Incidental Mutation 'R0437:Zfp936'
ID177950
Institutional Source Beutler Lab
Gene Symbol Zfp936
Ensembl Gene ENSMUSG00000064194
Gene Namezinc finger protein 936
SynonymsEG435970, Gm9272, I1C0022H11Rik
MMRRC Submission 038638-MU
Accession Numbers
Is this an essential gene? Possibly essential (E-score: 0.749) question?
Stock #R0437 (G1)
Quality Score39
Status Validated
Chromosome7
Chromosomal Location43114229-43192109 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to G at 43189310 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Serine at position 67 (I67S)
Ref Sequence ENSEMBL: ENSMUSP00000145999 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000072829] [ENSMUST00000200973] [ENSMUST00000202535] [ENSMUST00000205912]
Predicted Effect probably benign
Transcript: ENSMUST00000072829
AA Change: I66S

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000072608
Gene: ENSMUSG00000064194
AA Change: I66S

DomainStartEndE-ValueType
KRAB 3 65 5.32e-19 SMART
ZnF_C2H2 148 170 5.9e-3 SMART
ZnF_C2H2 176 198 5.9e-3 SMART
ZnF_C2H2 204 226 1.4e-4 SMART
ZnF_C2H2 232 254 1.2e-3 SMART
ZnF_C2H2 260 282 7.37e-4 SMART
ZnF_C2H2 288 310 2.27e-4 SMART
ZnF_C2H2 316 338 2.09e-3 SMART
ZnF_C2H2 344 366 1.45e-2 SMART
ZnF_C2H2 372 394 1.82e-3 SMART
ZnF_C2H2 400 422 2.53e-2 SMART
ZnF_C2H2 428 450 4.54e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000200973
SMART Domains Protein: ENSMUSP00000144191
Gene: ENSMUSG00000064194

DomainStartEndE-ValueType
KRAB 4 66 1.4e-21 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000202535
AA Change: I67S

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000143800
Gene: ENSMUSG00000064194
AA Change: I67S

DomainStartEndE-ValueType
KRAB 4 66 2.3e-21 SMART
ZnF_C2H2 149 171 2.6e-5 SMART
ZnF_C2H2 177 199 2.5e-5 SMART
ZnF_C2H2 205 227 5.9e-7 SMART
ZnF_C2H2 233 255 5.1e-6 SMART
ZnF_C2H2 261 283 3.1e-6 SMART
ZnF_C2H2 289 311 9.4e-7 SMART
ZnF_C2H2 317 339 8.7e-6 SMART
ZnF_C2H2 345 367 6.3e-5 SMART
ZnF_C2H2 373 395 7.7e-6 SMART
ZnF_C2H2 401 423 1.1e-4 SMART
ZnF_C2H2 429 451 2e-6 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000205912
AA Change: I67S

