Incidental Mutation 'IGL01862:Or8b9'
ID 178357
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or8b9
Ensembl Gene ENSMUSG00000066749
Gene Name olfactory receptor family 8 subfamily B member 9
Synonyms Olfr877, MOR161-5, GA_x6K02T2PVTD-31540342-31541277
Accession Numbers
Essential gene? Probably non essential (E-score: 0.076) question?
Stock # IGL01862
Quality Score
Status
Chromosome 9
Chromosomal Location 37766116-37767051 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 37766477 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 121 (D121G)
Ref Sequence ENSEMBL: ENSMUSP00000150698 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000086063] [ENSMUST00000213956]
AlphaFold Q8VF62
Predicted Effect probably damaging
Transcript: ENSMUST00000086063
AA Change: D121G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000083230
Gene: ENSMUSG00000066749
AA Change: D121G

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 1.4e-49 PFAM
Pfam:7tm_1 41 291 6.5e-20 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000213956
AA Change: D121G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca8b G T 11: 109,837,997 (GRCm39) S1085* probably null Het
Akap9 T G 5: 4,001,705 (GRCm39) S94A probably damaging Het
Akap9 T A 5: 4,115,856 (GRCm39) N3425K probably damaging Het
Anapc7 T A 5: 122,578,182 (GRCm39) I389N probably benign Het
Aqp7 G A 4: 41,045,321 (GRCm39) R20* probably null Het
Cacna1h C T 17: 25,602,457 (GRCm39) G1524R probably damaging Het
Cacng4 T C 11: 107,685,196 (GRCm39) Y32C probably damaging Het
Cep120 A C 18: 53,847,839 (GRCm39) S673R probably benign Het
Cep162 T C 9: 87,135,986 (GRCm39) E19G possibly damaging Het
Cpxm2 C T 7: 131,661,540 (GRCm39) V416I probably benign Het
Dapk1 A G 13: 60,874,424 (GRCm39) T427A probably benign Het
Ecm1 A T 3: 95,641,586 (GRCm39) D549E probably benign Het
Efemp1 T A 11: 28,871,428 (GRCm39) N342K probably damaging Het
Erc2 T C 14: 27,993,526 (GRCm39) probably benign Het
Fhip2b C T 14: 70,825,130 (GRCm39) R402H probably benign Het
Galnt13 T C 2: 54,747,926 (GRCm39) V269A probably damaging Het
Gm6465 T G 5: 11,899,020 (GRCm39) L171R probably damaging Het
Gpatch1 A G 7: 34,994,703 (GRCm39) V521A probably benign Het
Heatr5b A T 17: 79,103,914 (GRCm39) V1087E possibly damaging Het
Ikzf2 A T 1: 69,578,057 (GRCm39) V484D probably damaging Het
Ints4 T A 7: 97,190,360 (GRCm39) V953E probably damaging Het
Iqce T C 5: 140,685,480 (GRCm39) D15G possibly damaging Het
Kif3a T A 11: 53,461,368 (GRCm39) N4K possibly damaging Het
Lrch4 A T 5: 137,635,271 (GRCm39) I254F probably damaging Het
Ly75 A T 2: 60,129,516 (GRCm39) V1623D probably damaging Het
Mapt T A 11: 104,180,828 (GRCm39) probably benign Het
Mast1 A T 8: 85,639,875 (GRCm39) probably null Het
Mcc G T 18: 44,892,363 (GRCm39) Q84K probably benign Het
Mgat4f G A 1: 134,318,349 (GRCm39) V374I probably benign Het
Mtfr2 G A 10: 20,224,149 (GRCm39) V28M probably benign Het
Myh8 T A 11: 67,180,520 (GRCm39) Y585* probably null Het
Napsa T C 7: 44,231,917 (GRCm39) V202A probably damaging Het
Nsd2 A G 5: 34,001,080 (GRCm39) K199R probably null Het
Ntpcr C T 8: 126,462,837 (GRCm39) A18V probably benign Het
Or2aj4 A T 16: 19,385,426 (GRCm39) M69K probably damaging Het
