Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01861:Tex15'

178340

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tex15

Ensembl Gene

ENSMUSG00000009628

Gene Name

testis expressed gene 15

Synonyms

2210014E14Rik

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.291) question?

Stock #

IGL01861

Quality Score

Status

Chromosome

Chromosomal Location

34006766-34075610 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 34060717 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Serine at position 49 (N49S)

Ref Sequence

ENSEMBL: ENSMUSP00000009772 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000009772] [ENSMUST00000124496] [ENSMUST00000124501]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000009772
AA Change: N49S

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000009772
Gene: ENSMUSG00000009628
AA Change: N49S

Domain	Start	End	E-Value	Type
low complexity region	262	274	N/A	INTRINSIC
low complexity region	302	313	N/A	INTRINSIC
low complexity region	524	536	N/A	INTRINSIC
low complexity region	665	674	N/A	INTRINSIC
low complexity region	713	725	N/A	INTRINSIC
low complexity region	946	961	N/A	INTRINSIC
low complexity region	1497	1508	N/A	INTRINSIC
Pfam:TEX15	1572	1788	1.3e-109	PFAM
Pfam:TEX15	1901	2119	1.1e-16	PFAM
low complexity region	2758	2770	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000124496
AA Change: N323S

PolyPhen 2 Score 0.039 (Sensitivity: 0.94; Specificity: 0.83)

SMART Domains

Protein: ENSMUSP00000120744
Gene: ENSMUSG00000009628
AA Change: N323S

Domain	Start	End	E-Value	Type
Pfam:DUF3715	89	251	1.6e-58	PFAM
low complexity region	536	548	N/A	INTRINSIC
low complexity region	576	587	N/A	INTRINSIC
low complexity region	798	810	N/A	INTRINSIC
low complexity region	939	948	N/A	INTRINSIC
low complexity region	987	999	N/A	INTRINSIC
low complexity region	1220	1235	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000124501

SMART Domains

Protein: ENSMUSP00000138070
Gene: ENSMUSG00000009628

Domain	Start	End	E-Value	Type
Pfam:DUF3715	96	251	2.4e-52	PFAM

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Male mice are infertile due to arrest of meiosis stemming from failure to repair double-strand breaks. However, female mice are fertile. [provided by MGI curators]

Allele List at MGI

All alleles(4) : Targeted(3) Gene trapped(1)

Other mutations in this stock

Total: 32 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Arrdc5	T	C	17: 56,607,144 (GRCm39)	T34A	possibly damaging	Het
Atm	C	A	9: 53,405,912 (GRCm39)	R1252L	probably null	Het
Cd34	T	C	1: 194,640,888 (GRCm39)		probably benign	Het
Cmya5	A	G	13: 93,226,256 (GRCm39)	V2944A	probably damaging	Het
Cntnap3	C	T	13: 64,946,922 (GRCm39)	G169D	probably damaging	Het
Dnah7a	T	A	1: 53,679,508 (GRCm39)	T326S	probably benign	Het
Dnah7a	C	T	1: 53,623,608 (GRCm39)		probably benign	Het
Fam133b	A	G	5: 3,614,242 (GRCm39)		probably benign	Het
Fhod1	A	G	8: 106,057,808 (GRCm39)	S906P	probably damaging	Het
Gli3	A	G	13: 15,899,910 (GRCm39)	Y1099C	probably damaging	Het
Gpr63	C	T	4: 25,008,545 (GRCm39)	T423M	probably damaging	Het
Hpx	A	T	7: 105,241,393 (GRCm39)	Y339*	probably null	Het
Lingo2	A	T	4: 35,709,526 (GRCm39)	D151E	probably benign	Het
Mill2	A	T	7: 18,590,565 (GRCm39)	Q215L	probably damaging	Het
Naf1	T	C	8: 67,317,185 (GRCm39)		probably benign	Het
Ndufv1	A	G	19: 4,058,803 (GRCm39)	V235A	probably benign	Het
Or8b41	T	C	9: 38,055,046 (GRCm39)	I205T	probably damaging	Het
Pafah1b1	A	T	11: 74,581,403 (GRCm39)	N22K	possibly damaging	Het
Prune1	G	T	3: 95,172,868 (GRCm39)	R66S	probably damaging	Het
Ptcd1	A	T	5: 145,095,587 (GRCm39)	I291N	possibly damaging	Het
Ptprk	A	G	10: 28,259,441 (GRCm39)	I294V	possibly damaging	Het
Rfx6	G	A	10: 51,597,675 (GRCm39)	V471M	probably damaging	Het
Rnase6	C	A	14: 51,367,748 (GRCm39)	Q47K	probably benign	Het
Skint5	T	C	4: 113,417,021 (GRCm39)		probably benign	Het
Srcap	T	A	7: 127,124,457 (GRCm39)		probably benign	Het
Stap1	A	G	5: 86,244,383 (GRCm39)	I217V	possibly damaging	Het
Taf1d	T	C	9: 15,220,035 (GRCm39)		probably null	Het
Tecta	T	C	9: 42,284,658 (GRCm39)	H809R	probably benign	Het
Tubb4b-ps1	A	G	5: 7,229,374 (GRCm39)		probably benign	Het
Uhrf2	A	G	19: 30,063,804 (GRCm39)	Y589C	probably damaging	Het
Zfp616	A	T	11: 73,973,742 (GRCm39)	T4S	possibly damaging	Het
Zfp687	A	T	3: 94,919,171 (GRCm39)	F200L	probably damaging	Het

