Incidental Mutation 'R1583:Olfr1204'
ID 177231
Institutional Source Beutler Lab
Gene Symbol Olfr1204
Ensembl Gene ENSMUSG00000061798
Gene Name olfactory receptor 1204
Synonyms GA_x6K02T2Q125-50322618-50323547, MOR232-6
MMRRC Submission 039620-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.066) question?
Stock # R1583 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 88849292-88857920 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to G at 88852262 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Cysteine at position 104 (F104C)
Ref Sequence ENSEMBL: ENSMUSP00000150111 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078631] [ENSMUST00000213283]
AlphaFold Q7TR10
Predicted Effect probably damaging
Transcript: ENSMUST00000078631
AA Change: F104C

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000077701
Gene: ENSMUSG00000061798
AA Change: F104C

Pfam:7tm_4 29 303 1.5e-48 PFAM
Pfam:7tm_1 39 285 1.8e-16 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000213283
AA Change: F104C

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.0%
  • 10x: 95.2%
  • 20x: 88.8%
Validation Efficiency 99% (79/80)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 64 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aasdh A G 5: 76,882,681 (GRCm38) S691P probably benign Het
Adgrb3 T C 1: 25,226,831 (GRCm38) probably null Het
Ankar A G 1: 72,679,555 (GRCm38) probably benign Het
Aplf A T 6: 87,646,033 (GRCm38) Y355N probably damaging Het
Bms1 A G 6: 118,389,389 (GRCm38) probably benign Het
Catsperb T C 12: 101,463,114 (GRCm38) I182T probably damaging Het
Cd300ld2 T C 11: 115,013,777 (GRCm38) D88G probably benign Het
Cebpz T C 17: 78,934,752 (GRCm38) N491S probably damaging Het
Crybg2 T C 4: 134,081,459 (GRCm38) S1415P probably damaging Het
Ddc A G 11: 11,829,131 (GRCm38) V331A probably benign Het
Decr2 T C 17: 26,083,024 (GRCm38) E244G probably damaging Het
Dhrs11 A G 11: 84,823,117 (GRCm38) M136T probably damaging Het
Eapp G A 12: 54,685,948 (GRCm38) Q126* probably null Het
Fam111a T A 19: 12,587,778 (GRCm38) V297D probably damaging Het
Fam84a G A 12: 14,150,408 (GRCm38) A106V probably benign Het
Fbxo10 A C 4: 45,062,118 (GRCm38) L136R probably damaging Het
Fbxo30 T A 10: 11,291,374 (GRCm38) H613Q possibly damaging Het
Frk A T 10: 34,591,810 (GRCm38) probably null Het
Gm10392 T A 11: 77,517,481 (GRCm38) D104V probably benign Het
Gm960 T A 19: 4,652,171 (GRCm38) K282N probably damaging Het
Gpn1 A G 5: 31,497,338 (GRCm38) E78G possibly damaging Het
Hhip T C 8: 79,990,276 (GRCm38) Y506C probably damaging Het
Hid1 G A 11: 115,356,750 (GRCm38) S274L possibly damaging Het
Immp2l G T 12: 41,703,765 (GRCm38) probably benign Het
Klhl21 T C 4: 152,009,624 (GRCm38) F228L possibly damaging Het
Lamc1 T A 1: 153,243,478 (GRCm38) probably null Het
Lars G A 18: 42,210,050 (GRCm38) R1101C probably damaging Het
Magi2 T C 5: 19,227,332 (GRCm38) V15A probably benign Het
Map2k7 T C 8: 4,243,621 (GRCm38) probably null Het
Mga T A 2: 119,963,960 (GRCm38) H2590Q possibly damaging Het
Mlxip T C 5: 123,450,223 (GRCm38) I238T possibly damaging Het
Mylk T A 16: 34,875,586 (GRCm38) D230E probably benign Het