Or2g25 G T 17: 37,970,368 (GRCm39) N285K probably damaging Het
Or56b35 T A 7: 104,963,439 (GRCm39) I76N probably damaging Het
Or5g9 G T 2: 85,552,472 (GRCm39) C241F probably damaging Het
Os9 A G 10: 126,935,573 (GRCm39) V299A probably benign Het
Pcdhb7 T C 18: 37,476,915 (GRCm39) S684P possibly damaging Het
Phf19 A C 2: 34,787,067 (GRCm39) probably null Het
Pkd1l3 G A 8: 110,357,908 (GRCm39) probably null Het
Pkhd1 A G 1: 20,429,134 (GRCm39) I2422T probably damaging Het
Plxna2 T A 1: 194,326,258 (GRCm39) V64E possibly damaging Het
Psme4 T A 11: 30,762,038 (GRCm39) C459* probably null Het
Ptk6 T C 2: 180,841,433 (GRCm39) S159G probably benign Het
Rhd T C 4: 134,617,650 (GRCm39) I329T possibly damaging Het
Scfd1 A G 12: 51,492,494 (GRCm39) Y601C probably damaging Het
Shroom3 T C 5: 93,110,148 (GRCm39) S1753P probably damaging Het
Slc8a1 A C 17: 81,749,630 (GRCm39) probably null Het
Spg7 T A 8: 123,803,669 (GRCm39) L233Q probably damaging Het
Strip1 C A 3: 107,529,198 (GRCm39) R353L probably damaging Het
Ubr1 T C 2: 120,764,823 (GRCm39) N544D possibly damaging Het
Ubr4 A G 4: 139,204,469 (GRCm39) T4794A possibly damaging Het
Usp24 A G 4: 106,266,095 (GRCm39) probably benign Het
Vmn1r193 A T 13: 22,403,984 (GRCm39) C3S probably benign Het
Yju2b G T 8: 84,987,163 (GRCm39) probably benign Het
Zdhhc5 C T 2: 84,520,836 (GRCm39) R447H probably benign Het
Zfp202 A G 9: 40,123,124 (GRCm39) I629V probably benign Het
Zfp462 T A 4: 55,023,441 (GRCm39) C990S probably damaging Het
Other mutations in Or8b9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02108:Or8b9 APN 9 37,766,234 (GRCm39) missense possibly damaging 0.88
IGL02474:Or8b9 APN 9 37,766,656 (GRCm39) missense probably benign 0.08
R0006:Or8b9 UTSW 9 37,766,516 (GRCm39) missense possibly damaging 0.95
R0893:Or8b9 UTSW 9 37,766,492 (GRCm39) missense probably damaging 1.00
R1051:Or8b9 UTSW 9 37,766,657 (GRCm39) missense probably damaging 0.99
R1432:Or8b9 UTSW 9 37,766,548 (GRCm39) missense possibly damaging 0.79
R1718:Or8b9 UTSW 9 37,766,749 (GRCm39) missense probably benign 0.03
R1864:Or8b9 UTSW 9 37,766,560 (GRCm39) missense probably damaging 1.00
R4120:Or8b9 UTSW 9 37,766,705 (GRCm39) missense possibly damaging 0.66
R4507:Or8b9 UTSW 9 37,766,201 (GRCm39) missense possibly damaging 0.90
R4900:Or8b9 UTSW 9 37,766,608 (GRCm39) missense probably benign
R5406:Or8b9 UTSW 9 37,766,515 (GRCm39) missense probably benign 0.02
R6813:Or8b9 UTSW 9 37,766,810 (GRCm39) missense possibly damaging 0.83
R7061:Or8b9 UTSW 9 37,766,942 (GRCm39) missense possibly damaging 0.88
R7315:Or8b9 UTSW 9 37,766,543 (GRCm39) missense probably benign
R7500:Or8b9 UTSW 9 37,766,314 (GRCm39) missense probably damaging 1.00
R8021:Or8b9 UTSW 9 37,766,592 (GRCm39) missense probably damaging 1.00
R8188:Or8b9 UTSW 9 37,766,407 (GRCm39) missense probably benign 0.01
R9093:Or8b9 UTSW 9 37,766,294 (GRCm39) missense probably damaging 1.00
R9331:Or8b9 UTSW 9 37,766,710 (GRCm39) missense probably benign 0.03
R9373:Or8b9 UTSW 9 37,766,750 (GRCm39) missense probably damaging 0.97
R9696:Or8b9 UTSW 9 37,766,671 (GRCm39) missense probably benign 0.35
Z1088:Or8b9 UTSW 9 37,766,614 (GRCm39) missense probably benign 0.31
Z1177:Or8b9 UTSW 9 37,766,794 (GRCm39) missense possibly damaging 0.72
Posted On 2014-05-07