Incidental Mutation 'R0018:Sctr'
ID 177871
Institutional Source Beutler Lab
Gene Symbol Sctr
Ensembl Gene ENSMUSG00000026387
Gene Name secretin receptor
Synonyms 6530402O03Rik
MMRRC Submission 038313-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.073) question?
Stock # R0018 (G1)
Quality Score 77
Status Validated
Chromosome 1
Chromosomal Location 119934710-119991269 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) C to A at 119971286 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000139932 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000072886] [ENSMUST00000189037]
AlphaFold Q5FWI2
Predicted Effect probably benign
Transcript: ENSMUST00000072886
SMART Domains Protein: ENSMUSP00000072660
Gene: ENSMUSG00000026387

DomainStartEndE-ValueType
signal peptide 1 28 N/A INTRINSIC
low complexity region 36 53 N/A INTRINSIC
HormR 76 146 5.18e-21 SMART
Pfam:7tm_2 153 398 3.8e-88 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000189037
SMART Domains Protein: ENSMUSP00000139932
Gene: ENSMUSG00000026387

DomainStartEndE-ValueType
signal peptide 1 28 N/A INTRINSIC
low complexity region 36 53 N/A INTRINSIC
HormR 61 131 2.59e-21 SMART
Pfam:7tm_2 138 383 1.9e-89 PFAM
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 99.0%
  • 10x: 97.9%
  • 20x: 96.6%
Validation Efficiency 100% (64/64)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a G protein-coupled receptor and belongs to the glucagon-VIP-secretin receptor family. It binds secretin which is the most potent regulator of pancreatic bicarbonate, electrolyte and volume secretion. Secretin and its receptor are suggested to be involved in pancreatic cancer and autism. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygotes for a null allele show polydipsia, polyuria, decreased urine osmolality, higher serum glucose levels, kidney glomerular and tubular pathology, and impaired renal water reabsorption. Homozygotes for a different null allele show impaired synaptic plasticity and social behavior. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca17 T C 17: 24,532,162 (GRCm39) probably null Het
Afp A C 5: 90,654,600 (GRCm39) Q546P probably damaging Het
Api5 A T 2: 94,251,329 (GRCm39) probably null Het
Atp2b4 T A 1: 133,645,609 (GRCm39) I982F probably damaging Het
BC024139 G A 15: 76,005,087 (GRCm39) Q592* probably null Het
Capn7 T A 14: 31,076,069 (GRCm39) C290* probably null Het
Ccn1 A G 3: 145,355,186 (GRCm39) L23P probably damaging Het
Celsr1 T A 15: 85,915,243 (GRCm39) D910V possibly damaging Het
Chga T C 12: 102,524,764 (GRCm39) S45P probably damaging Het
Cpne2 T A 8: 95,282,681 (GRCm39) C59S possibly damaging Het
Cyp2b13 G A 7: 25,785,375 (GRCm39) R248H probably benign Het
Dennd1a T A 2: 37,748,472 (GRCm39) T336S possibly damaging Het
Drc7 A G 8: 95,800,862 (GRCm39) Y628C probably damaging Het
Dse A G 10: 34,029,464 (GRCm39) V542A probably benign Het
Dspp A T 5: 104,326,096 (GRCm39) S820C unknown Het