Other mutations in Tex15

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00639:Tex15	APN	8	34,065,339 (GRCm39)	missense	probably benign	0.18
IGL00705:Tex15	APN	8	34,071,620 (GRCm39)	missense	probably damaging	1.00
IGL00820:Tex15	APN	8	34,069,034 (GRCm39)	splice site	probably benign
IGL01288:Tex15	APN	8	34,061,412 (GRCm39)	missense	probably benign	0.02
IGL01328:Tex15	APN	8	34,061,424 (GRCm39)	nonsense	probably null
IGL01359:Tex15	APN	8	34,071,926 (GRCm39)	missense	probably damaging	0.99
IGL01603:Tex15	APN	8	34,063,575 (GRCm39)	missense	possibly damaging	0.93
IGL02052:Tex15	APN	8	34,072,493 (GRCm39)	missense	probably benign	0.28
IGL02560:Tex15	APN	8	34,071,779 (GRCm39)	missense	probably benign	0.00
IGL02677:Tex15	APN	8	34,061,108 (GRCm39)	missense	probably benign	0.03
IGL02739:Tex15	APN	8	34,071,721 (GRCm39)	missense	possibly damaging	0.68
Big_gulp	UTSW	8	34,071,762 (GRCm39)	missense	probably damaging	1.00
P0005:Tex15	UTSW	8	34,060,896 (GRCm39)	missense	probably benign	0.00
P0037:Tex15	UTSW	8	34,071,608 (GRCm39)	missense	probably benign	0.00
PIT4377001:Tex15	UTSW	8	34,061,129 (GRCm39)	missense	probably damaging	1.00
R0056:Tex15	UTSW	8	34,072,055 (GRCm39)	missense	probably benign	0.00
R0056:Tex15	UTSW	8	34,072,055 (GRCm39)	missense	probably benign	0.00
R0058:Tex15	UTSW	8	34,071,530 (GRCm39)	splice site	probably benign
R0058:Tex15	UTSW	8	34,071,530 (GRCm39)	splice site	probably benign
R0595:Tex15	UTSW	8	34,062,645 (GRCm39)	missense	probably damaging	1.00
R0646:Tex15	UTSW	8	34,072,354 (GRCm39)	missense	possibly damaging	0.83
R0688:Tex15	UTSW	8	34,063,528 (GRCm39)	missense	probably damaging	1.00
R0842:Tex15	UTSW	8	34,061,575 (GRCm39)	missense	possibly damaging	0.95
R0987:Tex15	UTSW	8	34,066,875 (GRCm39)	missense	probably damaging	1.00
R1084:Tex15	UTSW	8	34,067,032 (GRCm39)	missense	probably benign	0.28
R1183:Tex15	UTSW	8	34,064,893 (GRCm39)	missense	probably benign	0.35
R1186:Tex15	UTSW	8	34,061,661 (GRCm39)	missense	probably benign	0.19
R1378:Tex15	UTSW	8	34,065,244 (GRCm39)	missense	probably damaging	0.99
R1500:Tex15	UTSW	8	34,065,120 (GRCm39)	missense	probably damaging	0.96
R1508:Tex15	UTSW	8	34,066,880 (GRCm39)	missense	probably damaging	1.00
R1597:Tex15	UTSW	8	34,061,511 (GRCm39)	missense	probably damaging	0.96
R1636:Tex15	UTSW	8	34,066,415 (GRCm39)	nonsense	probably null
R1639:Tex15	UTSW	8	34,060,845 (GRCm39)	missense	possibly damaging	0.94
