Mutagenetix > Incidental Mutation

Incidental Mutation 'R1590:Dnah2'

177817

Institutional Source

Beutler Lab

Gene Symbol

Dnah2

Ensembl Gene

ENSMUSG00000005237

Gene Name

dynein, axonemal, heavy chain 2

Synonyms

Dnahc2, Dnhd3, D330014H01Rik, 2900022L05Rik

MMRRC Submission

039627-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R1590 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

69420809-69549110 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 69521198 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 246 (T246A)

Ref Sequence

ENSEMBL: ENSMUSP00000047329 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000035539] [ENSMUST00000108659] [ENSMUST00000208777]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000035539
AA Change: T246A

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)

SMART Domains

Protein: ENSMUSP00000047329
Gene: ENSMUSG00000005237
AA Change: T246A

Domain	Start	End	E-Value	Type
low complexity region	4	25	N/A	INTRINSIC
Pfam:DHC_N1	273	429	6.6e-37	PFAM
Pfam:DHC_N1	432	761	1.3e-54	PFAM
Pfam:DHC_N2	1253	1668	3.4e-144	PFAM
AAA	1826	1962	2.95e-1	SMART
Pfam:AAA_5	2108	2251	1.3e-5	PFAM
AAA	2437	2584	3.63e-5	SMART
Pfam:AAA_8	2752	3022	1.1e-75	PFAM
Pfam:MT	3034	3370	8.7e-55	PFAM
Pfam:AAA_9	3386	3616	7.4e-68	PFAM
Pfam:Dynein_heavy	3748	4453	1.2e-220	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000108659
AA Change: T246A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000104299
Gene: ENSMUSG00000005237
AA Change: T246A

Domain	Start	End	E-Value	Type
low complexity region	4	25	N/A	INTRINSIC
Pfam:DHC_N1	274	429	1.1e-47	PFAM
Pfam:DHC_N1	438	760	1.5e-75	PFAM
Pfam:DHC_N2	1255	1666	4.4e-144	PFAM
low complexity region	1711	1720	N/A	INTRINSIC
AAA	1832	1968	2.95e-1	SMART
Blast:AAA	2111	2251	2e-86	BLAST
AAA	2443	2590	3.63e-5	SMART
Pfam:AAA_8	2758	3028	5.5e-77	PFAM
Pfam:MT	3040	3376	7.6e-55	PFAM
Pfam:AAA_9	3396	3621	7.5e-94	PFAM
Pfam:Dynein_heavy	3759	4458	4.9e-264	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000149991

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000154985

Predicted Effect

probably benign
Transcript: ENSMUST00000208777

Meta Mutation Damage Score

0.1176

Coding Region Coverage

1x: 99.1%
3x: 98.3%
10x: 96.0%
20x: 91.4%

Validation Efficiency

97% (69/71)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Dyneins are microtubule-associated motor protein complexes composed of several heavy, light, and intermediate chains. The axonemal dyneins, found in cilia and flagella, are components of the outer and inner dynein arms attached to the peripheral microtubule doublets. DNAH2 is an axonemal inner arm dynein heavy chain (Chapelin et al., 1997 [PubMed 9256245]).[supplied by OMIM, Mar 2008]

