Incidental Mutation 'R1610:Vmn2r94'
ID 176761
Institutional Source Beutler Lab
Gene Symbol Vmn2r94
Ensembl Gene ENSMUSG00000090417
Gene Name vomeronasal 2, receptor 94
Synonyms EG665227
MMRRC Submission 039647-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.092) question?
Stock # R1610 (G1)
Quality Score 225
Status Not validated
Chromosome 17
Chromosomal Location 18461384-18498018 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 18463995 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 765 (V765A)
Ref Sequence ENSEMBL: ENSMUSP00000126386 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000172190] [ENSMUST00000231457] [ENSMUST00000231815]
AlphaFold E9PZK8
Predicted Effect probably damaging
Transcript: ENSMUST00000172190
AA Change: V765A

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000126386
Gene: ENSMUSG00000090417
AA Change: V765A

DomainStartEndE-ValueType
Pfam:ANF_receptor 42 425 1.7e-35 PFAM
Pfam:NCD3G 469 522 3.5e-21 PFAM
Pfam:7tm_3 553 790 1.7e-51 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000231457
Predicted Effect probably benign
Transcript: ENSMUST00000231815
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.4%
  • 10x: 96.5%
  • 20x: 93.1%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acbd5 G A 2: 22,980,563 (GRCm39) C312Y probably damaging Het
Adgrl1 T A 8: 84,659,002 (GRCm39) M601K probably benign Het
Agbl4 G A 4: 111,514,365 (GRCm39) E459K probably benign Het
Anxa2 TCCC TCC 9: 69,397,036 (GRCm39) probably null Het
Casz1 C T 4: 149,013,544 (GRCm39) A36V possibly damaging Het
Cfap20dc G T 14: 8,511,110 (GRCm38) H435N probably benign Het
Chpf A G 1: 75,453,292 (GRCm39) V327A probably damaging Het
Cldn23 A G 8: 36,293,084 (GRCm39) Y135H probably damaging Het
Cobll1 C T 2: 64,963,986 (GRCm39) D211N probably damaging Het
Cramp1 A G 17: 25,202,925 (GRCm39) V368A probably benign Het
Dnah6 T C 6: 73,121,946 (GRCm39) T1374A probably benign Het
Dpyd A G 3: 118,858,655 (GRCm39) H623R probably benign Het
Dyrk2 T C 10: 118,695,830 (GRCm39) N476S probably benign Het
Endog A T 2: 30,063,899 (GRCm39) I267F probably damaging Het
Ephb6 A T 6: 41,591,307 (GRCm39) K155* probably null Het
Far2 T C 6: 148,058,956 (GRCm39) V214A possibly damaging Het
Fat2 A G 11: 55,169,750 (GRCm39) V3003A probably damaging Het
Frg2f1 T A 4: 119,388,485 (GRCm39) T5S possibly damaging Het
Gm14496 A T 2: 181,637,972 (GRCm39) T349S probably benign Het
Golgb1 A G 16: 36,746,463 (GRCm39) T2951A probably benign Het
Hc G T 2: 34,896,173 (GRCm39) D1203E probably benign Het
Isg20 C A 7: 78,564,257 (GRCm39) Q55K possibly damaging Het
Jph4 G T 14: 55,351,560 (GRCm39) A152E probably damaging Het
Kcnq3 T C 15: 65,897,109 (GRCm39) T264A probably damaging Het
Kcnq5 T G 1: 21,527,685 (GRCm39) T463P probably damaging Het
Klra8 A G 6: 130,095,981 (GRCm39) S204P probably damaging Het
Ldlrad1 A G 4: 107,072,072 (GRCm39) D98G probably damaging Het
Lhfpl4 T C 6: 113,171,097 (GRCm39) T30A possibly damaging Het
Lig1 T A 7: 13,019,266 (GRCm39) L80Q probably damaging Het
Lmbrd2 A G 15: 9,186,699 (GRCm39) Y558C probably benign Het
Lrrn3 G T 12: 41,502,992 (GRCm39) L442I possibly damaging Het
Mc2r A G 18: 68,540,519 (GRCm39) F258S probably damaging Het
