Incidental Mutation 'R1610:Selenoo'
ID |
176757 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Selenoo
|
Ensembl Gene |
ENSMUSG00000035757 |
Gene Name |
selenoprotein O |
Synonyms |
Selo, 1300018J18Rik |
MMRRC Submission |
039647-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.101)
|
Stock # |
R1610 (G1)
|
Quality Score |
225 |
Status
|
Not validated
|
Chromosome |
15 |
Chromosomal Location |
88973287-88984543 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to G
at 88984119 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Glutamic Acid to Glycine
at position 645
(E645G)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000081020
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000041656]
[ENSMUST00000082439]
[ENSMUST00000109353]
[ENSMUST00000130700]
[ENSMUST00000166480]
|
AlphaFold |
no structure available at present |
Predicted Effect |
probably benign
Transcript: ENSMUST00000041656
|
SMART Domains |
Protein: ENSMUSP00000040132 Gene: ENSMUSG00000051786
Domain | Start | End | E-Value | Type |
Pfam:Spc97_Spc98
|
355 |
1667 |
3.3e-119 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000082439
AA Change: E645G
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
SMART Domains |
Protein: ENSMUSP00000081020 Gene: ENSMUSG00000035757 AA Change: E645G
Domain | Start | End | E-Value | Type |
low complexity region
|
24 |
38 |
N/A |
INTRINSIC |
Pfam:UPF0061
|
79 |
625 |
8.3e-131 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000109353
|
SMART Domains |
Protein: ENSMUSP00000104977 Gene: ENSMUSG00000051786
Domain | Start | End | E-Value | Type |
Pfam:Spc97_Spc98
|
355 |
1675 |
2.8e-94 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000130700
|
SMART Domains |
Protein: ENSMUSP00000138382 Gene: ENSMUSG00000035757
Domain | Start | End | E-Value | Type |
low complexity region
|
24 |
38 |
N/A |
INTRINSIC |
Pfam:UPF0061
|
80 |
241 |
1.5e-39 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000163290
|
SMART Domains |
Protein: ENSMUSP00000131359 Gene: ENSMUSG00000051786
Domain | Start | End | E-Value | Type |
Pfam:Spc97_Spc98
|
91 |
288 |
2.9e-37 |
PFAM |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000164717
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000169208
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000166994
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000168256
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000169069
|
SMART Domains |
Protein: ENSMUSP00000132786 Gene: ENSMUSG00000051786
Domain | Start | End | E-Value | Type |
coiled coil region
|
77 |
107 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000166480
|
SMART Domains |
Protein: ENSMUSP00000132108 Gene: ENSMUSG00000051786
Domain | Start | End | E-Value | Type |
Pfam:Spc97_Spc98
|
2 |
123 |
5e-18 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000170877
|
Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.4%
- 10x: 96.5%
- 20x: 93.1%
|
Validation Efficiency |
|
MGI Phenotype |
FUNCTION: This gene encodes a selenoprotein that is localized to the mitochondria. It is the largest mammalian selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. The exact function of this selenoprotein is not known, but it is thought to have redox activity. [provided by RefSeq, Jan 2017]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 54 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Acbd5 |
