Incidental Mutation 'R1584:Hecw1'
| ID |
177372 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Hecw1
|
| Ensembl Gene |
ENSMUSG00000021301 |
| Gene Name |
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 |
| Synonyms |
NEDL1, E130207I19Rik |
| MMRRC Submission |
039621-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R1584 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
13 |
| Chromosomal Location |
14401023-14697813 bp(-) (GRCm39) |
| Type of Mutation |
critical splice donor site (2 bp from exon) |
| DNA Base Change (assembly) |
A to G
at 14515328 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000106145
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000110516]
|
| AlphaFold |
Q8K4P8 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000110516
|
| SMART Domains |
Protein: ENSMUSP00000106145
Gene: ENSMUSG00000021301
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:HECW_N
|
65 |
184 |
6.5e-62 |
PFAM |
|
C2
|
206 |
317 |
1.02e-12 |
SMART |
|
low complexity region
|
463 |
477 |
N/A |
INTRINSIC |
|
low complexity region
|
497 |
512 |
N/A |
INTRINSIC |
|
low complexity region
|
577 |
598 |
N/A |
INTRINSIC |
|
low complexity region
|
677 |
704 |
N/A |
INTRINSIC |
|
low complexity region
|
731 |
745 |
N/A |
INTRINSIC |
|
WW
|
827 |
859 |
8.66e-13 |
SMART |
|
coiled coil region
|
873 |
898 |
N/A |
INTRINSIC |
|
low complexity region
|
917 |
930 |
N/A |
INTRINSIC |
|
WW
|
1017 |
1049 |
5.59e-7 |
SMART |
|
Blast:HECTc
|
1137 |
1192 |
3e-26 |
BLAST |
|
low complexity region
|
1193 |
1208 |
N/A |
INTRINSIC |
|
low complexity region
|
1212 |
1223 |
N/A |
INTRINSIC |
|
HECTc
|
1267 |
1604 |
1.36e-185 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000221863
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000222904
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000223317
|
| Meta Mutation Damage Score |
0.9493 |
| Coding Region Coverage |
- 1x: 99.0%
- 3x: 98.1%
- 10x: 95.6%
- 20x: 90.2%
|
| Validation Efficiency |
99% (106/107) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 93 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abhd15 |
C |
T |
11: 77,406,236 (GRCm39) |
A71V |
probably damaging |
Het |
| Ager |
A |
G |
17: 34,819,692 (GRCm39) |
E357G |
probably damaging |
Het |
| Akap13 |
T |
C |
7: 75,378,797 (GRCm39) |
S2095P |
possibly damaging |
Het |
| Ampd2 |
T |
C |
3: 107,987,653 (GRCm39) |
|
probably null |
Het |
| Arrdc1 |
T |
C |
2: 24,815,807 (GRCm39) |
I398V |
probably benign |
Het |
| Ash1l |
T |
C |
3: 88,959,372 (GRCm39) |
Y2250H |
probably damaging |
Het |
| Brca2 |
G |
A |
5: 150,475,723 (GRCm39) |
A2478T |
probably damaging |
Het |
| Btrc |
T |
A |
19: 45,501,821 (GRCm39) |
|
probably benign |
Het |
| C8g |
C |
T |
2: 25,390,228 (GRCm39) |
A6T |
probably benign |
Het |
| Ccdc121rt3 |
C |
T |
5: 112,502,630 (GRCm39) |
G358D |
probably benign |
Het |
| Cdc123 |
T |
A |
2: 5,808,788 (GRCm39) |
|
probably null |
Het |
| Cilp |
G |
A |
9: 65,186,997 (GRCm39) |
G1031S |
probably damaging |
Het |
| Cldn5 |
G |
A |
16: 18,596,227 (GRCm39) |
G161D |
probably damaging |
Het |
| Cndp2 |
G |
A |
18: 84,695,440 (GRCm39) |
|
probably benign |
Het |
| Cntnap1 |
C |
A |
11: 101,071,186 (GRCm39) |
F366L |
probably damaging |
Het |
| Corin |
C |
T |