Allele List at MGI

Other mutations in this stock

Total: 58 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aamp	A	G	1: 74,283,211 (GRCm38)	S95P	probably damaging	Het
Ankmy1	T	C	1: 92,888,675 (GRCm38)	Y239C	probably damaging	Het
Atp12a	T	C	14: 56,380,055 (GRCm38)	S601P	probably damaging	Het
Atp1b3	T	C	9: 96,343,349 (GRCm38)	T89A	probably benign	Het
B3galt4	G	A	17: 33,950,839 (GRCm38)	R142C	probably damaging	Het
Brme1	A	T	8: 84,167,086 (GRCm38)	Q294L	probably benign	Het
Btnl2	A	T	17: 34,361,140 (GRCm38)	I216F	possibly damaging	Het
Cabs1	A	T	5: 87,979,631 (GRCm38)	H47L	probably damaging	Het
Ccdc68	T	A	18: 69,940,180 (GRCm38)	D66E	probably benign	Het
Cdc42ep4	T	C	11: 113,728,566 (GRCm38)	D333G	possibly damaging	Het
Ckmt1	G	A	2: 121,363,522 (GRCm38)	D389N	possibly damaging	Het
Dact1	G	T	12: 71,317,575 (GRCm38)	V340F	probably benign	Het
Ecm1	G	A	3: 95,735,963 (GRCm38)	R342C	probably damaging	Het
Efcab14	A	G	4: 115,756,549 (GRCm38)		probably benign	Het
Eprs1	A	G	1: 185,401,510 (GRCm38)	T795A	probably damaging	Het
Esp36	T	A	17: 38,417,311 (GRCm38)	E26D	possibly damaging	Het
Fpr-rs7	T	C	17: 20,113,416 (GRCm38)	T271A	probably benign	Het
Fsip2	A	T	2: 82,982,787 (GRCm38)	H3150L	probably benign	Het
Gimap7	G	A	6: 48,724,019 (GRCm38)	V180M	probably damaging	Het
Gtf3c1	T	C	7: 125,676,661 (GRCm38)	H531R	possibly damaging	Het
Herc1	T	A	9: 66,491,953 (GRCm38)		probably benign	Het
Hip1r	A	G	5: 124,002,140 (GRCm38)	Y1061C	probably benign	Het
Ipo11	T	C	13: 106,886,717 (GRCm38)	Y420C	probably damaging	Het
Ipo8	T	C	6: 148,810,665 (GRCm38)		probably null	Het
Itga10	C	T	3: 96,651,738 (GRCm38)		probably benign	Het
Klhl1	A	T	14: 96,368,636 (GRCm38)	M243K	probably damaging	Het
Lrp2	A	G	2: 69,466,763 (GRCm38)		probably null	Het
Mag	T	C	7: 30,901,852 (GRCm38)	E439G	probably damaging	Het
Mcm3ap	T	A	10: 76,496,541 (GRCm38)	F1231I	probably benign	Het
Mcmdc2	C	T	1: 9,916,555 (GRCm38)	Q204*	probably null	Het
Mpl	A	C	4: 118,444,024 (GRCm38)	L548R	probably damaging	Het
Mrps2	C	T	2: 28,469,488 (GRCm38)	A119V	probably benign	Het
Myo18b	G	A	5: 112,875,266 (GRCm38)	Q87*	probably null	Het
Nfat5	A	G	8: 107,293,890 (GRCm38)	Y22C	probably damaging	Het
Nnt	T	A	13: 119,386,661 (GRCm38)	I232L	possibly damaging	Het
Or2a52	A	G	6: 43,167,912 (GRCm38)	N285D	probably damaging	Het
Or8g17	T	C	9: 39,018,957 (GRCm38)	N195D	probably benign	Het
Or9s13	G	A	1: 92,620,745 (GRCm38)	V280M	possibly damaging	Het
Parp2	C	T	14: 50,810,544 (GRCm38)	P76S	probably benign	Het
Pick1	C	T	15: 79,245,301 (GRCm38)	H169Y	probably benign	Het
Prtg	T	A	9: 72,842,807 (GRCm38)	F164L	probably benign	Het
Pygb	A	G	2: 150,817,663 (GRCm38)	D422G	possibly damaging	Het
Samd9l	C	A	6: 3,375,761 (GRCm38)	C500F	probably benign	Het
Sbno1	A	C	5: 124,384,504 (GRCm38)	N1083K	possibly damaging	Het
Semg1	A	G	2: 164,237,658 (GRCm38)	S110P	possibly damaging	Het
Septin7	C	T	9: 25,277,604 (GRCm38)	S77F	probably damaging	Het
Slc25a44	A	G	3: 88,416,007 (GRCm38)	V264A	possibly damaging	Het
Slco1a8	C	T	6: 141,980,872 (GRCm38)	S576N	probably benign	Het
Slf2	G	T	19: 44,942,073 (GRCm38)	E530*	probably null	Het
Tmbim7	G	T	5: 3,665,338 (GRCm38)		probably null	Het
Tpgs2	T	C	18: 25,140,573 (GRCm38)	D177G	probably damaging	Het
Uba1y	T	A	Y: 826,893 (GRCm38)	F516L	probably damaging	Het
Ulk1	A	G	5: 110,795,766 (GRCm38)	V211A	probably damaging	Het
Vmn1r237	T	A	17: 21,314,039 (GRCm38)	I8N	probably damaging	Het
Vmn2r103	G	T	17: 19,794,234 (GRCm38)	M429I	probably benign	Het
Vmn2r112	T	C	17: 22,615,008 (GRCm38)		probably null	Het
Vmn2r84	T	C	10: 130,391,480 (GRCm38)		probably null	Het
Vwa8	C	T	14: 78,908,230 (GRCm38)	R116C	probably damaging	Het