Mmp16 A G 4: 18,011,582 (GRCm39) T137A probably benign Het
Nfatc2ip A T 7: 125,986,579 (GRCm39) S359T probably damaging Het
Nup214 C T 2: 31,924,478 (GRCm39) S1669F probably damaging Het
Nup50l G T 6: 96,142,270 (GRCm39) P258Q probably damaging Het
Or10a48 T A 7: 108,425,131 (GRCm39) H25L probably benign Het
Or4c15b T C 2: 89,113,165 (GRCm39) H104R probably damaging Het
Or4s2b A T 2: 88,508,918 (GRCm39) K233* probably null Het
Or8b1b C T 9: 38,375,927 (GRCm39) L197F probably damaging Het
Pacc1 A G 1: 191,077,262 (GRCm39) D195G probably benign Het
Plagl1 C T 10: 13,004,706 (GRCm39) probably benign Het
Plxnb2 A T 15: 89,042,696 (GRCm39) S1531T probably damaging Het
Ptpn22 G A 3: 103,809,512 (GRCm39) probably null Het
Rtn1 T A 12: 72,266,053 (GRCm39) Q174L possibly damaging Het
Selenoo A G 15: 88,984,119 (GRCm39) E645G probably benign Het
Serpina1a A C 12: 103,820,096 (GRCm39) D383E possibly damaging Het
Slc6a18 T A 13: 73,816,344 (GRCm39) Y345F probably benign Het
Smbd1 A G 16: 32,627,135 (GRCm39) V51A possibly damaging Het
Tchh C T 3: 93,352,146 (GRCm39) R529W unknown Het
Tonsl A T 15: 76,522,757 (GRCm39) Y165N probably damaging Het
Trdmt1 G A 2: 13,520,870 (GRCm39) T344I probably damaging Het
Ubash3b C A 9: 40,954,796 (GRCm39) R116L probably damaging Het
Zfp474 C T 18: 52,771,437 (GRCm39) T30I probably benign Het
Other mutations in Vmn2r94
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01396:Vmn2r94 APN 17 18,477,301 (GRCm39) missense probably damaging 1.00
IGL01676:Vmn2r94 APN 17 18,477,272 (GRCm39) missense probably benign
IGL01687:Vmn2r94 APN 17 18,473,574 (GRCm39) missense possibly damaging 0.64
IGL02113:Vmn2r94 APN 17 18,477,937 (GRCm39) missense probably damaging 0.99
IGL02408:Vmn2r94 APN 17 18,473,523 (GRCm39) missense probably benign 0.01
IGL02451:Vmn2r94 APN 17 18,478,453 (GRCm39) missense possibly damaging 0.95
IGL02755:Vmn2r94 APN 17 18,464,761 (GRCm39) missense probably benign 0.01
IGL02822:Vmn2r94 APN 17 18,463,882 (GRCm39) missense probably benign 0.00
IGL02868:Vmn2r94 APN 17 18,464,316 (GRCm39) missense possibly damaging 0.75
IGL03008:Vmn2r94 APN 17 18,477,908 (GRCm39) missense probably benign 0.05
R0112:Vmn2r94 UTSW 17 18,463,866 (GRCm39) missense probably benign
R0371:Vmn2r94 UTSW 17 18,477,556 (GRCm39) missense probably benign 0.11
R0413:Vmn2r94 UTSW 17 18,464,080 (GRCm39) missense probably damaging 0.98
R0627:Vmn2r94 UTSW 17 18,477,427 (GRCm39) missense probably damaging 1.00
R0737:Vmn2r94 UTSW 17 18,497,695 (GRCm39) nonsense probably null
R0815:Vmn2r94 UTSW 17 18,477,973 (GRCm39) missense probably damaging 1.00
R0863:Vmn2r94 UTSW 17 18,477,973 (GRCm39) missense probably damaging 1.00
R1125:Vmn2r94 UTSW 17 18,477,717 (GRCm39) missense probably damaging 1.00
R1276:Vmn2r94 UTSW 17 18,477,344 (GRCm39) missense possibly damaging 0.47
R1491:Vmn2r94 UTSW 17 18,477,965 (GRCm39) missense probably damaging 1.00
R1500:Vmn2r94 UTSW 17 18,477,242 (GRCm39) missense probably benign 0.07
R1664:Vmn2r94 UTSW 17 18,464,406 (GRCm39) missense probably damaging 0.99
R1716:Vmn2r94 UTSW 17 18,477,635 (GRCm39) missense probably benign 0.01
R1843:Vmn2r94 UTSW 17 18,464,732 (GRCm39) missense probably benign 0.01
R1882:Vmn2r94 UTSW 17 18,464,476 (GRCm39) missense probably benign 0.07
