Mutagenetix > Incidental Mutations

Incidental Mutation 'R1607:Vmn2r82'

176561

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r82

Ensembl Gene

ENSMUSG00000091468

Gene Name

vomeronasal 2, receptor 82

Synonyms

EG624845

MMRRC Submission

039644-MU

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.071) question?

Stock #

R1607 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

79356576-79397198 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 79379419 bp

Zygosity

Heterozygous

Amino Acid Change

Histidine to Arginine at position 412 (H412R)

Ref Sequence

ENSEMBL: ENSMUSP00000130114 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000170596]

Predicted Effect

possibly damaging
Transcript: ENSMUST00000170596
AA Change: H412R

PolyPhen 2 Score 0.670 (Sensitivity: 0.86; Specificity: 0.91)

SMART Domains

Protein: ENSMUSP00000130114
Gene: ENSMUSG00000091468
AA Change: H412R

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	79	474	6e-35	PFAM
Pfam:NCD3G	517	570	9.3e-22	PFAM
Pfam:7tm_3	603	838	6.5e-49	PFAM

Coding Region Coverage

1x: 98.9%
3x: 98.0%
10x: 95.1%
20x: 88.5%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 62 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca14	C	T	7: 120,251,291	P789S	probably damaging	Het
Adam17	T	A	12: 21,334,138		probably null	Het
Afdn	C	T	17: 13,810,501	R224W	probably damaging	Het
Als2	A	G	1: 59,180,147	Y1215H	probably damaging	Het
Anks1b	A	T	10: 90,042,548	D73V	probably damaging	Het
Bpifb6	T	C	2: 153,906,861	F259S	probably damaging	Het
Cenpv	A	T	11: 62,525,176	M249K	probably benign	Het
Ces1d	C	T	8: 93,186,118	V231I	probably benign	Het
Clasp1	G	A	1: 118,504,959	V460I	probably damaging	Het
Cnot10	A	T	9: 114,629,095	Y114*	probably null	Het
Cpb1	G	T	3: 20,263,782	R193S	probably benign	Het
Ctc1	T	C	11: 69,036,150	S1207P	possibly damaging	Het
Cttnbp2	T	A	6: 18,435,433	K142M	probably damaging	Het
Dhrs7b	T	G	11: 60,851,891	D136E	probably benign	Het
Dnah7b	T	C	1: 46,290,646	S3217P	probably damaging	Het
Eif4g3	C	T	4: 138,126,563	S480L	probably benign	Het
Enah	A	T	1: 181,917,197		probably null	Het
Epx	T	C	11: 87,868,712	D517G	probably damaging	Het
Gabrg2	T	A	11: 41,976,663	D43V	probably damaging	Het
Gdf9	A	T	11: 53,437,511	E431D	possibly damaging	Het
Ghr	T	C	15: 3,320,574	D374G	probably damaging	Het
Gin1	A	T	1: 97,786,150	I392F	probably damaging	Het
Greb1l	A	G	18: 10,529,703	E786G	possibly damaging	Het
Grk4	T	C	5: 34,731,538	V342A	probably benign	Het
Hhipl2	A	T	1: 183,423,524	Y135F	possibly damaging	Het
Insig1	C	T	5: 28,071,708	R91W	probably damaging	Het
Kcnf1	C	G	12: 17,175,732	D163H	probably benign	Het
Kif11	A	T	19: 37,387,200	K190*	probably null	Het
Ldb2	T	G	5: 44,473,472	E309A	probably damaging	Het
Lipo4	T	G	19: 33,512,673	D143A	probably damaging	Het
Map3k6	T	G	4: 133,252,473	I1261S	probably damaging	Het
Mtus1	C	T	8: 41,015,409	V27I	possibly damaging	Het
Ndufaf2	C	T	13: 108,091,573	V60I	probably benign	Het
Nup133	A	G	8: 123,949,035	F48L	probably benign	Het
Olfr1131	T	A	2: 87,628,977	N171K	probably benign	Het
Olfr1357	G	T	10: 78,612,140	T167N	probably benign	Het
Olfr1362	A	C	13: 21,611,764	F68L	probably benign	Het
Pcdhb21	A	T	18: 37,515,479	N554Y	probably damaging	Het
Pcx	A	T	19: 4,603,159	D284V	possibly damaging	Het
Pcyt1a	T	C	16: 32,467,119	S203P	probably damaging	Het
Pdlim3	A	T	8: 45,896,859	I69F	probably damaging	Het
Pkp4	T	C	2: 59,322,554	V598A	probably benign	Het
Plbd1	T	C	6: 136,612,306	I509V	probably benign	Het
Polr3b	C	A	10: 84,652,783	T319N	probably benign	Het
Ptprj	T	C	2: 90,463,320	D380G	probably benign	Het
Ralgapa1	T	G	12: 55,741,536	R587S	probably damaging	Het
Scn5a	C	A	9: 119,486,092	R1850L	probably damaging	Het
Ssc5d	C	A	7: 4,944,043	T1132K	probably benign	Het
Stard7	T	A	2: 127,295,486	N285K	possibly damaging	Het
Tcp11l2	C	T	10: 84,613,487	R439W	probably damaging	Het
Tecrl	T	C	5: 83,280,508		probably null	Het
Tep1	A	T	14: 50,824,563	L2570Q	probably null	Het
Tex14	A	T	11: 87,554,928	D191V	probably damaging	Het
Tm7sf2	A	G	19: 6,063,019		probably null	Het
Tmem132e	A	G	11: 82,437,370	K408R	probably benign	Het
Tube1	A	G	10: 39,144,766	D216G	possibly damaging	Het
Ubap2	C	T	4: 41,199,872	A752T	probably benign	Het
Wtip	T	C	7: 34,116,595	E352G	probably damaging	Het
Xirp2	T	A	2: 67,510,295	L960*	probably null	Het
Zc3h11a	A	C	1: 133,624,687	S561A	probably benign	Het
Zfhx2	A	T	14: 55,062,985	D2436E	probably damaging	Het
Zfp763	T	C	17: 33,019,907	H88R	probably benign	Het