Nacad T A 11: 6,601,185 (GRCm38) T669S probably benign Het
Nin C T 12: 70,031,738 (GRCm38) M1691I probably benign Het
Nlrp4d C T 7: 10,382,237 (GRCm38) A203T probably damaging Het
Olfr1301 A T 2: 111,754,425 (GRCm38) M59L probably damaging Het
Olfr1495 A T 19: 13,768,510 (GRCm38) H56L probably benign Het
Olfr201 A G 16: 59,269,031 (GRCm38) V212A probably benign Het
Olfr433 T C 1: 174,042,480 (GRCm38) F177L probably benign Het
Olfr729 C A 14: 50,148,774 (GRCm38) M33I probably benign Het
Osbp C A 19: 11,977,829 (GRCm38) Q282K probably benign Het
Osbpl2 A G 2: 180,148,463 (GRCm38) S177G probably damaging Het
Pax1 A G 2: 147,366,255 (GRCm38) H261R possibly damaging Het
Pcif1 A T 2: 164,886,727 (GRCm38) L274F probably damaging Het
Pkhd1 A G 1: 20,117,825 (GRCm38) S3420P probably benign Het
Prss3 A C 6: 41,377,627 (GRCm38) probably benign Het
Ptk2b T C 14: 66,163,114 (GRCm38) T751A possibly damaging Het
Pus10 T C 11: 23,673,239 (GRCm38) V126A probably damaging Het
Rai14 A C 15: 10,587,916 (GRCm38) D258E probably damaging Het
Rbp3 T C 14: 33,954,524 (GRCm38) V143A possibly damaging Het
Sarm1 G A 11: 78,483,327 (GRCm38) Q625* probably null Het
Scgb1b21 T G 7: 33,527,667 (GRCm38) noncoding transcript Het
Scrn1 A T 6: 54,520,769 (GRCm38) V279E probably damaging Het
Sipa1l2 T C 8: 125,421,895 (GRCm38) T1670A probably damaging Het
Slc9a4 A T 1: 40,600,962 (GRCm38) I305F probably benign Het
Smarcc1 A G 9: 110,213,617 (GRCm38) T918A probably damaging Het
Tas2r109 A T 6: 132,980,426 (GRCm38) H180Q probably benign Het
Tas2r121 G A 6: 132,700,230 (GRCm38) R260* probably null Het
Tenm3 T C 8: 48,279,074 (GRCm38) D1249G probably benign Het
Tgtp1 C G 11: 48,987,530 (GRCm38) G116A probably damaging Het
Tial1 A G 7: 128,443,910 (GRCm38) Y317H probably damaging Het
Trim66 A T 7: 109,455,080 (GRCm38) W1308R probably damaging Het
Ulk2 T G 11: 61,783,545 (GRCm38) K878N possibly damaging Het
Zfp41 T A 15: 75,618,291 (GRCm38) S31T possibly damaging Het
Other mutations in Olfr1204
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01461:Olfr1204 APN 2 88,852,325 (GRCm38) missense probably damaging 0.99
R2151:Olfr1204 UTSW 2 88,852,784 (GRCm38) missense probably damaging 1.00
R2153:Olfr1204 UTSW 2 88,852,784 (GRCm38) missense probably damaging 1.00
R4959:Olfr1204 UTSW 2 88,852,172 (GRCm38) missense possibly damaging 0.79
R4973:Olfr1204 UTSW 2 88,852,172 (GRCm38) missense possibly damaging 0.79
R5048:Olfr1204 UTSW 2 88,852,463 (GRCm38) missense possibly damaging 0.91
R5164:Olfr1204 UTSW 2 88,852,570 (GRCm38) missense probably benign 0.30
R5319:Olfr1204 UTSW 2 88,852,778 (GRCm38) missense probably damaging 0.99
R5399:Olfr1204 UTSW 2 88,852,655 (GRCm38) missense probably damaging 1.00
R5688:Olfr1204 UTSW 2 88,852,679 (GRCm38) missense probably benign 0.07
R6339:Olfr1204 UTSW 2 88,852,871 (GRCm38) missense probably null
R6481:Olfr1204 UTSW 2 88,852,519 (GRCm38) missense probably damaging 1.00
R7456:Olfr1204 UTSW 2 88,852,219 (GRCm38) missense probably damaging 0.99
R7469:Olfr1204 UTSW 2 88,852,503 (GRCm38) missense probably benign
R9517:Olfr1204 UTSW 2 88,852,603 (GRCm38) missense probably benign 0.02
Predicted Primers PCR Primer

Sequencing Primer
Posted On 2014-04-24