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.0%
  • 20x: 94.8%
Validation Efficiency 100% (104/104)
Allele List at MGI
Other mutations in this stock
Total: 99 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110051M20Rik A G 2: 91,421,953 L21P probably damaging Het
4833420G17Rik G A 13: 119,470,095 R291K probably benign Het
4932438A13Rik A T 3: 36,989,804 H2820L possibly damaging Het
Abca2 T C 2: 25,442,845 S1519P probably damaging Het
Abcb11 G A 2: 69,257,295 A1042V probably damaging Het
Abcc10 A T 17: 46,312,919 probably null Het
Abcc10 G T 17: 46,312,920 probably benign Het
Alkbh3 A C 2: 93,981,569 L240V probably damaging Het
Apol10b T C 15: 77,585,408 S190G probably benign Het
Atp1a3 C A 7: 24,998,967 C135F probably benign Het
Atp4a C G 7: 30,720,101 R659G probably benign Het
BC030499 T C 11: 78,291,536 L57P probably benign Het
Bicra A G 7: 15,988,762 S277P possibly damaging Het
Bmp8a T C 4: 123,316,897 E275G probably benign Het
Ccdc102a T C 8: 94,913,426 E80G probably damaging Het
Cdh23 T C 10: 60,410,797 D954G probably damaging Het
Chrm4 A G 2: 91,928,443 T399A possibly damaging Het
Clcn3 A G 8: 60,934,537 V199A possibly damaging Het
Crlf1 T C 8: 70,499,514 probably null Het
Crx G T 7: 15,871,146 S57* probably null Het
Cyp4f16 A G 17: 32,537,098 I34V possibly damaging Het
Daxx T C 17: 33,913,624 V576A probably benign Het
Ddx17 C T 15: 79,537,471 R351H probably damaging Het
Dhx38 T C 8: 109,558,629 probably benign Het
Dnd1 T C 18: 36,764,499 probably benign Het
Dync1i2 A T 2: 71,227,825 probably null Het
E2f6 T C 12: 16,816,445 S52P probably benign Het
Epb41l4a A G 18: 33,880,273 F116S probably damaging Het
Ext1 T C 15: 53,106,106 N362S probably damaging Het
Fam227a C A 15: 79,643,988 K79N possibly damaging Het
Fam228a T A 12: 4,732,759 L111F probably damaging Het
Fat2 T C 11: 55,282,799 T2363A probably benign Het
Fat3 A T 9: 15,996,932 N2591K probably damaging Het
Frem2 A G 3: 53,653,015 M1357T possibly damaging Het
Frmd4b A T 6: 97,423,463 V29D probably damaging Het
G930045G22Rik A G 6: 50,846,938 noncoding transcript Het
Galnt3 A G 2: 66,107,229 S46P possibly damaging Het
Gmeb2 A G 2: 181,253,973 V468A possibly damaging Het
Herc2 C T 7: 56,219,815 R4271* probably null Het
Il5 C A 11: 53,723,906 probably benign Het
Ints9 G A 14: 64,986,369 probably benign Het
Itga10 T C 3: 96,649,137 F196S probably damaging Het
Itgb3bp T C 4: 99,781,889 T138A probably damaging Het
Kcnd1 G A X: 7,824,683 V281M probably benign Het
Lcp2 T C 11: 34,087,229 L391P probably benign Het
Lrrc66 T C 5: 73,607,687 Y671C probably benign Het
Mettl23 T C 11: 116,849,294 V197A possibly damaging Het
Mmp15 C A 8: 95,370,772 D456E probably benign Het
Mospd4 T C 18: 46,465,781 noncoding transcript Het
Mov10l1 C A 15: 89,005,312 H484N probably damaging Het
Mphosph9 T C 5: 124,315,568 Q197R probably benign Het
Ms4a1 T A 19: 11,256,569 probably null Het
Mybbp1a T C 11: 72,448,848 V919A possibly damaging Het
Mycbpap A T 11: 94,513,512 probably benign Het
Naip6 G A 13: 100,296,924 S1135F possibly damaging Het
Ndufc2 T A 7: 97,400,337 M50K probably benign Het
Npr2 T C 4: 43,648,082 V842A probably damaging Het
Ntsr2 G T 12: 16,653,695 G66W probably damaging Het
Obscn T C 11: 58,995,088 probably benign Het
Olfr1206 T A 2: 88,864,885 N93K probably benign Het
Olfr1219 T A 2: 89,074,612 I160F probably benign Het
Olfr427 G A 1: 174,100,399 G314R probably benign Het
Olfr820 T C 10: 130,018,096 V245A probably damaging Het
