481P	possibly damaging	Het
Zfp850	C	A	7: 27,989,391 (GRCm38)	R464L	probably benign	Het
Zfp985	T	C	4: 147,583,080 (GRCm38)	V135A	probably benign	Het

Other mutations in Kmt2c

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00436:Kmt2c	APN	5	25,281,261 (GRCm38)	missense	probably damaging	0.99
IGL00694:Kmt2c	APN	5	25,293,161 (GRCm38)	missense	probably damaging	0.99
IGL00780:Kmt2c	APN	5	25,311,051 (GRCm38)	missense	probably benign	0.00
IGL00811:Kmt2c	APN	5	25,374,533 (GRCm38)	missense	possibly damaging	0.75
IGL00885:Kmt2c	APN	5	25,409,171 (GRCm38)	missense	possibly damaging	0.80
IGL00948:Kmt2c	APN	5	25,377,161 (GRCm38)	missense	probably benign	0.08
IGL00959:Kmt2c	APN	5	25,276,229 (GRCm38)	missense	probably damaging	1.00
IGL01022:Kmt2c	APN	5	25,302,701 (GRCm38)	unclassified	probably benign
IGL01146:Kmt2c	APN	5	25,308,512 (GRCm38)	missense	probably damaging	0.96
IGL01154:Kmt2c	APN	5	25,284,399 (GRCm38)	missense	probably damaging	1.00
IGL01434:Kmt2c	APN	5	25,409,308 (GRCm38)	missense	probably damaging	1.00
IGL01464:Kmt2c	APN	5	25,352,244 (GRCm38)	missense	possibly damaging	0.90
IGL01525:Kmt2c	APN	5	25,329,441 (GRCm38)	splice site	probably benign
IGL01530:Kmt2c	APN	5	25,313,500 (GRCm38)	missense	probably benign	0.08
IGL01550:Kmt2c	APN	5	25,281,276 (GRCm38)	missense	probably damaging	1.00
IGL01598:Kmt2c	APN	5	25,273,666 (GRCm38)	makesense	probably null
IGL01598:Kmt2c	APN	5	25,354,771 (GRCm38)	missense	probably damaging	1.00
IGL01608:Kmt2c	APN	5	25,354,811 (GRCm38)	missense	probably damaging	0.97
IGL01663:Kmt2c	APN	5	25,310,670 (GRCm38)	missense	probably damaging	1.00
IGL01707:Kmt2c	APN	5	25,300,098 (GRCm38)	missense	probably damaging	1.00
IGL01714:Kmt2c	APN	5	25,313,400 (GRCm38)	missense	probably benign
IGL01784:Kmt2c	APN	5	25,313,526 (GRCm38)	missense	probably damaging	1.00
IGL01813:Kmt2c	APN	5	25,290,804 (GRCm38)	missense	possibly damaging	0.82
IGL01825:Kmt2c	APN	5	25,310,596 (GRCm38)	missense	probably damaging	1.00
IGL01834:Kmt2c	APN	5	25,395,455 (GRCm38)	missense	probably benign	0.05
IGL02072:Kmt2c	APN	5	25,405,432 (GRCm38)	missense	possibly damaging	0.96
IGL02159:Kmt2c	APN	5	25,311,343 (GRCm38)	missense	probably benign	0.18
IGL02303:Kmt2c	APN	5	25,310,157 (GRCm38)	missense	probably damaging	0.96
IGL02417:Kmt2c	APN	5	25,373,020 (GRCm38)	missense	probably benign
IGL02578:Kmt2c	APN	5	25,366,200 (GRCm38)	intron	probably benign
IGL02811:Kmt2c	APN	5	25,315,028 (GRCm38)	nonsense	probably null
IGL02943:Kmt2c	APN	5	25,290,823 (GRCm38)	missense	probably damaging	1.00
