Mutagenetix > Incidental Mutation

Incidental Mutation 'R1590:Fpr-rs7'

177829

Institutional Source

Beutler Lab

Gene Symbol

Fpr-rs7

Ensembl Gene

ENSMUSG00000071276

Gene Name

formyl peptide receptor, related sequence 7

Synonyms

MMRRC Submission

039627-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.110) question?

Stock #

R1590 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

20113210-20114226 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 20113416 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 271 (T271A)

Ref Sequence

ENSEMBL: ENSMUSP00000093297 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000095637]

AlphaFold

Q71MR7

Predicted Effect

probably benign
Transcript: ENSMUST00000095637
AA Change: T271A

PolyPhen 2 Score 0.052 (Sensitivity: 0.94; Specificity: 0.83)

SMART Domains

Protein: ENSMUSP00000093297
Gene: ENSMUSG00000071276
AA Change: T271A

Domain	Start	End	E-Value	Type
Pfam:7tm_1	43	297	1.2e-38	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000176711

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.1%
3x: 98.3%
10x: 96.0%
20x: 91.4%

Validation Efficiency

97% (69/71)

Allele List at MGI

Other mutations in this stock

Total: 59 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930432K21Rik	A	T	8: 84,167,086	Q294L	probably benign	Het
Aamp	A	G	1: 74,283,211	S95P	probably damaging	Het
Ankmy1	T	C	1: 92,888,675	Y239C	probably damaging	Het
Atp12a	T	C	14: 56,380,055	S601P	probably damaging	Het
Atp1b3	T	C	9: 96,343,349	T89A	probably benign	Het
B3galt4	G	A	17: 33,950,839	R142C	probably damaging	Het
Btnl2	A	T	17: 34,361,140	I216F	possibly damaging	Het
Cabs1	A	T	5: 87,979,631	H47L	probably damaging	Het
Ccdc68	T	A	18: 69,940,180	D66E	probably benign	Het
Cdc42ep4	T	C	11: 113,728,566	D333G	possibly damaging	Het
Ckmt1	G	A	2: 121,363,522	D389N	possibly damaging	Het
Dact1	G	T	12: 71,317,575	V340F	probably benign	Het
Dnah2	A	G	11: 69,422,754		probably null	Het
Dnah2	T	C	11: 69,521,198	T246A	probably benign	Het
Ecm1	G	A	3: 95,735,963	R342C	probably damaging	Het
Efcab14	A	G	4: 115,756,549		probably benign	Het
Eprs	A	G	1: 185,401,510	T795A	probably damaging	Het
Esp36	T	A	17: 38,417,311	E26D	possibly damaging	Het
Fsip2	A	T	2: 82,982,787	H3150L	probably benign	Het
Gimap7	G	A	6: 48,724,019	V180M	probably damaging	Het
Gm6614	C	T	6: 141,980,872	S576N	probably benign	Het
Gtf3c1	T	C	7: 125,676,661	H531R	possibly damaging	Het
Herc1	T	A	9: 66,491,953		probably benign	Het
Hip1r	A	G	5: 124,002,140	Y1061C	probably benign	Het
Ipo11	T	C	13: 106,886,717	Y420C	probably damaging	Het
Ipo8	T	C	6: 148,810,665		probably null	Het
Itga10	C	T	3: 96,651,738		probably benign	Het
Klhl1	A	T	14: 96,368,636	M243K	probably damaging	Het
Lrp2	A	G	2: 69,466,763		probably null	Het
Mag	T	C	7: 30,901,852	E439G	probably damaging	Het
Mcm3ap	T	A	10: 76,496,541	F1231I	probably benign	Het
Mcmdc2	C	T	1: 9,916,555	Q204*	probably null	Het
Mpl	A	C	4: 118,444,024	L548R	probably damaging	Het
Mrps2	C	T	2: 28,469,488	A119V	probably benign	Het
Myo18b	G	A	5: 112,875,266	Q87*	probably null	Het
Nfat5	A	G	8: 107,293,890	Y22C	probably damaging	Het
Nnt	T	A	13: 119,386,661	I232L	possibly damaging	Het
Olfr12	G	A	1: 92,620,745	V280M	possibly damaging	Het
Olfr146	T	C	9: 39,018,957	N195D	probably benign	Het
Olfr437	A	G	6: 43,167,912	N285D	probably damaging	Het
Parp2	C	T	14: 50,810,544	P76S	probably benign	Het
Pick1	C	T	15: 79,245,301	H169Y	probably benign	Het
Prtg	T	A	9: 72,842,807	F164L	probably benign	Het
Pygb	A	G	2: 150,817,663	D422G	possibly damaging	Het
Samd9l	C	A	6: 3,375,761	C500F	probably benign	Het
Sbno1	A	C	5: 124,384,504	N1083K	possibly damaging	Het
Sept7	C	T	9: 25,277,604	S77F	probably damaging	Het
Slc25a44	A	G	3: 88,416,007	V264A	possibly damaging	Het
Slf2	G	T	19: 44,942,073	E530*	probably null	Het
Svs2	A	G	2: 164,237,658	S110P	possibly damaging	Het
Tmbim7	G	T	5: 3,665,338		probably null	Het
Tpgs2	T	C	18: 25,140,573	D177G	probably damaging	Het
Uba1y	T	A	Y: 826,893	F516L	probably damaging	Het
Ulk1	A	G	5: 110,795,766	V211A	probably damaging	Het
Vmn1r237	T	A	17: 21,314,039	I8N	probably damaging	Het
Vmn2r103	G	T	17: 19,794,234	M429I	probably benign	Het
Vmn2r112	T	C	17: 22,615,008		probably null	Het
Vmn2r84	T	C	10: 130,391,480		probably null	Het
Vwa8	C	T	14: 78,908,230	R116C	probably damaging	Het

