Incidental Mutation 'IGL01863:Omg'
ID178423
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Omg
Ensembl Gene ENSMUSG00000049612
Gene Nameoligodendrocyte myelin glycoprotein
Synonyms
Accession Numbers
Is this an essential gene? Essential (E-score: 1.000) question?
Stock #IGL01863
Quality Score
Status
Chromosome11
Chromosomal Location79500982-79504084 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to T at 79502224 bp
ZygosityHeterozygous
Amino Acid Change Methionine to Isoleucine at position 269 (M269I)
Ref Sequence ENSEMBL: ENSMUSP00000132918 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071325] [ENSMUST00000108251] [ENSMUST00000164465]
Predicted Effect probably benign
Transcript: ENSMUST00000071325
SMART Domains Protein: ENSMUSP00000071289
Gene: ENSMUSG00000020716

DomainStartEndE-ValueType
RasGAP 1189 1559 2.56e-151 SMART
SEC14 1585 1737 2.36e-11 SMART
low complexity region 2619 2629 N/A INTRINSIC
low complexity region 2750 2763 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000108251
SMART Domains Protein: ENSMUSP00000103886
Gene: ENSMUSG00000020716

DomainStartEndE-ValueType
RasGAP 1189 1538 1.23e-153 SMART
SEC14 1564 1716 2.36e-11 SMART
low complexity region 2598 2608 N/A INTRINSIC
low complexity region 2729 2742 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000164465
AA Change: M269I

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000132918
Gene: ENSMUSG00000049612
AA Change: M269I

DomainStartEndE-ValueType
signal peptide 1 27 N/A INTRINSIC
LRRNT 28 62 5.02e-10 SMART
LRR 80 103 1.07e0 SMART
LRR_TYP 148 171 1.18e-2 SMART
LRR 172 192 2.33e2 SMART
LRR_TYP 193 216 4.01e-5 SMART
low complexity region 427 442 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a null allele exhibit improved recovery from spinal cord injuries when on a mixed 129S4/SvJae C57BL/6 background. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Afg1l T A 10: 42,339,911 I326F possibly damaging Het
Aimp1 T C 3: 132,672,092 T171A probably benign Het
Armc4 T C 18: 7,222,617 T551A probably damaging Het
Ash1l T A 3: 88,985,506 L1564* probably null Het
Atp1a1 G T 3: 101,591,889 Y131* probably null Het
Celsr2 T C 3: 108,394,022 E2686G probably benign Het
Cyp4f18 A G 8: 71,989,926 V395A possibly damaging Het
Ephb2 T C 4: 136,659,777 Q713R probably benign Het
Esf1 A T 2: 140,120,679 M824K probably benign Het
Fam46c C T 3: 100,472,664 D259N probably benign Het
Fat4 T C 3: 38,970,619 probably benign Het
Gem A G 4: 11,705,980 I23V probably benign Het
Gm10718 A T 9: 3,025,118 Y194F probably benign Het
Gm5862 A C 5: 26,022,771 W41G probably benign Het
Il6st A G 13: 112,504,210 E779G possibly damaging Het
Lama3 T A 18: 12,419,936 probably benign Het
Lipi A C 16: 75,550,226 I435R probably damaging Het
Lrrc6 A T 15: 66,396,974 probably benign Het
Olfr291 T C 7: 84,856,411 L14P probably damaging Het
Optn A T 2: 5,021,487 probably benign Het
Pex1 A G 5: 3,606,066 T298A probably benign Het
Rab27b T A 18: 69,989,554 R111S probably damaging Het
Rhbdf1 T G 11: 32,213,484 E329D probably benign Het
Slc2a13 T C 15: 91,516,492 I176V probably benign Het
Slc30a1 T A 1: 191,909,084 C281S probably damaging Het
Slc4a7 T A 14: 14,762,430 C509S probably damaging Het
Slfn9 T C 11: 82,981,325 R862G probably benign Het
Tbc1d2 A G 4: 46,607,064 I782T possibly damaging Het
Vmn2r-ps159 C T 4: 156,338,254 noncoding transcript Het
Vps33b T C 7: 80,274,311 probably null Het
Wrap73 A G 4: 154,145,333 I54V probably benign Het
Other mutations in Omg
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00742:Omg APN 11 79503913 utr 5 prime probably benign
IGL00850:Omg APN 11 79502714 missense possibly damaging 0.71
IGL03034:Omg APN 11 79502121 missense possibly damaging 0.53
E0374:Omg UTSW 11 79502949 missense probably benign 0.16
R0125:Omg UTSW 11 79502853 missense possibly damaging 0.53
R0413:Omg UTSW 11 79502835 missense possibly damaging 0.73
R1636:Omg UTSW 11 79502340 missense probably benign 0.21
R1659:Omg UTSW 11 79502900 missense possibly damaging 0.86
R1713:Omg UTSW 11 79502853 missense probably benign 0.03
R1882:Omg UTSW 11 79501719 intron probably benign
R3974:Omg UTSW 11 79502398 missense probably benign
R4668:Omg UTSW 11 79502423 missense probably damaging 0.98
R5560:Omg UTSW 11 79501758 missense possibly damaging 0.96
R6230:Omg UTSW 11 79502958 missense probably benign 0.03
R6803:Omg UTSW 11 79502268 missense possibly damaging 0.53
R6983:Omg UTSW 11 79501938 missense probably benign 0.00
R7557:Omg UTSW 11 79502853 missense possibly damaging 0.53
R7719:Omg UTSW 11 79502233 missense probably benign 0.33
R8014:Omg UTSW 11 79502903 missense possibly damaging 0.92
R8389:Omg UTSW 11 79502175 missense probably benign 0.01
R8425:Omg UTSW 11 79502000 missense possibly damaging 0.72
Z1088:Omg UTSW 11 79502320 missense possibly damaging 0.72
Posted On2014-05-07