R1809:Tex15	UTSW	8	34,064,262 (GRCm39)	missense	probably benign
R1843:Tex15	UTSW	8	34,066,682 (GRCm39)	missense	probably benign	0.27
R2029:Tex15	UTSW	8	34,061,302 (GRCm39)	missense	probably damaging	0.99
R2228:Tex15	UTSW	8	34,061,265 (GRCm39)	missense	probably benign	0.05
R2229:Tex15	UTSW	8	34,061,265 (GRCm39)	missense	probably benign	0.05
R2245:Tex15	UTSW	8	34,061,524 (GRCm39)	missense	possibly damaging	0.77
R2246:Tex15	UTSW	8	34,072,540 (GRCm39)	missense	possibly damaging	0.49
R2880:Tex15	UTSW	8	34,064,935 (GRCm39)	nonsense	probably null
R2881:Tex15	UTSW	8	34,064,935 (GRCm39)	nonsense	probably null
R2882:Tex15	UTSW	8	34,064,935 (GRCm39)	nonsense	probably null
R3001:Tex15	UTSW	8	34,064,556 (GRCm39)	missense	probably benign	0.15
R3002:Tex15	UTSW	8	34,064,556 (GRCm39)	missense	probably benign	0.15
R3020:Tex15	UTSW	8	34,066,698 (GRCm39)	missense	probably damaging	1.00
R3084:Tex15	UTSW	8	34,064,913 (GRCm39)	missense	probably benign	0.11
R3085:Tex15	UTSW	8	34,064,913 (GRCm39)	missense	probably benign	0.11
R3701:Tex15	UTSW	8	34,064,194 (GRCm39)	missense	probably benign	0.00
R3702:Tex15	UTSW	8	34,064,194 (GRCm39)	missense	probably benign	0.00
R3752:Tex15	UTSW	8	34,061,443 (GRCm39)	missense	probably benign
R4162:Tex15	UTSW	8	34,071,586 (GRCm39)	missense	probably damaging	1.00
R4231:Tex15	UTSW	8	34,062,165 (GRCm39)	missense	probably damaging	0.99
R4589:Tex15	UTSW	8	34,047,401 (GRCm39)	missense	probably damaging	1.00
R4707:Tex15	UTSW	8	34,072,525 (GRCm39)	missense	probably benign	0.00
R4773:Tex15	UTSW	8	34,072,760 (GRCm39)	missense	probably benign	0.42
R4967:Tex15	UTSW	8	34,064,498 (GRCm39)	missense	probably benign	0.34
R5063:Tex15	UTSW	8	34,072,638 (GRCm39)	missense	possibly damaging	0.59
R5121:Tex15	UTSW	8	34,061,794 (GRCm39)	missense	probably damaging	1.00
R5147:Tex15	UTSW	8	34,062,340 (GRCm39)	nonsense	probably null
R5166:Tex15	UTSW	8	34,066,420 (GRCm39)	missense	probably benign	0.07
R5173:Tex15	UTSW	8	34,061,768 (GRCm39)	missense	possibly damaging	0.73
R5439:Tex15	UTSW	8	34,064,199 (GRCm39)	missense	possibly damaging	0.93
R5537:Tex15	UTSW	8	34,061,641 (GRCm39)	missense	probably damaging	1.00
R5580:Tex15	UTSW	8	34,062,457 (GRCm39)	missense	probably damaging	1.00
R5588:Tex15	UTSW	8	34,067,215 (GRCm39)	missense	probably damaging	1.00
R5696:Tex15	UTSW	8	34,063,220 (GRCm39)	missense	probably benign	0.01
R5734:Tex15	UTSW	8	34,036,364 (GRCm39)	missense	probably benign	0.01