Other mutations in Fpr-rs7

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00332:Fpr-rs7	APN	17	20113218	nonsense	probably null
IGL01386:Fpr-rs7	APN	17	20114192	missense	probably damaging	0.98
IGL02293:Fpr-rs7	APN	17	20113970	missense	probably benign	0.01
IGL03303:Fpr-rs7	APN	17	20113739	missense	possibly damaging	0.55
R0731:Fpr-rs7	UTSW	17	20113854	missense	probably benign	0.00
R0826:Fpr-rs7	UTSW	17	20113626	missense	probably benign	0.01
R1439:Fpr-rs7	UTSW	17	20113607	missense	probably benign	0.10
R1778:Fpr-rs7	UTSW	17	20114015	missense	probably damaging	1.00
R4715:Fpr-rs7	UTSW	17	20113428	missense	probably benign	0.00
R4744:Fpr-rs7	UTSW	17	20114003	missense	probably benign	0.17
R4921:Fpr-rs7	UTSW	17	20113820	missense	possibly damaging	0.70
R5540:Fpr-rs7	UTSW	17	20114094	missense	probably damaging	1.00
R5677:Fpr-rs7	UTSW	17	20114103	missense	probably benign
R5959:Fpr-rs7	UTSW	17	20113749	missense	probably benign	0.01
R6042:Fpr-rs7	UTSW	17	20113215	missense	probably benign	0.00
R7921:Fpr-rs7	UTSW	17	20113405	missense	probably benign	0.03
R7984:Fpr-rs7	UTSW	17	20113409	missense	probably benign	0.01
R8137:Fpr-rs7	UTSW	17	20113793	missense	possibly damaging	0.49
R8172:Fpr-rs7	UTSW	17	20114181	missense	probably benign	0.04
R8762:Fpr-rs7	UTSW	17	20113527	missense	probably benign	0.07
R9134:Fpr-rs7	UTSW	17	20114063	missense	probably damaging	1.00
Z1176:Fpr-rs7	UTSW	17	20113393	missense	probably benign	0.02

Predicted Primers

PCR Primer
(F):5'- GGCACAGGAAACATTTCCATGACAC -3'
(R):5'- GCAATTTTGAATCCTGGGCTGCAAC -3'

Sequencing Primer
(F):5'- TCAGGTCCTATGTCTCAGAGTC -3'
(R):5'- GTTGGCTTCAGCATACCAATG -3'

Posted On

2014-04-24