Other mutations in Vmn2r82

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01800:Vmn2r82	APN	10	79356747	missense	probably benign	0.03
IGL01860:Vmn2r82	APN	10	79378857	missense	probably benign	0.18
IGL01927:Vmn2r82	APN	10	79378072	missense	probably damaging	1.00
IGL01929:Vmn2r82	APN	10	79378711	missense	probably damaging	1.00
IGL02028:Vmn2r82	APN	10	79379223	missense	probably benign
IGL02112:Vmn2r82	APN	10	79395999	missense	probably benign	0.19
IGL02632:Vmn2r82	APN	10	79356708	missense	probably benign	0.45
IGL02665:Vmn2r82	APN	10	79379371	missense	probably damaging	0.99
IGL02716:Vmn2r82	APN	10	79377844	missense	probably benign	0.20
IGL03030:Vmn2r82	APN	10	79381315	missense	possibly damaging	0.85
IGL03190:Vmn2r82	APN	10	79356809	splice site	probably null
IGL03349:Vmn2r82	APN	10	79377869	missense	probably benign	0.25
IGL03048:Vmn2r82	UTSW	10	79396626	missense	probably damaging	0.98
R0080:Vmn2r82	UTSW	10	79396505	missense	probably benign	0.00
R0193:Vmn2r82	UTSW	10	79381295	missense	probably damaging	1.00
R0217:Vmn2r82	UTSW	10	79378800	missense	possibly damaging	0.46
R0285:Vmn2r82	UTSW	10	79396557	missense	probably damaging	1.00
R1193:Vmn2r82	UTSW	10	79377905	nonsense	probably null
R1385:Vmn2r82	UTSW	10	79396491	nonsense	probably null
R1386:Vmn2r82	UTSW	10	79378711	missense	probably damaging	1.00
R1442:Vmn2r82	UTSW	10	79379367	missense	probably benign	0.03
R1467:Vmn2r82	UTSW	10	79396299	missense	probably benign	0.00
R1467:Vmn2r82	UTSW	10	79396299	missense	probably benign	0.00
R1518:Vmn2r82	UTSW	10	79378868	missense	probably damaging	1.00
R1538:Vmn2r82	UTSW	10	79356744	missense	possibly damaging	0.92
R1812:Vmn2r82	UTSW	10	79379212	missense	probably benign	0.33
R1906:Vmn2r82	UTSW	10	79396510	missense	probably damaging	1.00
R1954:Vmn2r82	UTSW	10	79396056	missense	probably damaging	1.00
R1972:Vmn2r82	UTSW	10	79378846	missense	probably damaging	1.00
R2093:Vmn2r82	UTSW	10	79395979	missense	probably benign	0.30
R2156:Vmn2r82	UTSW	10	79378888	missense	probably damaging	1.00
R2202:Vmn2r82	UTSW	10	79356685	missense	probably benign
R2442:Vmn2r82	UTSW	10	79385376	missense	probably damaging	1.00
R2444:Vmn2r82	UTSW	10	79377868	missense	possibly damaging	0.65
R2857:Vmn2r82	UTSW	10	79381256	missense	probably damaging	0.98
R2858:Vmn2r82	UTSW	10	79381256	missense	probably damaging	0.98
