Mutagenetix > Incidental Mutation

Incidental Mutation 'R0320:Vmn1r168'

177936

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r168

Ensembl Gene

ENSMUSG00000074291

Gene Name

vomeronasal 1 receptor 168

Synonyms

Gm10659

MMRRC Submission

038530-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.095) question?

Stock #

R0320 (G1)

Quality Score

Status

Validated

Chromosome

Chromosomal Location

23540720-23541649 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 23541342 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Arginine to Histidine at position 208 (R208H)

Ref Sequence

ENSEMBL: ENSMUSP00000096301 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000098704]

AlphaFold

K7N6B6

Predicted Effect

probably benign
Transcript: ENSMUST00000098704
AA Change: R208H

PolyPhen 2 Score 0.121 (Sensitivity: 0.93; Specificity: 0.86)

SMART Domains

Protein: ENSMUSP00000096301
Gene: ENSMUSG00000074291
AA Change: R208H

Domain	Start	End	E-Value	Type
Pfam:TAS2R	8	296	1.1e-12	PFAM
Pfam:V1R	41	295	2.5e-14	PFAM

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.1%
3x: 98.4%
10x: 96.5%
20x: 93.0%

Validation Efficiency

100% (71/71)

Allele List at MGI

Other mutations in this stock

Total: 56 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
3425401B19Rik	T	C	14: 32,662,614	T465A	probably benign	Het
9430007A20Rik	A	T	4: 144,522,420	H119L	probably damaging	Het
A430110L20Rik	T	G	1: 181,227,422		noncoding transcript	Het
Abcb10	C	T	8: 123,963,007	R439Q	probably benign	Het
Abcb8	T	C	5: 24,400,790	S199P	probably damaging	Het
Adam8	C	A	7: 139,986,442	C556F	probably damaging	Het
Akap11	T	C	14: 78,513,379	T523A	probably benign	Het
Aldh3b1	T	C	19: 3,918,999		probably benign	Het
Arhgap30	T	A	1: 171,403,804	W230R	possibly damaging	Het
Atp8b4	A	G	2: 126,459,694	I82T	possibly damaging	Het
Bptf	A	T	11: 107,072,819	L1850I	probably damaging	Het
C4b	C	A	17: 34,733,161	V1237L	probably benign	Het
Calu	C	A	6: 29,374,551		probably benign	Het
Ccdc129	T	C	6: 55,976,447	I916T	probably damaging	Het
Cit	C	A	5: 115,979,445	L1227M	possibly damaging	Het
Col4a1	C	T	8: 11,242,782		probably null	Het
Cp	T	C	3: 19,974,848		probably benign	Het
Cpd	T	C	11: 76,840,447	D311G	possibly damaging	Het
Ctc1	T	A	11: 69,033,537	S972T	probably damaging	Het
Dnah17	A	G	11: 118,052,674	F3201L	possibly damaging	Het
Dopey2	C	A	16: 93,810,147	R2113S	probably benign	Het
Dym	T	A	18: 75,199,262	D520E	probably damaging	Het
Eif5a	G	T	11: 69,917,479	T64K	probably benign	Het
Flt3	A	T	5: 147,369,579		probably benign	Het
Ints6	A	T	14: 62,707,635	Y415*	probably null	Het
Itga1	A	G	13: 114,977,594		probably benign	Het
Itgae	A	G	11: 73,130,999	H902R	possibly damaging	Het
Kdm5a	T	C	6: 120,389,620	I406T	probably benign	Het
Lmx1a	C	T	1: 167,791,404	Q111*	probably null	Het
Lrrc25	T	C	8: 70,618,246	Y226H	probably benign	Het
Mcam	T	A	9: 44,140,186	N447K	possibly damaging	Het
Mcm10	A	T	2: 5,004,086	D357E	probably benign	Het
Nrip1	T	C	16: 76,292,363	T769A	probably benign	Het
Ofcc1	G	C	13: 40,206,696	Q286E	probably benign	Het
Olfr382	T	G	11: 73,516,924	I92L	probably damaging	Het
Olfr689	A	T	7: 105,314,654	I217F	probably benign	Het
Parp3	T	A	9: 106,475,812	N55I	possibly damaging	Het
Parp4	T	C	14: 56,588,496		probably null	Het
Pilrb1	G	A	5: 137,854,998	T181I	probably benign	Het
Ppm1n	A	G	7: 19,278,356	V317A	probably damaging	Het
Prdm2	A	T	4: 143,179,351	F55L	probably damaging	Het
Psd2	C	T	18: 35,979,644	R131C	probably damaging	Het
Ralgps1	A	T	2: 33,141,015	C570S	possibly damaging	Het
Scaf8	T	C	17: 3,178,255	S443P	unknown	Het
Setd5	A	G	6: 113,111,481	K190R	probably damaging	Het
Spsb4	T	A	9: 96,996,108	H54L	probably damaging	Het
St7l	T	A	3: 104,870,913	L122*	probably null	Het
Stom	C	T	2: 35,321,634	R125H	probably damaging	Het
Tigd4	T	A	3: 84,595,174	V466E	probably benign	Het
Tmc3	A	C	7: 83,607,819		probably benign	Het
Vcl	C	T	14: 20,985,624		probably benign	Het
Vmn2r75	C	A	7: 86,165,080	V402L	probably benign	Het
Vps13b	A	T	15: 35,674,828	H1698L	probably damaging	Het
Wnt16	T	G	6: 22,297,993	V286G	possibly damaging	Het
Xirp1	C	A	9: 120,016,467	V1117L	probably benign	Het
Zfp788	C	T	7: 41,649,547	H536Y	probably damaging	Het