Other mutations in Dnah2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00087:Dnah2	APN	11	69,492,672 (GRCm38)	missense	possibly damaging	0.93
IGL00418:Dnah2	APN	11	69,495,066 (GRCm38)	splice site	probably benign
IGL00772:Dnah2	APN	11	69,451,257 (GRCm38)	missense	probably damaging	0.97
IGL00819:Dnah2	APN	11	69,473,350 (GRCm38)	critical splice donor site	probably null
IGL00827:Dnah2	APN	11	69,448,457 (GRCm38)	missense	probably damaging	1.00
IGL01060:Dnah2	APN	11	69,478,092 (GRCm38)	missense	possibly damaging	0.86
IGL01340:Dnah2	APN	11	69,493,184 (GRCm38)	missense	probably damaging	0.99
IGL01349:Dnah2	APN	11	69,475,606 (GRCm38)	missense	probably damaging	0.99
IGL01413:Dnah2	APN	11	69,432,964 (GRCm38)	missense	probably damaging	0.99
IGL01451:Dnah2	APN	11	69,474,191 (GRCm38)	splice site	probably benign
IGL01480:Dnah2	APN	11	69,458,371 (GRCm38)	missense	possibly damaging	0.91
IGL01537:Dnah2	APN	11	69,516,080 (GRCm38)	missense	probably benign	0.17
IGL01592:Dnah2	APN	11	69,431,087 (GRCm38)	missense	probably benign	0.14
IGL01612:Dnah2	APN	11	69,465,063 (GRCm38)	splice site	probably benign
IGL01667:Dnah2	APN	11	69,544,395 (GRCm38)	missense	probably benign
IGL01667:Dnah2	APN	11	69,520,941 (GRCm38)	missense	probably damaging	0.98
IGL01691:Dnah2	APN	11	69,539,443 (GRCm38)	missense	probably benign
IGL02019:Dnah2	APN	11	69,474,285 (GRCm38)	missense	probably damaging	1.00
IGL02039:Dnah2	APN	11	69,499,212 (GRCm38)	missense	probably damaging	1.00
IGL02076:Dnah2	APN	11	69,422,559 (GRCm38)	missense	probably damaging	0.99
IGL02085:Dnah2	APN	11	69,458,185 (GRCm38)	missense	probably benign	0.07
IGL02158:Dnah2	APN	11	69,458,123 (GRCm38)	missense	probably benign
IGL02381:Dnah2	APN	11	69,446,292 (GRCm38)	missense	probably benign	0.25
IGL02681:Dnah2	APN	11	69,452,933 (GRCm38)	missense	probably benign	0.40
IGL02957:Dnah2	APN	11	69,448,507 (GRCm38)	missense	possibly damaging	0.96
IGL02961:Dnah2	APN	11	69,518,414 (GRCm38)	missense	probably damaging	1.00
IGL02969:Dnah2	APN	11	69,521,187 (GRCm38)	missense	possibly damaging	0.80
IGL03117:Dnah2	APN	11	69,436,291 (GRCm38)	splice site	probably benign
IGL03120:Dnah2	APN	11	69,421,848 (GRCm38)	missense	probably damaging	1.00
IGL03183:Dnah2	APN	11	69,458,488 (GRCm38)	missense	possibly damaging	0.94
IGL03197:Dnah2	APN	11	69,459,263 (GRCm38)	missense	probably damaging	1.00
IGL03263:Dnah2	APN	11	69,529,381 (GRCm38)	critical splice donor site	probably null
IGL03333:Dnah2	APN	11	69,495,123 (GRCm38)	missense	probably damaging	1.00
IGL03338:Dnah2	APN	11	69,496,577 (GRCm38)	missense	probably benign	0.13
argyrios	UTSW	11	69,516,590 (GRCm38)	missense	possibly damaging	0.47
Aureus	UTSW	11	69,429,348 (GRCm38)	missense	probably damaging	1.00
platinum	UTSW	11	69,458,042 (GRCm38)	missense	probably damaging	0.96
R0334_dnah2_144	UTSW	11	69,436,836 (GRCm38)	missense	probably damaging	1.00
R2150_dnah2_212	UTSW	11	69,515,761 (GRCm38)	missense	probably benign	0.14
BB005:Dnah2	UTSW	11	69,430,835 (GRCm38)	missense	probably damaging	0.98
BB015:Dnah2	UTSW	11	69,430,835 (GRCm38)	missense	probably damaging	0.98
E0370:Dnah2	UTSW	11	69,515,615 (GRCm38)	splice site	probably null
P0026:Dnah2	UTSW	11	69,464,947 (GRCm38)	missense	probably damaging	1.00