Efcab3 G A 11: 104,612,378 (GRCm39) probably null Het
Eif5b T C 1: 38,057,970 (GRCm39) S91P unknown Het
Epop A G 11: 97,519,017 (GRCm39) V364A probably benign Het
Ext2 G A 2: 93,626,037 (GRCm39) P341L probably damaging Het
Galns T C 8: 123,311,724 (GRCm39) T429A probably benign Het
Gsx2 A G 5: 75,237,828 (GRCm39) K260R probably damaging Het
H2-M10.6 A C 17: 37,124,941 (GRCm39) H286P probably damaging Het
Hectd4 A G 5: 121,392,242 (GRCm39) N169D possibly damaging Het
Helz2 C A 2: 180,874,552 (GRCm39) G1981C probably damaging Het
Hmcn1 T C 1: 150,528,302 (GRCm39) D3282G probably benign Het
Hnmt T A 2: 23,893,640 (GRCm39) N285Y possibly damaging Het
Hr A G 14: 70,795,717 (GRCm39) R450G probably benign Het
Kat6a A G 8: 23,419,289 (GRCm39) D684G possibly damaging Het
Kif27 T G 13: 58,435,867 (GRCm39) I1309L probably benign Het
Mab21l4 T A 1: 93,082,327 (GRCm39) D264V probably benign Het
Man2b1 T A 8: 85,824,118 (GRCm39) V1005E probably damaging Het
Me2 A T 18: 73,924,923 (GRCm39) F265I possibly damaging Het
Myo9a A T 9: 59,779,007 (GRCm39) T1588S probably benign Het
Neu4 T A 1: 93,953,060 (GRCm39) D476E probably benign Het
Nlrp9c T A 7: 26,071,423 (GRCm39) Q895L possibly damaging Het
Or1e35 T C 11: 73,797,452 (GRCm39) I289V probably damaging Het
Or1p1c A C 11: 74,160,934 (GRCm39) T240P probably benign Het
Pdzd8 C T 19: 59,289,105 (GRCm39) R765H probably damaging Het
Plk1 T C 7: 121,768,208 (GRCm39) probably null Het
Ppfia2 A G 10: 106,678,647 (GRCm39) probably benign Het
Prkdc T C 16: 15,544,406 (GRCm39) Y1799H probably benign Het
Psmc1 T C 12: 100,082,951 (GRCm39) probably benign Het
Ptchd3 A C 11: 121,733,170 (GRCm39) I687L probably benign Het
Ptprh A G 7: 4,604,845 (GRCm39) probably null Het
Pus3 A G 9: 35,477,920 (GRCm39) D384G probably benign Het
Rab44 C T 17: 29,358,354 (GRCm39) P181S probably benign Het
Rasa2 A G 9: 96,454,016 (GRCm39) S307P probably damaging Het
Rbpms2 A G 9: 65,558,360 (GRCm39) D142G probably damaging Het
Reln A T 5: 22,130,369 (GRCm39) D2647E probably benign Het
Ryr2 G A 13: 11,610,109 (GRCm39) T4239I possibly damaging Het
Serpinb6e A T 13: 34,021,828 (GRCm39) Y167N probably damaging Het
Slc13a5 T C 11: 72,157,301 (GRCm39) I31V probably benign Het
Slc15a4 A T 5: 127,679,074 (GRCm39) I422N probably damaging Het
Stk24 G A 14: 121,545,419 (GRCm39) probably benign Het
Vmn1r213 T A 13: 23,196,311 (GRCm39) V298D probably damaging Het
Xdh C T 17: 74,232,020 (GRCm39) R230H probably benign Het
Zfp418 A T 7: 7,185,449 (GRCm39) S471C probably benign Het
Other mutations in Sctr
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00468:Sctr APN 1 119,972,450 (GRCm39) missense probably damaging 1.00
IGL01542:Sctr APN 1 119,972,499 (GRCm39) splice site probably benign
IGL02798:Sctr APN 1 119,949,910 (GRCm39) missense probably damaging 1.00
IGL02850:Sctr APN 1 119,949,909 (GRCm39) missense probably damaging 1.00
IGL02850:Sctr APN 1 119,972,393 (GRCm39) missense possibly damaging 0.95
