Incidental Mutation 'R0288:Kcnk3'
ID 177865
Institutional Source Beutler Lab
Gene Symbol Kcnk3
Ensembl Gene ENSMUSG00000049265
Gene Name potassium channel, subfamily K, member 3
Synonyms cTBAK-1, Task-1
MMRRC Submission 038507-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.126) question?
Stock # R0288 (G1)
Quality Score 46
Status Validated
Chromosome 5
Chromosomal Location 30745514-30782614 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 30745764 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Threonine at position 35 (M35T)
Ref Sequence ENSEMBL: ENSMUSP00000098987 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000066295]
AlphaFold O35111
Predicted Effect probably benign
Transcript: ENSMUST00000066295
AA Change: M35T

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000098987
Gene: ENSMUSG00000049265
AA Change: M35T

DomainStartEndE-ValueType
transmembrane domain 9 26 N/A INTRINSIC
low complexity region 37 49 N/A INTRINSIC
Pfam:Ion_trans_2 58 134 2.9e-20 PFAM
Pfam:Ion_trans_2 165 248 1.4e-21 PFAM
low complexity region 272 286 N/A INTRINSIC
low complexity region 296 308 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000199326
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 98.8%
  • 3x: 97.8%
  • 10x: 95.1%
  • 20x: 89.7%
Validation Efficiency 98% (62/63)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the superfamily of potassium channel proteins that contain two pore-forming P domains. The encoded protein is an outwardly rectifying channel that is sensitive to changes in extracellular pH and is inhibited by extracellular acidification. Also referred to as an acid-sensitive potassium channel, it is activated by the anesthetics halothane and isoflurane. Although three transcripts are detected in northern blots, there is currently no sequence available to confirm transcript variants for this gene. [provided by RefSeq, Aug 2008]
PHENOTYPE: Mice homozygous for a null alleles exhibit decreased pH sensitivitive of action potential in serotonergic neurons. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrg3 A G 8: 95,766,568 (GRCm39) E413G possibly damaging Het
Amigo2 G T 15: 97,143,560 (GRCm39) N287K probably damaging Het
Ankle2 T A 5: 110,384,256 (GRCm39) I260K probably damaging Het
Apob C T 12: 8,040,779 (GRCm39) R635* probably null Het
Camkv A G 9: 107,823,555 (GRCm39) Y153C probably damaging Het
Capn9 A G 8: 125,327,230 (GRCm39) probably benign Het
Ces2c A G 8: 105,576,376 (GRCm39) I130V probably benign Het
Cfap44 T A 16: 44,236,257 (GRCm39) probably benign Het
Cfhr3 A G 1: 139,525,425 (GRCm39) noncoding transcript Het
Chmp1a G T 8: 123,934,745 (GRCm39) D70E probably damaging Het
Coil G A 11: 88,872,694 (GRCm39) G352R probably damaging Het
Colq T C 14: 31,265,949 (GRCm39) E188G possibly damaging Het
Cyfip2 A G 11: 46,144,799 (GRCm39) F685S possibly damaging Het
Cyp4f39 A G 17: 32,711,410 (GRCm39) N519S probably benign Het
Dennd1c A T 17: 57,383,870 (GRCm39) probably null Het
Dnah9 A T 11: 65,915,960 (GRCm39) probably null Het
Dnmbp T C 19: 43,890,898 (GRCm39) T290A possibly damaging Het
Dsc2 T C 18: 20,166,177 (GRCm39) D818G probably damaging Het
Gnptab G A 10: 88,268,967 (GRCm39) V557I probably benign Het
Hdac4 A T 1: 91,898,728 (GRCm39) H675Q probably damaging Het
Kif1b A T 4: 149,283,795 (GRCm39) I1290N probably damaging Het
Klhl14 G A 18: 21,698,620 (GRCm39) R398W probably damaging Het
Marveld1 T C 19: 42,136,265 (GRCm39) F60L probably damaging Het
Miox C T 15: 89,220,477 (GRCm39) L189F possibly damaging Het
Ncoa6 TGC TGCGC 2: 155,250,211 (GRCm39) probably null Het
Ndst3 A T 3: 123,465,843 (GRCm39) V43D probably benign Het
Nhsl1 A G 10: 18,399,794 (GRCm39) D306G probably damaging Het
Nlrp2 A G 7: 5,331,544 (GRCm39) V284A probably benign Het
Pcdhb15 T C 18: 37,608,451 (GRCm39) V561A probably damaging Het
Pdcl2 T C 5: 76,460,344 (GRCm39) I177V possibly damaging Het
Pkd1l3 G A 8: 110,373,131 (GRCm39) probably null Het
Pla2g6 A C 15: 79,171,106 (GRCm39) probably benign Het
