Mutagenetix > Incidental Mutation

Incidental Mutation 'R1600:Zfp119a'

176113

Institutional Source

Beutler Lab

Gene Symbol

Zfp119a

Ensembl Gene

ENSMUSG00000057835

Gene Name

zinc finger protein 119a

Synonyms

Mzf13, Zfp119

MMRRC Submission

039637-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R1600 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

55864892-55878930 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 55868355 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Tryptophan to Arginine at position 47 (W47R)

Ref Sequence

ENSEMBL: ENSMUSP00000078587 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000079642]

AlphaFold

Q9JIC0

Predicted Effect

possibly damaging
Transcript: ENSMUST00000079642
AA Change: W47R

PolyPhen 2 Score 0.925 (Sensitivity: 0.81; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000078587
Gene: ENSMUSG00000057835
AA Change: W47R

Domain	Start	End	E-Value	Type
KRAB	4	66	6.16e-15	SMART
ZnF_C2H2	155	177	1.57e2	SMART
ZnF_C2H2	261	283	2.14e2	SMART
ZnF_C2H2	289	311	6.78e-3	SMART
ZnF_C2H2	317	339	1.98e-4	SMART
ZnF_C2H2	345	367	4.17e-3	SMART
ZnF_C2H2	373	395	3.39e-3	SMART
ZnF_C2H2	401	423	1.64e-1	SMART
ZnF_C2H2	429	451	5.5e-3	SMART
ZnF_C2H2	457	479	1.51e0	SMART
ZnF_C2H2	485	507	6.32e-3	SMART
ZnF_C2H2	513	535	1.69e-3	SMART

Meta Mutation Damage Score

0.1795

Coding Region Coverage

1x: 99.2%
3x: 98.4%
10x: 96.6%
20x: 93.6%

Validation Efficiency

85% (41/48)

Allele List at MGI

Other mutations in this stock

Total: 39 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acin1	T	C	14: 54,643,717		probably benign	Het
Acot3	C	T	12: 84,058,710	A317V	probably benign	Het
Ahrr	T	C	13: 74,214,378	D334G	probably benign	Het
Alpk2	C	T	18: 65,378,037	V30M	probably damaging	Het
Arhgef25	G	T	10: 127,185,289	H281N	probably damaging	Het
B3gntl1	A	G	11: 121,630,836	M175T	probably damaging	Het
BC080695	A	G	4: 143,571,967	E160G	possibly damaging	Het
Brca2	T	A	5: 150,560,830		probably benign	Het
Ccnj	A	T	19: 40,844,657		probably benign	Het
Cebpzos	A	G	17: 78,918,388	K11E	probably damaging	Het
Col6a6	A	G	9: 105,778,075	S816P	probably damaging	Het
Cul4a	A	G	8: 13,123,954	R64G	probably damaging	Het
Cul7	C	A	17: 46,651,822	C126*	probably null	Het
Ercc2	T	C	7: 19,385,941	Y176H	probably benign	Het
Frem2	T	G	3: 53,547,723	D2144A	probably damaging	Het
Gabrg3	A	T	7: 56,735,074	Y246*	probably null	Het
Gm21731	T	C	13: 120,240,833	V55A	probably benign	Het
Gpatch2l	T	C	12: 86,256,934		probably null	Het
Grk1	A	G	8: 13,405,406	T97A	probably benign	Het
Hmcn2	A	G	2: 31,430,787	E4004G	probably damaging	Het
Kcnu1	A	T	8: 25,849,793	R46S	probably damaging	Het
Lrrfip1	T	C	1: 91,114,667	S265P	probably damaging	Het
Lyve1	A	G	7: 110,853,695		probably null	Het
Mme	A	G	3: 63,365,058	Y659C	probably damaging	Het
Mrs2	G	T	13: 24,995,410	N299K	possibly damaging	Het
Mtnr1b	T	C	9: 15,863,319	Y148C	probably damaging	Het
Myo5b	T	A	18: 74,713,540		probably benign	Het
Neb	A	G	2: 52,271,604	Y2059H	probably damaging	Het
Nkain3	T	C	4: 20,469,528		probably benign	Het
Peg10	A	T	6: 4,757,080		probably benign	Het
Rufy2	A	G	10: 63,006,671	T458A	probably benign	Het
Sec14l1	G	A	11: 117,150,604	V448I	probably benign	Het
Tbx19	C	T	1: 165,142,567	G251D	possibly damaging	Het
Trappc9	G	A	15: 72,937,109	Q711*	probably null	Het
Trpm3	A	G	19: 22,139,155	R13G	probably benign	Het
Usp33	G	T	3: 152,379,610	A628S	probably damaging	Het
Vps13a	T	C	19: 16,666,272	N2080S	probably benign	Het
Wdr45b	A	T	11: 121,330,189	I221N	probably damaging	Het
Zswim9	A	G	7: 13,269,571	C118R	probably damaging	Het

Other mutations in Zfp119a

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00420:Zfp119a	APN	17	55865792	nonsense	probably null
R0421:Zfp119a	UTSW	17	55865248	nonsense	probably null
R1385:Zfp119a	UTSW	17	55865826	missense	probably damaging	1.00
R2310:Zfp119a	UTSW	17	55865440	missense	probably benign	0.00
R2924:Zfp119a	UTSW	17	55868343	missense	possibly damaging	0.96
R3910:Zfp119a	UTSW	17	55866520	missense	probably benign
R4594:Zfp119a	UTSW	17	55866325	missense	probably benign
R5217:Zfp119a	UTSW	17	55865425	nonsense	probably null
R5321:Zfp119a	UTSW	17	55865595	missense	probably damaging	1.00
R5392:Zfp119a	UTSW	17	55866328	missense	probably benign	0.03
R5678:Zfp119a	UTSW	17	55868336	missense	probably benign	0.03
R7033:Zfp119a	UTSW	17	55866009	missense	probably benign	0.04
R7355:Zfp119a	UTSW	17	55866287	nonsense	probably null
R7489:Zfp119a	UTSW	17	55866158	missense	probably damaging	1.00
R8130:Zfp119a	UTSW	17	55865971	missense	probably damaging	1.00
R8940:Zfp119a	UTSW	17	55865551	missense	probably damaging	1.00
R9542:Zfp119a	UTSW	17	55865593	nonsense	probably null
Z1176:Zfp119a	UTSW	17	55866011	missense	possibly damaging	0.61

Predicted Primers

Posted On

2014-04-24