Incidental Mutation 'IGL01863:Slfn9'
ID 178415
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Slfn9
Ensembl Gene ENSMUSG00000069793
Gene Name schlafen 9
Synonyms 9830137M10Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.059) question?
Stock # IGL01863
Quality Score
Status
Chromosome 11
Chromosomal Location 82869216-82882656 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 82872151 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Glycine at position 862 (R862G)
Ref Sequence ENSEMBL: ENSMUSP00000090515 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000038211] [ENSMUST00000092840] [ENSMUST00000138797]
AlphaFold B1ARD6
Predicted Effect probably benign
Transcript: ENSMUST00000038211
AA Change: R862G

PolyPhen 2 Score 0.273 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000044435
Gene: ENSMUSG00000069793
AA Change: R862G

DomainStartEndE-ValueType
low complexity region 28 44 N/A INTRINSIC
Pfam:AlbA_2 205 343 2.3e-17 PFAM
Pfam:DUF2075 592 766 9.7e-11 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000092840
AA Change: R862G

PolyPhen 2 Score 0.273 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000090515
Gene: ENSMUSG00000069793
AA Change: R862G

DomainStartEndE-ValueType
low complexity region 28 44 N/A INTRINSIC
Pfam:AAA_4 205 344 1.6e-18 PFAM
Pfam:DUF2075 592 766 1.2e-11 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000138797
SMART Domains Protein: ENSMUSP00000115273
Gene: ENSMUSG00000069793

