Incidental Mutation 'IGL01844:Kctd16'
ID 178125
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Kctd16
Ensembl Gene ENSMUSG00000051401
Gene Name potassium channel tetramerisation domain containing 16
Synonyms LOC383347, 2900055J20Rik, 4930434H12Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.098) question?
Stock # IGL01844
Quality Score
Status
Chromosome 18
Chromosomal Location 40390015-40664683 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 40390373 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Methionine at position 115 (I115M)
Ref Sequence ENSEMBL: ENSMUSP00000094323 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000091927] [ENSMUST00000096572]
AlphaFold Q5DTY9
Predicted Effect probably benign
Transcript: ENSMUST00000091927
SMART Domains Protein: ENSMUSP00000089547
Gene: ENSMUSG00000051401

DomainStartEndE-ValueType
BTB 25 130 8.7e-7 SMART
low complexity region 288 300 N/A INTRINSIC
low complexity region 374 396 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000096572
AA Change: I115M

PolyPhen 2 Score 0.985 (Sensitivity: 0.74; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000094323
Gene: ENSMUSG00000071860
AA Change: I115M

DomainStartEndE-ValueType
transmembrane domain 99 121 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Homozygous knockout leads to reduced extinction or increase of fear memory in cued or contextual conditioning behavior tests, respectively. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcg5 A G 17: 84,989,453 (GRCm39) I85T probably damaging Het
Amer2 A G 14: 60,617,356 (GRCm39) D391G possibly damaging Het
Atp13a3 A T 16: 30,180,781 (GRCm39) C83S probably benign Het
Bdh2 A T 3: 134,994,080 (GRCm39) Q54L probably benign Het
Cep128 A G 12: 90,975,628 (GRCm39) S1051P probably benign Het
Dop1a A G 9: 86,396,138 (GRCm39) T865A probably damaging Het
Epha8 C A 4: 136,658,360 (GRCm39) *1005L probably null Het
Etl4 T C 2: 20,811,493 (GRCm39) V1509A probably benign Het
Gucy1b1 T C 3: 81,953,833 (GRCm39) E161G possibly damaging Het
Hepacam T A 9: 37,291,912 (GRCm39) V80E probably damaging Het
Ireb2 A G 9: 54,772,641 (GRCm39) K24E probably benign Het
Itch T A 2: 155,014,467 (GRCm39) D101E possibly damaging Het
Itch T A 2: 155,014,406 (GRCm39) F81Y possibly damaging Het
Klf7 C A 1: 64,117,933 (GRCm39) Q221H probably benign Het
Kptn A G 7: 15,857,897 (GRCm39) T242A probably benign Het
Macf1 A G 4: 123,334,485 (GRCm39) F4420S probably benign Het
Mthfd2 A G 6: 83,288,792 (GRCm39) probably null Het
Mtrf1l A C 10: 5,764,112 (GRCm39) L284V probably null Het
Neb C T 2: 52,060,561 (GRCm39) V2259I probably benign Het
Or4c111 A T 2: 88,843,814 (GRCm39) V198E possibly damaging Het
Or9i14 A T 19: 13,792,180 (GRCm39) M258K possibly damaging Het
Padi1 A T 4: 140,556,746 (GRCm39) C154S probably damaging Het
Paxip1 T C 5: 27,956,036 (GRCm39) T903A probably benign Het
Phactr2 T A 10: 13,129,181 (GRCm39) L292F probably benign Het
Pkhd1l1 G A 15: 44,362,796 (GRCm39) probably benign Het
Pnpla7 T C 2: 24,940,985 (GRCm39) probably null Het
Rif1 T A 2: 52,002,555 (GRCm39) I2003K probably benign Het
Rxfp3 A T 15: 11,037,132 (GRCm39) V80E probably damaging Het
Sart3 T A 5: 113,883,709 (GRCm39) K768* probably null Het
