Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01845:Or10q3'

178206

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or10q3

Ensembl Gene

ENSMUSG00000067545

Gene Name

olfactory receptor family 10 subfamily Q member 3

Synonyms

GA_x6K02T2RE5P-2222521-2221490, Olfr1419, MOR266-10

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.055) question?

Stock #

IGL01845

Quality Score

Status

Chromosome

Chromosomal Location

11847510-11848669 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 11847888 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 231 (S231P)

Ref Sequence

ENSEMBL: ENSMUSP00000148848 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000087857] [ENSMUST00000213954] [ENSMUST00000217617]

AlphaFold

Q7TQS2

Predicted Effect

probably benign
Transcript: ENSMUST00000087857
AA Change: S231P

PolyPhen 2 Score 0.052 (Sensitivity: 0.94; Specificity: 0.83)

SMART Domains

Protein: ENSMUSP00000085163
Gene: ENSMUSG00000067545
AA Change: S231P

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	309	3.8e-55	PFAM
Pfam:7tm_1	41	291	2.8e-22	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000213954
AA Change: S231P

PolyPhen 2 Score 0.052 (Sensitivity: 0.94; Specificity: 0.83)

Predicted Effect

probably benign
Transcript: ENSMUST00000217617
AA Change: S231P

PolyPhen 2 Score 0.052 (Sensitivity: 0.94; Specificity: 0.83)

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 57 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1600012H06Rik	T	C	17: 15,164,380 (GRCm39)	L169P	probably damaging	Het
4933405L10Rik	C	A	8: 106,435,567 (GRCm39)	A75E	probably benign	Het
Abca1	A	G	4: 53,090,297 (GRCm39)	L384P	probably damaging	Het
Acox2	C	A	14: 8,251,617 (GRCm38)	M293I	probably damaging	Het
Acp6	A	G	3: 97,081,123 (GRCm39)	S288G	probably benign	Het
Arhgef12	T	A	9: 42,934,137 (GRCm39)	H127L	possibly damaging	Het
Arid2	T	G	15: 96,254,678 (GRCm39)	F175V	probably damaging	Het
Ccdc15	G	A	9: 37,226,532 (GRCm39)	Q468*	probably null	Het
Ccdc93	T	C	1: 121,390,859 (GRCm39)	I277T	probably damaging	Het
Cdh8	T	C	8: 99,825,586 (GRCm39)		probably benign	Het
Cdipt	T	C	7: 126,578,725 (GRCm39)	S145P	possibly damaging	Het
Cfap206	T	C	4: 34,719,610 (GRCm39)	N268S	possibly damaging	Het
Clcn3	A	T	8: 61,366,129 (GRCm39)	N814K	probably benign	Het
Col6a3	T	C	1: 90,724,293 (GRCm39)	D2019G	probably damaging	Het
Corin	C	A	5: 72,511,282 (GRCm39)	G432C	probably damaging	Het
Crppa	A	G	12: 36,597,918 (GRCm39)	R350G	probably benign	Het
Cyld	C	T	8: 89,432,403 (GRCm39)	Q134*	probably null	Het
Dhh	C	A	15: 98,795,864 (GRCm39)	R97L	probably damaging	Het
Dnah5	T	C	15: 28,449,315 (GRCm39)	V4239A	probably benign	Het
Dock2	T	C	11: 34,599,692 (GRCm39)	I296V	probably benign	Het
Gabbr1	T	C	17: 37,359,306 (GRCm39)		probably benign	Het
Gbp10	T	C	5: 105,367,815 (GRCm39)		probably null	Het
Itgam	T	A	7: 127,711,644 (GRCm39)	L753Q	probably damaging	Het
Kbtbd12	A	G	6: 88,590,922 (GRCm39)	V430A	probably benign	Het
Kdm4a	A	G	4: 118,017,656 (GRCm39)	V470A	possibly damaging	Het
Larp1b	A	T	3: 40,924,960 (GRCm39)	T146S	probably benign	Het
Lrrfip2	T	A	9: 111,028,728 (GRCm39)		probably benign	Het
Mier2	A	T	10: 79,385,418 (GRCm39)	C137S	possibly damaging	Het
Morc3	A	G	16: 93,657,455 (GRCm39)	Y393C	probably damaging	Het
Ms4a7	A	T	19: 11,299,751 (GRCm39)	M217K	possibly damaging	Het
Msl1	A	G	11: 98,696,191 (GRCm39)		probably null	Het
Myh2	A	G	11: 67,083,860 (GRCm39)	E1546G	probably benign	Het
Nlgn2	A	G	11: 69,716,675 (GRCm39)	L622P	possibly damaging	Het
Oga	T	A	19: 45,756,301 (GRCm39)	E447D	probably benign	Het
Or1e33	A	G	11: 73,738,298 (GRCm39)	Y218H	probably damaging	Het
Or1j11	A	C	2: 36,312,105 (GRCm39)	K232Q	probably benign	Het
Or56b1b	T	A	7: 108,164,343 (GRCm39)	I220L	possibly damaging	Het
Or5k17	T	C	16: 58,746,929 (GRCm39)	M2V	probably benign	Het
Phf20	C	A	2: 156,118,577 (GRCm39)	S427*	probably null	Het
Pirt	G	A	11: 66,816,794 (GRCm39)	S35N	probably damaging	Het
Prss28	C	A	17: 25,529,011 (GRCm39)	N117K	possibly damaging	Het
Rbbp8nl	A	G	2: 179,925,104 (GRCm39)	C34R	probably damaging	Het
Rtn3	A	T	19: 7,435,241 (GRCm39)	D231E	probably damaging	Het
Sema5a	T	C	15: 32,474,514 (GRCm39)		probably benign	Het
Sh3bp2	T	A	5: 34,713,347 (GRCm39)	L196Q	probably damaging	Het
Slc26a9	G	T	1: 131,685,256 (GRCm39)	D325Y	probably damaging	Het
Slc4a1	A	G	11: 102,244,729 (GRCm39)	V622A	probably benign	Het
Thbd	A	G	2: 148,249,016 (GRCm39)	V284A	probably benign	Het
Tmc5	T	C	7: 118,251,733 (GRCm39)	F609L	possibly damaging	Het
Tnr	T	C	1: 159,695,576 (GRCm39)		probably benign	Het
Ttc17	A	T	2: 94,163,177 (GRCm39)	Y881*	probably null	Het
Ttc41	A	T	10: 86,612,488 (GRCm39)	T1254S	probably benign	Het
Ttn	C	T	2: 76,640,347 (GRCm39)	D13754N	probably damaging	Het
Vmn2r16	T	A	5: 109,511,762 (GRCm39)	F656L	probably damaging	Het
Wdr19	A	G	5: 65,382,709 (GRCm39)	I478V	probably damaging	Het
Zan	T	C	5: 137,379,116 (GRCm39)		probably benign	Het
Zp2	T	A	7: 119,737,414 (GRCm39)	D258V	probably damaging	Het