IGL03000:Kmt2c	APN	5	25,284,172 (GRCm38)	missense	probably damaging	1.00
IGL03040:Kmt2c	APN	5	25,310,352 (GRCm38)	missense	probably benign
IGL03076:Kmt2c	APN	5	25,299,151 (GRCm38)	nonsense	probably null
IGL03088:Kmt2c	APN	5	25,299,804 (GRCm38)	missense	probably damaging	0.99
IGL03131:Kmt2c	APN	5	25,315,361 (GRCm38)	missense	probably benign	0.00
FR4304:Kmt2c	UTSW	5	25,315,766 (GRCm38)	small insertion	probably benign
FR4976:Kmt2c	UTSW	5	25,315,763 (GRCm38)	small insertion	probably benign
PIT4520001:Kmt2c	UTSW	5	25,315,666 (GRCm38)	missense	probably benign	0.12
PIT4585001:Kmt2c	UTSW	5	25,315,106 (GRCm38)	missense	probably benign	0.21
R0313:Kmt2c	UTSW	5	25,344,930 (GRCm38)	missense	probably damaging	1.00
R0374:Kmt2c	UTSW	5	25,309,708 (GRCm38)	missense	probably damaging	1.00
R0411:Kmt2c	UTSW	5	25,375,957 (GRCm38)	missense	probably damaging	1.00
R0422:Kmt2c	UTSW	5	25,315,664 (GRCm38)	missense	probably benign
R0453:Kmt2c	UTSW	5	25,354,747 (GRCm38)	missense	probably damaging	1.00
R0616:Kmt2c	UTSW	5	25,299,252 (GRCm38)	missense	probably benign
R0619:Kmt2c	UTSW	5	25,298,916 (GRCm38)	missense	probably benign	0.21
R0671:Kmt2c	UTSW	5	25,404,365 (GRCm38)	missense	probably damaging	1.00
R0736:Kmt2c	UTSW	5	25,295,434 (GRCm38)	missense	probably benign
R0745:Kmt2c	UTSW	5	25,359,698 (GRCm38)	splice site	probably null
R0760:Kmt2c	UTSW	5	25,353,317 (GRCm38)	missense	possibly damaging	0.68
R0784:Kmt2c	UTSW	5	25,310,895 (GRCm38)	missense	probably benign	0.00
R0882:Kmt2c	UTSW	5	25,295,607 (GRCm38)	missense	possibly damaging	0.90
R0893:Kmt2c	UTSW	5	25,351,270 (GRCm38)	splice site	probably benign
R0942:Kmt2c	UTSW	5	25,315,303 (GRCm38)	missense	probably benign	0.10
R1110:Kmt2c	UTSW	5	25,314,362 (GRCm38)	missense	probably benign	0.01
R1137:Kmt2c	UTSW	5	25,310,983 (GRCm38)	missense	possibly damaging	0.80
R1255:Kmt2c	UTSW	5	25,351,153 (GRCm38)	missense	probably damaging	1.00
R1300:Kmt2c	UTSW	5	25,405,454 (GRCm38)	missense	probably damaging	0.99
R1497:Kmt2c	UTSW	5	25,314,515 (GRCm38)	missense	possibly damaging	0.80
R1611:Kmt2c	UTSW	5	25,359,311 (GRCm38)	critical splice donor site	probably null
R1617:Kmt2c	UTSW	5	25,375,927 (GRCm38)	missense	probably benign	0.01
R1720:Kmt2c	UTSW	5	25,299,184 (GRCm38)	missense	probably benign	0.05
R1723:Kmt2c	UTSW	5	25,315,005 (GRCm38)	missense	probably damaging	1.00
R1724:Kmt2c	UTSW	5	25,315,005 (GRCm38)	missense	probably damaging	1.00
R1726:Kmt2c	UTSW	5	25,315,005 (GRCm38)	missense	probably damaging	1.00
R1736:Kmt2c	UTSW	5	25,290,527 (GRCm38)	missense	probably damaging	1.00
R1778:Kmt2c	UTSW	5	25,372,974 (GRCm38)	missense	probably benign	0.02