5: 72,460,133 (GRCm39) |
|
probably null |
Het |
| Ctdspl2 |
G |
A |
2: 121,834,410 (GRCm39) |
R332K |
probably benign |
Het |
| Dido1 |
G |
A |
2: 180,304,121 (GRCm39) |
P1261L |
probably damaging |
Het |
| Dop1a |
A |
T |
9: 86,430,225 (GRCm39) |
R2200* |
probably null |
Het |
| Dtx3l |
G |
A |
16: 35,753,098 (GRCm39) |
L503F |
probably damaging |
Het |
| Dysf |
A |
G |
6: 84,044,029 (GRCm39) |
K259R |
probably benign |
Het |
| Enpep |
T |
A |
3: 129,113,097 (GRCm39) |
T203S |
probably damaging |
Het |
| Epha2 |
T |
A |
4: 141,049,358 (GRCm39) |
|
probably null |
Het |
| Fam20b |
T |
C |
1: 156,513,758 (GRCm39) |
|
probably benign |
Het |
| Fbln7 |
A |
G |
2: 128,719,349 (GRCm39) |
T49A |
probably benign |
Het |
| Fgf14 |
T |
A |
14: 124,913,951 (GRCm39) |
K60M |
probably benign |
Het |
| Fhad1 |
T |
C |
4: 141,712,822 (GRCm39) |
I206V |
probably benign |
Het |
| Figla |
A |
G |
6: 85,997,764 (GRCm39) |
E164G |
probably benign |
Het |
| Gimap4 |
C |
A |
6: 48,668,216 (GRCm39) |
Q196K |
probably benign |
Het |
| Glcci1 |
C |
T |
6: 8,537,964 (GRCm39) |
T6I |
probably damaging |
Het |
| Grk4 |
T |
C |
5: 34,852,094 (GRCm39) |
S113P |
probably benign |
Het |
| Hectd3 |
G |
A |
4: 116,853,763 (GRCm39) |
E220K |
probably damaging |
Het |
| Helz2 |
G |
A |
2: 180,878,090 (GRCm39) |
P903S |
probably damaging |
Het |
| Hydin |
T |
C |
8: 111,307,447 (GRCm39) |
V3942A |
probably benign |
Het |
| Irs1 |
G |
T |
1: 82,267,165 (GRCm39) |
H350Q |
probably benign |
Het |
| Kdm1b |
G |
A |
13: 47,217,530 (GRCm39) |
E46K |
probably damaging |
Het |
| Klf11 |
A |
G |
12: 24,705,304 (GRCm39) |
N253D |
probably damaging |
Het |
| Klhl23 |
T |
C |
2: 69,664,232 (GRCm39) |
I527T |
probably damaging |
Het |
| Lars1 |
G |
A |
18: 42,343,115 (GRCm39) |
R1101C |
probably damaging |
Het |
| Lcn4 |
G |
A |
2: 26,558,588 (GRCm39) |
P166L |
probably damaging |
Het |
| Letmd1 |
T |
A |
15: 100,370,423 (GRCm39) |
|
probably null |
Het |
| Lilra6 |
T |
A |
7: 3,915,661 (GRCm39) |
D358V |
probably damaging |
Het |
| Mmrn2 |
A |
G |
14: 34,097,642 (GRCm39) |
D24G |
probably benign |
Het |
| Mroh2b |
G |
T |
15: 4,955,166 (GRCm39) |
D720Y |
probably damaging |
Het |
| Mrps35 |
C |
T |
6: 146,957,482 (GRCm39) |
T169M |
probably damaging |
Het |
| Muc4 |
G |
A |
16: 32,574,886 (GRCm39) |
G1157D |
probably benign |
Het |
| Naga |
T |
A |
15: 82,218,989 (GRCm39) |
M237L |
probably null |
Het |
| Nfu1 |
G |
A |
6: 86,997,791 (GRCm39) |
E225K |
probably damaging |
Het |
| Nin |
A |
T |
12: 70,089,443 (GRCm39) |
L1324Q |
probably benign |
Het |
| Oc90 |
T |
A |
15: 65,769,569 (GRCm39) |
Y96F |
probably damaging |
Het |
| Or4a80 |
C |
T |
2: 89,582,611 (GRCm39) |
C187Y |
probably damaging |
Het |
| Or5b116 |
T |
C |
19: 13,423,023 (GRCm39) |
Y216H |
probably damaging |
Het |
| Or5m11b |
T |
A |
2: 85,806,339 (GRCm39) |
F251I |
probably damaging |
Het |
| Or6ae1 |
A |
G |
7: 139,742,116 (GRCm39) |
V249A |
probably damaging |
Het |
| Or8c9 |
G |
A |
9: 38,241,427 (GRCm39) |
M181I |
possibly damaging |
Het |
| Orc4 |
A |
T |
2: 48,799,506 (GRCm39) |
C324S |
possibly damaging |
Het |
| Pals1 |
A |
G |
12: 78,876,501 (GRCm39) |
I482V |
probably benign |
Het |
| Pdzrn4 |
T |
C |
15: 92,668,418 (GRCm39) |
S857P |
probably benign |
Het |
| Plec |
C |
T |
