Incidental Mutation 'R1569:Zfp51'
ID 177148
Institutional Source Beutler Lab
Gene Symbol Zfp51
Ensembl Gene ENSMUSG00000023892
Gene Name zinc finger protein 51
Synonyms zfec12, Zfp-51
MMRRC Submission 039608-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.390) question?
Stock # R1569 (G1)
Quality Score 225
Status Validated
Chromosome 17
Chromosomal Location 21670636-21685849 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 21676642 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Leucine at position 38 (M38L)
Ref Sequence ENSEMBL: ENSMUSP00000045684 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000039577]
AlphaFold Q3U4L8
Predicted Effect probably benign
Transcript: ENSMUST00000039577
AA Change: M38L

PolyPhen 2 Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)
SMART Domains Protein: ENSMUSP00000045684
Gene: ENSMUSG00000023892
AA Change: M38L

DomainStartEndE-ValueType
KRAB 43 103 1.71e-22 SMART
ZnF_C2H2 214 236 2.36e-2 SMART
ZnF_C2H2 242 264 8.94e-3 SMART
ZnF_C2H2 270 292 7.9e-4 SMART
ZnF_C2H2 298 320 3.44e-4 SMART
ZnF_C2H2 326 348 7.15e-2 SMART
ZnF_C2H2 354 376 4.54e-4 SMART
ZnF_C2H2 382 404 3.44e-4 SMART
ZnF_C2H2 410 432 9.88e-5 SMART
ZnF_C2H2 438 460 3.16e-3 SMART
ZnF_C2H2 466 488 1.58e-3 SMART
ZnF_C2H2 494 517 2.57e-3 SMART
ZnF_C2H2 523 545 3.63e-3 SMART
ZnF_C2H2 551 573 1.4e-4 SMART
ZnF_C2H2 579 601 4.17e-3 SMART
ZnF_C2H2 607 629 2.79e-4 SMART
ZnF_C2H2 635 657 4.24e-4 SMART
ZnF_C2H2 663 685 9.08e-4 SMART
ZnF_C2H2 691 713 8.47e-4 SMART
ZnF_C2H2 719 741 1.36e-2 SMART
ZnF_C2H2 747 769 6.82e1 SMART
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.1%
  • 10x: 95.6%
  • 20x: 90.3%
Validation Efficiency 96% (72/75)
Allele List at MGI
Other mutations in this stock
Total: 67 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2010315B03Rik T A 9: 124,056,427 (GRCm39) K166* probably null Het
Abca2 T A 2: 25,329,197 (GRCm39) N1012K probably benign Het
Ahnak T C 19: 8,981,458 (GRCm39) V914A possibly damaging Het
Akap1 T A 11: 88,724,006 (GRCm39) M833L probably benign Het
Atp2b1 T A 10: 98,823,188 (GRCm39) H249Q probably benign Het
Atp6v0a4 A G 6: 38,027,560 (GRCm39) V750A probably damaging Het
Car6 T C 4: 150,285,499 (GRCm39) Y23C probably damaging Het
Celsr3 A G 9: 108,706,267 (GRCm39) T917A probably damaging Het
Clmn C A 12: 104,747,340 (GRCm39) D736Y probably damaging Het
Dclk2 C T 3: 86,712,946 (GRCm39) R503Q possibly damaging Het
Dennd4c G A 4: 86,704,331 (GRCm39) R282H possibly damaging Het
Dsg1b T A 18: 20,529,537 (GRCm39) N327K probably damaging Het
Eftud2 A T 11: 102,745,597 (GRCm39) probably benign Het
Esyt1 G T 10: 128,354,863 (GRCm39) S512R possibly damaging Het
Fam124b T C 1: 80,190,852 (GRCm39) Y177C possibly damaging Het
Fbxl5 A T 5: 43,922,803 (GRCm39) I205K probably damaging Het
Fcrl1 A G 3: 87,292,012 (GRCm39) Y57C probably damaging Het
Gabpb1 A T 2: 126,494,171 (GRCm39) D151E probably benign Het