G |
A |
2: 22,980,563 (GRCm39) |
C312Y |
probably damaging |
Het |
Adgrl1 |
T |
A |
8: 84,659,002 (GRCm39) |
M601K |
probably benign |
Het |
Agbl4 |
G |
A |
4: 111,514,365 (GRCm39) |
E459K |
probably benign |
Het |
Anxa2 |
TCCC |
TCC |
9: 69,397,036 (GRCm39) |
|
probably null |
Het |
Casz1 |
C |
T |
4: 149,013,544 (GRCm39) |
A36V |
possibly damaging |
Het |
Cfap20dc |
G |
T |
14: 8,511,110 (GRCm38) |
H435N |
probably benign |
Het |
Chpf |
A |
G |
1: 75,453,292 (GRCm39) |
V327A |
probably damaging |
Het |
Cldn23 |
A |
G |
8: 36,293,084 (GRCm39) |
Y135H |
probably damaging |
Het |
Cobll1 |
C |
T |
2: 64,963,986 (GRCm39) |
D211N |
probably damaging |
Het |
Cramp1 |
A |
G |
17: 25,202,925 (GRCm39) |
V368A |
probably benign |
Het |
Dnah6 |
T |
C |
6: 73,121,946 (GRCm39) |
T1374A |
probably benign |
Het |
Dpyd |
A |
G |
3: 118,858,655 (GRCm39) |
H623R |
probably benign |
Het |
Dyrk2 |
T |
C |
10: 118,695,830 (GRCm39) |
N476S |
probably benign |
Het |
Endog |
A |
T |
2: 30,063,899 (GRCm39) |
I267F |
probably damaging |
Het |
Ephb6 |
A |
T |
6: 41,591,307 (GRCm39) |
K155* |
probably null |
Het |
Far2 |
T |
C |
6: 148,058,956 (GRCm39) |
V214A |
possibly damaging |
Het |
Fat2 |
A |
G |
11: 55,169,750 (GRCm39) |
V3003A |
probably damaging |
Het |
Frg2f1 |
T |
A |
4: 119,388,485 (GRCm39) |
T5S |
possibly damaging |
Het |
Gm14496 |
A |
T |
2: 181,637,972 (GRCm39) |
T349S |
probably benign |
Het |
Golgb1 |
A |
G |
16: 36,746,463 (GRCm39) |
T2951A |
probably benign |
Het |
Hc |
G |
T |
2: 34,896,173 (GRCm39) |
D1203E |
probably benign |
Het |
Isg20 |
C |
A |
7: 78,564,257 (GRCm39) |
Q55K |
possibly damaging |
Het |
Jph4 |
G |
T |
14: 55,351,560 (GRCm39) |
A152E |
probably damaging |
Het |
Kcnq3 |
T |
C |
15: 65,897,109 (GRCm39) |
T264A |
probably damaging |
Het |
Kcnq5 |
T |
G |
1: 21,527,685 (GRCm39) |
T463P |
probably damaging |
Het |
Klra8 |
A |
G |
6: 130,095,981 (GRCm39) |
S204P |
probably damaging |
Het |
Ldlrad1 |
A |
G |
4: 107,072,072 (GRCm39) |
D98G |
probably damaging |
Het |
Lhfpl4 |
T |
C |
6: 113,171,097 (GRCm39) |
T30A |
possibly damaging |
Het |
Lig1 |
T |
A |
7: 13,019,266 (GRCm39) |
L80Q |
probably damaging |
Het |
Lmbrd2 |
A |
G |
15: 9,186,699 (GRCm39) |
Y558C |
probably benign |
Het |
Lrrn3 |
G |
T |
12: 41,502,992 (GRCm39) |
L442I |
possibly damaging |
Het |
Mc2r |
A |
G |
18: 68,540,519 (GRCm39) |
F258S |
probably damaging |
Het |
Mmp16 |
A |
G |
4: 18,011,582 (GRCm39) |
T137A |
probably benign |
Het |
Nfatc2ip |
A |
T |
7: 125,986,579 (GRCm39) |
S359T |
probably damaging |
Het |
Nup214 |
C |
T |
2: 31,924,478 (GRCm39) |
S1669F |
probably damaging |
Het |
Nup50l |
G |
T |
6: 96,142,270 (GRCm39) |
P258Q |
probably damaging |
Het |
Or10a48 |
T |
A |
7: 108,425,131 (GRCm39) |
H25L |
probably benign |
Het |
Or4c15b |
T |
C |
2: 89,113,165 (GRCm39) |
H104R |
probably damaging |
Het |
Or4s2b |
A |
T |
2: 88,508,918 (GRCm39) |
K233* |
probably null |
Het |
Or8b1b |
C |
T |
9: 38,375,927 (GRCm39) |
L197F |
probably damaging |
Het |
Pacc1 |
A |
G |
1: 191,077,262 (GRCm39) |
D195G |
probably benign |
Het |
Plagl1 |
C |
T |
10: 13,004,706 (GRCm39) |
|
probably benign |
Het |
Plxnb2 |
A |
T |