R2884:Vmn2r82	UTSW	10	79396248	missense	probably benign	0.00
R2886:Vmn2r82	UTSW	10	79396248	missense	probably benign	0.00
R4369:Vmn2r82	UTSW	10	79396080	missense	probably benign	0.01
R4445:Vmn2r82	UTSW	10	79379040	missense	possibly damaging	0.87
R4589:Vmn2r82	UTSW	10	79356714	missense	probably damaging	1.00
R4703:Vmn2r82	UTSW	10	79378807	missense	probably damaging	1.00
R4908:Vmn2r82	UTSW	10	79378755	missense	probably benign	0.00
R4937:Vmn2r82	UTSW	10	79379176	missense	probably benign	0.01
R5199:Vmn2r82	UTSW	10	79396087	missense	probably damaging	1.00
R5391:Vmn2r82	UTSW	10	79356657	missense	probably null	0.01
R5601:Vmn2r82	UTSW	10	79396191	missense	probably damaging	1.00
R5635:Vmn2r82	UTSW	10	79378818	missense	probably benign	0.33
R6065:Vmn2r82	UTSW	10	79385376	missense	probably damaging	1.00
R6074:Vmn2r82	UTSW	10	79396543	missense	probably damaging	1.00
R6340:Vmn2r82	UTSW	10	79395893	missense	probably benign	0.00
R6474:Vmn2r82	UTSW	10	79379037	missense	possibly damaging	0.55
R6995:Vmn2r82	UTSW	10	79396543	missense	probably damaging	1.00
R7111:Vmn2r82	UTSW	10	79378771	missense	probably benign	0.22
R7212:Vmn2r82	UTSW	10	79379434	missense	probably benign	0.00
R7335:Vmn2r82	UTSW	10	79378888	missense	probably damaging	1.00
R7353:Vmn2r82	UTSW	10	79396618	missense	probably benign	0.11
R7354:Vmn2r82	UTSW	10	79356630	missense	probably benign	0.00
R7362:Vmn2r82	UTSW	10	79396617	missense	probably benign	0.00
R7378:Vmn2r82	UTSW	10	79396442	nonsense	probably null
R7430:Vmn2r82	UTSW	10	79381253	missense	probably damaging	1.00
R7509:Vmn2r82	UTSW	10	79396008	missense	possibly damaging	0.82
R7874:Vmn2r82	UTSW	10	79396511	missense	probably damaging	1.00
R7943:Vmn2r82	UTSW	10	79396245	missense	possibly damaging	0.74
R8158:Vmn2r82	UTSW	10	79377802	missense	probably benign	0.12
R8324:Vmn2r82	UTSW	10	79378893	nonsense	probably null
R8340:Vmn2r82	UTSW	10	79381202	missense	probably benign	0.00
Z1088:Vmn2r82	UTSW	10	79356622	missense	probably damaging	1.00
Z1177:Vmn2r82	UTSW	10	79356595	missense	probably benign	0.03
Z1177:Vmn2r82	UTSW	10	79396535	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- AGAATCATCGACCGCAGACGTG -3'
(R):5'- CTGTTAAATGCAATCTTCCACAGGTGC -3'

Sequencing Primer
(F):5'- ACCCCATTATGAGGAGATTGCTG -3'
(R):5'- TGTACATTGATATCTAGGCACCG -3'

Posted On

2014-04-24