Mutagenetix > Incidental Mutation

Incidental Mutation 'R1610:Vmn2r94'

176761

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r94

Ensembl Gene

ENSMUSG00000090417

Gene Name

vomeronasal 2, receptor 94

Synonyms

EG665227

MMRRC Submission

039647-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.105) question?

Stock #

R1610 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

18240994-18277756 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 18243733 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Valine to Alanine at position 765 (V765A)

Ref Sequence

ENSEMBL: ENSMUSP00000126386 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000172190] [ENSMUST00000231457] [ENSMUST00000231815]

AlphaFold

E9PZK8

Predicted Effect

probably damaging
Transcript: ENSMUST00000172190
AA Change: V765A

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000126386
Gene: ENSMUSG00000090417
AA Change: V765A

Domain	Start	End	E-Value	Type
Pfam:ANF_receptor	42	425	1.7e-35	PFAM
Pfam:NCD3G	469	522	3.5e-21	PFAM
Pfam:7tm_3	553	790	1.7e-51	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000231457

Predicted Effect

probably benign
Transcript: ENSMUST00000231815

Coding Region Coverage

1x: 99.2%
3x: 98.4%
10x: 96.5%
20x: 93.1%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 54 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700123L14Rik	G	T	6: 96,165,289	P258Q	probably damaging	Het
4930452B06Rik	G	T	14: 8,511,110	H435N	probably benign	Het
Acbd5	G	A	2: 23,090,551	C312Y	probably damaging	Het
Adgrl1	T	A	8: 83,932,373	M601K	probably benign	Het
Agbl4	G	A	4: 111,657,168	E459K	probably benign	Het
Anxa2	TCCC	TCC	9: 69,489,754		probably null	Het
Casz1	C	T	4: 148,929,087	A36V	possibly damaging	Het
Chpf	A	G	1: 75,476,648	V327A	probably damaging	Het
Cldn23	A	G	8: 35,825,930	Y135H	probably damaging	Het
Cobll1	C	T	2: 65,133,642	D211N	probably damaging	Het
Cramp1l	A	G	17: 24,983,951	V368A	probably benign	Het
Dnah6	T	C	6: 73,144,963	T1374A	probably benign	Het
Dpyd	A	G	3: 119,065,006	H623R	probably benign	Het
Dyrk2	T	C	10: 118,859,925	N476S	probably benign	Het
Endog	A	T	2: 30,173,887	I267F	probably damaging	Het
Ephb6	A	T	6: 41,614,373	K155*	probably null	Het
Far2	T	C	6: 148,157,458	V214A	possibly damaging	Het
Fat2	A	G	11: 55,278,924	V3003A	probably damaging	Het
Frg2f1	T	A	4: 119,531,288	T5S	possibly damaging	Het
Gm14496	A	T	2: 181,996,179	T349S	probably benign	Het
Golgb1	A	G	16: 36,926,101	T2951A	probably benign	Het
Hc	G	T	2: 35,006,161	D1203E	probably benign	Het
Isg20	C	A	7: 78,914,509	Q55K	possibly damaging	Het
Jph4	G	T	14: 55,114,103	A152E	probably damaging	Het
Kcnq3	T	C	15: 66,025,260	T264A	probably damaging	Het
Kcnq5	T	G	1: 21,457,461	T463P	probably damaging	Het
Klra8	A	G	6: 130,119,018	S204P	probably damaging	Het
Ldlrad1	A	G	4: 107,214,875	D98G	probably damaging	Het
Lhfpl4	T	C	6: 113,194,136	T30A	possibly damaging	Het
Lig1	T	A	7: 13,285,340	L80Q	probably damaging	Het
Lmbrd2	A	G	15: 9,186,612	Y558C	probably benign	Het
Lrrn3	G	T	12: 41,452,993	L442I	possibly damaging	Het
Mc2r	A	G	18: 68,407,448	F258S	probably damaging	Het
Mmp16	A	G	4: 18,011,582	T137A	probably benign	Het
Nfatc2ip	A	T	7: 126,387,407	S359T	probably damaging	Het
Nup214	C	T	2: 32,034,466	S1669F	probably damaging	Het
Olfr1193	A	T	2: 88,678,574	K233*	probably null	Het
Olfr1229	T	C	2: 89,282,821	H104R	probably damaging	Het
Olfr514	T	A	7: 108,825,924	H25L	probably benign	Het
Olfr904	C	T	9: 38,464,631	L197F	probably damaging	Het
Plagl1	C	T	10: 13,128,962		probably benign	Het
Plxnb2	A	T	15: 89,158,493	S1531T	probably damaging	Het
Ptpn22	G	A	3: 103,902,196		probably null	Het
Rtn1	T	A	12: 72,219,279	Q174L	possibly damaging	Het
Selenoo	A	G	15: 89,099,916	E645G	probably benign	Het
Serpina1a	A	C	12: 103,853,837	D383E	possibly damaging	Het
Slc6a18	T	A	13: 73,668,225	Y345F	probably benign	Het
Smbd1	A	G	16: 32,806,765	V51A	possibly damaging	Het
Tchh	C	T	3: 93,444,839	R529W	unknown	Het
Tmem206	A	G	1: 191,345,065	D195G	probably benign	Het
Tonsl	A	T	15: 76,638,557	Y165N	probably damaging	Het
Trdmt1	G	A	2: 13,516,059	T344I	probably damaging	Het
Ubash3b	C	A	9: 41,043,500	R116L	probably damaging	Het
Zfp474	C	T	18: 52,638,365	T30I	probably benign	Het

