Incidental Mutation 'R1569:Zfp976'
ID 177117
Institutional Source Beutler Lab
Gene Symbol Zfp976
Ensembl Gene ENSMUSG00000074158
Gene Name zinc finger protein 976
Synonyms 9830147E19Rik
MMRRC Submission 039608-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.097) question?
Stock # R1569 (G1)
Quality Score 163
Status Validated
Chromosome 7
Chromosomal Location 42258950-42292012 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 42262806 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Asparagine at position 344 (H344N)
Ref Sequence ENSEMBL: ENSMUSP00000141023 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000098503] [ENSMUST00000187616]
AlphaFold E9Q981
Predicted Effect probably damaging
Transcript: ENSMUST00000098503
AA Change: H345N

PolyPhen 2 Score 0.958 (Sensitivity: 0.78; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000096105
Gene: ENSMUSG00000074158
AA Change: H345N

DomainStartEndE-ValueType
KRAB 4 66 1.73e-18 SMART
ZnF_C2H2 131 153 7.78e-3 SMART
ZnF_C2H2 159 181 1.67e-2 SMART
ZnF_C2H2 187 209 5.9e-3 SMART
ZnF_C2H2 215 237 1.38e-3 SMART
ZnF_C2H2 243 265 8.94e-3 SMART
ZnF_C2H2 271 293 2.24e-3 SMART
ZnF_C2H2 299 321 1.03e-2 SMART
ZnF_C2H2 327 349 1.58e-3 SMART
ZnF_C2H2 355 377 7.9e-4 SMART
ZnF_C2H2 383 405 5.9e-3 SMART
ZnF_C2H2 411 433 2.57e-3 SMART
ZnF_C2H2 439 461 3.16e-3 SMART
ZnF_C2H2 467 489 1.26e-2 SMART
ZnF_C2H2 495 517 8.34e-3 SMART
ZnF_C2H2 523 545 3.63e-3 SMART
ZnF_C2H2 551 573 4.79e-3 SMART
ZnF_C2H2 579 601 9.73e-4 SMART
ZnF_C2H2 607 629 3.63e-3 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000107994
Predicted Effect probably damaging
Transcript: ENSMUST00000187616
AA Change: H344N

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000141023
Gene: ENSMUSG00000074158
AA Change: H344N

DomainStartEndE-ValueType
KRAB 3 65 7.4e-21 SMART
ZnF_C2H2 130 152 3.2e-5 SMART
ZnF_C2H2 158 180 7.1e-5 SMART
ZnF_C2H2 186 208 2.4e-5 SMART
ZnF_C2H2 214 236 5.7e-6 SMART
ZnF_C2H2 242 264 3.8e-5 SMART
ZnF_C2H2 270 292 9.7e-6 SMART
ZnF_C2H2 298 320 4.2e-5 SMART
ZnF_C2H2 326 348 6.6e-6 SMART
ZnF_C2H2 354 376 3.3e-6 SMART
ZnF_C2H2 382 404 2.5e-5 SMART
ZnF_C2H2 410 432 1e-5 SMART
ZnF_C2H2 438 460 1.3e-5 SMART
ZnF_C2H2 466 488 5.2e-5 SMART
ZnF_C2H2 494 516 3.6e-5 SMART
ZnF_C2H2 522 544 1.6e-5 SMART
ZnF_C2H2 550 572 2e-5 SMART
ZnF_C2H2 578 600 4e-6 SMART
ZnF_C2H2 606 628 1.5e-5 SMART
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.1%
  • 10x: 95.6%
  • 20x: 90.3%
Validation Efficiency 96% (72/75)
Allele List at MGI
Other mutations in this stock
Total: 67 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2010315B03Rik T A 9: 124,056,427 (GRCm39) K166* probably null Het
Abca2 T A 2: 25,329,197 (GRCm39) N1012K probably benign Het
Ahnak T C 19: 8,981,458 (GRCm39) V914A possibly damaging Het
Akap1 T A 11: 88,724,006 (GRCm39) M833L probably benign Het
Atp2b1 T A 10: 98,823,188 (GRCm39) H249Q probably benign Het
Atp6v0a4 A G 6: 38,027,560 (GRCm39) V750A probably damaging Het
Car6 T C 4: 150,285,499 (GRCm39) Y23C probably damaging Het
Celsr3 A G 9: 108,706,267 (GRCm39) T917A probably damaging Het
Clmn C A 12: 104,747,340 (GRCm39) D736Y probably damaging Het