DomainStartEndE-ValueType
low complexity region 28 44 N/A INTRINSIC
Pfam:AAA_4 205 344 3.8e-19 PFAM
Pfam:DUF2075 592 642 1.9e-7 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000183379
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Afg1l T A 10: 42,215,907 (GRCm39) I326F possibly damaging Het
Aimp1 T C 3: 132,377,853 (GRCm39) T171A probably benign Het
Ash1l T A 3: 88,892,813 (GRCm39) L1564* probably null Het
Atp1a1 G T 3: 101,499,205 (GRCm39) Y131* probably null Het
Celsr2 T C 3: 108,301,338 (GRCm39) E2686G probably benign Het
Cyp4f18 A G 8: 72,743,770 (GRCm39) V395A possibly damaging Het
Dnaaf11 A T 15: 66,268,823 (GRCm39) probably benign Het
Ephb2 T C 4: 136,387,088 (GRCm39) Q713R probably benign Het
Esf1 A T 2: 139,962,599 (GRCm39) M824K probably benign Het
Fat4 T C 3: 39,024,768 (GRCm39) probably benign Het
Gem A G 4: 11,705,980 (GRCm39) I23V probably benign Het
Gm10718 A T 9: 3,025,118 (GRCm39) Y194F probably benign Het
Gm5862 A C 5: 26,227,769 (GRCm39) W41G probably benign Het
Il6st A G 13: 112,640,744 (GRCm39) E779G possibly damaging Het
Lama3 T A 18: 12,552,993 (GRCm39) probably benign Het
Lipi A C 16: 75,347,114 (GRCm39) I435R probably damaging Het
Odad2 T C 18: 7,222,617 (GRCm39) T551A probably damaging Het
Omg C T 11: 79,393,050 (GRCm39) M269I probably benign Het
Optn A T 2: 5,026,298 (GRCm39) probably benign Het
Or5ae2 T C 7: 84,505,619 (GRCm39) L14P probably damaging Het
Pex1 A G 5: 3,656,066 (GRCm39) T298A probably benign Het
Rab27b T A 18: 70,122,625 (GRCm39) R111S probably damaging Het
Rhbdf1 T G 11: 32,163,484 (GRCm39) E329D probably benign Het
Slc2a13 T C 15: 91,400,695 (GRCm39) I176V probably benign Het
Slc30a1 T A 1: 191,641,196 (GRCm39) C281S probably damaging Het
Slc4a7 T A 14: 14,762,430 (GRCm38) C509S probably damaging Het
Tbc1d2 A G 4: 46,607,064 (GRCm39) I782T possibly damaging Het
Tent5c C T 3: 100,379,980 (GRCm39) D259N probably benign Het
Vmn2r129 C T 4: 156,690,549 (GRCm39) noncoding transcript Het
Vps33b T C 7: 79,924,059 (GRCm39) probably null Het
Wrap73 A G 4: 154,229,790 (GRCm39) I54V probably benign Het
Other mutations in Slfn9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00900:Slfn9 APN 11 82,872,197 (GRCm39) nonsense probably null
IGL01340:Slfn9 APN 11 82,872,577 (GRCm39) missense probably benign 0.29
IGL01543:Slfn9 APN 11 82,878,775 (GRCm39) missense probably benign
IGL01735:Slfn9 APN 11 82,873,158 (GRCm39) missense probably damaging 1.00
IGL01778:Slfn9 APN 11 82,878,200 (GRCm39) missense probably damaging 0.98
IGL01997:Slfn9 APN 11 82,878,503 (GRCm39) missense possibly damaging 0.80
IGL02380:Slfn9 APN 11 82,872,046 (GRCm39) missense probably benign 0.23
IGL02993:Slfn9 APN 11 82,872,022 (GRCm39) missense probably benign 0.18
R1463:Slfn9 UTSW 11 82,872,524 (GRCm39) missense possibly damaging 0.78
R1687:Slfn9 UTSW 11 82,872,983 (GRCm39) missense probably damaging 0.99
R1786:Slfn9 UTSW 11 82,872,133 (GRCm39) missense probably damaging 0.99
R1796:Slfn9 UTSW 11 82,872,781 (GRCm39) missense probably benign 0.00
R1870:Slfn9 UTSW 11 82,872,402 (GRCm39) missense probably benign
R1871:Slfn9 UTSW 11 82,872,402 (GRCm39) missense probably benign
R2004:Slfn9 UTSW 11 82,879,027 (GRCm39) missense probably benign 0.25
R2024:Slfn9 UTSW 11 82,872,507 (GRCm39) missense probably damaging 1.00
R2106:Slfn9 UTSW 11 82,878,506 (GRCm39) missense possibly damaging 0.89
R2140:Slfn9 UTSW 11 82,875,481 (GRCm39) missense possibly damaging 0.76
R3004:Slfn9 UTSW 11 82,872,590 (GRCm39) missense possibly damaging 0.94
R4293:Slfn9 UTSW 11 82,873,334 (GRCm39) missense probably benign 0.01
R4927:Slfn9 UTSW 11 82,872,216 (GRCm39) missense possibly damaging 0.47
R4950:Slfn9 UTSW 11 82,872,730 (GRCm39) missense probably benign
R5471:Slfn9 UTSW 11 82,873,613 (GRCm39) missense possibly damaging 0.85
R5543:Slfn9 UTSW 11 82,873,207 (GRCm39) missense probably damaging 1.00
R5576:Slfn9 UTSW 11 82,872,258 (GRCm39) missense probably benign
R5996:Slfn9 UTSW 11 82,878,310 (GRCm39) missense possibly damaging 0.67
R7272:Slfn9 UTSW 11 82,872,387 (GRCm39) missense probably benign 0.36
R7421:Slfn9 UTSW 11 82,878,562 (GRCm39) missense probably damaging 0.96
R7421:Slfn9 UTSW 11 82,872,197 (GRCm39) nonsense probably null
R7498:Slfn9 UTSW 11 82,873,013 (GRCm39) missense probably damaging 0.98
R7788:Slfn9 UTSW 11 82,873,467 (GRCm39) missense possibly damaging 0.85
R8286:Slfn9 UTSW 11 82,872,095 (GRCm39) missense probably damaging 0.99
R8304:Slfn9 UTSW 11 82,873,605 (GRCm39) missense probably benign 0.14
R8388:Slfn9 UTSW 11 82,878,112 (GRCm39) missense probably benign
R8678:Slfn9 UTSW 11 82,872,370 (GRCm39) missense probably benign 0.33
R8730:Slfn9 UTSW 11 82,878,194 (GRCm39) missense possibly damaging 0.80
R8914:Slfn9 UTSW 11 82,872,132 (GRCm39) missense probably damaging 0.99
R9050:Slfn9 UTSW 11 82,879,120 (GRCm39) missense probably benign 0.00
R9424:Slfn9 UTSW 11 82,878,211 (GRCm39) missense possibly damaging 0.75
R9576:Slfn9 UTSW 11 82,878,211 (GRCm39) missense possibly damaging 0.75
Z1176:Slfn9 UTSW 11 82,873,261 (GRCm39) missense probably benign 0.01
Posted On 2014-05-07