15: 89,042,696 (GRCm39) |
S1531T |
probably damaging |
Het |
Ptpn22 |
G |
A |
3: 103,809,512 (GRCm39) |
|
probably null |
Het |
Rtn1 |
T |
A |
12: 72,266,053 (GRCm39) |
Q174L |
possibly damaging |
Het |
Serpina1a |
A |
C |
12: 103,820,096 (GRCm39) |
D383E |
possibly damaging |
Het |
Slc6a18 |
T |
A |
13: 73,816,344 (GRCm39) |
Y345F |
probably benign |
Het |
Smbd1 |
A |
G |
16: 32,627,135 (GRCm39) |
V51A |
possibly damaging |
Het |
Tchh |
C |
T |
3: 93,352,146 (GRCm39) |
R529W |
unknown |
Het |
Tonsl |
A |
T |
15: 76,522,757 (GRCm39) |
Y165N |
probably damaging |
Het |
Trdmt1 |
G |
A |
2: 13,520,870 (GRCm39) |
T344I |
probably damaging |
Het |
Ubash3b |
C |
A |
9: 40,954,796 (GRCm39) |
R116L |
probably damaging |
Het |
Vmn2r94 |
A |
G |
17: 18,463,995 (GRCm39) |
V765A |
probably damaging |
Het |
Zfp474 |
C |
T |
18: 52,771,437 (GRCm39) |
T30I |
probably benign |
Het |
|
Other mutations in Selenoo |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00496:Selenoo
|
APN |
15 |
88,979,875 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01922:Selenoo
|
APN |
15 |
88,983,852 (GRCm39) |
missense |
probably benign |
0.06 |
IGL02103:Selenoo
|
APN |
15 |
88,984,173 (GRCm39) |
missense |
probably damaging |
1.00 |
R0655:Selenoo
|
UTSW |
15 |
88,979,858 (GRCm39) |
missense |
probably damaging |
1.00 |
R0960:Selenoo
|
UTSW |
15 |
88,980,957 (GRCm39) |
missense |
probably benign |
0.08 |
R2152:Selenoo
|
UTSW |
15 |
88,983,485 (GRCm39) |
missense |
probably benign |
0.01 |
R4177:Selenoo
|
UTSW |
15 |
88,983,662 (GRCm39) |
unclassified |
probably benign |
|
R4588:Selenoo
|
UTSW |
15 |
88,980,921 (GRCm39) |
missense |
probably benign |
0.01 |
R4622:Selenoo
|
UTSW |
15 |
88,979,910 (GRCm39) |
nonsense |
probably null |
|
R4731:Selenoo
|
UTSW |
15 |
88,983,531 (GRCm39) |
missense |
probably benign |
0.00 |
R4926:Selenoo
|
UTSW |
15 |
88,983,881 (GRCm39) |
missense |
probably damaging |
0.98 |
R4934:Selenoo
|
UTSW |
15 |
88,982,970 (GRCm39) |
missense |
probably damaging |
0.98 |
R4999:Selenoo
|
UTSW |
15 |
88,978,387 (GRCm39) |
missense |
probably damaging |
1.00 |
R5000:Selenoo
|
UTSW |
15 |
88,978,387 (GRCm39) |
missense |
probably damaging |
1.00 |
R5033:Selenoo
|
UTSW |
15 |
88,976,969 (GRCm39) |
missense |
probably damaging |
1.00 |
R5120:Selenoo
|
UTSW |
15 |
88,978,508 (GRCm39) |
missense |
possibly damaging |
0.79 |
R6034:Selenoo
|
UTSW |
15 |
88,983,546 (GRCm39) |
missense |
probably benign |
0.00 |
R6034:Selenoo
|
UTSW |
15 |
88,983,546 (GRCm39) |
missense |
probably benign |
0.00 |
R7238:Selenoo
|
UTSW |
15 |
88,973,427 (GRCm39) |
missense |
probably benign |
0.15 |
R7287:Selenoo
|
UTSW |
15 |
88,982,903 (GRCm39) |
missense |
probably benign |
0.01 |
R7378:Selenoo
|
UTSW |
15 |
88,973,681 (GRCm39) |
missense |
probably benign |
0.07 |
R7818:Selenoo
|
UTSW |
15 |
88,981,019 (GRCm39) |
missense |
probably damaging |
1.00 |
R8058:Selenoo
|
UTSW |
15 |
88,976,942 (GRCm39) |
missense |
possibly damaging |
0.95 |
R9233:Selenoo
|
UTSW |
15 |
88,984,044 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Predicted Primers |
PCR Primer
(F):5'- GCCATTGAAGCTGCTGAAAATGGAG -3'
(R):5'- AGCATGAAGCACTGTGTGCTAAGG -3'
Sequencing Primer
(F):5'- GACTTTTCAGAGGCAAGCAC -3'
(R):5'- CAGGTTTTGACTGGAGACCTC -3'
|
Posted On |
2014-04-24 |