Incidental Mutation 'R1584:Nin'
| ID |
177368 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Nin
|
| Ensembl Gene |
ENSMUSG00000021068 |
| Gene Name |
ninein |
| Synonyms |
3110068G20Rik |
| MMRRC Submission |
039621-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R1584 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
12 |
| Chromosomal Location |
70011435-70113717 bp(-) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 70042669 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Leucine to Glutamine
at position 1324
(L1324Q)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000152240
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000021468]
[ENSMUST00000085314]
[ENSMUST00000095666]
[ENSMUST00000169074]
[ENSMUST00000220689]
[ENSMUST00000222237]
[ENSMUST00000222835]
[ENSMUST00000223257]
|
| AlphaFold |
Q61043 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000021468
AA Change: L1324Q
PolyPhen 2
Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
|
| SMART Domains |
Protein: ENSMUSP00000021468
Gene: ENSMUSG00000021068
AA Change: L1324Q
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
7 |
67 |
7.83e-8 |
PROSPERO |
|
low complexity region
|
97 |
108 |
N/A |
INTRINSIC |
|
low complexity region
|
115 |
132 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
181 |
242 |
7.83e-8 |
PROSPERO |
|
low complexity region
|
276 |
289 |
N/A |
INTRINSIC |
|
low complexity region
|
336 |
353 |
N/A |
INTRINSIC |
|
coiled coil region
|
358 |
570 |
N/A |
INTRINSIC |
|
coiled coil region
|
625 |
802 |
N/A |
INTRINSIC |
|
coiled coil region
|
834 |
926 |
N/A |
INTRINSIC |
|
coiled coil region
|
957 |
1008 |
N/A |
INTRINSIC |
|
low complexity region
|
1035 |
1044 |
N/A |
INTRINSIC |
|
low complexity region
|
1047 |
1057 |
N/A |
INTRINSIC |
|
coiled coil region
|
1069 |
1094 |
N/A |
INTRINSIC |
|
coiled coil region
|
1178 |
1325 |
N/A |
INTRINSIC |
|
low complexity region
|
1374 |
1385 |
N/A |
INTRINSIC |
|
coiled coil region
|
1425 |
1806 |
N/A |
INTRINSIC |
|
coiled coil region
|
1980 |
2013 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000085314
AA Change: L1324Q
PolyPhen 2
Score 0.031 (Sensitivity: 0.95; Specificity: 0.82)
|
| SMART Domains |
Protein: ENSMUSP00000082422
Gene: ENSMUSG00000021068
AA Change: L1324Q
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
7 |
67 |
4.15e-8 |
PROSPERO |
|
low complexity region
|
97 |
108 |
N/A |
INTRINSIC |
|
low complexity region
|
115 |
132 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
181 |
242 |
4.15e-8 |
PROSPERO |
|
low complexity region
|
276 |
289 |
N/A |
INTRINSIC |
|
low complexity region
|
336 |
353 |
N/A |
INTRINSIC |
|
coiled coil region
|
358 |
570 |
N/A |
INTRINSIC |
|
coiled coil region
|
625 |
802 |
N/A |
INTRINSIC |
|
coiled coil region
|
834 |
926 |
N/A |
INTRINSIC |
|
coiled coil region
|
957 |
1008 |
N/A |
INTRINSIC |
|
low complexity region
|
1035 |
1044 |
N/A |
INTRINSIC |
|
low complexity region
|
1047 |
1057 |
N/A |
INTRINSIC |
|
coiled coil region
|
1069 |
1094 |
N/A |
INTRINSIC |
|
coiled coil region
|
1178 |
1325 |
N/A |
INTRINSIC |
|
low complexity region
|
1374 |
1385 |
N/A |
INTRINSIC |
|
coiled coil region
|
1425 |
1806 |