R1809:Kmt2c	UTSW	5	25,284,192 (GRCm38)	missense	probably damaging	1.00
R1845:Kmt2c	UTSW	5	25,373,436 (GRCm38)	missense	probably benign	0.45
R1895:Kmt2c	UTSW	5	25,315,154 (GRCm38)	missense	probably benign	0.34
R1946:Kmt2c	UTSW	5	25,315,154 (GRCm38)	missense	probably benign	0.34
R1989:Kmt2c	UTSW	5	25,498,544 (GRCm38)	missense	possibly damaging	0.93
R2039:Kmt2c	UTSW	5	25,329,040 (GRCm38)	missense	possibly damaging	0.53
R2049:Kmt2c	UTSW	5	25,285,079 (GRCm38)	missense	probably damaging	1.00
R2079:Kmt2c	UTSW	5	25,352,280 (GRCm38)	missense	possibly damaging	0.82
R2080:Kmt2c	UTSW	5	25,354,717 (GRCm38)	missense	probably damaging	1.00
R2107:Kmt2c	UTSW	5	25,309,824 (GRCm38)	missense	probably benign	0.01
R2186:Kmt2c	UTSW	5	25,287,112 (GRCm38)	missense	probably damaging	1.00
R2395:Kmt2c	UTSW	5	25,315,152 (GRCm38)	missense	probably benign
R2983:Kmt2c	UTSW	5	25,315,757 (GRCm38)	small deletion	probably benign
R3109:Kmt2c	UTSW	5	25,275,735 (GRCm38)	missense	probably damaging	1.00
R3500:Kmt2c	UTSW	5	25,299,479 (GRCm38)	missense	probably benign	0.02
R3738:Kmt2c	UTSW	5	25,405,383 (GRCm38)	missense	probably benign	0.41
R3809:Kmt2c	UTSW	5	25,409,138 (GRCm38)	missense	possibly damaging	0.87
R4088:Kmt2c	UTSW	5	25,287,713 (GRCm38)	missense	probably benign
R4107:Kmt2c	UTSW	5	25,298,920 (GRCm38)	missense	possibly damaging	0.51
R4212:Kmt2c	UTSW	5	25,347,359 (GRCm38)	critical splice donor site	probably null
R4376:Kmt2c	UTSW	5	25,315,326 (GRCm38)	missense	probably benign	0.00
R4377:Kmt2c	UTSW	5	25,315,326 (GRCm38)	missense	probably benign	0.00
R4383:Kmt2c	UTSW	5	25,351,062 (GRCm38)	missense	possibly damaging	0.77
R4435:Kmt2c	UTSW	5	25,314,877 (GRCm38)	missense	possibly damaging	0.63
R4456:Kmt2c	UTSW	5	25,310,212 (GRCm38)	missense	probably benign
R4461:Kmt2c	UTSW	5	25,299,876 (GRCm38)	missense	probably benign	0.00
R4519:Kmt2c	UTSW	5	25,363,477 (GRCm38)	missense	probably damaging	1.00
R4550:Kmt2c	UTSW	5	25,300,174 (GRCm38)	missense	probably damaging	1.00
R4557:Kmt2c	UTSW	5	25,300,315 (GRCm38)	missense	probably damaging	1.00
R4610:Kmt2c	UTSW	5	25,354,384 (GRCm38)	missense	probably damaging	1.00
R4671:Kmt2c	UTSW	5	25,366,177 (GRCm38)	missense	probably damaging	1.00
R4704:Kmt2c	UTSW	5	25,314,027 (GRCm38)	nonsense	probably null
R4781:Kmt2c	UTSW	5	25,443,825 (GRCm38)	missense	probably damaging	1.00
R4844:Kmt2c	UTSW	5	25,315,113 (GRCm38)	missense	probably benign
R4855:Kmt2c	UTSW	5	25,314,557 (GRCm38)	missense	probably benign	0.00
R4919:Kmt2c	UTSW	5	25,314,395 (GRCm38)	missense	possibly damaging	0.80