Other mutations in Or10q3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01979:Or10q3	APN	19	11,848,587 (GRCm39)	splice site	probably benign
IGL02961:Or10q3	APN	19	11,847,695 (GRCm39)	missense	probably damaging	1.00
R0285:Or10q3	UTSW	19	11,848,502 (GRCm39)	missense	probably damaging	0.97
R0347:Or10q3	UTSW	19	11,847,797 (GRCm39)	missense	probably damaging	1.00
R1577:Or10q3	UTSW	19	11,847,741 (GRCm39)	missense	probably damaging	1.00
R2391:Or10q3	UTSW	19	11,848,180 (GRCm39)	nonsense	probably null
R3977:Or10q3	UTSW	19	11,847,869 (GRCm39)	missense	possibly damaging	0.82
R4660:Or10q3	UTSW	19	11,848,412 (GRCm39)	missense	possibly damaging	0.64
R5201:Or10q3	UTSW	19	11,847,995 (GRCm39)	missense	probably benign	0.21
R5995:Or10q3	UTSW	19	11,848,226 (GRCm39)	missense	possibly damaging	0.89
R6393:Or10q3	UTSW	19	11,848,091 (GRCm39)	missense	probably damaging	1.00
R7466:Or10q3	UTSW	19	11,847,680 (GRCm39)	missense	possibly damaging	0.94
R7828:Or10q3	UTSW	19	11,848,169 (GRCm39)	missense	probably damaging	1.00
R8400:Or10q3	UTSW	19	11,848,578 (GRCm39)	start codon destroyed	probably damaging	0.96
R9644:Or10q3	UTSW	19	11,848,574 (GRCm39)	missense	probably benign	0.01

Posted On

2014-05-07