R1936:Vmn2r94 UTSW 17 18,464,554 (GRCm39) nonsense probably null
R2273:Vmn2r94 UTSW 17 18,477,593 (GRCm39) missense probably benign 0.00
R2508:Vmn2r94 UTSW 17 18,477,736 (GRCm39) missense probably benign 0.32
R3436:Vmn2r94 UTSW 17 18,478,650 (GRCm39) splice site probably benign
R3917:Vmn2r94 UTSW 17 18,464,620 (GRCm39) missense probably benign
R3968:Vmn2r94 UTSW 17 18,478,647 (GRCm39) missense possibly damaging 0.95
R3969:Vmn2r94 UTSW 17 18,478,647 (GRCm39) missense possibly damaging 0.95
R4257:Vmn2r94 UTSW 17 18,464,433 (GRCm39) missense probably damaging 1.00
R4271:Vmn2r94 UTSW 17 18,463,940 (GRCm39) missense probably damaging 1.00
R4349:Vmn2r94 UTSW 17 18,464,605 (GRCm39) missense probably benign 0.01
R4436:Vmn2r94 UTSW 17 18,478,645 (GRCm39) missense probably damaging 1.00
R4603:Vmn2r94 UTSW 17 18,477,647 (GRCm39) missense probably benign 0.33
R4821:Vmn2r94 UTSW 17 18,477,293 (GRCm39) missense probably benign 0.02
R5288:Vmn2r94 UTSW 17 18,464,728 (GRCm39) missense probably damaging 1.00
R5725:Vmn2r94 UTSW 17 18,476,489 (GRCm39) missense possibly damaging 0.88
R5735:Vmn2r94 UTSW 17 18,464,066 (GRCm39) missense probably damaging 1.00
R6066:Vmn2r94 UTSW 17 18,477,695 (GRCm39) missense probably damaging 0.99
R6124:Vmn2r94 UTSW 17 18,464,321 (GRCm39) missense probably benign 0.01
R6189:Vmn2r94 UTSW 17 18,477,996 (GRCm39) missense probably benign 0.25
R6245:Vmn2r94 UTSW 17 18,478,385 (GRCm39) missense probably damaging 1.00
R6574:Vmn2r94 UTSW 17 18,476,421 (GRCm39) missense probably damaging 1.00
R7236:Vmn2r94 UTSW 17 18,477,811 (GRCm39) missense possibly damaging 0.49
R7317:Vmn2r94 UTSW 17 18,463,882 (GRCm39) missense probably benign 0.00
R7398:Vmn2r94 UTSW 17 18,477,603 (GRCm39) missense probably benign 0.00
R7399:Vmn2r94 UTSW 17 18,464,765 (GRCm39) critical splice acceptor site probably null
R7478:Vmn2r94 UTSW 17 18,477,767 (GRCm39) missense probably benign
R8099:Vmn2r94 UTSW 17 18,477,659 (GRCm39) missense probably benign 0.00
R8189:Vmn2r94 UTSW 17 18,478,618 (GRCm39) missense probably damaging 1.00
R8217:Vmn2r94 UTSW 17 18,463,986 (GRCm39) missense probably damaging 1.00
R8303:Vmn2r94 UTSW 17 18,464,433 (GRCm39) missense probably damaging 1.00
R8543:Vmn2r94 UTSW 17 18,463,984 (GRCm39) missense possibly damaging 0.45
R8684:Vmn2r94 UTSW 17 18,497,912 (GRCm39) start gained probably benign
R8889:Vmn2r94 UTSW 17 18,464,335 (GRCm39) missense possibly damaging 0.83
R8892:Vmn2r94 UTSW 17 18,464,335 (GRCm39) missense possibly damaging 0.83
R9282:Vmn2r94 UTSW 17 18,497,751 (GRCm39) missense possibly damaging 0.89
R9526:Vmn2r94 UTSW 17 18,477,261 (GRCm39) missense probably benign
R9647:Vmn2r94 UTSW 17 18,463,884 (GRCm39) missense probably benign 0.00
R9748:Vmn2r94 UTSW 17 18,463,989 (GRCm39) missense probably benign 0.21
R9789:Vmn2r94 UTSW 17 18,464,038 (GRCm39) missense probably damaging 1.00
RF014:Vmn2r94 UTSW 17 18,473,549 (GRCm39) nonsense probably null
X0011:Vmn2r94 UTSW 17 18,464,710 (GRCm39) missense possibly damaging 0.76
X0028:Vmn2r94 UTSW 17 18,464,237 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AGGCGTCAGGACTTAGACTCAGAG -3'
(R):5'- AGATGCTCACACTGAACATGGACAC -3'

Sequencing Primer
(F):5'- CTTAGACTCAGAGATGCTGAATCAC -3'
(R):5'- CTGAACATGGACACATCATCCTTTTG -3'
Posted On 2014-04-24