R4971:Kmt2c	UTSW	5	25,310,872 (GRCm38)	missense	probably benign	0.00
R4983:Kmt2c	UTSW	5	25,295,511 (GRCm38)	missense	possibly damaging	0.51
R5012:Kmt2c	UTSW	5	25,299,712 (GRCm38)	nonsense	probably null
R5033:Kmt2c	UTSW	5	25,314,708 (GRCm38)	missense	probably benign	0.03
R5093:Kmt2c	UTSW	5	25,409,207 (GRCm38)	missense	probably benign	0.17
R5125:Kmt2c	UTSW	5	25,284,381 (GRCm38)	missense	probably damaging	0.99
R5231:Kmt2c	UTSW	5	25,315,473 (GRCm38)	missense	possibly damaging	0.89
R5254:Kmt2c	UTSW	5	25,314,594 (GRCm38)	missense	probably benign	0.01
R5396:Kmt2c	UTSW	5	25,294,734 (GRCm38)	splice site	probably null
R5415:Kmt2c	UTSW	5	25,314,701 (GRCm38)	missense	probably benign	0.21
R5523:Kmt2c	UTSW	5	25,299,339 (GRCm38)	missense	probably benign	0.00
R5554:Kmt2c	UTSW	5	25,294,610 (GRCm38)	missense	probably damaging	1.00
R5701:Kmt2c	UTSW	5	25,314,017 (GRCm38)	missense	probably benign	0.16
R5762:Kmt2c	UTSW	5	25,310,457 (GRCm38)	missense	probably benign	0.01
R5819:Kmt2c	UTSW	5	25,409,132 (GRCm38)	critical splice donor site	probably null
R5838:Kmt2c	UTSW	5	25,284,471 (GRCm38)	missense	probably damaging	1.00
R5912:Kmt2c	UTSW	5	25,347,469 (GRCm38)	missense	possibly damaging	0.80
R5951:Kmt2c	UTSW	5	25,330,803 (GRCm38)	missense	probably benign	0.15
R5988:Kmt2c	UTSW	5	25,311,120 (GRCm38)	missense	probably benign	0.02
R5999:Kmt2c	UTSW	5	25,284,205 (GRCm38)	missense	probably damaging	1.00
R6104:Kmt2c	UTSW	5	25,299,129 (GRCm38)	missense	probably benign
R6254:Kmt2c	UTSW	5	25,349,874 (GRCm38)	missense	possibly damaging	0.94
R6311:Kmt2c	UTSW	5	25,443,818 (GRCm38)	critical splice donor site	probably null
R6329:Kmt2c	UTSW	5	25,315,602 (GRCm38)	missense	probably benign	0.01
R6347:Kmt2c	UTSW	5	25,310,835 (GRCm38)	missense	possibly damaging	0.54
R6364:Kmt2c	UTSW	5	25,309,636 (GRCm38)	missense	probably null	0.99
R6379:Kmt2c	UTSW	5	25,359,341 (GRCm38)	missense	probably damaging	1.00
R6588:Kmt2c	UTSW	5	25,323,789 (GRCm38)	missense	probably damaging	0.99
R6628:Kmt2c	UTSW	5	25,298,928 (GRCm38)	missense	probably benign
R6733:Kmt2c	UTSW	5	25,409,293 (GRCm38)	missense	probably damaging	1.00
R6787:Kmt2c	UTSW	5	25,275,739 (GRCm38)	splice site	probably null
R6816:Kmt2c	UTSW	5	25,405,532 (GRCm38)	splice site	probably null
R6862:Kmt2c	UTSW	5	25,310,517 (GRCm38)	missense	probably damaging	1.00
R7150:Kmt2c	UTSW	5	25,300,362 (GRCm38)	missense	possibly damaging	0.89
R7220:Kmt2c	UTSW	5	25,344,925 (GRCm38)	missense	probably damaging	1.00
R7250:Kmt2c	UTSW	5	25,309,807 (GRCm38)	missense	probably benign	0.00
