Incidental Mutation 'R1609:Vmn1r22'
| ID |
176670 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn1r22
|
| Ensembl Gene |
ENSMUSG00000115091 |
| Gene Name |
vomeronasal 1 receptor 22 |
| Synonyms |
V1rc23 |
| MMRRC Submission |
039646-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.095)
|
| Stock # |
R1609 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
6 |
| Chromosomal Location |
57877067-57877975 bp(-) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
G to T
at 57877733 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Stop codon
at position 81
(Y81*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000154301
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000177435]
[ENSMUST00000227342]
[ENSMUST00000227650]
[ENSMUST00000228076]
[ENSMUST00000228257]
[ENSMUST00000228322]
[ENSMUST00000228905]
|
| AlphaFold |
Q8R2D1 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000177435
AA Change: Y81*
|
| SMART Domains |
Protein: ENSMUSP00000135207
Gene: ENSMUSG00000114982
AA Change: Y81*
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:V1R
|
28 |
293 |
3.9e-57 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000227342
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000227650
AA Change: Y81*
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000228076
AA Change: Y81*
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000228257
AA Change: Y81*
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000228322
AA Change: Y81*
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000228905
|
| Meta Mutation Damage Score |
0.9755 |
| Coding Region Coverage |
- 1x: 98.9%
- 3x: 98.0%
- 10x: 95.1%
- 20x: 88.1%
|
| Validation Efficiency |
96% (49/51) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 38 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acot2 |
C |
T |
12: 84,039,630 (GRCm39) |
R380C |
possibly damaging |
Het |
| Allc |
A |
T |
12: 28,603,993 (GRCm39) |
D363E |
probably damaging |
Het |
| Anxa2 |
TCCC |
TCC |
9: 69,397,036 (GRCm39) |
|
probably null |
Het |
| App |
C |
A |
16: 84,876,837 (GRCm39) |
V185L |
probably damaging |
Het |
| Atp5if1 |
T |
C |
4: 132,258,078 (GRCm39) |
D47G |
probably benign |
Het |
| Auh |
G |
A |
13: 52,989,532 (GRCm39) |
P308L |
probably benign |
Het |
| Cbr4 |
T |
A |
8: 61,956,192 (GRCm39) |
Y220N |
probably damaging |
Het |
| Ccdc6 |
C |
A |
10: 70,002,877 (GRCm39) |
Q203K |
probably damaging |
Het |
| Cntnap2 |
T |
C |
6: 45,992,264 (GRCm39) |
V397A |
probably benign |
Het |
| Dmxl2 |
A |
G |
9: 54,316,547 (GRCm39) |
I1613T |
possibly damaging |
Het |
| Dnah14 |
T |
C |
1: 181,577,742 (GRCm39) |
S3020P |
probably damaging |
Het |
| Dnah7b |
T |
C |
1: 46,392,126 (GRCm39) |
L3829P |
probably damaging |
Het |
| Fbxw25 |
C |
T |
9: 109,492,578 (GRCm39) |
C53Y |
probably benign |
Het |
| Fndc1 |
G |
T |
17: 7,991,598 (GRCm39) |
H699Q |
unknown |
Het |
| Gnaq |
G |
A |
19: 16,360,618 (GRCm39) |
V314M |
possibly damaging |
Het |
| Gpr158 |
A |
G |
2: 21,788,104 (GRCm39) |
T582A |
possibly damaging |
Het |
| Mapk1 |
T |
C |
16: 16,856,170 (GRCm39) |
|
probably benign |
Het |
| Med1 |
T |
A |
11: 98,051,996 (GRCm39) |
H456L |
possibly damaging |
Het |
| Myo6 |
G |
A |
9: 80,195,499 (GRCm39) |
|
probably null |
Het |
| Nipbl |
A |
G |
15: 8,396,148 (GRCm39) |
Y142H |
probably damaging |
Het |
| Or4c113 |
A |
T |
2: 88,885,688 (GRCm39) |
F27L |
probably benign |
Het |
| Or8k24 |
A |
G |
2: 86,215,838 (GRCm39) |
I308T |
probably benign |
Het |
| Or8k33 |
A |
C |
2: 86,383,949 (GRCm39) |
V173G |
probably damaging |
