Mutagenetix > Incidental Mutations

Incidental Mutation 'R0109:Ncapg'

17677

Institutional Source

Beutler Lab

Gene Symbol

Ncapg

Ensembl Gene

ENSMUSG00000015880

Gene Name

non-SMC condensin I complex, subunit G

Synonyms

5730507H05Rik, MFT.M05.13, Hcapg

MMRRC Submission

038395-MU

Accession Numbers

Is this an essential gene?

Probably essential (E-score: 0.930) question?

Stock #

R0109 (G1)

Quality Score

Status

Validated

Chromosome

Chromosomal Location

45669919-45700546 bp(+) (GRCm38)

Type of Mutation

splice site

DNA Base Change (assembly)

A to G at 45693748 bp

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000112871 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000045586] [ENSMUST00000117396] [ENSMUST00000190036]

Predicted Effect

probably benign
Transcript: ENSMUST00000045586

SMART Domains

Protein: ENSMUSP00000042677
Gene: ENSMUSG00000015882

Domain	Start	End	E-Value	Type
low complexity region	234	253	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000117396

SMART Domains

Protein: ENSMUSP00000112871
Gene: ENSMUSG00000015880

Domain	Start	End	E-Value	Type
Pfam:Cnd3	557	863	7.4e-87	PFAM
low complexity region	864	874	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000123396

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000134090

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000134309

Predicted Effect

probably benign
Transcript: ENSMUST00000190036

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000198274

Meta Mutation Damage Score

0.9755

Coding Region Coverage

1x: 90.6%
3x: 88.5%
10x: 83.8%
20x: 77.5%

Validation Efficiency

90% (95/106)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a subunit of the condensin complex, which is responsible for the condensation and stabilization of chromosomes during mitosis and meiosis. Phosphorylation of the encoded protein activates the condensin complex. There are pseudogenes for this gene on chromosomes 8 and 15. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