R7250:Kmt2c	UTSW	5	25,299,491 (GRCm38)	missense	probably damaging	1.00
R7402:Kmt2c	UTSW	5	25,395,420 (GRCm38)	missense	probably damaging	1.00
R7465:Kmt2c	UTSW	5	25,302,849 (GRCm38)	missense	probably damaging	1.00
R7467:Kmt2c	UTSW	5	25,308,532 (GRCm38)	missense	probably damaging	1.00
R7491:Kmt2c	UTSW	5	25,284,564 (GRCm38)	missense	probably damaging	0.99
R7549:Kmt2c	UTSW	5	25,414,970 (GRCm38)	missense	possibly damaging	0.95
R7637:Kmt2c	UTSW	5	25,315,095 (GRCm38)	missense	probably damaging	1.00
R7652:Kmt2c	UTSW	5	25,315,719 (GRCm38)	missense	probably benign	0.01
R7714:Kmt2c	UTSW	5	25,375,366 (GRCm38)	missense	probably benign
R7838:Kmt2c	UTSW	5	25,294,699 (GRCm38)	missense	possibly damaging	0.57
R7891:Kmt2c	UTSW	5	25,300,111 (GRCm38)	missense	probably damaging	1.00
R7892:Kmt2c	UTSW	5	25,299,816 (GRCm38)	missense	probably benign	0.18
R7895:Kmt2c	UTSW	5	25,373,176 (GRCm38)	missense	possibly damaging	0.65
R7960:Kmt2c	UTSW	5	25,315,196 (GRCm38)	missense	probably benign	0.01
R7974:Kmt2c	UTSW	5	25,300,563 (GRCm38)	missense	probably damaging	1.00
R7978:Kmt2c	UTSW	5	25,359,678 (GRCm38)	missense	probably benign	0.00
R8011:Kmt2c	UTSW	5	25,351,234 (GRCm38)	missense	probably damaging	0.99
R8021:Kmt2c	UTSW	5	25,287,119 (GRCm38)	missense	possibly damaging	0.88
R8022:Kmt2c	UTSW	5	25,281,680 (GRCm38)	missense	possibly damaging	0.83
R8079:Kmt2c	UTSW	5	25,302,732 (GRCm38)	missense	probably damaging	0.98
R8087:Kmt2c	UTSW	5	25,329,252 (GRCm38)	missense	probably damaging	1.00
R8109:Kmt2c	UTSW	5	25,281,384 (GRCm38)	missense	probably damaging	1.00
R8161:Kmt2c	UTSW	5	25,374,564 (GRCm38)	missense	probably benign	0.00
R8169:Kmt2c	UTSW	5	25,354,687 (GRCm38)	missense	probably damaging	1.00
R8206:Kmt2c	UTSW	5	25,314,539 (GRCm38)	missense	probably damaging	0.98
R8218:Kmt2c	UTSW	5	25,283,106 (GRCm38)	missense	probably damaging	1.00
R8223:Kmt2c	UTSW	5	25,324,218 (GRCm38)	missense	possibly damaging	0.89
R8260:Kmt2c	UTSW	5	25,405,516 (GRCm38)	missense	possibly damaging	0.87
R8330:Kmt2c	UTSW	5	25,304,694 (GRCm38)	missense	probably null	1.00
R8355:Kmt2c	UTSW	5	25,354,501 (GRCm38)	critical splice acceptor site	probably null
R8455:Kmt2c	UTSW	5	25,354,501 (GRCm38)	critical splice acceptor site	probably null
R8508:Kmt2c	UTSW	5	25,314,122 (GRCm38)	missense	probably benign	0.34
R8885:Kmt2c	UTSW	5	25,315,079 (GRCm38)	missense	probably benign	0.34
R8907:Kmt2c	UTSW	5	25,309,611 (GRCm38)	missense	probably damaging	1.00
R8924:Kmt2c	UTSW	5	25,298,887 (GRCm38)	missense	probably benign
R8969:Kmt2c	UTSW	5	25,314,389 (GRCm38)	missense	possibly damaging	0.82
