Incidental Mutation 'IGL01860:Tram2'
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tram2
Ensembl Gene ENSMUSG00000041779
Gene Nametranslocating chain-associating membrane protein 2
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL01860
Quality Score
Chromosomal Location20996299-21079229 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 21003859 bp
Amino Acid Change Asparagine to Serine at position 285 (N285S)
Ref Sequence ENSEMBL: ENSMUSP00000047992 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000037998]
Predicted Effect possibly damaging
Transcript: ENSMUST00000037998
AA Change: N285S

PolyPhen 2 Score 0.899 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000047992
Gene: ENSMUSG00000041779
AA Change: N285S

Pfam:TRAM1 46 110 1.3e-22 PFAM
TLC 112 321 4.2e-60 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000187210
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] TRAM2 is a component of the translocon, a gated macromolecular channel that controls the posttranslational processing of nascent secretory and membrane proteins at the endoplasmic reticulum (ER) membrane.[supplied by OMIM, Jul 2004]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700034J05Rik T A 6: 146,952,416 N248Y possibly damaging Het
Adamts13 G A 2: 26,978,011 V128M probably damaging Het
Agl A T 3: 116,772,526 probably benign Het
Arfgef1 A T 1: 10,154,396 M1405K probably damaging Het
Atp6v1a G T 16: 44,099,956 L426M probably damaging Het
Cdc123 A G 2: 5,803,941 probably benign Het
Cept1 A G 3: 106,531,128 probably benign Het
Cipc T A 12: 86,960,273 D60E probably damaging Het
Exosc3 A G 4: 45,319,659 I121T probably benign Het
Fam155a A T 8: 9,207,831 V439E probably damaging Het
Fam26f A G 10: 34,126,565 V174A probably damaging Het
Fbln5 A G 12: 101,809,869 Y89H probably damaging Het
Fhod3 T C 18: 24,897,681 F128L probably damaging Het
Fhod3 T A 18: 24,903,948 I154N probably damaging Het
Fpgt T C 3: 155,086,846 T515A probably benign Het
Gas2l2 G A 11: 83,422,080 T802I probably benign Het
Gm10424 G A 5: 95,270,651 T162I probably benign Het
Gm10710 T A 3: 83,127,849 probably benign Het
Gm11639 T C 11: 104,690,921 S30P probably benign Het
Hdac4 A G 1: 91,933,695 M1051T probably benign Het
Heatr5b A G 17: 78,808,480 V849A probably damaging Het
Helb T C 10: 120,102,833 I579V probably damaging Het
Hspa1l A G 17: 34,978,811 I609V probably benign Het
Itgam C A 7: 128,070,943 Q136K probably benign Het
Kcnc1 T C 7: 46,428,130 L452P probably damaging Het
Ltbp4 T A 7: 27,319,646 T1083S probably damaging Het
Mki67 T C 7: 135,698,957 I1449M probably damaging Het
Mpp5 T C 12: 78,830,907 V531A possibly damaging Het
P2rx5 T A 11: 73,165,559 V103E probably damaging Het
Pappa A G 4: 65,205,092 D888G possibly damaging Het
Pcdhb21 G T 18: 37,514,905 M362I probably benign Het
Pde1a A G 2: 79,875,284 S333P probably damaging Het
Ppm1j A G 3: 104,784,092 T299A probably damaging Het
Ptdss2 A G 7: 141,152,836 E168G probably damaging Het
Rspry1 A G 8: 94,649,816 N322S probably benign Het
Slc7a9 T A 7: 35,457,060 V309E probably damaging Het
Slco6c1 A G 1: 97,075,823 probably benign Het
Tas2r120 T A 6: 132,657,264 M103K probably damaging Het
Tbxas1 T A 6: 38,948,627 F59I probably damaging Het
Tfpi A G 2: 84,444,034 S203P probably benign Het
Trio T A 15: 27,846,810 D980V probably damaging Het
Trpv5 T A 6: 41,660,295 H419L probably damaging Het
Usp28 C T 9: 49,032,243 R361* probably null Het
Vmn1r6 T A 6: 57,002,689 L112* probably null Het
Vmn2r12 A T 5: 109,092,159 N179K probably benign Het
Vmn2r82 G T 10: 79,378,857 A225S probably benign Het
Zcchc4 A G 5: 52,808,356 Y334C probably damaging Het
Zfp609 T C 9: 65,702,834 E949G possibly damaging Het
Other mutations in Tram2
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0057:Tram2 UTSW 1 21006154 missense probably damaging 0.98
R0299:Tram2 UTSW 1 21004244 missense probably damaging 0.99
R1633:Tram2 UTSW 1 21003922 missense probably damaging 0.99
R1703:Tram2 UTSW 1 21004234 missense probably damaging 0.96
R2032:Tram2 UTSW 1 21003956 missense probably null 0.98
R3690:Tram2 UTSW 1 21005600 missense probably damaging 1.00
R3859:Tram2 UTSW 1 21003980 missense probably damaging 1.00
R4583:Tram2 UTSW 1 21013449 missense probably benign 0.01
R6022:Tram2 UTSW 1 21079137 start gained probably benign
R6432:Tram2 UTSW 1 21004233 missense possibly damaging 0.63
R8209:Tram2 UTSW 1 21005577 missense probably damaging 1.00
X0058:Tram2 UTSW 1 21079103 missense probably damaging 1.00
Posted On2014-05-07