R5756:Tex15	UTSW	8	34,065,861 (GRCm39)	missense	probably benign	0.17
R5823:Tex15	UTSW	8	34,060,962 (GRCm39)	missense	possibly damaging	0.67
R6126:Tex15	UTSW	8	34,063,591 (GRCm39)	missense	probably benign	0.19
R6129:Tex15	UTSW	8	34,064,158 (GRCm39)	missense	possibly damaging	0.90
R6276:Tex15	UTSW	8	34,067,217 (GRCm39)	missense	possibly damaging	0.93
R6374:Tex15	UTSW	8	34,065,940 (GRCm39)	missense	probably damaging	1.00
R6430:Tex15	UTSW	8	34,061,329 (GRCm39)	missense	probably benign	0.01
R6452:Tex15	UTSW	8	34,062,844 (GRCm39)	missense	probably damaging	1.00
R6471:Tex15	UTSW	8	34,071,762 (GRCm39)	missense	probably damaging	1.00
R6700:Tex15	UTSW	8	34,064,917 (GRCm39)	missense	possibly damaging	0.93
R6918:Tex15	UTSW	8	34,063,212 (GRCm39)	missense	probably benign	0.27
R6958:Tex15	UTSW	8	34,060,899 (GRCm39)	missense	probably benign	0.01
R6970:Tex15	UTSW	8	34,047,456 (GRCm39)	missense	probably benign	0.03
R7059:Tex15	UTSW	8	34,064,758 (GRCm39)	missense	possibly damaging	0.57
R7069:Tex15	UTSW	8	34,060,748 (GRCm39)	missense	probably benign
R7072:Tex15	UTSW	8	34,065,459 (GRCm39)	missense	possibly damaging	0.85
R7212:Tex15	UTSW	8	34,063,023 (GRCm39)	missense	probably damaging	1.00
R7212:Tex15	UTSW	8	34,060,854 (GRCm39)	nonsense	probably null
R7216:Tex15	UTSW	8	34,063,014 (GRCm39)	missense	possibly damaging	0.93
R7219:Tex15	UTSW	8	34,036,268 (GRCm39)	missense	probably benign	0.40
R7313:Tex15	UTSW	8	34,064,845 (GRCm39)	missense	possibly damaging	0.82
R7315:Tex15	UTSW	8	34,071,544 (GRCm39)	missense	probably benign	0.01
R7444:Tex15	UTSW	8	34,066,590 (GRCm39)	missense	possibly damaging	0.92
R7455:Tex15	UTSW	8	34,067,025 (GRCm39)	missense	possibly damaging	0.91
R7643:Tex15	UTSW	8	34,065,148 (GRCm39)	missense	probably damaging	1.00
R7644:Tex15	UTSW	8	34,064,445 (GRCm39)	missense	probably benign	0.01
R7724:Tex15	UTSW	8	34,036,291 (GRCm39)	missense	possibly damaging	0.60
R7779:Tex15	UTSW	8	34,065,309 (GRCm39)	missense	probably damaging	1.00
R7798:Tex15	UTSW	8	34,071,875 (GRCm39)	missense	possibly damaging	0.69
R7816:Tex15	UTSW	8	34,071,683 (GRCm39)	missense	probably benign	0.14
R7820:Tex15	UTSW	8	34,065,090 (GRCm39)	missense	probably damaging	0.98
R8041:Tex15	UTSW	8	34,065,874 (GRCm39)	missense	probably damaging	1.00
R8150:Tex15	UTSW	8	34,063,534 (GRCm39)	missense	probably benign	0.06
R8152:Tex15	UTSW	8	34,062,921 (GRCm39)	missense	possibly damaging	0.82
