Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL01863:Slfn9'

178415

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Slfn9

Ensembl Gene

ENSMUSG00000069793

Gene Name

schlafen 9

Synonyms

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.065) question?

Stock #

IGL01863

Quality Score

Status

Chromosome

Chromosomal Location

82978390-82991830 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 82981325 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Arginine to Glycine at position 862 (R862G)

Ref Sequence

ENSEMBL: ENSMUSP00000090515 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000038211] [ENSMUST00000092840] [ENSMUST00000138797]

AlphaFold

B1ARD6

Predicted Effect

probably benign
Transcript: ENSMUST00000038211
AA Change: R862G

PolyPhen 2 Score 0.273 (Sensitivity: 0.91; Specificity: 0.88)

SMART Domains

Protein: ENSMUSP00000044435
Gene: ENSMUSG00000069793
AA Change: R862G

Domain	Start	End	E-Value	Type
low complexity region	28	44	N/A	INTRINSIC
Pfam:AlbA_2	205	343	2.3e-17	PFAM
Pfam:DUF2075	592	766	9.7e-11	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000092840
AA Change: R862G

PolyPhen 2 Score 0.273 (Sensitivity: 0.91; Specificity: 0.88)

SMART Domains

Protein: ENSMUSP00000090515
Gene: ENSMUSG00000069793
AA Change: R862G

Domain	Start	End	E-Value	Type
low complexity region	28	44	N/A	INTRINSIC
Pfam:AAA_4	205	344	1.6e-18	PFAM
Pfam:DUF2075	592	766	1.2e-11	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000138797

SMART Domains

Protein: ENSMUSP00000115273
Gene: ENSMUSG00000069793

Domain	Start	End	E-Value	Type
low complexity region	28	44	N/A	INTRINSIC
Pfam:AAA_4	205	344	3.8e-19	PFAM
Pfam:DUF2075	592	642	1.9e-7	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000183379

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 31 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Afg1l	T	A	10: 42,339,911	I326F	possibly damaging	Het
Aimp1	T	C	3: 132,672,092	T171A	probably benign	Het
Armc4	T	C	18: 7,222,617	T551A	probably damaging	Het
Ash1l	T	A	3: 88,985,506	L1564*	probably null	Het
Atp1a1	G	T	3: 101,591,889	Y131*	probably null	Het
Celsr2	T	C	3: 108,394,022	E2686G	probably benign	Het
Cyp4f18	A	G	8: 71,989,926	V395A	possibly damaging	Het
Ephb2	T	C	4: 136,659,777	Q713R	probably benign	Het
Esf1	A	T	2: 140,120,679	M824K	probably benign	Het
Fam46c	C	T	3: 100,472,664	D259N	probably benign	Het
Fat4	T	C	3: 38,970,619		probably benign	Het
Gem	A	G	4: 11,705,980	I23V	probably benign	Het
Gm10718	A	T	9: 3,025,118	Y194F	probably benign	Het
Gm5862	A	C	5: 26,022,771	W41G	probably benign	Het
Il6st	A	G	13: 112,504,210	E779G	possibly damaging	Het
Lama3	T	A	18: 12,419,936		probably benign	Het
Lipi	A	C	16: 75,550,226	I435R	probably damaging	Het
Lrrc6	A	T	15: 66,396,974		probably benign	Het
Olfr291	T	C	7: 84,856,411	L14P	probably damaging	Het
Omg	C	T	11: 79,502,224	M269I	probably benign	Het
Optn	A	T	2: 5,021,487		probably benign	Het
Pex1	A	G	5: 3,606,066	T298A	probably benign	Het
Rab27b	T	A	18: 69,989,554	R111S	probably damaging	Het
Rhbdf1	T	G	11: 32,213,484	E329D	probably benign	Het
Slc2a13	T	C	15: 91,516,492	I176V	probably benign	Het
Slc30a1	T	A	1: 191,909,084	C281S	probably damaging	Het
Slc4a7	T	A	14: 14,762,430	C509S	probably damaging	Het
Tbc1d2	A	G	4: 46,607,064	I782T	possibly damaging	Het
Vmn2r-ps159	C	T	4: 156,338,254		noncoding transcript	Het
Vps33b	T	C	7: 80,274,311		probably null	Het
Wrap73	A	G	4: 154,145,333	I54V	probably benign	Het

Other mutations in Slfn9

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00900:Slfn9	APN	11	82981371	nonsense	probably null
IGL01340:Slfn9	APN	11	82981751	missense	probably benign	0.29
IGL01543:Slfn9	APN	11	82987949	missense	probably benign
IGL01735:Slfn9	APN	11	82982332	missense	probably damaging	1.00
IGL01778:Slfn9	APN	11	82987374	missense	probably damaging	0.98
IGL01997:Slfn9	APN	11	82987677	missense	possibly damaging	0.80
IGL02380:Slfn9	APN	11	82981220	missense	probably benign	0.23
IGL02993:Slfn9	APN	11	82981196	missense	probably benign	0.18
R1463:Slfn9	UTSW	11	82981698	missense	possibly damaging	0.78
R1687:Slfn9	UTSW	11	82982157	missense	probably damaging	0.99
R1786:Slfn9	UTSW	11	82981307	missense	probably damaging	0.99
R1796:Slfn9	UTSW	11	82981955	missense	probably benign	0.00
R1870:Slfn9	UTSW	11	82981576	missense	probably benign
R1871:Slfn9	UTSW	11	82981576	missense	probably benign
R2004:Slfn9	UTSW	11	82988201	missense	probably benign	0.25
R2024:Slfn9	UTSW	11	82981681	missense	probably damaging	1.00
R2106:Slfn9	UTSW	11	82987680	missense	possibly damaging	0.89
R2140:Slfn9	UTSW	11	82984655	missense	possibly damaging	0.76
R3004:Slfn9	UTSW	11	82981764	missense	possibly damaging	0.94
R4293:Slfn9	UTSW	11	82982508	missense	probably benign	0.01
R4927:Slfn9	UTSW	11	82981390	missense	possibly damaging	0.47
R4950:Slfn9	UTSW	11	82981904	missense	probably benign
R5471:Slfn9	UTSW	11	82982787	missense	possibly damaging	0.85
R5543:Slfn9	UTSW	11	82982381	missense	probably damaging	1.00
R5576:Slfn9	UTSW	11	82981432	missense	probably benign
R5996:Slfn9	UTSW	11	82987484	missense	possibly damaging	0.67
R7272:Slfn9	UTSW	11	82981561	missense	probably benign	0.36
R7421:Slfn9	UTSW	11	82981371	nonsense	probably null
R7421:Slfn9	UTSW	11	82987736	missense	probably damaging	0.96
R7498:Slfn9	UTSW	11	82982187	missense	probably damaging	0.98
R7788:Slfn9	UTSW	11	82982641	missense	possibly damaging	0.85
R8286:Slfn9	UTSW	11	82981269	missense	probably damaging	0.99
R8304:Slfn9	UTSW	11	82982779	missense	probably benign	0.14
R8388:Slfn9	UTSW	11	82987286	missense	probably benign
R8678:Slfn9	UTSW	11	82981544	missense	probably benign	0.33
R8730:Slfn9	UTSW	11	82987368	missense	possibly damaging	0.80
R8914:Slfn9	UTSW	11	82981306	missense	probably damaging	0.99
R9050:Slfn9	UTSW	11	82988294	missense	probably benign	0.00
R9424:Slfn9	UTSW	11	82987385	missense	possibly damaging	0.75
Z1176:Slfn9	UTSW	11	82982435	missense	probably benign	0.01

Posted On

2014-05-07