Plekhj1 A T 10: 80,632,444 (GRCm39) I122N probably damaging Het
Pmel T C 10: 128,550,175 (GRCm39) I70T probably benign Het
Psip1 T C 4: 83,383,196 (GRCm39) D273G probably damaging Het
Rictor A G 15: 6,816,021 (GRCm39) I1098V probably benign Het
Rif1 T C 2: 52,000,025 (GRCm39) S1160P probably damaging Het
Rsbn1l T C 5: 21,125,038 (GRCm39) I255V probably damaging Het
Slc15a5 A G 6: 137,994,914 (GRCm39) probably benign Het
Slc29a1 G A 17: 45,900,730 (GRCm39) R111W probably damaging Het
Slc36a1 G A 11: 55,109,913 (GRCm39) A74T probably damaging Het
Slc5a7 A T 17: 54,600,046 (GRCm39) Y122* probably null Het
Slc6a3 G T 13: 73,709,047 (GRCm39) G324W probably damaging Het
Sltm T C 9: 70,486,633 (GRCm39) S433P probably damaging Het
Spta1 T C 1: 174,070,745 (GRCm39) S2190P probably damaging Het
Sry A T Y: 2,662,818 (GRCm39) F281I unknown Het
Stk32a T A 18: 43,438,060 (GRCm39) probably null Het
Sytl2 T C 7: 90,052,228 (GRCm39) probably benign Het
Tbl3 G A 17: 24,920,781 (GRCm39) H612Y probably damaging Het
Tmem144 G A 3: 79,746,580 (GRCm39) probably benign Het
Top2a A G 11: 98,907,249 (GRCm39) probably benign Het
Usp9y A T Y: 1,333,606 (GRCm39) probably benign Het
Vldlr G A 19: 27,218,051 (GRCm39) probably benign Het
Vmn1r28 G A 6: 58,242,702 (GRCm39) A182T probably benign Het
Vmn2r28 A G 7: 5,491,020 (GRCm39) L409P probably damaging Het
Vps13c T C 9: 67,834,648 (GRCm39) V1659A probably damaging Het
Wdr17 C T 8: 55,146,131 (GRCm39) A90T possibly damaging Het
Zfp280d A T 9: 72,238,621 (GRCm39) K646* probably null Het
Zfp36 A G 7: 28,077,666 (GRCm39) S81P probably benign Het
Zfp618 A T 4: 63,051,171 (GRCm39) T651S possibly damaging Het
Other mutations in Kcnk3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02481:Kcnk3 APN 5 30,779,727 (GRCm39) missense probably damaging 0.99
IGL02719:Kcnk3 APN 5 30,779,324 (GRCm39) missense probably damaging 1.00
PIT4802001:Kcnk3 UTSW 5 30,779,712 (GRCm39) missense probably damaging 1.00
R0834:Kcnk3 UTSW 5 30,779,979 (GRCm39) missense probably damaging 1.00
R1740:Kcnk3 UTSW 5 30,779,321 (GRCm39) missense possibly damaging 0.95
R2656:Kcnk3 UTSW 5 30,780,015 (GRCm39) missense possibly damaging 0.55
R2923:Kcnk3 UTSW 5 30,779,414 (GRCm39) missense probably damaging 1.00
R3740:Kcnk3 UTSW 5 30,779,274 (GRCm39) missense possibly damaging 0.93
R4584:Kcnk3 UTSW 5 30,745,730 (GRCm39) missense probably damaging 0.99
R5010:Kcnk3 UTSW 5 30,780,149 (GRCm39) missense possibly damaging 0.79
R5070:Kcnk3 UTSW 5 30,779,730 (GRCm39) missense possibly damaging 0.77
R5427:Kcnk3 UTSW 5 30,779,639 (GRCm39) missense possibly damaging 0.86
R5669:Kcnk3 UTSW 5 30,779,693 (GRCm39) missense probably damaging 0.99
R5956:Kcnk3 UTSW 5 30,745,854 (GRCm39) missense probably damaging 1.00
R5982:Kcnk3 UTSW 5 30,780,014 (GRCm39) missense probably benign 0.18
R5986:Kcnk3 UTSW 5 30,745,722 (GRCm39) missense possibly damaging 0.68
R6318:Kcnk3 UTSW 5 30,779,930 (GRCm39) missense probably damaging 0.98
R6860:Kcnk3 UTSW 5 30,779,397 (GRCm39) missense possibly damaging 0.86
R6919:Kcnk3 UTSW 5 30,779,744 (GRCm39) missense probably benign 0.00
R7350:Kcnk3 UTSW 5 30,779,310 (GRCm39) missense probably damaging 1.00
R7418:Kcnk3 UTSW 5 30,779,675 (GRCm39) missense possibly damaging 0.57
R7502:Kcnk3 UTSW 5 30,780,062 (GRCm39) missense possibly damaging 0.85
R7922:Kcnk3 UTSW 5 30,745,875 (GRCm39) missense probably damaging 1.00
R8899:Kcnk3 UTSW 5 30,779,580 (GRCm39) missense probably benign 0.37
R8953:Kcnk3 UTSW 5 30,779,382 (GRCm39) missense probably damaging 1.00
R9180:Kcnk3 UTSW 5 30,745,532 (GRCm39) start gained probably benign
R9570:Kcnk3 UTSW 5 30,779,433 (GRCm39) missense possibly damaging 0.94
Z1177:Kcnk3 UTSW 5 30,780,048 (GRCm39) missense possibly damaging 0.80
Z1177:Kcnk3 UTSW 5 30,779,837 (GRCm39) missense probably benign
Z1177:Kcnk3 UTSW 5 30,745,618 (GRCm39) start gained probably benign
Predicted Primers PCR Primer
(F):5'- TGGTGCTGAAGGGACAGCTCCG -3'
(R):5'- GGTTCCCGCAGAGCAGACACAC -3'

Sequencing Primer
(F):5'- TGGAGATCCGCGAGCGCAGCCATGCC -3'
(R):5'- AGCATCCCAGGTccccg -3'
Posted On 2014-04-30