Allele List at MGI

Other mutations in this stock

Total: 75 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A2m	C	A	6: 121,659,303	H710Q	probably benign	Het
Abca14	A	T	7: 120,318,762	K1496*	probably null	Het
Anapc1	C	A	2: 128,634,693	R1335L	probably damaging	Het
Arhgef10l	A	T	4: 140,578,294	S203T	probably benign	Het
Astn1	C	T	1: 158,664,104	T41I	possibly damaging	Het
Atrnl1	T	A	19: 57,755,517	Y1184N	possibly damaging	Het
Avil	A	G	10: 127,013,644	N603S	probably benign	Het
Brca1	T	C	11: 101,531,090	D149G	possibly damaging	Het
Car14	C	A	3: 95,899,451	A234S	probably benign	Het
Cep164	A	C	9: 45,771,587	L935R	probably damaging	Het
Cps1	T	C	1: 67,229,418	V1435A	possibly damaging	Het
Csmd2	T	G	4: 128,544,743	S3038R	probably benign	Het
Cyp2j6	A	T	4: 96,518,157	I459N	probably damaging	Het
Cyth1	T	C	11: 118,182,306	E242G	probably damaging	Het
Dclk3	T	G	9: 111,467,670	L94R	possibly damaging	Het
Disp2	T	C	2: 118,791,816	S1010P	probably damaging	Het
Dlec1	G	A	9: 119,105,824	R145H	probably damaging	Het
Dsg3	T	C	18: 20,540,134	V954A	probably damaging	Het
Dync2h1	T	A	9: 7,111,487	D309V	probably damaging	Het
Fam13b	A	G	18: 34,451,308	I601T	probably benign	Het
Fgd5	T	A	6: 91,988,235	M325K	possibly damaging	Het
Frmpd1	A	T	4: 45,279,340	E688D	probably benign	Het
Gabrb1	C	T	5: 72,121,946		probably benign	Het
Gm10130	A	T	2: 150,323,841		probably benign	Het
Gm6590	A	T	6: 130,484,906		noncoding transcript	Het
Gse1	T	A	8: 120,567,785	S284T	probably damaging	Het
Ipo13	C	T	4: 117,905,016	R387Q	possibly damaging	Het
Kctd16	A	G	18: 40,259,151	E264G	probably benign	Het
Krt73	A	T	15: 101,796,395	L352*	probably null	Het
Mapk15	A	T	15: 75,996,077	K153*	probably null	Het
Mcemp1	C	A	8: 3,667,055	Y65*	probably null	Het
Mcoln2	C	G	3: 146,175,718	R210G	probably damaging	Het
Miox	G	A	15: 89,335,581	V91I	probably benign	Het
Myh7b	A	G	2: 155,611,674	E6G	possibly damaging	Het
Nfyb	G	A	10: 82,755,002	A65V	possibly damaging	Het
Olfr1241	A	G	2: 89,482,803	F111L	probably benign	Het
Olfr1442	C	A	19: 12,674,860	F218L	probably benign	Het
Olfr646	T	C	7: 104,106,605	S109P	probably damaging	Het
Osbp2	A	C	11: 3,711,791	S754A	probably benign	Het
Pard3	C	T	8: 127,398,666	R712C	probably damaging	Het
Parp9	T	C	16: 35,948,341	I64T	probably damaging	Het
Pcm1	T	A	8: 41,257,937	H81Q	possibly damaging	Het
Pcnt	G	A	10: 76,389,196	P1825S	probably benign	Het
Pfkfb4	T	C	9: 108,998,889	V43A	probably benign	Het
Pgap1	A	T	1: 54,494,825	V643E	probably damaging	Het
Pip5k1a	T	C	3: 95,065,442	T433A	probably benign	Het
Pip5k1b	T	A	19: 24,379,047	M176L	probably benign	Het
Polg2	T	C	11: 106,777,132		probably benign	Het
Pomp	T	A	5: 147,875,513	H136Q	probably benign	Het
Ppfia4	A	T	1: 134,324,217		probably null	Het
Prdx2	G	A	8: 84,970,251	G4S	probably benign	Het
Rbm28	C	T	6: 29,160,105	G70D	probably benign	Het
Rdh10	T	A	1: 16,106,265	I83N	probably damaging	Het
Rin3	A	G	12: 102,313,081	I50V	possibly damaging	Het
Rnf122	T	C	8: 31,124,849		probably benign	Het
Sik2	A	G	9: 50,899,475	M447T	possibly damaging	Het
Sla2	A	G	2: 156,883,587		probably null	Het
Slc51a	T	A	16: 32,477,607	I192L	probably benign	Het
Sorcs1	T	C	19: 50,378,891		probably benign	Het
Spata16	T	A	3: 26,913,267	F389I	probably damaging	Het
Srebf1	G	A	11: 60,201,804	A793V	probably benign	Het
Tbc1d9b	T	C	11: 50,158,434	V736A	probably benign	Het
Tbx15	C	A	3: 99,351,866	T351N	possibly damaging	Het
Tep1	A	G	14: 50,851,916		probably null	Het
Tmed11	T	A	5: 108,777,412	D178V	probably damaging	Het
Traf7	A	G	17: 24,513,926	F110L	probably benign	Het
Ubqlnl	C	T	7: 104,150,192	V33M	probably damaging	Het
Vcan	A	T	13: 89,678,073		probably null	Het
Vmn1r194	A	G	13: 22,245,047	Y278C	probably damaging	Het
Vmn1r46	T	C	6: 89,977,062	F298L	probably benign	Het
Vps13b	A	G	15: 35,572,119	T961A	probably benign	Het
Wdr48	G	A	9: 119,918,568		probably benign	Het
Wwp1	G	A	4: 19,641,725		probably benign	Het
Zfp217	C	T	2: 170,115,462	A539T	probably benign	Het
Zfp839	G	A	12: 110,860,874	E400K	possibly damaging	Het