15: 76,070,108 (GRCm39) |
E1000K |
possibly damaging |
Het |
| Plvap |
A |
T |
8: 71,961,125 (GRCm39) |
V149D |
probably benign |
Het |
| Pm20d2 |
A |
T |
4: 33,174,772 (GRCm39) |
N371K |
probably damaging |
Het |
| Ppp2r5d |
A |
G |
17: 46,995,610 (GRCm39) |
Y480H |
probably benign |
Het |
| Prkd1 |
A |
T |
12: 50,472,298 (GRCm39) |
V205E |
probably damaging |
Het |
| R3hdm2 |
A |
G |
10: 127,312,559 (GRCm39) |
I434V |
probably benign |
Het |
| Rel |
T |
A |
11: 23,695,546 (GRCm39) |
T246S |
probably damaging |
Het |
| Rnf215 |
T |
A |
11: 4,086,719 (GRCm39) |
V172E |
probably damaging |
Het |
| Scara3 |
T |
C |
14: 66,158,553 (GRCm39) |
D485G |
probably damaging |
Het |
| Sec16a |
A |
T |
2: 26,321,169 (GRCm39) |
Y1308N |
probably damaging |
Het |
| Sis |
A |
T |
3: 72,839,393 (GRCm39) |
D824E |
possibly damaging |
Het |
| Slc27a4 |
T |
A |
2: 29,701,202 (GRCm39) |
V331E |
probably damaging |
Het |
| Srebf1 |
C |
T |
11: 60,091,528 (GRCm39) |
R999H |
probably benign |
Het |
| St3gal3 |
A |
C |
4: 117,964,859 (GRCm39) |
M1R |
probably null |
Het |
| Tapbp |
C |
T |
17: 34,138,914 (GRCm39) |
|
probably null |
Het |
| Tep1 |
A |
T |
14: 51,103,494 (GRCm39) |
N265K |
probably damaging |
Het |
| Thoc2l |
T |
A |
5: 104,666,123 (GRCm39) |
I215N |
probably damaging |
Het |
| Tln2 |
T |
A |
9: 67,203,696 (GRCm39) |
N470I |
probably damaging |
Het |
| Trim43a |
G |
T |
9: 88,470,211 (GRCm39) |
W339L |
probably damaging |
Het |
| Ttc22 |
T |
C |
4: 106,479,977 (GRCm39) |
F77S |
probably damaging |
Het |
| Ttc8 |
A |
G |
12: 98,887,023 (GRCm39) |
E32G |
probably benign |
Het |
| Uhmk1 |
A |
T |
1: 170,036,222 (GRCm39) |
|
probably null |
Het |
| Usp17lc |
A |
G |
7: 103,068,148 (GRCm39) |
H481R |
possibly damaging |
Het |
| Vamp8 |
G |
A |
6: 72,362,617 (GRCm39) |
T35M |
probably damaging |
Het |
| Vill |
A |
G |
9: 118,894,654 (GRCm39) |
Y53C |
probably damaging |
Het |
| Vmn1r222 |
A |
T |
13: 23,416,932 (GRCm39) |
S94T |
probably damaging |
Het |
| Vmn2r93 |
A |
G |
17: 18,525,413 (GRCm39) |
Y357C |
possibly damaging |
Het |
| Vps13c |
T |
A |
9: 67,800,394 (GRCm39) |
V536D |
possibly damaging |
Het |
| Vrtn |
G |
A |
12: 84,696,855 (GRCm39) |
C535Y |
probably damaging |
Het |
| Vwa3a |
A |
G |
7: 120,367,388 (GRCm39) |
Y181C |
probably damaging |
Het |
| Wfikkn2 |
G |
A |
11: 94,129,721 (GRCm39) |
T140I |
probably damaging |
Het |
| Ykt6 |
T |
A |
11: 5,912,349 (GRCm39) |
F101I |
probably damaging |
Het |
| Zfp277 |
C |
T |
12: 40,428,825 (GRCm39) |
G174D |
probably benign |
Het |
| Zfp638 |
A |
G |
6: 83,955,047 (GRCm39) |
|
probably null |
Het |
| Zzef1 |
C |
T |
11: 72,815,505 (GRCm39) |
P2942S |
probably damaging |
Het |
|
| Other mutations in Hecw1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00591:Hecw1
|
APN |
13 |
14,440,565 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
IGL00813:Hecw1
|
APN |
13 |
14,452,961 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
IGL00843:Hecw1
|
APN |
13 |
14,422,158 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL00942:Hecw1
|
APN |
13 |
14,515,325 (GRCm39) |
splice site |
probably benign |
|
|
IGL00976:Hecw1
|
APN |
13 |
14,493,557 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01289:Hecw1
|
APN |
13 |
14,438,719 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01675:Hecw1