N/A |
INTRINSIC |
|
coiled coil region
|
1971 |
2045 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000095666
AA Change: L1324Q
PolyPhen 2
Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
|
| SMART Domains |
Protein: ENSMUSP00000093327
Gene: ENSMUSG00000021068
AA Change: L1324Q
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
7 |
67 |
7.83e-8 |
PROSPERO |
|
low complexity region
|
97 |
108 |
N/A |
INTRINSIC |
|
low complexity region
|
115 |
132 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
181 |
242 |
7.83e-8 |
PROSPERO |
|
low complexity region
|
276 |
289 |
N/A |
INTRINSIC |
|
low complexity region
|
336 |
353 |
N/A |
INTRINSIC |
|
coiled coil region
|
358 |
570 |
N/A |
INTRINSIC |
|
coiled coil region
|
625 |
802 |
N/A |
INTRINSIC |
|
coiled coil region
|
834 |
926 |
N/A |
INTRINSIC |
|
coiled coil region
|
957 |
1008 |
N/A |
INTRINSIC |
|
low complexity region
|
1035 |
1044 |
N/A |
INTRINSIC |
|
low complexity region
|
1047 |
1057 |
N/A |
INTRINSIC |
|
coiled coil region
|
1069 |
1094 |
N/A |
INTRINSIC |
|
coiled coil region
|
1178 |
1325 |
N/A |
INTRINSIC |
|
low complexity region
|
1374 |
1385 |
N/A |
INTRINSIC |
|
coiled coil region
|
1425 |
1806 |
N/A |
INTRINSIC |
|
coiled coil region
|
1980 |
2013 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000169074
AA Change: L1324Q
PolyPhen 2
Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
|
| SMART Domains |
Protein: ENSMUSP00000129648
Gene: ENSMUSG00000021068
AA Change: L1324Q
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
7 |
67 |
7.83e-8 |
PROSPERO |
|
low complexity region
|
97 |
108 |
N/A |
INTRINSIC |
|
low complexity region
|
115 |
132 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
181 |
242 |
7.83e-8 |
PROSPERO |
|
low complexity region
|
276 |
289 |
N/A |
INTRINSIC |
|
low complexity region
|
336 |
353 |
N/A |
INTRINSIC |
|
coiled coil region
|
358 |
570 |
N/A |
INTRINSIC |
|
coiled coil region
|
625 |
802 |
N/A |
INTRINSIC |
|
coiled coil region
|
834 |
926 |
N/A |
INTRINSIC |
|
coiled coil region
|
957 |
1008 |
N/A |
INTRINSIC |
|
low complexity region
|
1035 |
1044 |
N/A |
INTRINSIC |
|
low complexity region
|
1047 |
1057 |
N/A |
INTRINSIC |
|
coiled coil region
|
1069 |
1094 |
N/A |
INTRINSIC |
|
coiled coil region
|
1178 |
1325 |
N/A |
INTRINSIC |
|
low complexity region
|
1374 |
1385 |
N/A |
INTRINSIC |
|
coiled coil region
|
1425 |
1806 |
N/A |
INTRINSIC |
|
coiled coil region
|
1980 |
2013 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000220689
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000221486
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000222237
AA Change: L1324Q
PolyPhen 2
Score 0.031 (Sensitivity: 0.95; Specificity: 0.82)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000222835
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000223257
AA Change: L1324Q
PolyPhen 2
Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000223316
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 99.0%
- 3x: 98.1%
- 10x: 95.6%
- 20x: 90.2%
|
| Validation Efficiency |