Slc35f5 C T 1: 125,517,612 (GRCm39) T470I probably damaging Het
Smg8 A T 11: 86,971,102 (GRCm39) Y890N probably damaging Het
Spata31 T C 13: 65,068,968 (GRCm39) V372A possibly damaging Het
Tbc1d30 A T 10: 121,103,084 (GRCm39) D649E probably benign Het
Tctn3 G A 19: 40,600,581 (GRCm39) T3I probably damaging Het
Tns3 G A 11: 8,387,177 (GRCm39) P1337S possibly damaging Het
Vmn2r15 T A 5: 109,434,135 (GRCm39) *856C probably null Het
Vmn2r61 A T 7: 41,909,639 (GRCm39) I55F probably benign Het
Zbtb41 C T 1: 139,375,065 (GRCm39) P842S probably benign Het
Zc3h13 A G 14: 75,581,209 (GRCm39) probably benign Het
Other mutations in Kctd16
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00501:Kctd16 APN 18 40,390,440 (GRCm39) unclassified probably benign
IGL00954:Kctd16 APN 18 40,391,853 (GRCm39) missense probably benign 0.01
IGL02001:Kctd16 APN 18 40,391,733 (GRCm39) missense possibly damaging 0.48
IGL02173:Kctd16 APN 18 40,663,906 (GRCm39) missense probably benign 0.01
IGL02890:Kctd16 APN 18 40,390,080 (GRCm39) unclassified probably benign
IGL03112:Kctd16 APN 18 40,391,853 (GRCm39) missense probably benign 0.08
R0109:Kctd16 UTSW 18 40,392,204 (GRCm39) missense probably benign 0.06
R0109:Kctd16 UTSW 18 40,392,204 (GRCm39) missense probably benign 0.06
R0267:Kctd16 UTSW 18 40,663,930 (GRCm39) missense probably benign 0.02
R0554:Kctd16 UTSW 18 40,391,492 (GRCm39) missense probably benign
R0732:Kctd16 UTSW 18 40,391,616 (GRCm39) missense probably damaging 1.00
R0883:Kctd16 UTSW 18 40,663,828 (GRCm39) missense probably damaging 0.98
R2140:Kctd16 UTSW 18 40,392,231 (GRCm39) missense possibly damaging 0.89
R2141:Kctd16 UTSW 18 40,392,231 (GRCm39) missense possibly damaging 0.89
R2142:Kctd16 UTSW 18 40,392,231 (GRCm39) missense possibly damaging 0.89
R2160:Kctd16 UTSW 18 40,392,138 (GRCm39) missense probably damaging 1.00
R3723:Kctd16 UTSW 18 40,391,912 (GRCm39) missense possibly damaging 0.79
R3724:Kctd16 UTSW 18 40,391,912 (GRCm39) missense possibly damaging 0.79
R4712:Kctd16 UTSW 18 40,390,233 (GRCm39) unclassified probably benign
R5483:Kctd16 UTSW 18 40,663,929 (GRCm39) missense probably benign
R5538:Kctd16 UTSW 18 40,390,319 (GRCm39) nonsense probably null
R5589:Kctd16 UTSW 18 40,392,061 (GRCm39) missense probably damaging 1.00
R5767:Kctd16 UTSW 18 40,391,922 (GRCm39) missense probably benign 0.13
R5811:Kctd16 UTSW 18 40,391,505 (GRCm39) missense probably damaging 1.00
R5875:Kctd16 UTSW 18 40,390,447 (GRCm39) unclassified probably benign
R5911:Kctd16 UTSW 18 40,663,905 (GRCm39) missense probably benign 0.11
R5930:Kctd16 UTSW 18 40,663,882 (GRCm39) missense probably benign 0.10
R6017:Kctd16 UTSW 18 40,391,996 (GRCm39) missense probably damaging 1.00
R6603:Kctd16 UTSW 18 40,391,544 (GRCm39) missense probably benign
R6984:Kctd16 UTSW 18 40,390,101 (GRCm39) unclassified probably benign
R7404:Kctd16 UTSW 18 40,391,826 (GRCm39) missense probably damaging 1.00
R7597:Kctd16 UTSW 18 40,663,848 (GRCm39) missense possibly damaging 0.70
R9079:Kctd16 UTSW 18 40,390,080 (GRCm39) unclassified probably benign
R9133:Kctd16 UTSW 18 40,392,069 (GRCm39) missense probably damaging 1.00
R9283:Kctd16 UTSW 18 40,392,233 (GRCm39) missense possibly damaging 0.54
Posted On 2014-05-07