Incidental Mutation 'R1614:Zfp955a'
| ID |
177020 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Zfp955a
|
| Ensembl Gene |
ENSMUSG00000094441 |
| Gene Name |
zinc finger protein 955A |
| Synonyms |
AI842447 |
| MMRRC Submission |
039651-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.069)
|
| Stock # |
R1614 (G1)
|
| Quality Score |
220 |
|
Status
|
Validated
|
| Chromosome |
17 |
| Chromosomal Location |
33458692-33474119 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 33461306 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Asparagine to Lysine
at position 275
(N275K)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000008830
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000008830]
|
| AlphaFold |
Q80XR7 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000008830
AA Change: N275K
PolyPhen 2
Score 0.719 (Sensitivity: 0.86; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000008830
Gene: ENSMUSG00000094441
AA Change: N275K
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
10 |
71 |
7.08e-15 |
SMART |
|
ZnF_C2H2
|
230 |
252 |
7.29e0 |
SMART |
|
ZnF_C2H2
|
258 |
280 |
5.72e-1 |
SMART |
|
ZnF_C2H2
|
290 |
312 |
6.57e-1 |
SMART |
|
ZnF_C2HC
|
291 |
307 |
9.75e0 |
SMART |
|
ZnF_C2H2
|
318 |
340 |
7.67e-2 |
SMART |
|
ZnF_C2H2
|
346 |
368 |
3.16e-3 |
SMART |
|
ZnF_C2H2
|
374 |
396 |
1.18e-2 |
SMART |
|
ZnF_C2H2
|
402 |
424 |
2.99e-4 |
SMART |
|
ZnF_C2H2
|
430 |
452 |
2.09e-3 |
SMART |
|
ZnF_C2H2
|
458 |
480 |
6.57e-1 |
SMART |
|
ZnF_C2HC
|
459 |
475 |
4.03e1 |
SMART |
|
ZnF_C2H2
|
486 |
508 |
1.28e-3 |
SMART |
|
ZnF_C2H2
|
514 |
536 |
2.36e-2 |
SMART |
|
| Meta Mutation Damage Score |
0.0956 |
| Coding Region Coverage |
- 1x: 99.0%
- 3x: 98.1%
- 10x: 95.4%
- 20x: 89.4%
|
| Validation Efficiency |
100% (53/53) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 46 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Arl9 |
A |
G |
5: 77,158,412 (GRCm39) |
T165A |
probably benign |
Het |
| Atpaf1 |
A |
T |
4: 115,653,954 (GRCm39) |
K201N |
possibly damaging |
Het |
| Cacna1b |
G |
T |
2: 24,580,819 (GRCm39) |
Q676K |
possibly damaging |
Het |
| Ccdc88c |
A |
T |
12: 100,879,243 (GRCm39) |
H1959Q |
probably benign |
Het |
| Cep162 |
T |
C |
9: 87,094,985 (GRCm39) |
D808G |
probably damaging |
Het |
| Chct1 |
T |
G |
11: 85,063,690 (GRCm39) |
S28A |
possibly damaging |
Het |
| Chtf18 |
A |
G |
17: 25,946,064 (GRCm39) |
L42P |
probably benign |
Het |
| Cox7c |
A |
G |
13: 86,193,904 (GRCm39) |
F40L |
probably benign |
Het |
| Dock7 |
C |
T |
4: 98,949,517 (GRCm39) |
V442I |
probably benign |
Het |
| Dst |
T |
C |
1: 34,314,344 (GRCm39) |
F4198S |
probably damaging |
Het |
| Fam13a |
T |
A |
6: 58,917,169 (GRCm39) |
D569V |
probably damaging |
Het |
| Gm6741 |
T |
A |
17: 91,544,424 (GRCm39) |
H62Q |
probably benign |
Het |
| Gnptab |
A |
G |
10: 88,250,451 (GRCm39) |
T172A |
probably benign |
Het |
| Greb1 |
A |
G |
12: 16,751,172 (GRCm39) |
S1013P |
probably damaging |
Het |
| Insl5 |
A |
T |
4: 102,883,846 (GRCm39) |
