Incidental Mutation 'R1609:Vmn2r31'
ID 176673
Institutional Source Beutler Lab
Gene Symbol Vmn2r31
Ensembl Gene ENSMUSG00000096373
Gene Name vomeronasal 2, receptor 31
Synonyms
MMRRC Submission 039646-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.192) question?
Stock # R1609 (G1)
Quality Score 141
Status Validated
Chromosome 7
Chromosomal Location 7386984-7402626 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 7387888 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 561 (E561G)
Ref Sequence ENSEMBL: ENSMUSP00000074613 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000075108]
AlphaFold L7N1Z4
Predicted Effect probably damaging
Transcript: ENSMUST00000075108
AA Change: E561G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000074613
Gene: ENSMUSG00000096373
AA Change: E561G

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:ANF_receptor 73 469 1e-33 PFAM
Pfam:NCD3G 512 565 1.4e-20 PFAM
Pfam:7tm_3 598 833 8.1e-55 PFAM
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 98.9%
  • 3x: 98.0%
  • 10x: 95.1%
  • 20x: 88.1%
Validation Efficiency 96% (49/51)
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acot2 C T 12: 84,039,630 (GRCm39) R380C possibly damaging Het
Allc A T 12: 28,603,993 (GRCm39) D363E probably damaging Het
Anxa2 TCCC TCC 9: 69,397,036 (GRCm39) probably null Het
App C A 16: 84,876,837 (GRCm39) V185L probably damaging Het
Atp5if1 T C 4: 132,258,078 (GRCm39) D47G probably benign Het
Auh G A 13: 52,989,532 (GRCm39) P308L probably benign Het
Cbr4 T A 8: 61,956,192 (GRCm39) Y220N probably damaging Het
Ccdc6 C A 10: 70,002,877 (GRCm39) Q203K probably damaging Het
Cntnap2 T C 6: 45,992,264 (GRCm39) V397A probably benign Het
Dmxl2 A G 9: 54,316,547 (GRCm39) I1613T possibly damaging Het
Dnah14 T C 1: 181,577,742 (GRCm39) S3020P probably damaging Het
Dnah7b T C 1: 46,392,126 (GRCm39) L3829P probably damaging Het
Fbxw25 C T 9: 109,492,578 (GRCm39) C53Y probably benign Het
Fndc1 G T 17: 7,991,598 (GRCm39) H699Q unknown Het
Gnaq G A 19: 16,360,618 (GRCm39) V314M possibly damaging Het
Gpr158 A G 2: 21,788,104 (GRCm39) T582A possibly damaging Het
Mapk1 T C 16: 16,856,170 (GRCm39) probably benign Het
Med1 T A 11: 98,051,996 (GRCm39) H456L possibly damaging Het
Myo6 G A 9: 80,195,499 (GRCm39) probably null Het
Nipbl A G 15: 8,396,148 (GRCm39) Y142H probably damaging Het
Or4c113 A T 2: 88,885,688 (GRCm39) F27L probably benign Het
Or8k24 A G 2: 86,215,838 (GRCm39) I308T probably benign Het
Or8k33 A C 2: 86,383,949 (GRCm39) V173G probably damaging Het
Pgbd5 T C 8: 125,160,750 (GRCm39) D39G probably benign Het
Pnisr G T 4: 21,871,440 (GRCm39) G387* probably null Het
Pnpla6 T C 8: 3,567,135 (GRCm39) L61P probably damaging Het
Prkra A T 2: 76,463,936 (GRCm39) I242N probably benign Het
Rp1 A G 1: 4,419,424 (GRCm39) S563P probably damaging Het
Rtp3 A G 9: 110,815,085 (GRCm39) probably benign Het
Sema3d A G 5: 12,591,023 (GRCm39) T301A probably damaging Het
Setmar A G 6: 108,053,076 (GRCm39) D190G probably benign Het
Sf3b2 A G 19: 5,345,061 (GRCm39) probably benign Het
Taf4b A G 18: 14,968,938 (GRCm39) K692E probably damaging Het
Tktl2 A G 8: 66,965,504 (GRCm39) E354G probably benign Het
Tspan4 A G 7: 141,071,557 (GRCm39) T135A probably damaging Het
Vmn1r22 G T 6: 57,877,733 (GRCm39) Y81* probably null Het
Xrn1 A T 9: 95,856,946 (GRCm39) K389N probably benign Het
Zfp277 A T 12: 40,378,719 (GRCm39) N379K probably damaging Het
Other mutations in Vmn2r31
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01104:Vmn2r31 APN 7 7,399,565 (GRCm39) missense probably damaging 0.98
IGL01536:Vmn2r31 APN 7 7,387,847 (GRCm39) missense probably damaging 1.00
IGL01985:Vmn2r31 APN 7 7,397,510 (GRCm39) missense probably benign
IGL02116:Vmn2r31 APN 7 7,397,548 (GRCm39) missense probably damaging 0.97
FR4304:Vmn2r31 UTSW 7 7,387,607 (GRCm39) missense probably damaging 1.00
R4647:Vmn2r31 UTSW 7 7,387,367 (GRCm39) missense probably damaging 1.00
R4724:Vmn2r31 UTSW 7 7,387,757 (GRCm39) missense possibly damaging 0.63
R4824:Vmn2r31 UTSW 7 7,390,062 (GRCm39) critical splice donor site probably null
R5619:Vmn2r31 UTSW 7 7,387,529 (GRCm39) nonsense probably null
R6225:Vmn2r31 UTSW 7 7,397,638 (GRCm39) missense probably benign 0.19
R6610:Vmn2r31 UTSW 7 7,387,588 (GRCm39) missense probably damaging 0.97
R6956:Vmn2r31 UTSW 7 7,397,505 (GRCm39) missense probably benign
R7111:Vmn2r31 UTSW 7 7,399,480 (GRCm39) missense probably damaging 0.99
R7219:Vmn2r31 UTSW 7 7,397,397 (GRCm39) missense probably damaging 0.97
R7219:Vmn2r31 UTSW 7 7,390,105 (GRCm39) missense probably benign
R7300:Vmn2r31 UTSW 7 7,387,775 (GRCm39) missense possibly damaging 0.61
R7395:Vmn2r31 UTSW 7 7,387,744 (GRCm39) missense probably damaging 1.00
R7481:Vmn2r31 UTSW 7 7,387,579 (GRCm39) missense possibly damaging 0.94
R8015:Vmn2r31 UTSW 7 7,387,199 (GRCm39) missense probably damaging 1.00
R8434:Vmn2r31 UTSW 7 7,387,699 (GRCm39) missense probably damaging 1.00
R8781:Vmn2r31 UTSW 7 7,387,400 (GRCm39) missense possibly damaging 0.65
R8972:Vmn2r31 UTSW 7 7,399,654 (GRCm39) missense probably benign 0.00
R9034:Vmn2r31 UTSW 7 7,397,680 (GRCm39) missense probably benign 0.08
R9596:Vmn2r31 UTSW 7 7,397,292 (GRCm39) missense probably benign 0.01
R9711:Vmn2r31 UTSW 7 7,387,085 (GRCm39) missense probably damaging 0.99
R9714:Vmn2r31 UTSW 7 7,387,367 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GGTGGCTCTGTTAGGATGACCAATG -3'
(R):5'- TGGATTGAAAGCAATGCTCAGCAAC -3'

Sequencing Primer
(F):5'- CTGTTATTGGCCTTCACAATAGG -3'
(R):5'- GCAACAATATCCTTCACGTTACATTC -3'
Posted On 2014-04-24