Incidental Mutation 'R1607:Gin1'
ID 176526
Institutional Source Beutler Lab
Gene Symbol Gin1
Ensembl Gene ENSMUSG00000026333
Gene Name gypsy retrotransposon integrase 1
Synonyms 4930429M06, Zh2c2
MMRRC Submission 039644-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R1607 (G1)
Quality Score 225
Status Not validated
Chromosome 1
Chromosomal Location 97770172-97793709 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to T at 97786150 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 392 (I392F)
Ref Sequence ENSEMBL: ENSMUSP00000108464 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027571] [ENSMUST00000112844] [ENSMUST00000138142]
AlphaFold Q8K259
Predicted Effect possibly damaging
Transcript: ENSMUST00000027571
AA Change: I303F

PolyPhen 2 Score 0.663 (Sensitivity: 0.86; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000027571
Gene: ENSMUSG00000026333
AA Change: I303F

DomainStartEndE-ValueType
low complexity region 63 73 N/A INTRINSIC
SCOP:d1exqa_ 112 208 2e-5 SMART
low complexity region 254 264 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000112844
AA Change: I392F

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000108464
Gene: ENSMUSG00000026333
AA Change: I392F

DomainStartEndE-ValueType
low complexity region 63 73 N/A INTRINSIC
PDB:4IKF|B 84 289 3e-8 PDB
SCOP:d1exqa_ 145 297 4e-16 SMART
low complexity region 343 353 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000138142
Predicted Effect probably benign
Transcript: ENSMUST00000189031
Coding Region Coverage
  • 1x: 98.9%
  • 3x: 98.0%
  • 10x: 95.1%
  • 20x: 88.5%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 62 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca14 C T 7: 120,251,291 (GRCm38) P789S probably damaging Het
Adam17 T A 12: 21,334,138 (GRCm38) probably null Het
Afdn C T 17: 13,810,501 (GRCm38) R224W probably damaging Het
Als2 A G 1: 59,180,147 (GRCm38) Y1215H probably damaging Het
Anks1b A T 10: 90,042,548 (GRCm38) D73V probably damaging Het
Bpifb6 T C 2: 153,906,861 (GRCm38) F259S probably damaging Het
Cenpv A T 11: 62,525,176 (GRCm38) M249K probably benign Het
Ces1d C T 8: 93,186,118 (GRCm38) V231I probably benign Het
Clasp1 G A 1: 118,504,959 (GRCm38) V460I probably damaging Het
Cnot10 A T 9: 114,629,095 (GRCm38) Y114* probably null Het
Cpb1 G T 3: 20,263,782 (GRCm38) R193S probably benign Het
Ctc1 T C 11: 69,036,150 (GRCm38) S1207P possibly damaging Het
Cttnbp2 T A 6: 18,435,433 (GRCm38) K142M probably damaging Het
Dhrs7b T G 11: 60,851,891 (GRCm38) D136E probably benign Het
Dnah7b T C 1: 46,290,646 (GRCm38) S3217P probably damaging Het
Eif4g3 C T 4: 138,126,563 (GRCm38) S480L probably benign Het
Enah A T 1: 181,917,197 (GRCm38) probably null Het
Epx T C 11: 87,868,712 (GRCm38) D517G probably damaging Het
Gabrg2 T A 11: 41,976,663 (GRCm38) D43V probably damaging Het
Gdf9 A T 11: 53,437,511 (GRCm38) E431D possibly damaging Het
Ghr T C 15: 3,320,574 (GRCm38) D374G probably damaging Het
Greb1l A G 18: 10,529,703 (GRCm38) E786G possibly damaging Het
Grk4 T C 5: 34,731,538 (GRCm38) V342A probably benign Het
Hhipl2 A T 1: 183,423,524 (GRCm38) Y135F possibly damaging Het
Insig1 C T 5: 28,071,708 (GRCm38) R91W probably damaging Het
Kcnf1 C G 12: 17,175,732 (GRCm38) D163H probably benign Het
Kif11 A T 19: 37,387,200 (GRCm38) K190* probably null Het
Ldb2 T G 5: 44,473,472 (GRCm38) E309A probably damaging Het
Lipo4 T G 19: 33,512,673 (GRCm38) D143A probably damaging Het
Map3k6 T G 4: 133,252,473 (GRCm38) I1261S probably damaging Het
Mtus1 C T 8: 41,015,409 (GRCm38) V27I possibly damaging Het
Ndufaf2 C T 13: 108,091,573 (GRCm38) V60I probably benign Het
Nup133 A G 8: 123,949,035 (GRCm38) F48L probably benign Het
Olfr1131 T A 2: 87,628,977 (GRCm38) N171K probably benign Het
Olfr1357 G T 10: 78,612,140 (GRCm38) T167N probably benign Het
Olfr1362 A C 13: 21,611,764 (GRCm38) F68L probably benign Het