R0133:Dnah2	UTSW	11	69,421,009 (GRCm38)	missense	probably damaging	1.00
R0190:Dnah2	UTSW	11	69,435,249 (GRCm38)	missense	probably damaging	1.00
R0334:Dnah2	UTSW	11	69,436,836 (GRCm38)	missense	probably damaging	1.00
R0359:Dnah2	UTSW	11	69,529,531 (GRCm38)	missense	probably benign	0.00
R0386:Dnah2	UTSW	11	69,447,861 (GRCm38)	missense	probably damaging	1.00
R0414:Dnah2	UTSW	11	69,499,238 (GRCm38)	missense	probably benign	0.26
R0427:Dnah2	UTSW	11	69,452,879 (GRCm38)	missense	probably damaging	0.99
R0433:Dnah2	UTSW	11	69,459,288 (GRCm38)	missense	probably damaging	1.00
R0442:Dnah2	UTSW	11	69,448,542 (GRCm38)	missense	probably damaging	1.00
R0462:Dnah2	UTSW	11	69,459,201 (GRCm38)	missense	probably damaging	1.00
R0463:Dnah2	UTSW	11	69,423,126 (GRCm38)	missense	probably damaging	1.00
R0611:Dnah2	UTSW	11	69,499,194 (GRCm38)	missense	probably damaging	1.00
R0626:Dnah2	UTSW	11	69,477,683 (GRCm38)	missense	probably benign	0.07
R0924:Dnah2	UTSW	11	69,421,308 (GRCm38)	missense	probably damaging	1.00
R0968:Dnah2	UTSW	11	69,448,519 (GRCm38)	missense	possibly damaging	0.67
R1066:Dnah2	UTSW	11	69,447,819 (GRCm38)	missense	probably damaging	1.00
R1183:Dnah2	UTSW	11	69,446,648 (GRCm38)	missense	possibly damaging	0.95
R1184:Dnah2	UTSW	11	69,499,190 (GRCm38)	missense	probably damaging	1.00
R1186:Dnah2	UTSW	11	69,515,700 (GRCm38)	missense	probably damaging	0.99
R1453:Dnah2	UTSW	11	69,451,050 (GRCm38)	missense	probably damaging	0.99
R1498:Dnah2	UTSW	11	69,520,667 (GRCm38)	splice site	probably null
R1538:Dnah2	UTSW	11	69,477,202 (GRCm38)	missense	probably benign	0.17
R1574:Dnah2	UTSW	11	69,514,688 (GRCm38)	missense	probably benign	0.26
R1574:Dnah2	UTSW	11	69,514,688 (GRCm38)	missense	probably benign	0.26
R1590:Dnah2	UTSW	11	69,422,754 (GRCm38)	critical splice donor site	probably null
R1655:Dnah2	UTSW	11	69,473,854 (GRCm38)	missense	probably damaging	1.00
R1695:Dnah2	UTSW	11	69,514,691 (GRCm38)	missense	possibly damaging	0.74
R1726:Dnah2	UTSW	11	69,497,889 (GRCm38)	missense	probably damaging	1.00
R1764:Dnah2	UTSW	11	69,423,543 (GRCm38)	missense	probably damaging	1.00
R1815:Dnah2	UTSW	11	69,475,574 (GRCm38)	missense	probably damaging	1.00
R1822:Dnah2	UTSW	11	69,514,804 (GRCm38)	missense	probably damaging	1.00
R1859:Dnah2	UTSW	11	69,437,886 (GRCm38)	missense	probably damaging	0.99
R1911:Dnah2	UTSW	11	69,515,752 (GRCm38)	missense	possibly damaging	0.64
R1913:Dnah2	UTSW	11	69,464,930 (GRCm38)	missense	probably damaging	1.00
R1981:Dnah2	UTSW	11	69,474,325 (GRCm38)	missense	probably damaging	1.00
R2010:Dnah2	UTSW	11	69,458,358 (GRCm38)	critical splice donor site	probably null
R2016:Dnah2	UTSW	11	69,437,070 (GRCm38)	missense	probably damaging	0.97
R2017:Dnah2	UTSW	11	69,437,070 (GRCm38)	missense	probably damaging	0.97
R2044:Dnah2	UTSW	11	69,524,240 (GRCm38)	missense	probably benign	0.14
R2077:Dnah2	UTSW	11	69,496,606 (GRCm38)	missense	possibly damaging	0.73
R2096:Dnah2	UTSW	11	69,455,916 (GRCm38)	missense	probably damaging	0.98
R2099:Dnah2	UTSW	11	69,493,237 (GRCm38)	missense	probably damaging	1.00
R2127:Dnah2	UTSW	11	69,458,185 (GRCm38)	missense	probably benign	0.02
R2128:Dnah2	UTSW	11	69,458,185 (GRCm38)	missense	probably benign	0.02
R2146:Dnah2	UTSW	11	69,515,761 (GRCm38)	missense	probably benign	0.14