Gcc2 C T 10: 58,105,993 (GRCm39) L310F probably benign Het
Hsd11b1 C G 1: 192,922,635 (GRCm39) E141Q probably damaging Het
Htr1b A G 9: 81,514,340 (GRCm39) V89A probably benign Het
Ibsp A T 5: 104,458,017 (GRCm39) T185S probably damaging Het
Igfn1 T C 1: 135,896,771 (GRCm39) D1265G probably benign Het
Ints9 T C 14: 65,217,571 (GRCm39) Y33H possibly damaging Het
Kif1a A T 1: 92,986,532 (GRCm39) probably benign Het
Lama1 A T 17: 68,087,613 (GRCm39) probably null Het
Lbp A T 2: 158,161,607 (GRCm39) D223V probably damaging Het
Lck C A 4: 129,449,449 (GRCm39) D283Y probably damaging Het
Lcmt2 A G 2: 120,970,309 (GRCm39) F258S probably damaging Het
Lsg1 G T 16: 30,399,823 (GRCm39) probably null Het
Maip1 T C 1: 57,452,554 (GRCm39) probably benign Het
Mark3 T G 12: 111,600,180 (GRCm39) I465S probably benign Het
Marveld2 C T 13: 100,737,506 (GRCm39) V128I probably benign Het
Mcm3ap A G 10: 76,319,022 (GRCm39) H750R possibly damaging Het
Mdn1 A T 4: 32,723,501 (GRCm39) Q2479L probably null Het
Met A T 6: 17,531,503 (GRCm39) K594* probably null Het
Pak2 G T 16: 31,856,113 (GRCm39) S241R probably damaging Het
Plxna4 T C 6: 32,162,410 (GRCm39) I1368V possibly damaging Het
Pparg T C 6: 115,416,960 (GRCm39) I51T probably benign Het
Ppp1r18 A G 17: 36,179,595 (GRCm39) E62G probably damaging Het
Prkag2 T C 5: 25,152,475 (GRCm39) S86G possibly damaging Het
Rabgap1l A T 1: 160,529,960 (GRCm39) I347K probably benign Het
Rdh1 A T 10: 127,598,941 (GRCm39) M141L probably benign Het
Rfx2 A T 17: 57,111,326 (GRCm39) I82N possibly damaging Het
Sh2b2 G A 5: 136,260,589 (GRCm39) A209V possibly damaging Het
Sh3d19 G A 3: 86,033,951 (GRCm39) R768H possibly damaging Het
Sh3rf1 C T 8: 61,837,896 (GRCm39) P814S probably damaging Het
Shbg T A 11: 69,508,415 (GRCm39) probably benign Het
Slc15a2 T C 16: 36,576,745 (GRCm39) T430A probably benign Het
Slc17a3 A T 13: 24,039,591 (GRCm39) I250F probably benign Het
Snrnp40 C G 4: 130,271,836 (GRCm39) probably null Het
Spg11 A G 2: 121,932,187 (GRCm39) S552P probably damaging Het
Srpk2 A G 5: 23,719,024 (GRCm39) I597T probably damaging Het
St6galnac1 T G 11: 116,660,097 (GRCm39) N72T possibly damaging Het
Tecpr2 T A 12: 110,911,321 (GRCm39) probably null Het
Tmem208 T A 8: 106,061,462 (GRCm39) C163S possibly damaging Het
Tpte T C 8: 22,835,047 (GRCm39) V401A probably damaging Het
Trhde A G 10: 114,282,093 (GRCm39) W795R possibly damaging Het
Trpm3 G A 19: 22,866,809 (GRCm39) probably null Het
Ttn T A 2: 76,626,063 (GRCm39) T14999S possibly damaging Het
Txndc2 A T 17: 65,945,921 (GRCm39) N85K probably benign Het
Yes1 A G 5: 32,810,507 (GRCm39) Y192C probably damaging Het
Zan A G 5: 137,427,392 (GRCm39) V2415A unknown Het
Zfp410 T A 12: 84,379,726 (GRCm39) C311S probably damaging Het
Zfp560 A T 9: 20,260,011 (GRCm39) C284S possibly damaging Het
Zfp808 C T 13: 62,320,714 (GRCm39) R648* probably null Het
Zfp976 G T 7: 42,262,806 (GRCm39) H344N probably damaging Het