Dclk2 C T 3: 86,712,946 (GRCm39) R503Q possibly damaging Het
Dennd4c G A 4: 86,704,331 (GRCm39) R282H possibly damaging Het
Dsg1b T A 18: 20,529,537 (GRCm39) N327K probably damaging Het
Eftud2 A T 11: 102,745,597 (GRCm39) probably benign Het
Esyt1 G T 10: 128,354,863 (GRCm39) S512R possibly damaging Het
Fam124b T C 1: 80,190,852 (GRCm39) Y177C possibly damaging Het
Fbxl5 A T 5: 43,922,803 (GRCm39) I205K probably damaging Het
Fcrl1 A G 3: 87,292,012 (GRCm39) Y57C probably damaging Het
Gabpb1 A T 2: 126,494,171 (GRCm39) D151E probably benign Het
Gcc2 C T 10: 58,105,993 (GRCm39) L310F probably benign Het
Hsd11b1 C G 1: 192,922,635 (GRCm39) E141Q probably damaging Het
Htr1b A G 9: 81,514,340 (GRCm39) V89A probably benign Het
Ibsp A T 5: 104,458,017 (GRCm39) T185S probably damaging Het
Igfn1 T C 1: 135,896,771 (GRCm39) D1265G probably benign Het
Ints9 T C 14: 65,217,571 (GRCm39) Y33H possibly damaging Het
Kif1a A T 1: 92,986,532 (GRCm39) probably benign Het
Lama1 A T 17: 68,087,613 (GRCm39) probably null Het
Lbp A T 2: 158,161,607 (GRCm39) D223V probably damaging Het
Lck C A 4: 129,449,449 (GRCm39) D283Y probably damaging Het
Lcmt2 A G 2: 120,970,309 (GRCm39) F258S probably damaging Het
Lsg1 G T 16: 30,399,823 (GRCm39) probably null Het
Maip1 T C 1: 57,452,554 (GRCm39) probably benign Het
Mark3 T G 12: 111,600,180 (GRCm39) I465S probably benign Het
Marveld2 C T 13: 100,737,506 (GRCm39) V128I probably benign Het
Mcm3ap A G 10: 76,319,022 (GRCm39) H750R possibly damaging Het
Mdn1 A T 4: 32,723,501 (GRCm39) Q2479L probably null Het
Met A T 6: 17,531,503 (GRCm39) K594* probably null Het
Pak2 G T 16: 31,856,113 (GRCm39) S241R probably damaging Het
Plxna4 T C 6: 32,162,410 (GRCm39) I1368V possibly damaging Het
Pparg T C 6: 115,416,960 (GRCm39) I51T probably benign Het
Ppp1r18 A G 17: 36,179,595 (GRCm39) E62G probably damaging Het
Prkag2 T C 5: 25,152,475 (GRCm39) S86G possibly damaging Het
Rabgap1l A T 1: 160,529,960 (GRCm39) I347K probably benign Het
Rdh1 A T 10: 127,598,941 (GRCm39) M141L probably benign Het
Rfx2 A T 17: 57,111,326 (GRCm39) I82N possibly damaging Het
Sh2b2 G A 5: 136,260,589 (GRCm39) A209V possibly damaging Het
Sh3d19 G A 3: 86,033,951 (GRCm39) R768H possibly damaging Het
Sh3rf1 C T 8: 61,837,896 (GRCm39) P814S probably damaging Het
Shbg T A 11: 69,508,415 (GRCm39) probably benign Het
Slc15a2 T C 16: 36,576,745 (GRCm39) T430A probably benign Het
Slc17a3 A T 13: 24,039,591 (GRCm39) I250F probably benign Het
Snrnp40 C G 4: 130,271,836 (GRCm39) probably null Het
Spg11 A G 2: 121,932,187 (GRCm39) S552P probably damaging Het
Srpk2 A G 5: 23,719,024 (GRCm39) I597T probably damaging Het
St6galnac1 T G 11: 116,660,097 (GRCm39) N72T possibly damaging Het
Tecpr2 T A 12: 110,911,321 (GRCm39) probably null Het
Tmem208 T A 8: 106,061,462 (GRCm39) C163S possibly damaging Het
Tpte T C 8: 22,835,047 (GRCm39) V401A probably damaging Het
Trhde A G 10: 114,282,093 (GRCm39) W795R possibly damaging Het
Trpm3 G A 19: 22,866,809 (GRCm39) probably null Het
Ttn T A 2: 76,626,063 (GRCm39) T14999S possibly damaging Het
Txndc2 A T 17: 65,945,921 (GRCm39) N85K probably benign Het
Yes1 A G 5: 32,810,507 (GRCm39) Y192C probably damaging Het