Het |
| Pgbd5 |
T |
C |
8: 125,160,750 (GRCm39) |
D39G |
probably benign |
Het |
| Pnisr |
G |
T |
4: 21,871,440 (GRCm39) |
G387* |
probably null |
Het |
| Pnpla6 |
T |
C |
8: 3,567,135 (GRCm39) |
L61P |
probably damaging |
Het |
| Prkra |
A |
T |
2: 76,463,936 (GRCm39) |
I242N |
probably benign |
Het |
| Rp1 |
A |
G |
1: 4,419,424 (GRCm39) |
S563P |
probably damaging |
Het |
| Rtp3 |
A |
G |
9: 110,815,085 (GRCm39) |
|
probably benign |
Het |
| Sema3d |
A |
G |
5: 12,591,023 (GRCm39) |
T301A |
probably damaging |
Het |
| Setmar |
A |
G |
6: 108,053,076 (GRCm39) |
D190G |
probably benign |
Het |
| Sf3b2 |
A |
G |
19: 5,345,061 (GRCm39) |
|
probably benign |
Het |
| Taf4b |
A |
G |
18: 14,968,938 (GRCm39) |
K692E |
probably damaging |
Het |
| Tktl2 |
A |
G |
8: 66,965,504 (GRCm39) |
E354G |
probably benign |
Het |
| Tspan4 |
A |
G |
7: 141,071,557 (GRCm39) |
T135A |
probably damaging |
Het |
| Vmn2r31 |
T |
C |
7: 7,387,888 (GRCm39) |
E561G |
probably damaging |
Het |
| Xrn1 |
A |
T |
9: 95,856,946 (GRCm39) |
K389N |
probably benign |
Het |
| Zfp277 |
A |
T |
12: 40,378,719 (GRCm39) |
N379K |
probably damaging |
Het |
|
| Other mutations in Vmn1r22 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
R0089:Vmn1r22
|
UTSW |
6 |
57,877,513 (GRCm39) |
missense |
probably benign |
0.06 |
|
R0415:Vmn1r22
|
UTSW |
6 |
57,877,317 (GRCm39) |
missense |
probably benign |
0.18 |
|
R1132:Vmn1r22
|
UTSW |
6 |
57,877,826 (GRCm39) |
missense |
probably benign |
0.43 |
|
R1666:Vmn1r22
|
UTSW |
6 |
57,877,704 (GRCm39) |
missense |
probably benign |
0.07 |
|
R1668:Vmn1r22
|
UTSW |
6 |
57,877,704 (GRCm39) |
missense |
probably benign |
0.07 |
|
R1708:Vmn1r22
|
UTSW |
6 |
57,877,481 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R1796:Vmn1r22
|
UTSW |
6 |
57,877,134 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2359:Vmn1r22
|
UTSW |
6 |
57,877,974 (GRCm39) |
start codon destroyed |
probably null |
1.00 |
|
R4600:Vmn1r22
|
UTSW |
6 |
57,877,860 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5302:Vmn1r22
|
UTSW |
6 |
57,877,960 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R5560:Vmn1r22
|
UTSW |
6 |
57,877,723 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6026:Vmn1r22
|
UTSW |
6 |
57,877,390 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6066:Vmn1r22
|
UTSW |
6 |
57,877,864 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6343:Vmn1r22
|
UTSW |
6 |
57,877,563 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R6639:Vmn1r22
|
UTSW |
6 |
57,877,699 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7106:Vmn1r22
|
UTSW |
6 |
57,877,296 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7683:Vmn1r22
|
UTSW |
6 |
57,877,404 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8126:Vmn1r22
|
UTSW |
6 |
57,877,669 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R9216:Vmn1r22
|
UTSW |
6 |
57,877,257 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R9486:Vmn1r22
|
UTSW |
6 |
57,877,404 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9707:Vmn1r22
|
UTSW |
6 |
57,877,890 (GRCm39) |
missense |
probably benign |
0.37 |
|
R9722:Vmn1r22
|
UTSW |
6 |
57,877,631 (GRCm39) |
missense |
probably benign |
0.04 |
|
S24628:Vmn1r22
|
UTSW |
6 |
57,877,317 (GRCm39) |
missense |
probably benign |
0.18 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGTGGTCAGCATGACTCCTACAAGAAA -3'
(R):5'- ACTCAGGTGAAATGCAGGGAAAATGT -3'
Sequencing Primer
(F):5'- GGTCTCACTCCTATTGTTAAAACCAC -3'
(R):5'- GGAGTTCTAGCCAATATGTTTCTAC -3'
|
| Posted On |
2014-04-24 |
Incidental Mutation