R9019:Kmt2c	UTSW	5	25,283,210 (GRCm38)	missense	probably damaging	1.00
R9035:Kmt2c	UTSW	5	25,319,012 (GRCm38)	missense	probably damaging	1.00
R9074:Kmt2c	UTSW	5	25,284,345 (GRCm38)	missense	probably damaging	1.00
R9125:Kmt2c	UTSW	5	25,284,196 (GRCm38)	missense	possibly damaging	0.86
R9130:Kmt2c	UTSW	5	25,311,104 (GRCm38)	missense	probably benign	0.01
R9171:Kmt2c	UTSW	5	25,281,311 (GRCm38)	missense	probably damaging	1.00
R9235:Kmt2c	UTSW	5	25,299,999 (GRCm38)	missense	probably damaging	1.00
R9288:Kmt2c	UTSW	5	25,349,862 (GRCm38)	missense	probably benign	0.34
R9288:Kmt2c	UTSW	5	25,292,909 (GRCm38)	missense	probably damaging	1.00
R9336:Kmt2c	UTSW	5	25,409,167 (GRCm38)	missense	probably benign	0.06
R9443:Kmt2c	UTSW	5	25,310,047 (GRCm38)	missense	probably damaging	1.00
R9481:Kmt2c	UTSW	5	25,292,909 (GRCm38)	missense	probably damaging	1.00
R9481:Kmt2c	UTSW	5	25,349,862 (GRCm38)	missense	probably benign	0.34
R9526:Kmt2c	UTSW	5	25,281,357 (GRCm38)	missense	probably damaging	1.00
R9653:Kmt2c	UTSW	5	25,302,821 (GRCm38)	missense	probably damaging	1.00
R9729:Kmt2c	UTSW	5	25,284,760 (GRCm38)	missense	probably damaging	1.00
R9731:Kmt2c	UTSW	5	25,372,958 (GRCm38)	missense	probably benign	0.18
R9784:Kmt2c	UTSW	5	25,344,961 (GRCm38)	missense	probably damaging	1.00
RF001:Kmt2c	UTSW	5	25,315,775 (GRCm38)	small insertion	probably benign
RF006:Kmt2c	UTSW	5	25,315,772 (GRCm38)	small insertion	probably benign
RF011:Kmt2c	UTSW	5	25,338,459 (GRCm38)	missense	probably damaging	1.00
RF041:Kmt2c	UTSW	5	25,315,775 (GRCm38)	small insertion	probably benign
RF047:Kmt2c	UTSW	5	25,315,760 (GRCm38)	small insertion	probably benign
RF051:Kmt2c	UTSW	5	25,313,479 (GRCm38)	unclassified	probably benign
RF055:Kmt2c	UTSW	5	25,315,772 (GRCm38)	small insertion	probably benign
RF059:Kmt2c	UTSW	5	25,313,479 (GRCm38)	unclassified	probably benign
RF063:Kmt2c	UTSW	5	25,315,764 (GRCm38)	small insertion	probably benign
X0024:Kmt2c	UTSW	5	25,405,485 (GRCm38)	missense	probably benign	0.26
X0027:Kmt2c	UTSW	5	25,330,887 (GRCm38)	missense	possibly damaging	0.90
Z1176:Kmt2c	UTSW	5	25,354,413 (GRCm38)	missense	probably damaging	1.00
Z1177:Kmt2c	UTSW	5	25,366,197 (GRCm38)	critical splice acceptor site	probably null
Z1177:Kmt2c	UTSW	5	25,300,003 (GRCm38)	missense	probably benign	0.00
Z1177:Kmt2c	UTSW	5	25,295,397 (GRCm38)	critical splice donor site	probably null

Predicted Primers

PCR Primer
(F):5'- AACCCTCTGAAGTCCTTGGCCTTG -3'
(R):5'- TCATTGACACCTGCCCCATTGG -3'

Sequencing Primer
(F):5'- ACAAACATGTCTGTCTGTGGAG -3'
(R):5'- GGGTAATGGGCCTTTTAAGACC -3'

Posted On

2014-04-24