99% (106/107) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes one of the proteins important for centrosomal function. This protein is important for positioning and anchoring the microtubules minus-ends in epithelial cells. Localization of this protein to the centrosome requires three leucine zippers in the central coiled-coil domain. Multiple alternatively spliced transcript variants that encode different isoforms have been reported. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 93 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abhd15 |
C |
T |
11: 77,515,410 (GRCm38) |
A71V |
probably damaging |
Het |
| Ager |
A |
G |
17: 34,600,718 (GRCm38) |
E357G |
probably damaging |
Het |
| Akap13 |
T |
C |
7: 75,729,049 (GRCm38) |
S2095P |
possibly damaging |
Het |
| Ampd2 |
T |
C |
3: 108,080,337 (GRCm38) |
|
probably null |
Het |
| Arrdc1 |
T |
C |
2: 24,925,795 (GRCm38) |
I398V |
probably benign |
Het |
| Ash1l |
T |
C |
3: 89,052,065 (GRCm38) |
Y2250H |
probably damaging |
Het |
| BC005561 |
T |
A |
5: 104,518,257 (GRCm38) |
I215N |
probably damaging |
Het |
| Brca2 |
G |
A |
5: 150,552,258 (GRCm38) |
A2478T |
probably damaging |
Het |
| Btrc |
T |
A |
19: 45,513,382 (GRCm38) |
|
probably benign |
Het |
| C8g |
C |
T |
2: 25,500,216 (GRCm38) |
A6T |
probably benign |
Het |
| Cdc123 |
T |
A |
2: 5,803,977 (GRCm38) |
|
probably null |
Het |
| Cilp |
G |
A |
9: 65,279,715 (GRCm38) |
G1031S |
probably damaging |
Het |
| Cldn5 |
G |
A |
16: 18,777,477 (GRCm38) |
G161D |
probably damaging |
Het |
| Cndp2 |
G |
A |
18: 84,677,315 (GRCm38) |
|
probably benign |
Het |
| Cntnap1 |
C |
A |
11: 101,180,360 (GRCm38) |
F366L |
probably damaging |
Het |
| Corin |
C |
T |
5: 72,302,790 (GRCm38) |
|
probably null |
Het |
| Ctdspl2 |
G |
A |
2: 122,003,929 (GRCm38) |
R332K |
probably benign |
Het |
| Dido1 |
G |
A |
2: 180,662,328 (GRCm38) |
P1261L |
probably damaging |
Het |
| Dopey1 |
A |
T |
9: 86,548,172 (GRCm38) |
R2200* |
probably null |
Het |
| Dtx3l |
G |
A |
16: 35,932,728 (GRCm38) |
L503F |
probably damaging |
Het |
| Dysf |
A |
G |
6: 84,067,047 (GRCm38) |
K259R |
probably benign |
Het |
| Enpep |
T |
A |
3: 129,319,448 (GRCm38) |
T203S |
probably damaging |
Het |
| Epha2 |
T |
A |
4: 141,322,047 (GRCm38) |
|
probably null |
Het |
| Fam20b |
T |
C |
1: 156,686,188 (GRCm38) |
|
probably benign |
Het |
| Fbln7 |
A |
G |
2: 128,877,429 (GRCm38) |
T49A |
probably benign |
Het |
| Fgf14 |
T |
A |
14: 124,676,539 (GRCm38) |
K60M |
probably benign |
Het |
| Fhad1 |
T |
C |
4: 141,985,511 (GRCm38) |
I206V |
probably benign |
Het |
| Figla |
A |
G |
6: 86,020,782 (GRCm38) |
E164G |
probably benign |
Het |
| Gimap4 |
C |
A |
6: 48,691,282 (GRCm38) |
Q196K |
probably benign |
Het |
| Glcci1 |
C |
T |
6: 8,537,964 (GRCm38) |
T6I |
probably damaging |
Het |
| Gm6583 |
C |
T |
5: 112,354,764 (GRCm38) |
G358D |
probably benign |
Het |
| Grk4 |
T |
C |
5: 34,694,750 (GRCm38) |
S113P |
probably benign |
Het |
| Hectd3 |
G |
A |
4: 116,996,566 (GRCm38) |
E220K |
probably damaging |
Het |
| Hecw1 |
A |
G |
13: 14,340,743 (GRCm38) |
|
probably null |
Het |
| Helz2 |
G |
A |
2: 181,236,297 (GRCm38) |
P903S |
probably damaging |
Het |
| Hydin |
T |
C |
8: 110,580,815 (GRCm38) |
V3942A |
probably benign |
Het |
| Irs1 |
G |
T |
1: 82,289,444 (GRCm38) |
H350Q |
