Mutagenetix > Incidental Mutation

Incidental Mutation 'R1590:Vmn2r103'

177828

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r103

Ensembl Gene

ENSMUSG00000091771

Gene Name

vomeronasal 2, receptor 103

Synonyms

EG627636

MMRRC Submission

039627-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.059) question?

Stock #

R1590 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

19773363-19812536 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to T at 19794234 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Isoleucine at position 429 (M429I)

Ref Sequence

ENSEMBL: ENSMUSP00000126756 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000172203]

AlphaFold

E9PWW0

Predicted Effect

probably benign
Transcript: ENSMUST00000172203
AA Change: M429I

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000126756
Gene: ENSMUSG00000091771
AA Change: M429I

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	82	449	1.3e-37	PFAM
Pfam:NCD3G	509	562	3.5e-22	PFAM
Pfam:7tm_3	595	830	1.1e-51	PFAM

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.1%
3x: 98.3%
10x: 96.0%
20x: 91.4%

Validation Efficiency

97% (69/71)

Allele List at MGI

Other mutations in this stock

Total: 59 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930432K21Rik	A	T	8: 84,167,086	Q294L	probably benign	Het
Aamp	A	G	1: 74,283,211	S95P	probably damaging	Het
Ankmy1	T	C	1: 92,888,675	Y239C	probably damaging	Het
Atp12a	T	C	14: 56,380,055	S601P	probably damaging	Het
Atp1b3	T	C	9: 96,343,349	T89A	probably benign	Het
B3galt4	G	A	17: 33,950,839	R142C	probably damaging	Het
Btnl2	A	T	17: 34,361,140	I216F	possibly damaging	Het
Cabs1	A	T	5: 87,979,631	H47L	probably damaging	Het
Ccdc68	T	A	18: 69,940,180	D66E	probably benign	Het
Cdc42ep4	T	C	11: 113,728,566	D333G	possibly damaging	Het
Ckmt1	G	A	2: 121,363,522	D389N	possibly damaging	Het
Dact1	G	T	12: 71,317,575	V340F	probably benign	Het
Dnah2	T	C	11: 69,521,198	T246A	probably benign	Het
Dnah2	A	G	11: 69,422,754		probably null	Het
Ecm1	G	A	3: 95,735,963	R342C	probably damaging	Het
Efcab14	A	G	4: 115,756,549		probably benign	Het
Eprs	A	G	1: 185,401,510	T795A	probably damaging	Het
Esp36	T	A	17: 38,417,311	E26D	possibly damaging	Het
Fpr-rs7	T	C	17: 20,113,416	T271A	probably benign	Het
Fsip2	A	T	2: 82,982,787	H3150L	probably benign	Het
Gimap7	G	A	6: 48,724,019	V180M	probably damaging	Het
Gm6614	C	T	6: 141,980,872	S576N	probably benign	Het
Gtf3c1	T	C	7: 125,676,661	H531R	possibly damaging	Het
Herc1	T	A	9: 66,491,953		probably benign	Het
Hip1r	A	G	5: 124,002,140	Y1061C	probably benign	Het
Ipo11	T	C	13: 106,886,717	Y420C	probably damaging	Het
Ipo8	T	C	6: 148,810,665		probably null	Het
Itga10	C	T	3: 96,651,738		probably benign	Het
Klhl1	A	T	14: 96,368,636	M243K	probably damaging	Het
Lrp2	A	G	2: 69,466,763		probably null	Het
Mag	T	C	7: 30,901,852	E439G	probably damaging	Het
Mcm3ap	T	A	10: 76,496,541	F1231I	probably benign	Het
Mcmdc2	C	T	1: 9,916,555	Q204*	probably null	Het
Mpl	A	C	4: 118,444,024	L548R	probably damaging	Het
Mrps2	C	T	2: 28,469,488	A119V	probably benign	Het
Myo18b	G	A	5: 112,875,266	Q87*	probably null	Het
Nfat5	A	G	8: 107,293,890	Y22C	probably damaging	Het
Nnt	T	A	13: 119,386,661	I232L	possibly damaging	Het
Olfr12	G	A	1: 92,620,745	V280M	possibly damaging	Het
Olfr146	T	C	9: 39,018,957	N195D	probably benign	Het
Olfr437	A	G	6: 43,167,912	N285D	probably damaging	Het
Parp2	C	T	14: 50,810,544	P76S	probably benign	Het
Pick1	C	T	15: 79,245,301	H169Y	probably benign	Het
Prtg	T	A	9: 72,842,807	F164L	probably benign	Het
Pygb	A	G	2: 150,817,663	D422G	possibly damaging	Het
Samd9l	C	A	6: 3,375,761	C500F	probably benign	Het
Sbno1	A	C	5: 124,384,504	N1083K	possibly damaging	Het
Sept7	C	T	9: 25,277,604	S77F	probably damaging	Het
Slc25a44	A	G	3: 88,416,007	V264A	possibly damaging	Het
Slf2	G	T	19: 44,942,073	E530*	probably null	Het
Svs2	A	G	2: 164,237,658	S110P	possibly damaging	Het
Tmbim7	G	T	5: 3,665,338		probably null	Het
Tpgs2	T	C	18: 25,140,573	D177G	probably damaging	Het
Uba1y	T	A	Y: 826,893	F516L	probably damaging	Het
Ulk1	A	G	5: 110,795,766	V211A	probably damaging	Het
Vmn1r237	T	A	17: 21,314,039	I8N	probably damaging	Het
Vmn2r112	T	C	17: 22,615,008		probably null	Het
Vmn2r84	T	C	10: 130,391,480		probably null	Het
Vwa8	C	T	14: 78,908,230	R116C	probably damaging	Het