IGL03256:Sctr APN 1 119,959,289 (GRCm39) splice site probably benign
PIT4677001:Sctr UTSW 1 119,989,634 (GRCm39) missense probably damaging 1.00
R0166:Sctr UTSW 1 119,983,124 (GRCm39) missense probably damaging 0.97
R1678:Sctr UTSW 1 119,964,169 (GRCm39) critical splice donor site probably null
R1728:Sctr UTSW 1 119,990,987 (GRCm39) missense possibly damaging 0.67
R1728:Sctr UTSW 1 119,959,386 (GRCm39) missense probably benign 0.00
R1729:Sctr UTSW 1 119,990,987 (GRCm39) missense possibly damaging 0.67
R1729:Sctr UTSW 1 119,959,386 (GRCm39) missense probably benign 0.00
R1729:Sctr UTSW 1 119,990,976 (GRCm39) missense probably benign 0.16
R1730:Sctr UTSW 1 119,990,987 (GRCm39) missense possibly damaging 0.67
R1730:Sctr UTSW 1 119,959,386 (GRCm39) missense probably benign 0.00
R1739:Sctr UTSW 1 119,959,386 (GRCm39) missense probably benign 0.00
R1739:Sctr UTSW 1 119,990,976 (GRCm39) missense probably benign 0.16
R1739:Sctr UTSW 1 119,990,987 (GRCm39) missense possibly damaging 0.67
R1762:Sctr UTSW 1 119,990,987 (GRCm39) missense possibly damaging 0.67
R1762:Sctr UTSW 1 119,990,976 (GRCm39) missense probably benign 0.16
R1762:Sctr UTSW 1 119,959,386 (GRCm39) missense probably benign 0.00
R1783:Sctr UTSW 1 119,959,386 (GRCm39) missense probably benign 0.00
R1785:Sctr UTSW 1 119,990,987 (GRCm39) missense possibly damaging 0.67
R1785:Sctr UTSW 1 119,990,976 (GRCm39) missense probably benign 0.16
R1785:Sctr UTSW 1 119,959,386 (GRCm39) missense probably benign 0.00
R2116:Sctr UTSW 1 119,959,312 (GRCm39) missense probably damaging 1.00
R5522:Sctr UTSW 1 119,964,146 (GRCm39) missense probably benign 0.10
R5776:Sctr UTSW 1 119,984,137 (GRCm39) missense probably damaging 1.00
R5781:Sctr UTSW 1 119,959,350 (GRCm39) missense probably damaging 0.99
R6333:Sctr UTSW 1 119,984,182 (GRCm39) missense probably damaging 1.00
R7084:Sctr UTSW 1 119,991,001 (GRCm39) missense possibly damaging 0.77
R7263:Sctr UTSW 1 119,949,955 (GRCm39) missense probably benign
R7265:Sctr UTSW 1 119,949,955 (GRCm39) missense probably benign
R7266:Sctr UTSW 1 119,949,955 (GRCm39) missense probably benign
R7304:Sctr UTSW 1 119,949,970 (GRCm39) missense probably damaging 1.00
R7343:Sctr UTSW 1 119,949,955 (GRCm39) missense probably benign
R8063:Sctr UTSW 1 119,991,005 (GRCm39) missense probably benign 0.09
R8914:Sctr UTSW 1 119,959,386 (GRCm39) missense probably benign 0.00
R9146:Sctr UTSW 1 119,982,010 (GRCm39) missense probably damaging 1.00
R9391:Sctr UTSW 1 119,983,178 (GRCm39) missense probably benign 0.00
R9495:Sctr UTSW 1 119,959,403 (GRCm39) critical splice donor site probably null
X0067:Sctr UTSW 1 119,935,029 (GRCm39) missense probably benign
Z1088:Sctr UTSW 1 119,964,136 (GRCm39) frame shift probably null
Z1176:Sctr UTSW 1 119,949,979 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- TGCTGGTAAAGGGACCTGCCAA -3'
(R):5'- CAACCACCGCCTTCTGGATTTGA -3'

Sequencing Primer
(F):5'- gggacctgcCAACAGCC -3'
(R):5'- ttgtgagttacaaaaaaaaacccc -3'
Posted On 2014-04-30