probably benign |
Het |
| Kdm1b |
G |
A |
13: 47,064,054 (GRCm38) |
E46K |
probably damaging |
Het |
| Klf11 |
A |
G |
12: 24,655,305 (GRCm38) |
N253D |
probably damaging |
Het |
| Klhl23 |
T |
C |
2: 69,833,888 (GRCm38) |
I527T |
probably damaging |
Het |
| Lars |
G |
A |
18: 42,210,050 (GRCm38) |
R1101C |
probably damaging |
Het |
| Lcn4 |
G |
A |
2: 26,668,576 (GRCm38) |
P166L |
probably damaging |
Het |
| Letmd1 |
T |
A |
15: 100,472,542 (GRCm38) |
|
probably null |
Het |
| Lilra6 |
T |
A |
7: 3,912,662 (GRCm38) |
D358V |
probably damaging |
Het |
| Mmrn2 |
A |
G |
14: 34,375,685 (GRCm38) |
D24G |
probably benign |
Het |
| Mpp5 |
A |
G |
12: 78,829,727 (GRCm38) |
I482V |
probably benign |
Het |
| Mroh2b |
G |
T |
15: 4,925,684 (GRCm38) |
D720Y |
probably damaging |
Het |
| Mrps35 |
C |
T |
6: 147,055,984 (GRCm38) |
T169M |
probably damaging |
Het |
| Muc4 |
G |
A |
16: 32,753,595 (GRCm38) |
G1157D |
probably benign |
Het |
| Naga |
T |
A |
15: 82,334,788 (GRCm38) |
M237L |
probably null |
Het |
| Nfu1 |
G |
A |
6: 87,020,809 (GRCm38) |
E225K |
probably damaging |
Het |
| Oc90 |
T |
A |
15: 65,897,720 (GRCm38) |
Y96F |
probably damaging |
Het |
| Olfr1029 |
T |
A |
2: 85,975,995 (GRCm38) |
F251I |
probably damaging |
Het |
| Olfr1253 |
C |
T |
2: 89,752,267 (GRCm38) |
C187Y |
probably damaging |
Het |
| Olfr1471 |
T |
C |
19: 13,445,659 (GRCm38) |
Y216H |
probably damaging |
Het |
| Olfr25 |
G |
A |
9: 38,330,131 (GRCm38) |
M181I |
possibly damaging |
Het |
| Olfr522 |
A |
G |
7: 140,162,203 (GRCm38) |
V249A |
probably damaging |
Het |
| Orc4 |
A |
T |
2: 48,909,494 (GRCm38) |
C324S |
possibly damaging |
Het |
| Pdzrn4 |
T |
C |
15: 92,770,537 (GRCm38) |
S857P |
probably benign |
Het |
| Plec |
C |
T |
15: 76,185,908 (GRCm38) |
E1000K |
possibly damaging |
Het |
| Plvap |
A |
T |
8: 71,508,481 (GRCm38) |
V149D |
probably benign |
Het |
| Pm20d2 |
A |
T |
4: 33,174,772 (GRCm38) |
N371K |
probably damaging |
Het |
| Ppp2r5d |
A |
G |
17: 46,684,684 (GRCm38) |
Y480H |
probably benign |
Het |
| Prkd1 |
A |
T |
12: 50,425,515 (GRCm38) |
V205E |
probably damaging |
Het |
| R3hdm2 |
A |
G |
10: 127,476,690 (GRCm38) |
I434V |
probably benign |
Het |
| Rel |
T |
A |
11: 23,745,546 (GRCm38) |
T246S |
probably damaging |
Het |
| Rnf215 |
T |
A |
11: 4,136,719 (GRCm38) |
V172E |
probably damaging |
Het |
| Scara3 |
T |
C |
14: 65,921,104 (GRCm38) |
D485G |
probably damaging |
Het |
| Sec16a |
A |
T |
2: 26,431,157 (GRCm38) |
Y1308N |
probably damaging |
Het |
| Sis |
A |
T |
3: 72,932,060 (GRCm38) |
D824E |
possibly damaging |
Het |
| Slc27a4 |
T |
A |
2: 29,811,190 (GRCm38) |
V331E |
probably damaging |
Het |
| Srebf1 |
C |
T |
11: 60,200,702 (GRCm38) |
R999H |
probably benign |
Het |
| St3gal3 |
A |
C |
4: 118,107,662 (GRCm38) |
M1R |
probably null |
Het |
| Tapbp |
C |
T |
17: 33,919,940 (GRCm38) |
|
probably null |
Het |
| Tep1 |
A |
T |
14: 50,866,037 (GRCm38) |
N265K |
probably damaging |
Het |
| Tln2 |
T |
A |
9: 67,296,414 (GRCm38) |
N470I |
probably damaging |
Het |
| Trim43a |
G |
T |
9: 88,588,158 (GRCm38) |
W339L |
probably damaging |
Het |
| Ttc22 |
T |
C |
4: 106,622,780 (GRCm38) |
F77S |
probably damaging |
Het |
| Ttc8 |
A |
G |
