Incidental Mutation 'R1594:Or9a7'
ID 175553
Institutional Source Beutler Lab
Gene Symbol Or9a7
Ensembl Gene ENSMUSG00000068259
Gene Name olfactory receptor family 9 subfamily A member 7
Synonyms GA_x6K02T2P3E9-6973252-6974193, Olfr461, MOR120-3
MMRRC Submission 039631-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.087) question?
Stock # R1594 (G1)
Quality Score 225
Status Validated
Chromosome 6
Chromosomal Location 40520970-40521911 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 40521281 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 211 (I211V)
Ref Sequence ENSEMBL: ENSMUSP00000150632 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000089490] [ENSMUST00000215009]
AlphaFold Q8VF30
Predicted Effect probably benign
Transcript: ENSMUST00000089490
AA Change: I211V

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000086917
Gene: ENSMUSG00000068259
AA Change: I211V

DomainStartEndE-ValueType
Pfam:7tm_4 30 306 2e-41 PFAM
Pfam:7tm_1 40 289 1.3e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000215009
AA Change: I211V

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000215125
Predicted Effect noncoding transcript
Transcript: ENSMUST00000216766
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.3%
  • 10x: 96.0%
  • 20x: 91.7%
Validation Efficiency 100% (55/55)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acap2 G A 16: 30,946,205 (GRCm39) A264V probably benign Het
Adam17 A G 12: 21,390,471 (GRCm39) probably null Het
Adcy10 A G 1: 165,352,602 (GRCm39) N479D probably benign Het
C2cd2l A G 9: 44,228,070 (GRCm39) S84P probably damaging Het
Capn13 A G 17: 73,658,474 (GRCm39) V198A probably benign Het
Cblc G A 7: 19,526,471 (GRCm39) S206F probably damaging Het
Ccdc7b A T 8: 129,904,838 (GRCm39) T159S possibly damaging Het
Clpx A G 9: 65,231,552 (GRCm39) T546A probably damaging Het
Col18a1 A G 10: 76,948,870 (GRCm39) V214A possibly damaging Het
Csgalnact1 A T 8: 68,811,284 (GRCm39) V462E probably damaging Het
Cts6 G A 13: 61,346,181 (GRCm39) T202I probably damaging Het
Cwf19l2 A G 9: 3,430,973 (GRCm39) Y435C probably benign Het
D630003M21Rik T A 2: 158,053,550 (GRCm39) Q646L probably damaging Het
E2f2 A G 4: 135,914,141 (GRCm39) Q297R possibly damaging Het
Eef1d T C 15: 75,768,195 (GRCm39) E189G probably damaging Het
Fam114a2 A C 11: 57,404,066 (GRCm39) probably null Het
Fam24b A C 7: 130,928,025 (GRCm39) Y55D probably benign Het
Gimap6 T C 6: 48,679,125 (GRCm39) T304A probably benign Het
Gm11232 T C 4: 71,675,572 (GRCm39) E63G possibly damaging Het
Hbs1l A G 10: 21,227,922 (GRCm39) M152V probably benign Het
Herc3 C A 6: 58,864,569 (GRCm39) probably benign Het
Hmx2 A G 7: 131,157,231 (GRCm39) D115G probably benign Het
Igsf3 C A 3: 101,358,393 (GRCm39) Y761* probably null Het
Kbtbd13 A G 9: 65,298,901 (GRCm39) W12R probably benign Het
Kif2c C A 4: 117,035,385 (GRCm39) R21L probably benign Het
Kmt2c T C 5: 25,519,876 (GRCm39) N2078S probably benign Het
Mgst3 T A 1: 167,201,379 (GRCm39) Y102F probably damaging Het
Mov10 G T 3: 104,702,727 (GRCm39) T946N probably damaging Het
Nbeal1 T A 1: 60,344,450 (GRCm39) I2317N possibly damaging Het
Nid2 T A 14: 19,831,329 (GRCm39) I741N probably benign Het
Nlrp9a G A 7: 26,269,932 (GRCm39) W786* probably null Het
Or8g20 A C 9: 39,396,042 (GRCm39) I166S probably benign Het
Pi4ka G T 16: 17,191,283 (GRCm39) probably benign Het
Plcb4 A G 2: 135,812,310 (GRCm39) probably benign Het
Psg16 A G 7: 16,827,748 (GRCm39) T144A probably damaging Het
Sec24b A G 3: 129,785,000 (GRCm39) V1002A probably benign Het
Shank1 A T 7: 43,976,647 (GRCm39) K582* probably null Het
Slc22a7 T C 17: 46,748,957 (GRCm39) D120G possibly damaging Het
Slco6c1 T A 1: 96,990,163 (GRCm39) T676S probably benign Het
Sulf2 A G 2: 165,926,367 (GRCm39) probably benign Het
Tgm1 T C 14: 55,946,976 (GRCm39) D344G probably damaging Het
Tle4 C T 19: 14,430,970 (GRCm39) W604* probably null Het
Tmco3 T C 8: 13,342,052 (GRCm39) S109P probably damaging Het
Unc13d T G 11: 115,959,538 (GRCm39) D647A probably benign Het
Usp19 T C 9: 108,375,721 (GRCm39) V887A probably damaging Het
Vmn2r49 A T 7: 9,710,550 (GRCm39) D727E probably damaging Het
Ypel1 A G 16: 16,899,985 (GRCm39) H72R probably damaging Het
Zfp407 A G 18: 84,227,456 (GRCm39) V2051A probably benign Het
Zfp438 A G 18: 5,213,515 (GRCm39) L481P possibly damaging Het
Zfp850 C A 7: 27,688,816 (GRCm39) R464L probably benign Het
Zfp985 T C 4: 147,667,537 (GRCm39) V135A probably benign Het
Other mutations in Or9a7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02232:Or9a7 APN 6 40,520,980 (GRCm39) missense probably damaging 0.96
IGL03245:Or9a7 APN 6 40,521,076 (GRCm39) missense probably damaging 0.98
R0325:Or9a7 UTSW 6 40,521,057 (GRCm39) missense possibly damaging 0.95
R0835:Or9a7 UTSW 6 40,521,272 (GRCm39) missense probably benign 0.01
R2437:Or9a7 UTSW 6 40,521,856 (GRCm39) missense probably benign 0.37
R6360:Or9a7 UTSW 6 40,521,647 (GRCm39) missense possibly damaging 0.83
R6970:Or9a7 UTSW 6 40,521,590 (GRCm39) missense probably benign 0.31
R7252:Or9a7 UTSW 6 40,521,703 (GRCm39) missense probably benign 0.06
R7326:Or9a7 UTSW 6 40,521,829 (GRCm39) missense probably damaging 0.97
R8766:Or9a7 UTSW 6 40,521,485 (GRCm39) missense probably benign
R9201:Or9a7 UTSW 6 40,521,293 (GRCm39) missense probably benign 0.00
RF003:Or9a7 UTSW 6 40,521,296 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- AAACCACCCTGTTGTACTCTGCTG -3'
(R):5'- GGCTGTCTGCAACCCTTTGAGATAC -3'

Sequencing Primer
(F):5'- GTACTCTGCTGCCTGTGTCTG -3'
(R):5'- AGCAGCTATACTTGTACCTGG -3'
Posted On 2014-04-24