Other mutations in Vmn1r168

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01761:Vmn1r168	APN	7	23541645	missense	possibly damaging	0.73
IGL02621:Vmn1r168	APN	7	23541355	missense	probably damaging	1.00
IGL02650:Vmn1r168	APN	7	23541491	missense	probably benign	0.13
PIT4466001:Vmn1r168	UTSW	7	23540996	missense	probably damaging	1.00
R1595:Vmn1r168	UTSW	7	23541195	missense	probably damaging	1.00
R1618:Vmn1r168	UTSW	7	23541300	missense	probably benign	0.02
R1808:Vmn1r168	UTSW	7	23540759	missense	probably benign	0.05
R2418:Vmn1r168	UTSW	7	23541399	missense	probably benign	0.05
R2419:Vmn1r168	UTSW	7	23541399	missense	probably benign	0.05
R4846:Vmn1r168	UTSW	7	23541065	missense	probably damaging	1.00
R4864:Vmn1r168	UTSW	7	23541482	missense	probably damaging	0.98
R5269:Vmn1r168	UTSW	7	23541414	missense	probably benign	0.40
R6265:Vmn1r168	UTSW	7	23541536	missense	probably benign
R6353:Vmn1r168	UTSW	7	23541519	missense	probably benign	0.02
R6768:Vmn1r168	UTSW	7	23541035	missense	probably damaging	1.00
R6921:Vmn1r168	UTSW	7	23540898	missense	probably damaging	1.00
R8247:Vmn1r168	UTSW	7	23541062	missense	possibly damaging	0.61
R8749:Vmn1r168	UTSW	7	23541003	missense	probably benign	0.10
R9749:Vmn1r168	UTSW	7	23540812	missense	probably damaging	0.98
R9768:Vmn1r168	UTSW	7	23541084	missense	probably benign	0.02

Predicted Primers

PCR Primer
(F):5'- GCCCCAAGGTCATAAGCTATTCCTG -3'
(R):5'- GCCTCAACCACAGATTGGAGTCTAC -3'

Sequencing Primer
(F):5'- AGGTCATAAGCTATTCCTGTTGTAG -3'
(R):5'- CAGATTGGAGTCTACAAAAACAATG -3'

Posted On

2014-05-01