12: 98,920,764 (GRCm38) |
E32G |
probably benign |
Het |
| Uhmk1 |
A |
T |
1: 170,208,653 (GRCm38) |
|
probably null |
Het |
| Usp17lc |
A |
G |
7: 103,418,941 (GRCm38) |
H481R |
possibly damaging |
Het |
| Vamp8 |
G |
A |
6: 72,385,634 (GRCm38) |
T35M |
probably damaging |
Het |
| Vill |
A |
G |
9: 119,065,586 (GRCm38) |
Y53C |
probably damaging |
Het |
| Vmn1r222 |
A |
T |
13: 23,232,762 (GRCm38) |
S94T |
probably damaging |
Het |
| Vmn2r93 |
A |
G |
17: 18,305,151 (GRCm38) |
Y357C |
possibly damaging |
Het |
| Vps13c |
T |
A |
9: 67,893,112 (GRCm38) |
V536D |
possibly damaging |
Het |
| Vrtn |
G |
A |
12: 84,650,081 (GRCm38) |
C535Y |
probably damaging |
Het |
| Vwa3a |
A |
G |
7: 120,768,165 (GRCm38) |
Y181C |
probably damaging |
Het |
| Wfikkn2 |
G |
A |
11: 94,238,895 (GRCm38) |
T140I |
probably damaging |
Het |
| Ykt6 |
T |
A |
11: 5,962,349 (GRCm38) |
F101I |
probably damaging |
Het |
| Zfp277 |
C |
T |
12: 40,378,826 (GRCm38) |
G174D |
probably benign |
Het |
| Zfp638 |
A |
G |
6: 83,978,065 (GRCm38) |
|
probably null |
Het |
| Zzef1 |
C |
T |
11: 72,924,679 (GRCm38) |
P2942S |
probably damaging |
Het |
|
| Other mutations in Nin |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00472:Nin
|
APN |
12 |
70,030,088 (GRCm38) |
missense |
probably damaging |
0.98 |
|
IGL00677:Nin
|
APN |
12 |
70,026,860 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL00823:Nin
|
APN |
12 |
70,014,793 (GRCm38) |
missense |
probably benign |
0.01 |
|
IGL01103:Nin
|
APN |
12 |
70,056,758 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL01113:Nin
|
APN |
12 |
70,031,779 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01420:Nin
|
APN |
12 |
70,045,414 (GRCm38) |
missense |
probably benign |
0.08 |
|
IGL01556:Nin
|
APN |
12 |
70,043,188 (GRCm38) |
missense |
probably benign |
0.01 |
|
IGL01663:Nin
|
APN |
12 |
70,043,665 (GRCm38) |
missense |
possibly damaging |
0.72 |
|
IGL02002:Nin
|
APN |
12 |
70,062,699 (GRCm38) |
nonsense |
probably null |
|
|
IGL02030:Nin
|
APN |
12 |
70,045,268 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02202:Nin
|
APN |
12 |
70,055,436 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02207:Nin
|
APN |
12 |
70,056,657 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL02257:Nin
|
APN |
12 |
70,102,691 (GRCm38) |
missense |
possibly damaging |
0.71 |
|
IGL02394:Nin
|
APN |
12 |
70,044,031 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02531:Nin
|
APN |
12 |
70,020,932 (GRCm38) |
missense |
probably benign |
0.02 |
|
IGL03028:Nin
|
APN |
12 |
70,035,270 (GRCm38) |
missense |
probably benign |
0.13 |
|
IGL03155:Nin
|
APN |
12 |
70,031,770 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03197:Nin
|
APN |
12 |
70,026,810 (GRCm38) |
missense |
probably benign |
0.03 |
|
IGL02835:Nin
|
UTSW |
12 |
70,056,738 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0131:Nin
|
UTSW |
12 |
70,051,141 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0131:Nin
|
UTSW |
12 |
70,051,141 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0132:Nin
|
UTSW |
12 |
70,051,141 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0211:Nin
|
UTSW |
12 |
70,014,875 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0211:Nin