R2147:Dnah2	UTSW	11	69,515,761 (GRCm38)	missense	probably benign	0.14
R2150:Dnah2	UTSW	11	69,515,761 (GRCm38)	missense	probably benign	0.14
R2404:Dnah2	UTSW	11	69,437,221 (GRCm38)	missense	probably damaging	0.99
R2510:Dnah2	UTSW	11	69,524,206 (GRCm38)	nonsense	probably null
R2517:Dnah2	UTSW	11	69,516,644 (GRCm38)	missense	probably damaging	1.00
R3014:Dnah2	UTSW	11	69,430,478 (GRCm38)	missense	probably benign
R3741:Dnah2	UTSW	11	69,448,469 (GRCm38)	missense	probably damaging	1.00
R3814:Dnah2	UTSW	11	69,492,650 (GRCm38)	splice site	probably null
R3872:Dnah2	UTSW	11	69,429,348 (GRCm38)	missense	probably damaging	1.00
R3873:Dnah2	UTSW	11	69,429,348 (GRCm38)	missense	probably damaging	1.00
R3874:Dnah2	UTSW	11	69,429,348 (GRCm38)	missense	probably damaging	1.00
R3875:Dnah2	UTSW	11	69,429,348 (GRCm38)	missense	probably damaging	1.00
R3881:Dnah2	UTSW	11	69,451,347 (GRCm38)	missense	possibly damaging	0.94
R3953:Dnah2	UTSW	11	69,454,103 (GRCm38)	missense	probably damaging	1.00
R3956:Dnah2	UTSW	11	69,484,021 (GRCm38)	missense	probably benign	0.00
R4501:Dnah2	UTSW	11	69,477,659 (GRCm38)	missense	probably benign
R4515:Dnah2	UTSW	11	69,465,631 (GRCm38)	missense	possibly damaging	0.61
R4612:Dnah2	UTSW	11	69,483,367 (GRCm38)	missense	possibly damaging	0.93
R4625:Dnah2	UTSW	11	69,463,661 (GRCm38)	missense	probably damaging	1.00
R4627:Dnah2	UTSW	11	69,465,376 (GRCm38)	missense	probably damaging	1.00
R4642:Dnah2	UTSW	11	69,496,559 (GRCm38)	missense	probably benign	0.00
R4683:Dnah2	UTSW	11	69,458,942 (GRCm38)	missense	probably damaging	1.00
R4698:Dnah2	UTSW	11	69,498,532 (GRCm38)	missense	probably damaging	1.00
R4710:Dnah2	UTSW	11	69,478,077 (GRCm38)	missense	probably damaging	1.00
R4712:Dnah2	UTSW	11	69,516,590 (GRCm38)	missense	possibly damaging	0.47
R4713:Dnah2	UTSW	11	69,476,688 (GRCm38)	missense	probably damaging	1.00
R4717:Dnah2	UTSW	11	69,429,357 (GRCm38)	missense	probably benign	0.00
R4740:Dnah2	UTSW	11	69,458,042 (GRCm38)	missense	probably damaging	0.96
R4780:Dnah2	UTSW	11	69,473,871 (GRCm38)	missense	probably damaging	0.97
R4825:Dnah2	UTSW	11	69,423,205 (GRCm38)	missense	probably damaging	1.00
R4864:Dnah2	UTSW	11	69,422,590 (GRCm38)	missense	probably damaging	0.98
R4868:Dnah2	UTSW	11	69,463,648 (GRCm38)	missense	probably damaging	1.00
R4879:Dnah2	UTSW	11	69,476,691 (GRCm38)	missense	probably damaging	1.00
R4908:Dnah2	UTSW	11	69,521,147 (GRCm38)	missense	probably benign	0.00
R4911:Dnah2	UTSW	11	69,499,104 (GRCm38)	critical splice donor site	probably null
R4954:Dnah2	UTSW	11	69,539,496 (GRCm38)	missense	possibly damaging	0.61
R4962:Dnah2	UTSW	11	69,455,973 (GRCm38)	nonsense	probably null
R5015:Dnah2	UTSW	11	69,497,882 (GRCm38)	missense	possibly damaging	0.89
R5049:Dnah2	UTSW	11	69,448,166 (GRCm38)	missense	probably damaging	1.00
R5055:Dnah2	UTSW	11	69,520,773 (GRCm38)	missense	possibly damaging	0.67
R5153:Dnah2	UTSW	11	69,520,933 (GRCm38)	missense	possibly damaging	0.84
R5155:Dnah2	UTSW	11	69,422,536 (GRCm38)	missense	probably damaging	1.00
R5186:Dnah2	UTSW	11	69,435,884 (GRCm38)	missense	probably damaging	1.00
R5187:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R5208:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R5252:Dnah2	UTSW	11	69,529,469 (GRCm38)	missense	probably damaging	0.98