Other mutations in Vmn2r94

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01396:Vmn2r94	APN	17	18257039	missense	probably damaging	1.00
IGL01676:Vmn2r94	APN	17	18257010	missense	probably benign
IGL01687:Vmn2r94	APN	17	18253312	missense	possibly damaging	0.64
IGL02113:Vmn2r94	APN	17	18257675	missense	probably damaging	0.99
IGL02408:Vmn2r94	APN	17	18253261	missense	probably benign	0.01
IGL02451:Vmn2r94	APN	17	18258191	missense	possibly damaging	0.95
IGL02755:Vmn2r94	APN	17	18244499	missense	probably benign	0.01
IGL02822:Vmn2r94	APN	17	18243620	missense	probably benign	0.00
IGL02868:Vmn2r94	APN	17	18244054	missense	possibly damaging	0.75
IGL03008:Vmn2r94	APN	17	18257646	missense	probably benign	0.05
R0112:Vmn2r94	UTSW	17	18243604	missense	probably benign
R0371:Vmn2r94	UTSW	17	18257294	missense	probably benign	0.11
R0413:Vmn2r94	UTSW	17	18243818	missense	probably damaging	0.98
R0627:Vmn2r94	UTSW	17	18257165	missense	probably damaging	1.00
R0737:Vmn2r94	UTSW	17	18277433	nonsense	probably null
R0815:Vmn2r94	UTSW	17	18257711	missense	probably damaging	1.00
R0863:Vmn2r94	UTSW	17	18257711	missense	probably damaging	1.00
R1125:Vmn2r94	UTSW	17	18257455	missense	probably damaging	1.00
R1276:Vmn2r94	UTSW	17	18257082	missense	possibly damaging	0.47
R1491:Vmn2r94	UTSW	17	18257703	missense	probably damaging	1.00
R1500:Vmn2r94	UTSW	17	18256980	missense	probably benign	0.07
R1664:Vmn2r94	UTSW	17	18244144	missense	probably damaging	0.99
R1716:Vmn2r94	UTSW	17	18257373	missense	probably benign	0.01
R1843:Vmn2r94	UTSW	17	18244470	missense	probably benign	0.01
R1882:Vmn2r94	UTSW	17	18244214	missense	probably benign	0.07
R1936:Vmn2r94	UTSW	17	18244292	nonsense	probably null
R2273:Vmn2r94	UTSW	17	18257331	missense	probably benign	0.00
R2508:Vmn2r94	UTSW	17	18257474	missense	probably benign	0.32
R3436:Vmn2r94	UTSW	17	18258388	splice site	probably benign
R3917:Vmn2r94	UTSW	17	18244358	missense	probably benign
R3968:Vmn2r94	UTSW	17	18258385	missense	possibly damaging	0.95
R3969:Vmn2r94	UTSW	17	18258385	missense	possibly damaging	0.95
R4257:Vmn2r94	UTSW	17	18244171	missense	probably damaging	1.00
R4271:Vmn2r94	UTSW	17	18243678	missense	probably damaging	1.00
R4349:Vmn2r94	UTSW	17	18244343	missense	probably benign	0.01