Pcdhb21 A T 18: 37,515,479 (GRCm38) N554Y probably damaging Het
Pcx A T 19: 4,603,159 (GRCm38) D284V possibly damaging Het
Pcyt1a T C 16: 32,467,119 (GRCm38) S203P probably damaging Het
Pdlim3 A T 8: 45,896,859 (GRCm38) I69F probably damaging Het
Pkp4 T C 2: 59,322,554 (GRCm38) V598A probably benign Het
Plbd1 T C 6: 136,612,306 (GRCm38) I509V probably benign Het
Polr3b C A 10: 84,652,783 (GRCm38) T319N probably benign Het
Ptprj T C 2: 90,463,320 (GRCm38) D380G probably benign Het
Ralgapa1 T G 12: 55,741,536 (GRCm38) R587S probably damaging Het
Scn5a C A 9: 119,486,092 (GRCm38) R1850L probably damaging Het
Ssc5d C A 7: 4,944,043 (GRCm38) T1132K probably benign Het
Stard7 T A 2: 127,295,486 (GRCm38) N285K possibly damaging Het
Tcp11l2 C T 10: 84,613,487 (GRCm38) R439W probably damaging Het
Tecrl T C 5: 83,280,508 (GRCm38) probably null Het
Tep1 A T 14: 50,824,563 (GRCm38) L2570Q probably null Het
Tex14 A T 11: 87,554,928 (GRCm38) D191V probably damaging Het
Tm7sf2 A G 19: 6,063,019 (GRCm38) probably null Het
Tmem132e A G 11: 82,437,370 (GRCm38) K408R probably benign Het
Tube1 A G 10: 39,144,766 (GRCm38) D216G possibly damaging Het
Ubap2 C T 4: 41,199,872 (GRCm38) A752T probably benign Het
Vmn2r82 A G 10: 79,379,419 (GRCm38) H412R possibly damaging Het
Wtip T C 7: 34,116,595 (GRCm38) E352G probably damaging Het
Xirp2 T A 2: 67,510,295 (GRCm38) L960* probably null Het
Zc3h11a A C 1: 133,624,687 (GRCm38) S561A probably benign Het
Zfhx2 A T 14: 55,062,985 (GRCm38) D2436E probably damaging Het
Zfp763 T C 17: 33,019,907 (GRCm38) H88R probably benign Het
Other mutations in Gin1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01479:Gin1 APN 1 97,792,372 (GRCm38) missense possibly damaging 0.95
IGL01508:Gin1 APN 1 97,777,437 (GRCm38) missense probably benign
IGL01874:Gin1 APN 1 97,783,072 (GRCm38) missense probably damaging 1.00
R0136:Gin1 UTSW 1 97,783,016 (GRCm38) missense possibly damaging 0.86
R0299:Gin1 UTSW 1 97,783,016 (GRCm38) missense possibly damaging 0.86
R1302:Gin1 UTSW 1 97,775,589 (GRCm38) nonsense probably null
R1675:Gin1 UTSW 1 97,786,055 (GRCm38) nonsense probably null
R1739:Gin1 UTSW 1 97,786,104 (GRCm38) missense probably damaging 0.99
R1769:Gin1 UTSW 1 97,792,437 (GRCm38) missense probably benign 0.02
R1817:Gin1 UTSW 1 97,785,226 (GRCm38) splice site probably null
R1818:Gin1 UTSW 1 97,785,226 (GRCm38) splice site probably null
R1819:Gin1 UTSW 1 97,785,226 (GRCm38) splice site probably null
R1907:Gin1 UTSW 1 97,775,447 (GRCm38) unclassified probably benign
R2325:Gin1 UTSW 1 97,792,561 (GRCm38) missense probably damaging 1.00
R4206:Gin1 UTSW 1 97,792,420 (GRCm38) missense possibly damaging 0.90
R4571:Gin1 UTSW 1 97,785,076 (GRCm38) missense probably damaging 1.00
R4576:Gin1 UTSW 1 97,792,339 (GRCm38) missense probably damaging 1.00
R4670:Gin1 UTSW 1 97,784,840 (GRCm38) missense probably damaging 1.00
R4671:Gin1 UTSW 1 97,784,840 (GRCm38) missense probably damaging 1.00
R5659:Gin1 UTSW 1 97,775,532 (GRCm38) missense possibly damaging 0.95
R6360:Gin1 UTSW 1 97,792,539 (GRCm38) missense possibly damaging 0.90
R7035:Gin1 UTSW 1 97,792,375 (GRCm38) missense possibly damaging 0.92
R7229:Gin1 UTSW 1 97,785,151 (GRCm38) missense probably benign 0.02
R8269:Gin1 UTSW 1 97,783,204 (GRCm38) missense probably damaging 0.98
R8877:Gin1 UTSW 1 97,783,216 (GRCm38) missense possibly damaging 0.47
R9149:Gin1 UTSW 1 97,783,094 (GRCm38) missense probably damaging 1.00
R9480:Gin1 UTSW 1 97,777,473 (GRCm38) missense probably damaging 1.00
R9643:Gin1 UTSW 1 97,784,773 (GRCm38) missense probably benign 0.08
R9697:Gin1 UTSW 1 97,785,172 (GRCm38) missense probably benign 0.00
R9787:Gin1 UTSW 1 97,775,486 (GRCm38) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CAGCTCAGGAGCAGTTCAATAATAGCA -3'
(R):5'- TTGTGGAAACTAACACCCTAGAGAGGT -3'

Sequencing Primer
(F):5'- GGAGCAGTTCAATAATAGCATTGCC -3'
(R):5'- GAGGTAGCAGATACTTACCCTG -3'
Posted On 2014-04-24