R5296:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R5298:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R5299:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R5301:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R5324:Dnah2	UTSW	11	69,457,993 (GRCm38)	missense	probably benign	0.07
R5350:Dnah2	UTSW	11	69,516,036 (GRCm38)	missense	possibly damaging	0.48
R5377:Dnah2	UTSW	11	69,421,848 (GRCm38)	missense	probably damaging	1.00
R5393:Dnah2	UTSW	11	69,500,857 (GRCm38)	missense	probably benign
R5421:Dnah2	UTSW	11	69,435,636 (GRCm38)	missense	probably damaging	1.00
R5452:Dnah2	UTSW	11	69,524,383 (GRCm38)	missense	probably damaging	1.00
R5461:Dnah2	UTSW	11	69,473,351 (GRCm38)	critical splice donor site	probably null
R5474:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R5476:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R5477:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R5510:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R5527:Dnah2	UTSW	11	69,437,188 (GRCm38)	nonsense	probably null
R5566:Dnah2	UTSW	11	69,516,569 (GRCm38)	nonsense	probably null
R5587:Dnah2	UTSW	11	69,437,242 (GRCm38)	missense	probably damaging	1.00
R5628:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R5688:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R5690:Dnah2	UTSW	11	69,491,544 (GRCm38)	missense	probably benign	0.15
R5711:Dnah2	UTSW	11	69,435,390 (GRCm38)	missense	probably damaging	1.00
R5735:Dnah2	UTSW	11	69,430,817 (GRCm38)	missense	possibly damaging	0.93
R5826:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R5913:Dnah2	UTSW	11	69,448,430 (GRCm38)	missense	probably damaging	1.00
R5914:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R5960:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R5961:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R5961:Dnah2	UTSW	11	69,431,148 (GRCm38)	missense	probably damaging	1.00
R5977:Dnah2	UTSW	11	69,520,881 (GRCm38)	missense	possibly damaging	0.79
R6020:Dnah2	UTSW	11	69,500,839 (GRCm38)	missense	probably benign
R6036:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R6036:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R6050:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R6086:Dnah2	UTSW	11	69,516,008 (GRCm38)	missense	probably benign	0.30
R6115:Dnah2	UTSW	11	69,446,649 (GRCm38)	missense	probably damaging	1.00
R6123:Dnah2	UTSW	11	69,518,359 (GRCm38)	missense	probably benign	0.29
R6159:Dnah2	UTSW	11	69,458,920 (GRCm38)	missense	probably benign	0.15
R6159:Dnah2	UTSW	11	69,458,542 (GRCm38)	missense	probably damaging	1.00
R6163:Dnah2	UTSW	11	69,520,903 (GRCm38)	nonsense	probably null
R6171:Dnah2	UTSW	11	69,423,042 (GRCm38)	missense	probably damaging	1.00
R6263:Dnah2	UTSW	11	69,457,412 (GRCm38)	missense	probably damaging	1.00
R6298:Dnah2	UTSW	11	69,491,641 (GRCm38)	missense	probably benign	0.25
R6352:Dnah2	UTSW	11	69,448,227 (GRCm38)	missense	probably damaging	1.00
R6399:Dnah2	UTSW	11	69,458,518 (GRCm38)	missense	probably damaging	0.98
R6466:Dnah2	UTSW	11	69,539,415 (GRCm38)	missense	probably benign
R6478:Dnah2	UTSW	11	69,516,010 (GRCm38)	missense	probably benign	0.01
R6516:Dnah2	UTSW	11	69,465,386 (GRCm38)	missense	probably benign	0.34