Optn C T 2: 5,024,115 G526R probably damaging Het
Otud4 T A 8: 79,669,997 H628Q probably benign Het
Padi6 T C 4: 140,728,929 T585A probably benign Het
Pex16 G T 2: 92,375,592 R10L probably damaging Het
Pitpnm2 A G 5: 124,131,089 probably benign Het
Pom121l2 A G 13: 21,983,205 T549A possibly damaging Het
Prdm15 A T 16: 97,812,559 M470K probably benign Het
Prkag2 T A 5: 25,028,505 D49V possibly damaging Het
Prl3c1 A G 13: 27,199,464 M38V probably benign Het
Prpf18 T A 2: 4,643,761 I85F possibly damaging Het
Psg27 A G 7: 18,560,711 probably benign Het
Relt A G 7: 100,848,784 probably benign Het
Serpina3b A T 12: 104,130,670 N70I probably damaging Het
Slc19a3 T C 1: 83,022,565 S244G probably benign Het
Slc39a5 T C 10: 128,399,847 T81A possibly damaging Het
Slc7a2 G A 8: 40,904,526 G277D probably damaging Het
Slc9c1 C T 16: 45,599,887 probably benign Het
Slx1b A G 7: 126,692,581 F104L probably benign Het
Smg6 G A 11: 74,929,701 S266N probably damaging Het
Spata9 T C 13: 75,998,495 V162A possibly damaging Het
Szrd1 T C 4: 141,118,744 I47V probably benign Het
Tha1 G T 11: 117,868,575 L363M probably benign Het
Tmc6 G A 11: 117,778,261 T89I possibly damaging Het
Tmem132d C T 5: 127,789,785 G684R probably damaging Het
Trim55 G A 3: 19,670,978 G220S probably benign Het
Ttn A G 2: 76,770,530 L18836P probably damaging Het
Ubn1 G T 16: 5,072,184 probably benign Het
Ush2a T G 1: 188,911,031 W4197G probably benign Het
Vmn1r189 A T 13: 22,102,061 V202E probably damaging Het
Vmn1r209 T C 13: 22,806,356 I55V probably benign Het
Vmn2r86 A T 10: 130,446,543 C735S probably damaging Het
Vwf A T 6: 125,566,318 D174V probably damaging Het
Zfp438 T C 18: 5,214,910 N16S probably damaging Het
Zfp444 C T 7: 6,189,409 T142I probably benign Het
Zfp804a A G 2: 82,053,791 M1V probably null Het
Zfp948 A T 17: 21,586,998 N151Y unknown Het
Other mutations in Zfp936
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02231:Zfp936 APN 7 43187485 splice site probably null
IGL02245:Zfp936 APN 7 43187298 critical splice donor site probably null
IGL02335:Zfp936 APN 7 43187267 missense probably damaging 1.00
FR4340:Zfp936 UTSW 7 43189489 missense possibly damaging 0.63
R3899:Zfp936 UTSW 7 43189734 missense possibly damaging 0.93
R4120:Zfp936 UTSW 7 43190206 missense probably benign 0.10
R4406:Zfp936 UTSW 7 43190324 missense possibly damaging 0.82
R4959:Zfp936 UTSW 7 43189610 missense probably damaging 1.00
R5023:Zfp936 UTSW 7 43187257 missense probably damaging 1.00
R5163:Zfp936 UTSW 7 43190240 missense probably damaging 1.00
R5182:Zfp936 UTSW 7 43189907 missense probably damaging 1.00
R5292:Zfp936 UTSW 7 43189335 nonsense probably null
R5668:Zfp936 UTSW 7 43190434 missense possibly damaging 0.93
R6057:Zfp936 UTSW 7 43190363 missense probably benign 0.00
R6901:Zfp936 UTSW 7 43190043 missense probably damaging 1.00
R7139:Zfp936 UTSW 7 43190291 missense possibly damaging 0.54
R7258:Zfp936 UTSW 7 43190379 missense probably damaging 1.00
R7440:Zfp936 UTSW 7 43187261 missense probably damaging 1.00
R7537:Zfp936 UTSW 7 43189815 nonsense probably null
R7561:Zfp936 UTSW 7 43189915 missense probably damaging 0.98
R7662:Zfp936 UTSW 7 43189912 nonsense probably null
R7775:Zfp936 UTSW 7 43190296 missense possibly damaging 0.70
R7778:Zfp936 UTSW 7 43190296 missense possibly damaging 0.70
R8016:Zfp936 UTSW 7 43189424 missense possibly damaging 0.61
R8121:Zfp936 UTSW 7 43190123 missense possibly damaging 0.55
Predicted Primers
Posted On2014-05-06