Other mutations in Zfp51
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00420:Zfp51 APN 17 21,683,714 (GRCm39) missense probably benign 0.11
IGL00971:Zfp51 APN 17 21,683,844 (GRCm39) missense probably benign 0.03
IGL02002:Zfp51 APN 17 21,684,221 (GRCm39) missense probably damaging 0.98
IGL02268:Zfp51 APN 17 21,683,681 (GRCm39) nonsense probably null
IGL03249:Zfp51 APN 17 21,683,701 (GRCm39) missense probably damaging 1.00
R1853:Zfp51 UTSW 17 21,684,585 (GRCm39) missense probably damaging 1.00
R1989:Zfp51 UTSW 17 21,676,582 (GRCm39) missense possibly damaging 0.90
R2285:Zfp51 UTSW 17 21,684,137 (GRCm39) missense probably damaging 1.00
R2407:Zfp51 UTSW 17 21,684,093 (GRCm39) missense probably damaging 0.98
R2890:Zfp51 UTSW 17 21,684,118 (GRCm39) missense probably damaging 1.00
R3918:Zfp51 UTSW 17 21,683,702 (GRCm39) missense probably benign
R4529:Zfp51 UTSW 17 21,684,998 (GRCm39) missense probably damaging 1.00
R4587:Zfp51 UTSW 17 21,685,178 (GRCm39) nonsense probably null
R4866:Zfp51 UTSW 17 21,682,012 (GRCm39) missense possibly damaging 0.61
R4872:Zfp51 UTSW 17 21,684,933 (GRCm39) missense probably benign 0.26
R4961:Zfp51 UTSW 17 21,676,615 (GRCm39) missense probably benign 0.01
R5392:Zfp51 UTSW 17 21,685,584 (GRCm39) missense possibly damaging 0.60
R5611:Zfp51 UTSW 17 21,684,354 (GRCm39) missense probably damaging 1.00
R7109:Zfp51 UTSW 17 21,683,831 (GRCm39) missense possibly damaging 0.80
R7129:Zfp51 UTSW 17 21,681,971 (GRCm39) missense probably damaging 1.00
R7269:Zfp51 UTSW 17 21,683,960 (GRCm39) missense probably benign 0.09
R7303:Zfp51 UTSW 17 21,684,058 (GRCm39) missense probably benign 0.24
R7514:Zfp51 UTSW 17 21,683,762 (GRCm39) missense probably benign 0.37
R7665:Zfp51 UTSW 17 21,683,843 (GRCm39) missense probably benign 0.00
R8073:Zfp51 UTSW 17 21,684,294 (GRCm39) missense probably damaging 1.00
R8177:Zfp51 UTSW 17 21,684,129 (GRCm39) missense probably benign 0.05
R8560:Zfp51 UTSW 17 21,685,635 (GRCm39) missense probably benign 0.00
R8877:Zfp51 UTSW 17 21,682,017 (GRCm39) missense probably damaging 1.00
R9032:Zfp51 UTSW 17 21,684,660 (GRCm39) missense probably damaging 1.00
R9085:Zfp51 UTSW 17 21,684,660 (GRCm39) missense probably damaging 1.00
R9307:Zfp51 UTSW 17 21,684,733 (GRCm39) missense probably benign 0.30
R9489:Zfp51 UTSW 17 21,684,291 (GRCm39) missense probably damaging 1.00
R9605:Zfp51 UTSW 17 21,684,291 (GRCm39) missense probably damaging 1.00
R9686:Zfp51 UTSW 17 21,683,871 (GRCm39) missense probably damaging 1.00
R9735:Zfp51 UTSW 17 21,685,413 (GRCm39) nonsense probably null
R9795:Zfp51 UTSW 17 21,682,051 (GRCm39) critical splice donor site probably null
X0062:Zfp51 UTSW 17 21,685,257 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- GTACTGTGCTGCTTTAGGGAACTGAAT -3'
(R):5'- ACTGAATGCAGGTAGTGAAATGCAGTTA -3'

Sequencing Primer
(F):5'- GTAACTTTTTTGAGTGCAGCACC -3'
(R):5'- AGTTCTCAATGACTAATGTAACCAC -3'
Posted On 2014-04-24