|
UTSW |
12 |
70,014,875 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0734:Nin
|
UTSW |
12 |
70,030,113 (GRCm38) |
missense |
probably benign |
0.01 |
|
R0947:Nin
|
UTSW |
12 |
70,061,186 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1085:Nin
|
UTSW |
12 |
70,020,962 (GRCm38) |
missense |
possibly damaging |
0.91 |
|
R1367:Nin
|
UTSW |
12 |
70,043,929 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1452:Nin
|
UTSW |
12 |
70,017,650 (GRCm38) |
nonsense |
probably null |
|
|
R1477:Nin
|
UTSW |
12 |
70,044,184 (GRCm38) |
missense |
possibly damaging |
0.87 |
|
R1518:Nin
|
UTSW |
12 |
70,014,773 (GRCm38) |
missense |
probably benign |
0.27 |
|
R1566:Nin
|
UTSW |
12 |
70,054,479 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1572:Nin
|
UTSW |
12 |
70,038,750 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1583:Nin
|
UTSW |
12 |
70,031,738 (GRCm38) |
missense |
probably benign |
|
|
R1699:Nin
|
UTSW |
12 |
70,045,563 (GRCm38) |
missense |
possibly damaging |
0.87 |
|
R1699:Nin
|
UTSW |
12 |
70,030,938 (GRCm38) |
missense |
probably benign |
0.40 |
|
R1765:Nin
|
UTSW |
12 |
70,042,891 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1794:Nin
|
UTSW |
12 |
70,043,795 (GRCm38) |
nonsense |
probably null |
|
|
R1952:Nin
|
UTSW |
12 |
70,030,926 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2004:Nin
|
UTSW |
12 |
70,025,477 (GRCm38) |
missense |
probably benign |
0.01 |
|
R2025:Nin
|
UTSW |
12 |
70,030,008 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2060:Nin
|
UTSW |
12 |
70,042,418 (GRCm38) |
missense |
possibly damaging |
0.64 |
|
R2213:Nin
|
UTSW |
12 |
70,045,354 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2224:Nin
|
UTSW |
12 |
70,061,230 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2247:Nin
|
UTSW |
12 |
70,054,545 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2972:Nin
|
UTSW |
12 |
70,062,713 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3776:Nin
|
UTSW |
12 |
70,038,682 (GRCm38) |
missense |
possibly damaging |
0.71 |
|
R3881:Nin
|
UTSW |
12 |
70,042,541 (GRCm38) |
missense |
probably benign |
0.00 |
|
R3930:Nin
|
UTSW |
12 |
70,078,242 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3959:Nin
|
UTSW |
12 |
70,050,752 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4229:Nin
|
UTSW |
12 |
70,051,210 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R4359:Nin
|
UTSW |
12 |
70,014,938 (GRCm38) |
missense |
probably benign |
0.00 |
|
R4423:Nin
|
UTSW |
12 |
70,042,978 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4461:Nin
|
UTSW |
12 |
70,042,585 (GRCm38) |
missense |
probably benign |
0.37 |
|
R4639:Nin
|
UTSW |
12 |
70,038,601 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R4791:Nin
|
UTSW |
12 |
70,043,807 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R4839:Nin
|
UTSW |
12 |
70,090,551 (GRCm38) |
missense |
possibly damaging |
0.46 |
|
R4912:Nin
|
UTSW |
12 |
70,044,063 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5712:Nin
|
UTSW |
12 |
70,042,769 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5726:Nin
|
UTSW |
12 |
70,078,179 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5804:Nin