R4436:Vmn2r94	UTSW	17	18258383	missense	probably damaging	1.00
R4603:Vmn2r94	UTSW	17	18257385	missense	probably benign	0.33
R4821:Vmn2r94	UTSW	17	18257031	missense	probably benign	0.02
R5288:Vmn2r94	UTSW	17	18244466	missense	probably damaging	1.00
R5725:Vmn2r94	UTSW	17	18256227	missense	possibly damaging	0.88
R5735:Vmn2r94	UTSW	17	18243804	missense	probably damaging	1.00
R6066:Vmn2r94	UTSW	17	18257433	missense	probably damaging	0.99
R6124:Vmn2r94	UTSW	17	18244059	missense	probably benign	0.01
R6189:Vmn2r94	UTSW	17	18257734	missense	probably benign	0.25
R6245:Vmn2r94	UTSW	17	18258123	missense	probably damaging	1.00
R6574:Vmn2r94	UTSW	17	18256159	missense	probably damaging	1.00
R7236:Vmn2r94	UTSW	17	18257549	missense	possibly damaging	0.49
R7317:Vmn2r94	UTSW	17	18243620	missense	probably benign	0.00
R7398:Vmn2r94	UTSW	17	18257341	missense	probably benign	0.00
R7399:Vmn2r94	UTSW	17	18244503	critical splice acceptor site	probably null
R7478:Vmn2r94	UTSW	17	18257505	missense	probably benign
R8099:Vmn2r94	UTSW	17	18257397	missense	probably benign	0.00
R8189:Vmn2r94	UTSW	17	18258356	missense	probably damaging	1.00
R8217:Vmn2r94	UTSW	17	18243724	missense	probably damaging	1.00
R8303:Vmn2r94	UTSW	17	18244171	missense	probably damaging	1.00
R8543:Vmn2r94	UTSW	17	18243722	missense	possibly damaging	0.45
R8684:Vmn2r94	UTSW	17	18277650	start gained	probably benign
R8889:Vmn2r94	UTSW	17	18244073	missense	possibly damaging	0.83
R8892:Vmn2r94	UTSW	17	18244073	missense	possibly damaging	0.83
R9282:Vmn2r94	UTSW	17	18277489	missense	possibly damaging	0.89
R9526:Vmn2r94	UTSW	17	18256999	missense	probably benign
R9647:Vmn2r94	UTSW	17	18243622	missense	probably benign	0.00
R9748:Vmn2r94	UTSW	17	18243727	missense	probably benign	0.21
R9789:Vmn2r94	UTSW	17	18243776	missense	probably damaging	1.00
RF014:Vmn2r94	UTSW	17	18253287	nonsense	probably null
X0011:Vmn2r94	UTSW	17	18244448	missense	possibly damaging	0.76
X0028:Vmn2r94	UTSW	17	18243975	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- AGGCGTCAGGACTTAGACTCAGAG -3'
(R):5'- AGATGCTCACACTGAACATGGACAC -3'

Sequencing Primer
(F):5'- CTTAGACTCAGAGATGCTGAATCAC -3'
(R):5'- CTGAACATGGACACATCATCCTTTTG -3'

Posted On

2014-04-24