Other mutations in Vmn2r103

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00333:Vmn2r103	APN	17	19793102	missense	probably damaging	0.98
IGL00939:Vmn2r103	APN	17	19794965	missense	probably benign	0.00
IGL01120:Vmn2r103	APN	17	19792997	missense	probably benign	0.06
IGL01403:Vmn2r103	APN	17	19792967	missense	probably benign
IGL01404:Vmn2r103	APN	17	19812434	missense	probably damaging	1.00
IGL01713:Vmn2r103	APN	17	19794068	missense	probably damaging	1.00
IGL01802:Vmn2r103	APN	17	19799208	missense	probably benign
IGL02251:Vmn2r103	APN	17	19793969	missense	possibly damaging	0.84
IGL02466:Vmn2r103	APN	17	19773369	missense	probably benign
IGL02555:Vmn2r103	APN	17	19811611	missense	probably damaging	1.00
IGL02668:Vmn2r103	APN	17	19794127	missense	probably benign	0.03
IGL02715:Vmn2r103	APN	17	19793956	missense	probably damaging	0.97
IGL02735:Vmn2r103	APN	17	19812248	missense	probably benign	0.27
IGL03101:Vmn2r103	APN	17	19773520	missense	probably damaging	0.98
R0003:Vmn2r103	UTSW	17	19811979	missense	probably damaging	0.99
R0052:Vmn2r103	UTSW	17	19811641	missense	probably benign	0.01
R0375:Vmn2r103	UTSW	17	19792859	missense	probably benign	0.06
R0375:Vmn2r103	UTSW	17	19793464	missense	probably benign	0.12
R0755:Vmn2r103	UTSW	17	19773568	missense	probably benign	0.01
R0837:Vmn2r103	UTSW	17	19793927	missense	probably damaging	0.99
R1345:Vmn2r103	UTSW	17	19794247	missense	probably damaging	1.00
R1396:Vmn2r103	UTSW	17	19792968	missense	probably benign
R1488:Vmn2r103	UTSW	17	19793660	missense	probably damaging	0.97
R1533:Vmn2r103	UTSW	17	19773400	missense	probably benign	0.01
R1928:Vmn2r103	UTSW	17	19811767	missense	possibly damaging	0.95
R1942:Vmn2r103	UTSW	17	19812300	missense	probably benign	0.02
R2071:Vmn2r103	UTSW	17	19793794	missense	probably benign
R2219:Vmn2r103	UTSW	17	19793647	missense	probably damaging	1.00
R2442:Vmn2r103	UTSW	17	19773531	missense	probably benign	0.00
R2889:Vmn2r103	UTSW	17	19793600	missense	probably damaging	1.00
R3762:Vmn2r103	UTSW	17	19812149	missense	probably damaging	0.98
R4014:Vmn2r103	UTSW	17	19793604	missense	possibly damaging	0.67
R4331:Vmn2r103	UTSW	17	19794233	missense	probably benign	0.00
R4630:Vmn2r103	UTSW	17	19793696	missense	probably benign	0.04
R4631:Vmn2r103	UTSW	17	19793696	missense	probably benign	0.04
R4632:Vmn2r103	UTSW	17	19793696	missense	probably benign	0.04