Zan A G 5: 137,427,392 (GRCm39) V2415A unknown Het
Zfp410 T A 12: 84,379,726 (GRCm39) C311S probably damaging Het
Zfp51 A T 17: 21,676,642 (GRCm39) M38L probably benign Het
Zfp560 A T 9: 20,260,011 (GRCm39) C284S possibly damaging Het
Zfp808 C T 13: 62,320,714 (GRCm39) R648* probably null Het
Other mutations in Zfp976
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00465:Zfp976 APN 7 42,263,109 (GRCm39) missense unknown
IGL01102:Zfp976 APN 7 42,263,333 (GRCm39) nonsense probably null
IGL01111:Zfp976 APN 7 42,265,711 (GRCm39) missense probably damaging 0.99
IGL01628:Zfp976 APN 7 42,261,935 (GRCm39) missense unknown
IGL02008:Zfp976 APN 7 42,263,656 (GRCm39) splice site probably benign
IGL02548:Zfp976 APN 7 42,261,953 (GRCm39) missense unknown
R0190:Zfp976 UTSW 7 42,291,948 (GRCm39) start gained probably benign
R0685:Zfp976 UTSW 7 42,263,141 (GRCm39) missense probably damaging 0.98
R1310:Zfp976 UTSW 7 42,262,610 (GRCm39) missense probably damaging 1.00
R1353:Zfp976 UTSW 7 42,265,442 (GRCm39) missense probably damaging 0.99
R1447:Zfp976 UTSW 7 42,262,023 (GRCm39) missense possibly damaging 0.79
R1702:Zfp976 UTSW 7 42,265,424 (GRCm39) missense possibly damaging 0.86
R1829:Zfp976 UTSW 7 42,265,735 (GRCm39) missense probably damaging 1.00
R1939:Zfp976 UTSW 7 42,263,105 (GRCm39) missense unknown
R1978:Zfp976 UTSW 7 42,263,265 (GRCm39) missense probably damaging 1.00
R1981:Zfp976 UTSW 7 42,263,046 (GRCm39) missense probably damaging 0.99
R2160:Zfp976 UTSW 7 42,263,354 (GRCm39) missense probably benign
R2192:Zfp976 UTSW 7 42,262,695 (GRCm39) missense probably damaging 1.00
R3121:Zfp976 UTSW 7 42,262,938 (GRCm39) missense probably damaging 1.00
R4210:Zfp976 UTSW 7 42,265,749 (GRCm39) missense probably damaging 0.99
R4724:Zfp976 UTSW 7 42,262,457 (GRCm39) missense possibly damaging 0.91
R4943:Zfp976 UTSW 7 42,261,846 (GRCm39) unclassified probably benign
R5047:Zfp976 UTSW 7 42,262,843 (GRCm39) nonsense probably null
R5071:Zfp976 UTSW 7 42,262,354 (GRCm39) nonsense probably null
R5125:Zfp976 UTSW 7 42,261,925 (GRCm39) splice site probably null
R5178:Zfp976 UTSW 7 42,261,925 (GRCm39) splice site probably null
R5305:Zfp976 UTSW 7 42,262,902 (GRCm39) missense probably benign 0.00
R5777:Zfp976 UTSW 7 42,263,504 (GRCm39) missense probably benign 0.00
R6153:Zfp976 UTSW 7 42,263,610 (GRCm39) missense probably damaging 0.99
R6694:Zfp976 UTSW 7 42,263,610 (GRCm39) missense probably damaging 0.99
R7226:Zfp976 UTSW 7 42,262,684 (GRCm39) nonsense probably null
R7479:Zfp976 UTSW 7 42,262,603 (GRCm39) missense probably benign 0.01
R7561:Zfp976 UTSW 7 42,265,701 (GRCm39) missense probably damaging 1.00
R8178:Zfp976 UTSW 7 42,262,959 (GRCm39) missense probably benign 0.03
R8261:Zfp976 UTSW 7 42,262,125 (GRCm39) missense unknown
R8715:Zfp976 UTSW 7 42,262,869 (GRCm39) missense possibly damaging 0.89
R8921:Zfp976 UTSW 7 42,262,575 (GRCm39) missense possibly damaging 0.57
R9168:Zfp976 UTSW 7 42,263,011 (GRCm39) nonsense probably null
R9575:Zfp976 UTSW 7 42,262,041 (GRCm39) missense unknown
Z1088:Zfp976 UTSW 7 42,262,184 (GRCm39) missense possibly damaging 0.71
Predicted Primers
Posted On 2014-04-24