L25* |
probably null |
Het |
| Ipo13 |
A |
G |
4: 117,761,815 (GRCm39) |
S462P |
probably benign |
Het |
| Itgb1 |
G |
A |
8: 129,446,546 (GRCm39) |
C401Y |
probably damaging |
Het |
| Kcnh7 |
G |
T |
2: 62,680,948 (GRCm39) |
A213E |
probably benign |
Het |
| Kcnv1 |
G |
A |
15: 44,977,840 (GRCm39) |
T66M |
probably damaging |
Het |
| Mesp2 |
T |
C |
7: 79,461,367 (GRCm39) |
S231P |
probably benign |
Het |
| Nabp1 |
T |
C |
1: 51,510,511 (GRCm39) |
N164D |
possibly damaging |
Het |
| Nop53 |
A |
G |
7: 15,679,890 (GRCm39) |
V30A |
probably benign |
Het |
| Or1j17 |
T |
G |
2: 36,578,321 (GRCm39) |
Y102* |
probably null |
Het |
| Or4a73 |
T |
A |
2: 89,421,040 (GRCm39) |
I140L |
possibly damaging |
Het |
| Or4f54 |
T |
A |
2: 111,123,411 (GRCm39) |
V266E |
probably damaging |
Het |
| Or4f62 |
T |
A |
2: 111,986,862 (GRCm39) |
C189S |
probably damaging |
Het |
| Pcsk5 |
G |
A |
19: 17,492,620 (GRCm39) |
R918C |
probably damaging |
Het |
| Pecam1 |
T |
C |
11: 106,571,905 (GRCm39) |
D554G |
probably benign |
Het |
| Polr2a |
T |
C |
11: 69,634,199 (GRCm39) |
I744V |
possibly damaging |
Het |
| Pop1 |
C |
A |
15: 34,530,356 (GRCm39) |
A918D |
possibly damaging |
Het |
| Ppp2r5e |
C |
G |
12: 75,516,341 (GRCm39) |
A239P |
probably damaging |
Het |
| Prmt3 |
A |
T |
7: 49,476,467 (GRCm39) |
I359F |
possibly damaging |
Het |
| Proz |
G |
A |
8: 13,116,904 (GRCm39) |
C152Y |
probably damaging |
Het |
| Ptgfr |
A |
C |
3: 151,507,416 (GRCm39) |
Y316D |
probably benign |
Het |
| Ralgapa2 |
G |
T |
2: 146,230,532 (GRCm39) |
S1011Y |
probably damaging |
Het |
| Rnf43 |
C |
T |
11: 87,622,485 (GRCm39) |
R529* |
probably null |
Het |
| Slc17a6 |
G |
A |
7: 51,296,025 (GRCm39) |
|
probably benign |
Het |
| Slc25a19 |
A |
T |
11: 115,507,449 (GRCm39) |
C224* |
probably null |
Het |
| Smarcd3 |
A |
G |
5: 24,799,874 (GRCm39) |
S299P |
possibly damaging |
Het |
| Stard9 |
T |
C |
2: 120,528,156 (GRCm39) |
F1471S |
possibly damaging |
Het |
| Strada |
A |
C |
11: 106,059,145 (GRCm39) |
V211G |
probably damaging |
Het |
| Tom1l1 |
T |
C |
11: 90,574,080 (GRCm39) |
E68G |
probably damaging |
Het |
| Vmn2r27 |
T |
G |
6: 124,200,893 (GRCm39) |
I355L |
probably benign |
Het |
| Vmn2r68 |
A |
T |
7: 84,870,946 (GRCm39) |
M779K |
possibly damaging |
Het |
| Zbtb18 |
T |
C |
1: 177,274,736 (GRCm39) |
L23P |
probably damaging |
Het |
| Zfp112 |
G |
T |
7: 23,826,024 (GRCm39) |
C664F |
probably damaging |
Het |
|
| Other mutations in Zfp955a |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01115:Zfp955a
|
APN |
17 |
33,461,554 (GRCm39) |
nonsense |
probably null |
|
|
IGL01859:Zfp955a
|
APN |
17 |
33,462,693 (GRCm39) |
missense |
probably benign |
0.45 |
|
IGL02612:Zfp955a
|
APN |
17 |
33,463,039 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02894:Zfp955a
|
APN |
17 |
33,461,426 (GRCm39) |
nonsense |
probably null |
|
|
IGL02933:Zfp955a
|
APN |
17 |
33,462,683 (GRCm39) |
splice site |
probably null |
|
|
R0145:Zfp955a
|
UTSW |
17 |