Other mutations in Ncapg

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00662:Ncapg	APN	5	45693160	missense	possibly damaging	0.53
IGL00777:Ncapg	APN	5	45695765	missense	possibly damaging	0.93
IGL00857:Ncapg	APN	5	45676585	splice site	probably null
IGL00916:Ncapg	APN	5	45671192	missense	probably benign	0.37
IGL01293:Ncapg	APN	5	45681854	missense	probably benign	0.01
IGL01360:Ncapg	APN	5	45674385	nonsense	probably null
IGL01462:Ncapg	APN	5	45671135	missense	probably benign	0.02
IGL01527:Ncapg	APN	5	45672384	missense	possibly damaging	0.71
IGL01732:Ncapg	APN	5	45693853	missense	probably damaging	1.00
IGL01788:Ncapg	APN	5	45671081	missense	probably damaging	0.97
IGL01871:Ncapg	APN	5	45688581	missense	probably benign	0.09
IGL03106:Ncapg	APN	5	45695668	missense	probably damaging	1.00
IGL03124:Ncapg	APN	5	45671209	missense	probably benign
R0086:Ncapg	UTSW	5	45676744	splice site	probably null
R0110:Ncapg	UTSW	5	45693147	unclassified	probably benign
R0377:Ncapg	UTSW	5	45693817	missense	probably benign
R0432:Ncapg	UTSW	5	45672428	missense	probably damaging	0.99
R0637:Ncapg	UTSW	5	45687324	missense	probably damaging	1.00
R0835:Ncapg	UTSW	5	45681448	missense	probably damaging	0.96
R0894:Ncapg	UTSW	5	45679894	missense	probably null	0.24
R1069:Ncapg	UTSW	5	45675930	intron	probably benign
R1216:Ncapg	UTSW	5	45699919	missense	possibly damaging	0.68
R1967:Ncapg	UTSW	5	45699910	missense	probably damaging	0.99
R2396:Ncapg	UTSW	5	45678373	missense	probably benign	0.00
R3157:Ncapg	UTSW	5	45676058	missense	probably benign
R3735:Ncapg	UTSW	5	45696127	missense	probably benign	0.00
R3736:Ncapg	UTSW	5	45696127	missense	probably benign	0.00
R3887:Ncapg	UTSW	5	45674363	missense	probably benign
R4371:Ncapg	UTSW	5	45678455	missense	probably benign
R4545:Ncapg	UTSW	5	45671212	missense	probably damaging	1.00
R4546:Ncapg	UTSW	5	45671212	missense	probably damaging	1.00
R4558:Ncapg	UTSW	5	45676644	missense	probably benign	0.00
R4615:Ncapg	UTSW	5	45687399	missense	probably benign	0.00
R4938:Ncapg	UTSW	5	45671209	missense	probably benign
R5839:Ncapg	UTSW	5	45672278	missense	probably damaging	0.99
R5871:Ncapg	UTSW	5	45695697	missense	probably damaging	1.00
R6086:Ncapg	UTSW	5	45693236	missense	probably damaging	1.00
R6418:Ncapg	UTSW	5	45681816	missense	probably damaging	1.00
R6617:Ncapg	UTSW	5	45670132	missense	probably benign	0.03
R7145:Ncapg	UTSW	5	45670030	missense	possibly damaging	0.82
R7408:Ncapg	UTSW	5	45695793	missense	probably benign	0.00
R7443:Ncapg	UTSW	5	45672310	missense	probably benign	0.31
R7463:Ncapg	UTSW	5	45694092	splice site	probably null
R7509:Ncapg	UTSW	5	45696108	missense	probably benign	0.01
R7687:Ncapg	UTSW	5	45699885	missense	probably benign	0.03
R7919:Ncapg	UTSW	5	45696048	missense	probably benign	0.00
R8022:Ncapg	UTSW	5	45681794	missense	probably damaging	1.00
R8177:Ncapg	UTSW	5	45693753	missense	probably benign	0.00
R8261:Ncapg	UTSW	5	45687388	missense	possibly damaging	0.90
R8263:Ncapg	UTSW	5	45691792	missense	probably benign	0.44
R8324:Ncapg	UTSW	5	45695668	missense	probably damaging	1.00
R8333:Ncapg	UTSW	5	45674463	missense	probably damaging	0.96
RF019:Ncapg	UTSW	5	45698856	missense	probably benign	0.00
Z1088:Ncapg	UTSW	5	45679880	missense	probably damaging	1.00
Z1177:Ncapg	UTSW	5	45672502	critical splice donor site	probably null

Posted On

2013-01-31