|
APN |
13 |
14,409,007 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01783:Hecw1
|
APN |
13 |
14,452,878 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01941:Hecw1
|
APN |
13 |
14,490,895 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02170:Hecw1
|
APN |
13 |
14,438,743 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
IGL02172:Hecw1
|
APN |
13 |
14,438,734 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02214:Hecw1
|
APN |
13 |
14,474,978 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02350:Hecw1
|
APN |
13 |
14,422,923 (GRCm39) |
splice site |
probably null |
|
|
IGL02357:Hecw1
|
APN |
13 |
14,422,923 (GRCm39) |
splice site |
probably null |
|
|
IGL02372:Hecw1
|
APN |
13 |
14,438,706 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02591:Hecw1
|
APN |
13 |
14,531,821 (GRCm39) |
splice site |
probably benign |
|
|
IGL02718:Hecw1
|
APN |
13 |
14,481,520 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
IGL02795:Hecw1
|
APN |
13 |
14,497,102 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02941:Hecw1
|
APN |
13 |
14,552,311 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03256:Hecw1
|
APN |
13 |
14,455,070 (GRCm39) |
missense |
probably benign |
0.36 |
|
IGL03256:Hecw1
|
APN |
13 |
14,455,069 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03366:Hecw1
|
APN |
13 |
14,552,382 (GRCm39) |
missense |
probably damaging |
1.00 |
|
deflated
|
UTSW |
13 |
14,422,205 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
Demoralized
|
UTSW |
13 |
14,491,403 (GRCm39) |
nonsense |
probably null |
|
|
Letdown
|
UTSW |
13 |
14,491,077 (GRCm39) |
missense |
probably benign |
0.40 |
|
BB001:Hecw1
|
UTSW |
13 |
14,497,113 (GRCm39) |
missense |
probably damaging |
1.00 |
|
BB011:Hecw1
|
UTSW |
13 |
14,497,113 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03014:Hecw1
|
UTSW |
13 |
14,420,393 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4378001:Hecw1
|
UTSW |
13 |
14,552,368 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0555:Hecw1
|
UTSW |
13 |
14,411,526 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0617:Hecw1
|
UTSW |
13 |
14,455,027 (GRCm39) |
missense |
probably benign |
0.44 |
|
R1476:Hecw1
|
UTSW |
13 |
14,480,671 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1479:Hecw1
|
UTSW |
13 |
14,491,077 (GRCm39) |
missense |
probably benign |
0.40 |
|
R1551:Hecw1
|
UTSW |
13 |
14,491,528 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1579:Hecw1
|
UTSW |
13 |
14,552,492 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1735:Hecw1
|
UTSW |
13 |
14,552,350 (GRCm39) |
missense |
probably null |
0.09 |
|
R1872:Hecw1
|
UTSW |
13 |
14,455,034 (GRCm39) |
nonsense |
probably null |
|
|
R1897:Hecw1
|
UTSW |
13 |
14,552,525 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2054:Hecw1
|
UTSW |
13 |
14,471,998 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2085:Hecw1
|
UTSW |
13 |
14,438,672 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R2134:Hecw1
|
UTSW |
13 |
14,552,285 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2172:Hecw1
|
UTSW |
13 |
14,552,291 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2258:Hecw1
|
UTSW |
13 |
14,490,723 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2274:Hecw1