|
UTSW |
12 |
70,045,601 (GRCm38) |
missense |
possibly damaging |
0.58 |
|
R5874:Nin
|
UTSW |
12 |
70,030,918 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R5992:Nin
|
UTSW |
12 |
70,045,524 (GRCm38) |
missense |
possibly damaging |
0.83 |
|
R6077:Nin
|
UTSW |
12 |
70,019,232 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6184:Nin
|
UTSW |
12 |
70,043,737 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6307:Nin
|
UTSW |
12 |
70,014,857 (GRCm38) |
missense |
possibly damaging |
0.91 |
|
R6315:Nin
|
UTSW |
12 |
70,045,615 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6326:Nin
|
UTSW |
12 |
70,045,181 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R6492:Nin
|
UTSW |
12 |
70,054,534 (GRCm38) |
missense |
probably benign |
0.22 |
|
R6562:Nin
|
UTSW |
12 |
70,055,954 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6578:Nin
|
UTSW |
12 |
70,061,194 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R6613:Nin
|
UTSW |
12 |
70,030,954 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7112:Nin
|
UTSW |
12 |
70,102,799 (GRCm38) |
missense |
|
|
|
R7170:Nin
|
UTSW |
12 |
70,044,239 (GRCm38) |
missense |
|
|
|
R7324:Nin
|
UTSW |
12 |
70,043,734 (GRCm38) |
missense |
|
|
|
R7338:Nin
|
UTSW |
12 |
70,044,064 (GRCm38) |
missense |
|
|
|
R7372:Nin
|
UTSW |
12 |
70,056,029 (GRCm38) |
missense |
|
|
|
R7431:Nin
|
UTSW |
12 |
70,078,223 (GRCm38) |
missense |
|
|
|
R7577:Nin
|
UTSW |
12 |
70,062,706 (GRCm38) |
missense |
|
|
|
R7655:Nin
|
UTSW |
12 |
70,042,768 (GRCm38) |
missense |
|
|
|
R7656:Nin
|
UTSW |
12 |
70,042,768 (GRCm38) |
missense |
|
|
|
R7683:Nin
|
UTSW |
12 |
70,078,182 (GRCm38) |
missense |
|
|
|
R7769:Nin
|
UTSW |
12 |
70,043,230 (GRCm38) |
missense |
|
|
|
R7981:Nin
|
UTSW |
12 |
70,042,817 (GRCm38) |
missense |
|
|
|
R8138:Nin
|
UTSW |
12 |
70,042,898 (GRCm38) |
missense |
|
|
|
R8141:Nin
|
UTSW |
12 |
70,030,021 (GRCm38) |
missense |
|
|
|
R8754:Nin
|
UTSW |
12 |
70,031,013 (GRCm38) |
intron |
probably benign |
|
|
R8790:Nin
|
UTSW |
12 |
70,021,019 (GRCm38) |
missense |
|
|
|
R8899:Nin
|
UTSW |
12 |
70,030,936 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8974:Nin
|
UTSW |
12 |
70,078,158 (GRCm38) |
missense |
|
|
|
R9085:Nin
|
UTSW |
12 |
70,030,012 (GRCm38) |
nonsense |
probably null |
|
|
R9143:Nin
|
UTSW |
12 |
70,090,575 (GRCm38) |
missense |
|
|
|
R9380:Nin
|
UTSW |
12 |
70,028,031 (GRCm38) |
missense |
|
|
|
R9496:Nin
|
UTSW |
12 |
70,055,988 (GRCm38) |
missense |
|
|
|
R9638:Nin
|
UTSW |
12 |
70,020,844 (GRCm38) |
missense |
|
|
|
R9709:Nin
|
UTSW |
12 |
70,102,694 (GRCm38) |
missense |
|
|
|
R9745:Nin
|
UTSW |
12 |
70,043,125 (GRCm38) |
missense |
|
|
|
R9792:Nin
|
UTSW |
12 |
70,047,235 (GRCm38) |
missense |
|
|
|
Z1176:Nin
|
UTSW |
12 |
70,049,164 (GRCm38) |
critical splice acceptor site |
probably null |
|
|
Z1177:Nin
|
UTSW |
12 |
70,054,426 (GRCm38) |
missense |
|
|
|
Z1177:Nin
|
UTSW |
12 |
70,044,095 (GRCm38) |
missense |
|
|
|
| Predicted Primers |
PCR Primer
(F):5'- CCTCCTGCTGAAGATGCTTGTCTTG -3'
(R):5'- CGCTGGACAGCAACAAAGAGCTTAC -3'
Sequencing Primer
(F):5'- gagcagcacttccctcc -3'
(R):5'- TTACGGCGGAGGTCTACAG -3'
|
| Posted On |
2014-04-24 |
Incidental Mutation