R6538:Dnah2	UTSW	11	69,437,197 (GRCm38)	missense	possibly damaging	0.87
R6802:Dnah2	UTSW	11	69,423,690 (GRCm38)	missense	probably damaging	1.00
R6861:Dnah2	UTSW	11	69,455,963 (GRCm38)	missense	possibly damaging	0.64
R6869:Dnah2	UTSW	11	69,429,471 (GRCm38)	missense	probably damaging	1.00
R6894:Dnah2	UTSW	11	69,484,260 (GRCm38)	missense	probably benign	0.12
R6935:Dnah2	UTSW	11	69,421,741 (GRCm38)	missense	probably damaging	1.00
R7017:Dnah2	UTSW	11	69,491,547 (GRCm38)	nonsense	probably null
R7073:Dnah2	UTSW	11	69,430,492 (GRCm38)	nonsense	probably null
R7111:Dnah2	UTSW	11	69,446,753 (GRCm38)	splice site	probably null
R7125:Dnah2	UTSW	11	69,436,182 (GRCm38)	missense	probably damaging	0.99
R7137:Dnah2	UTSW	11	69,491,555 (GRCm38)	missense	probably damaging	1.00
R7190:Dnah2	UTSW	11	69,549,097 (GRCm38)	splice site	probably null
R7214:Dnah2	UTSW	11	69,431,109 (GRCm38)	missense	probably damaging	1.00
R7227:Dnah2	UTSW	11	69,421,396 (GRCm38)	missense	probably damaging	0.99
R7238:Dnah2	UTSW	11	69,459,146 (GRCm38)	critical splice donor site	probably null
R7256:Dnah2	UTSW	11	69,431,094 (GRCm38)	missense	probably damaging	1.00
R7267:Dnah2	UTSW	11	69,500,817 (GRCm38)	missense	probably damaging	1.00
R7420:Dnah2	UTSW	11	69,478,797 (GRCm38)	missense	possibly damaging	0.94
R7421:Dnah2	UTSW	11	69,492,805 (GRCm38)	missense	probably benign	0.25
R7437:Dnah2	UTSW	11	69,498,627 (GRCm38)	missense	probably damaging	1.00
R7461:Dnah2	UTSW	11	69,548,990 (GRCm38)	critical splice donor site	probably null
R7473:Dnah2	UTSW	11	69,491,658 (GRCm38)	missense	probably damaging	0.99
R7528:Dnah2	UTSW	11	69,500,796 (GRCm38)	missense	probably damaging	0.99
R7613:Dnah2	UTSW	11	69,548,990 (GRCm38)	critical splice donor site	probably null
R7615:Dnah2	UTSW	11	69,435,304 (GRCm38)	missense	probably damaging	0.99
R7626:Dnah2	UTSW	11	69,498,685 (GRCm38)	missense	probably damaging	0.99
R7745:Dnah2	UTSW	11	69,451,318 (GRCm38)	nonsense	probably null
R7764:Dnah2	UTSW	11	69,458,158 (GRCm38)	missense	probably benign	0.29
R7793:Dnah2	UTSW	11	69,495,214 (GRCm38)	missense	probably benign	0.00
R7819:Dnah2	UTSW	11	69,516,593 (GRCm38)	missense	probably benign	0.01
R7881:Dnah2	UTSW	11	69,431,238 (GRCm38)	missense	probably damaging	1.00
R7900:Dnah2	UTSW	11	69,518,428 (GRCm38)	missense	probably damaging	1.00
R7916:Dnah2	UTSW	11	69,421,148 (GRCm38)	critical splice acceptor site	probably null
R7921:Dnah2	UTSW	11	69,520,834 (GRCm38)	missense	probably benign
R7928:Dnah2	UTSW	11	69,430,835 (GRCm38)	missense	probably damaging	0.98
R7937:Dnah2	UTSW	11	69,517,685 (GRCm38)	nonsense	probably null
R7995:Dnah2	UTSW	11	69,520,737 (GRCm38)	missense	possibly damaging	0.77
R8202:Dnah2	UTSW	11	69,478,823 (GRCm38)	missense	probably benign	0.00
R8208:Dnah2	UTSW	11	69,520,852 (GRCm38)	missense	probably benign	0.05
R8215:Dnah2	UTSW	11	69,435,367 (GRCm38)	missense	probably damaging	1.00
R8279:Dnah2	UTSW	11	69,475,573 (GRCm38)	missense	probably damaging	1.00
R8338:Dnah2	UTSW	11	69,487,296 (GRCm38)	missense	probably damaging	1.00
R8348:Dnah2	UTSW	11	69,429,447 (GRCm38)	missense	possibly damaging	0.95
R8405:Dnah2	UTSW	11	69,458,463 (GRCm38)	missense	probably damaging	1.00
R8407:Dnah2	UTSW	11	69,459,278 (GRCm38)	missense	probably benign	0.00