R8237:Tex15	UTSW	8	34,067,427 (GRCm39)	missense	possibly damaging	0.72
R8250:Tex15	UTSW	8	34,055,233 (GRCm39)	missense	probably null	0.27
R8264:Tex15	UTSW	8	34,072,390 (GRCm39)	missense	probably benign	0.18
R8279:Tex15	UTSW	8	34,061,765 (GRCm39)	missense	probably damaging	0.96
R8353:Tex15	UTSW	8	34,066,899 (GRCm39)	nonsense	probably null
R8388:Tex15	UTSW	8	34,065,237 (GRCm39)	missense	probably benign	0.00
R8432:Tex15	UTSW	8	34,066,572 (GRCm39)	missense	probably damaging	0.99
R8453:Tex15	UTSW	8	34,066,899 (GRCm39)	nonsense	probably null
R8489:Tex15	UTSW	8	34,067,574 (GRCm39)	missense	probably benign	0.02
R8670:Tex15	UTSW	8	34,064,746 (GRCm39)	missense	probably benign	0.19
R8703:Tex15	UTSW	8	34,062,724 (GRCm39)	missense	probably benign	0.00
R8871:Tex15	UTSW	8	34,066,992 (GRCm39)	missense	possibly damaging	0.62
R8945:Tex15	UTSW	8	34,064,724 (GRCm39)	missense	probably benign	0.00
R9104:Tex15	UTSW	8	34,060,950 (GRCm39)	missense	possibly damaging	0.86
R9132:Tex15	UTSW	8	34,067,554 (GRCm39)	missense	possibly damaging	0.84
R9207:Tex15	UTSW	8	34,065,784 (GRCm39)	missense	probably damaging	1.00
R9210:Tex15	UTSW	8	34,064,319 (GRCm39)	missense	possibly damaging	0.91
R9330:Tex15	UTSW	8	34,065,143 (GRCm39)	missense	probably benign	0.01
R9354:Tex15	UTSW	8	34,063,344 (GRCm39)	missense	possibly damaging	0.86
R9365:Tex15	UTSW	8	34,064,564 (GRCm39)	missense	possibly damaging	0.56
R9440:Tex15	UTSW	8	34,072,273 (GRCm39)	missense	possibly damaging	0.90
R9534:Tex15	UTSW	8	34,060,999 (GRCm39)	missense	probably benign	0.45
R9570:Tex15	UTSW	8	34,067,309 (GRCm39)	missense	probably damaging	0.96
R9574:Tex15	UTSW	8	34,064,509 (GRCm39)	missense	probably benign	0.09
R9618:Tex15	UTSW	8	34,062,397 (GRCm39)	missense	probably benign	0.35
R9655:Tex15	UTSW	8	34,066,784 (GRCm39)	nonsense	probably null
R9786:Tex15	UTSW	8	34,062,457 (GRCm39)	missense	probably damaging	1.00
R9798:Tex15	UTSW	8	34,062,721 (GRCm39)	missense	probably damaging	0.98
RF005:Tex15	UTSW	8	34,066,705 (GRCm39)	missense	probably benign	0.05
X0020:Tex15	UTSW	8	34,066,607 (GRCm39)	missense	probably benign	0.03
X0065:Tex15	UTSW	8	34,065,545 (GRCm39)	nonsense	probably null
Z1088:Tex15	UTSW	8	34,061,343 (GRCm39)	missense	possibly damaging	0.89
Z1088:Tex15	UTSW	8	34,064,898 (GRCm39)	missense	probably benign
Z1088:Tex15	UTSW	8	34,061,838 (GRCm39)	missense	possibly damaging	0.68
Z1176:Tex15	UTSW	8	34,064,754 (GRCm39)	missense	possibly damaging	0.84

Posted On

2014-05-07