33,461,430 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0577:Zfp955a
|
UTSW |
17 |
33,461,068 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0963:Zfp955a
|
UTSW |
17 |
33,462,726 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1588:Zfp955a
|
UTSW |
17 |
33,460,791 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1704:Zfp955a
|
UTSW |
17 |
33,460,699 (GRCm39) |
nonsense |
probably null |
|
|
R1994:Zfp955a
|
UTSW |
17 |
33,460,620 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2043:Zfp955a
|
UTSW |
17 |
33,461,527 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2091:Zfp955a
|
UTSW |
17 |
33,461,731 (GRCm39) |
nonsense |
probably null |
|
|
R2091:Zfp955a
|
UTSW |
17 |
33,461,731 (GRCm39) |
nonsense |
probably null |
|
|
R4077:Zfp955a
|
UTSW |
17 |
33,460,675 (GRCm39) |
missense |
probably benign |
0.15 |
|
R4078:Zfp955a
|
UTSW |
17 |
33,460,675 (GRCm39) |
missense |
probably benign |
0.15 |
|
R4689:Zfp955a
|
UTSW |
17 |
33,461,040 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4735:Zfp955a
|
UTSW |
17 |
33,460,696 (GRCm39) |
missense |
probably benign |
0.09 |
|
R4870:Zfp955a
|
UTSW |
17 |
33,460,699 (GRCm39) |
nonsense |
probably null |
|
|
R4904:Zfp955a
|
UTSW |
17 |
33,461,162 (GRCm39) |
nonsense |
probably null |
|
|
R5180:Zfp955a
|
UTSW |
17 |
33,461,592 (GRCm39) |
missense |
probably benign |
0.15 |
|
R6006:Zfp955a
|
UTSW |
17 |
33,460,660 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7132:Zfp955a
|
UTSW |
17 |
33,460,589 (GRCm39) |
nonsense |
probably null |
|
|
R7403:Zfp955a
|
UTSW |
17 |
33,462,720 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7457:Zfp955a
|
UTSW |
17 |
33,463,025 (GRCm39) |
nonsense |
probably null |
|
|
R7547:Zfp955a
|
UTSW |
17 |
33,461,797 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8263:Zfp955a
|
UTSW |
17 |
33,463,087 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8265:Zfp955a
|
UTSW |
17 |
33,463,087 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8330:Zfp955a
|
UTSW |
17 |
33,463,087 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8947:Zfp955a
|
UTSW |
17 |
33,460,955 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9052:Zfp955a
|
UTSW |
17 |
33,461,279 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R9352:Zfp955a
|
UTSW |
17 |
33,461,335 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9557:Zfp955a
|
UTSW |
17 |
33,461,107 (GRCm39) |
nonsense |
probably null |
|
|
R9683:Zfp955a
|
UTSW |
17 |
33,461,587 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9784:Zfp955a
|
UTSW |
17 |
33,461,149 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9797:Zfp955a
|
UTSW |
17 |
33,461,888 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
X0062:Zfp955a
|
UTSW |
17 |
33,460,976 (GRCm39) |
missense |
probably benign |
0.37 |
|
| Predicted Primers |
PCR Primer
(F):5'- AACGCTTTGCCACACTGAGCAC -3'
(R):5'- CACGCTGGAGATGAGCTACATGAG -3'
Sequencing Primer
(F):5'- ACTGAGCACATGTATACCGTTTC -3'
(R):5'- GAGCTACATGAGTGTAAACAATTTG -3'
|
| Posted On |
2014-04-24 |
Incidental Mutation