|
UTSW |
13 |
14,520,653 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2275:Hecw1
|
UTSW |
13 |
14,520,653 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2937:Hecw1
|
UTSW |
13 |
14,420,421 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R3830:Hecw1
|
UTSW |
13 |
14,520,643 (GRCm39) |
missense |
probably benign |
0.13 |
|
R3971:Hecw1
|
UTSW |
13 |
14,411,514 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4065:Hecw1
|
UTSW |
13 |
14,491,016 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4066:Hecw1
|
UTSW |
13 |
14,491,016 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4235:Hecw1
|
UTSW |
13 |
14,491,724 (GRCm39) |
missense |
probably benign |
0.42 |
|
R4366:Hecw1
|
UTSW |
13 |
14,490,749 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4382:Hecw1
|
UTSW |
13 |
14,490,749 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4385:Hecw1
|
UTSW |
13 |
14,490,749 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4510:Hecw1
|
UTSW |
13 |
14,531,776 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4511:Hecw1
|
UTSW |
13 |
14,531,776 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4558:Hecw1
|
UTSW |
13 |
14,422,190 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4804:Hecw1
|
UTSW |
13 |
14,480,570 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4854:Hecw1
|
UTSW |
13 |
14,491,477 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5104:Hecw1
|
UTSW |
13 |
14,515,377 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5113:Hecw1
|
UTSW |
13 |
14,520,614 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R5167:Hecw1
|
UTSW |
13 |
14,460,242 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5392:Hecw1
|
UTSW |
13 |
14,420,347 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5394:Hecw1
|
UTSW |
13 |
14,497,174 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5504:Hecw1
|
UTSW |
13 |
14,515,487 (GRCm39) |
missense |
probably benign |
0.04 |
|
R5764:Hecw1
|
UTSW |
13 |
14,497,094 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6038:Hecw1
|
UTSW |
13 |
14,520,647 (GRCm39) |
missense |
probably benign |
0.28 |
|
R6038:Hecw1
|
UTSW |
13 |
14,520,647 (GRCm39) |
missense |
probably benign |
0.28 |
|
R6228:Hecw1
|
UTSW |
13 |
14,520,623 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6247:Hecw1
|
UTSW |
13 |
14,409,010 (GRCm39) |
nonsense |
probably null |
|
|
R6252:Hecw1
|
UTSW |
13 |
14,446,664 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6291:Hecw1
|
UTSW |
13 |
14,697,592 (GRCm39) |
unclassified |
probably benign |
|
|
R6321:Hecw1
|
UTSW |
13 |
14,697,414 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6325:Hecw1
|
UTSW |
13 |
14,491,031 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6328:Hecw1
|
UTSW |
13 |
14,422,205 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R6557:Hecw1
|
UTSW |
13 |
14,491,231 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R6566:Hecw1
|
UTSW |
13 |
14,471,868 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6597:Hecw1
|
UTSW |
13 |
14,491,403 (GRCm39) |
nonsense |
probably null |
|
|
R6821:Hecw1
|
UTSW |
13 |
14,438,719 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6914:Hecw1
|
UTSW |
13 |
14,491,423 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7078:Hecw1