R4660:Vmn2r103	UTSW	17	19811815	missense	probably damaging	1.00
R4801:Vmn2r103	UTSW	17	19795076	missense	probably benign	0.06
R4802:Vmn2r103	UTSW	17	19795076	missense	probably benign	0.06
R4931:Vmn2r103	UTSW	17	19811769	missense	probably benign	0.01
R4995:Vmn2r103	UTSW	17	19773511	missense	probably benign	0.14
R5309:Vmn2r103	UTSW	17	19793034	missense	probably benign	0.01
R5312:Vmn2r103	UTSW	17	19793034	missense	probably benign	0.01
R5329:Vmn2r103	UTSW	17	19812171	missense	probably damaging	1.00
R5611:Vmn2r103	UTSW	17	19793642	missense	probably damaging	0.99
R5684:Vmn2r103	UTSW	17	19792989	missense	probably benign	0.02
R5715:Vmn2r103	UTSW	17	19794939	missense	probably benign	0.17
R5907:Vmn2r103	UTSW	17	19812453	missense	possibly damaging	0.67
R6029:Vmn2r103	UTSW	17	19794216	nonsense	probably null
R6114:Vmn2r103	UTSW	17	19812325	missense	probably damaging	0.99
R6285:Vmn2r103	UTSW	17	19812144	missense	probably benign
R6292:Vmn2r103	UTSW	17	19793604	missense	possibly damaging	0.67
R6334:Vmn2r103	UTSW	17	19794082	missense	probably damaging	0.97
R6501:Vmn2r103	UTSW	17	19811904	missense	probably benign	0.29
R6710:Vmn2r103	UTSW	17	19811977	missense	probably damaging	1.00
R6774:Vmn2r103	UTSW	17	19773511	missense	probably benign	0.14
R6981:Vmn2r103	UTSW	17	19793477	missense	probably benign	0.00
R7768:Vmn2r103	UTSW	17	19812052	missense	probably damaging	0.99
R7816:Vmn2r103	UTSW	17	19794214	missense	probably benign	0.06
R7885:Vmn2r103	UTSW	17	19793123	missense	probably benign	0.25
R8002:Vmn2r103	UTSW	17	19799249	missense	probably damaging	1.00
R8031:Vmn2r103	UTSW	17	19793497	missense	probably benign	0.00
R8140:Vmn2r103	UTSW	17	19811796	missense	probably damaging	1.00
R8186:Vmn2r103	UTSW	17	19811943	missense	probably damaging	1.00
R8559:Vmn2r103	UTSW	17	19812384	missense	probably benign	0.01
R9413:Vmn2r103	UTSW	17	19811896	missense	possibly damaging	0.54
R9591:Vmn2r103	UTSW	17	19811659	missense	possibly damaging	0.70
R9652:Vmn2r103	UTSW	17	19793765	missense	probably benign	0.01
R9680:Vmn2r103	UTSW	17	19799263	nonsense	probably null
R9743:Vmn2r103	UTSW	17	19812213	missense	probably damaging	1.00
Z1088:Vmn2r103	UTSW	17	19795047	missense	probably benign	0.08

Predicted Primers

PCR Primer
(F):5'- CAGCCACATGGACTTCACATTTTGC -3'
(R):5'- TGCTCCTGGTATGTTACACACGATTTC -3'

Sequencing Primer
(F):5'- CACAGAATGTCTGGATCATGAAC -3'
(R):5'- CAGAACATCATTCACTGGAATTGAC -3'

Posted On

2014-04-24