|Institutional Source||Beutler Lab|
|Gene Name||keratin 78|
|Is this an essential gene?||Probably non essential (E-score: 0.071)|
|Stock #||R1612 (G1)|
|Chromosomal Location||101946001-101954287 bp(-) (GRCm38)|
|Type of Mutation||splice site|
|DNA Base Change (assembly)||A to T at 101951844 bp|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000126197 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000164932]|
|Predicted Effect||probably null
|Meta Mutation Damage Score||0.9755|
|Coding Region Coverage||
|Validation Efficiency||97% (69/71)|
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the type II keratin gene family and encodes a protein with an intermediate filament domain. Keratins are the major structural proteins in epithelial cells, forming a cytoplasmic network of 10 to 12 nm wide intermediate filaments and creating a scaffold that gives cells the ability to withstand mechanical and non-mechanical stresses. The genes of the type II keratin family are located as a gene cluster at 12p13.13. Four pseudogenes of this gene family have been identified. [provided by RefSeq, Jul 2008]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Krt78||
(F):5'- CACTGAGACTGCTGCTTCTGTCTG -3'
(R):5'- AAGCCAAGATCTGACTGAAGTGCTG -3'
(F):5'- CTGTCAAATGATGAGTGACCAC -3'
(R):5'- ACAGGCTCTGGGCTTACTAC -3'