|
UTSW |
13 |
14,609,044 (GRCm39) |
start codon destroyed |
probably null |
0.21 |
|
R7114:Hecw1
|
UTSW |
13 |
14,486,356 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7140:Hecw1
|
UTSW |
13 |
14,491,118 (GRCm39) |
missense |
probably benign |
|
|
R7150:Hecw1
|
UTSW |
13 |
14,609,045 (GRCm39) |
start codon destroyed |
probably benign |
|
|
R7288:Hecw1
|
UTSW |
13 |
14,490,821 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7447:Hecw1
|
UTSW |
13 |
14,531,789 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7479:Hecw1
|
UTSW |
13 |
14,515,425 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7552:Hecw1
|
UTSW |
13 |
14,490,835 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7590:Hecw1
|
UTSW |
13 |
14,438,668 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7787:Hecw1
|
UTSW |
13 |
14,493,494 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7803:Hecw1
|
UTSW |
13 |
14,408,927 (GRCm39) |
missense |
probably benign |
0.25 |
|
R7924:Hecw1
|
UTSW |
13 |
14,497,113 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7967:Hecw1
|
UTSW |
13 |
14,552,332 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8176:Hecw1
|
UTSW |
13 |
14,422,286 (GRCm39) |
splice site |
probably null |
|
|
R8195:Hecw1
|
UTSW |
13 |
14,480,692 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8252:Hecw1
|
UTSW |
13 |
14,515,425 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8696:Hecw1
|
UTSW |
13 |
14,531,743 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R8827:Hecw1
|
UTSW |
13 |
14,438,720 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8867:Hecw1
|
UTSW |
13 |
14,422,275 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R8914:Hecw1
|
UTSW |
13 |
14,422,188 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8942:Hecw1
|
UTSW |
13 |
14,481,395 (GRCm39) |
missense |
probably benign |
0.28 |
|
R9126:Hecw1
|
UTSW |
13 |
14,546,608 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9185:Hecw1
|
UTSW |
13 |
14,491,628 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9203:Hecw1
|
UTSW |
13 |
14,491,243 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9236:Hecw1
|
UTSW |
13 |
14,490,643 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R9291:Hecw1
|
UTSW |
13 |
14,491,522 (GRCm39) |
missense |
probably benign |
|
|
R9312:Hecw1
|
UTSW |
13 |
14,546,567 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9438:Hecw1
|
UTSW |
13 |
14,481,414 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9502:Hecw1
|
UTSW |
13 |
14,546,567 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9642:Hecw1
|
UTSW |
13 |
14,515,394 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF001:Hecw1
|
UTSW |
13 |
14,472,009 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0020:Hecw1
|
UTSW |
13 |
14,405,308 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
X0066:Hecw1
|
UTSW |
13 |
14,455,045 (GRCm39) |
missense |
probably benign |
0.13 |
|
Z1176:Hecw1
|
UTSW |
13 |
14,474,918 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
| Predicted Primers |
PCR Primer
(F):5'- GGGACAATAATCCCAGACCCTGGAG -3'
(R):5'- TGCATAGGACCTGTAGATACTCAACCTC -3'
Sequencing Primer
(F):5'- AGACCCTGGAGTTGGAGGC -3'
(R):5'- AGGGATGTTTTTCAACCCCG -3'
|
| Posted On |
2014-04-24 |
Incidental Mutation