R8493:Dnah2	UTSW	11	69,452,978 (GRCm38)	missense	probably damaging	1.00
R8673:Dnah2	UTSW	11	69,514,697 (GRCm38)	missense	probably benign	0.23
R8725:Dnah2	UTSW	11	69,524,179 (GRCm38)	missense	probably damaging	1.00
R8727:Dnah2	UTSW	11	69,524,179 (GRCm38)	missense	probably damaging	1.00
R8730:Dnah2	UTSW	11	69,493,261 (GRCm38)	missense	possibly damaging	0.73
R8804:Dnah2	UTSW	11	69,465,685 (GRCm38)	missense	probably benign	0.01
R8876:Dnah2	UTSW	11	69,491,522 (GRCm38)	missense	probably damaging	1.00
R8894:Dnah2	UTSW	11	69,492,222 (GRCm38)	missense	probably benign	0.01
R8938:Dnah2	UTSW	11	69,437,928 (GRCm38)	missense	probably damaging	0.99
R9044:Dnah2	UTSW	11	69,529,421 (GRCm38)	missense	probably benign
R9085:Dnah2	UTSW	11	69,429,398 (GRCm38)	missense	possibly damaging	0.69
R9110:Dnah2	UTSW	11	69,544,382 (GRCm38)	missense	probably benign
R9156:Dnah2	UTSW	11	69,422,861 (GRCm38)	missense
R9251:Dnah2	UTSW	11	69,515,793 (GRCm38)	missense	probably damaging	1.00
R9258:Dnah2	UTSW	11	69,477,253 (GRCm38)	missense	probably damaging	1.00
R9279:Dnah2	UTSW	11	69,518,278 (GRCm38)	missense	probably benign	0.01
R9318:Dnah2	UTSW	11	69,484,329 (GRCm38)	missense	probably benign	0.07
R9321:Dnah2	UTSW	11	69,448,113 (GRCm38)	critical splice donor site	probably null
R9350:Dnah2	UTSW	11	69,493,247 (GRCm38)	missense	probably benign	0.10
R9358:Dnah2	UTSW	11	69,515,766 (GRCm38)	missense	probably damaging	0.99
R9417:Dnah2	UTSW	11	69,436,164 (GRCm38)	missense	probably damaging	1.00
R9420:Dnah2	UTSW	11	69,478,116 (GRCm38)	missense	probably benign	0.09
R9438:Dnah2	UTSW	11	69,473,394 (GRCm38)	missense	probably damaging	1.00
R9469:Dnah2	UTSW	11	69,431,070 (GRCm38)	missense	probably damaging	1.00
R9487:Dnah2	UTSW	11	69,515,791 (GRCm38)	missense	possibly damaging	0.47
R9495:Dnah2	UTSW	11	69,454,382 (GRCm38)	missense	possibly damaging	0.89
R9579:Dnah2	UTSW	11	69,477,215 (GRCm38)	missense	probably damaging	1.00
R9608:Dnah2	UTSW	11	69,454,062 (GRCm38)	missense	probably null	1.00
R9651:Dnah2	UTSW	11	69,450,998 (GRCm38)	critical splice donor site	probably null
R9662:Dnah2	UTSW	11	69,452,937 (GRCm38)	missense	probably benign
RF004:Dnah2	UTSW	11	69,437,187 (GRCm38)	missense	probably benign	0.24
U24488:Dnah2	UTSW	11	69,483,822 (GRCm38)	missense	probably damaging	0.99
X0021:Dnah2	UTSW	11	69,448,562 (GRCm38)	missense	possibly damaging	0.81
Z1088:Dnah2	UTSW	11	69,430,793 (GRCm38)	missense	probably damaging	1.00
Z1176:Dnah2	UTSW	11	69,421,821 (GRCm38)	missense	possibly damaging	0.46
Z1176:Dnah2	UTSW	11	69,516,523 (GRCm38)	missense	probably damaging	1.00
Z1176:Dnah2	UTSW	11	69,516,481 (GRCm38)	missense	probably damaging	1.00
Z1176:Dnah2	UTSW	11	69,498,667 (GRCm38)	missense	probably benign	0.12
Z1176:Dnah2	UTSW	11	69,487,054 (GRCm38)	missense	possibly damaging	0.46
Z1176:Dnah2	UTSW	11	69,451,120 (GRCm38)	missense	probably benign
Z1177:Dnah2	UTSW	11	69,544,557 (GRCm38)	critical splice acceptor site	probably null
Z1177:Dnah2	UTSW	11	69,463,453 (GRCm38)	missense	possibly damaging	0.63

Predicted Primers

PCR Primer
(F):5'- TCGATCTCCTCCAAAGGGCCTAAG -3'
(R):5'- ACCCAAGGCAGCCGAGTTATTTC -3'

Sequencing Primer
(F):5'- AAAGGGCCTAAGTTCTCTCCG -3'
(R):5'- GCAGCCGAGTTATTTCTGAATTG -3'

Posted On

2014-04-24