Incidental Mutation 'IGL01863:Omg'
ID 178423
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Omg
Ensembl Gene ENSMUSG00000049612
Gene Name oligodendrocyte myelin glycoprotein
Synonyms
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # IGL01863
Quality Score
Status
Chromosome 11
Chromosomal Location 79391808-79394908 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 79393050 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Isoleucine at position 269 (M269I)
Ref Sequence ENSEMBL: ENSMUSP00000132918 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071325] [ENSMUST00000108251] [ENSMUST00000164465]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000071325
SMART Domains Protein: ENSMUSP00000071289
Gene: ENSMUSG00000020716

DomainStartEndE-ValueType
RasGAP 1189 1559 2.56e-151 SMART
SEC14 1585 1737 2.36e-11 SMART
low complexity region 2619 2629 N/A INTRINSIC
low complexity region 2750 2763 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000108251
SMART Domains Protein: ENSMUSP00000103886
Gene: ENSMUSG00000020716

DomainStartEndE-ValueType
RasGAP 1189 1538 1.23e-153 SMART
SEC14 1564 1716 2.36e-11 SMART
low complexity region 2598 2608 N/A INTRINSIC
low complexity region 2729 2742 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000164465
AA Change: M269I

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000132918
Gene: ENSMUSG00000049612
AA Change: M269I

DomainStartEndE-ValueType
signal peptide 1 27 N/A INTRINSIC
LRRNT 28 62 5.02e-10 SMART
LRR 80 103 1.07e0 SMART
LRR_TYP 148 171 1.18e-2 SMART
LRR 172 192 2.33e2 SMART
LRR_TYP 193 216 4.01e-5 SMART
low complexity region 427 442 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a null allele exhibit improved recovery from spinal cord injuries when on a mixed 129S4/SvJae C57BL/6 background. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Afg1l T A 10: 42,215,907 (GRCm39) I326F possibly damaging Het
Aimp1 T C 3: 132,377,853 (GRCm39) T171A probably benign Het
Ash1l T A 3: 88,892,813 (GRCm39) L1564* probably null Het
Atp1a1 G T 3: 101,499,205 (GRCm39) Y131* probably null Het
Celsr2 T C 3: 108,301,338 (GRCm39) E2686G probably benign Het
Cyp4f18 A G 8: 72,743,770 (GRCm39) V395A possibly damaging Het
Dnaaf11 A T 15: 66,268,823 (GRCm39) probably benign Het
Ephb2 T C 4: 136,387,088 (GRCm39) Q713R probably benign Het
Esf1 A T 2: 139,962,599 (GRCm39) M824K probably benign Het
Fat4 T C 3: 39,024,768 (GRCm39) probably benign Het
Gem A G 4: 11,705,980 (GRCm39) I23V probably benign Het
Gm10718 A T 9: 3,025,118 (GRCm39) Y194F probably benign Het
Gm5862 A C 5: 26,227,769 (GRCm39) W41G probably benign Het
Il6st A G 13: 112,640,744 (GRCm39) E779G possibly damaging Het
Lama3 T A 18: 12,552,993 (GRCm39) probably benign Het
Lipi A C 16: 75,347,114 (GRCm39) I435R probably damaging Het
Odad2 T C 18: 7,222,617 (GRCm39) T551A probably damaging Het
Optn A T 2: 5,026,298 (GRCm39) probably benign Het
Or5ae2 T C 7: 84,505,619 (GRCm39) L14P probably damaging Het
Pex1 A G 5: 3,656,066 (GRCm39) T298A probably benign Het
Rab27b T A 18: 70,122,625 (GRCm39) R111S probably damaging Het
Rhbdf1 T G 11: 32,163,484 (GRCm39) E329D probably benign Het
Slc2a13 T C 15: 91,400,695 (GRCm39) I176V probably benign Het
Slc30a1 T A 1: 191,641,196 (GRCm39) C281S probably damaging Het
Slc4a7 T A 14: 14,762,430 (GRCm38) C509S probably damaging Het
Slfn9 T C 11: 82,872,151 (GRCm39) R862G probably benign Het
Tbc1d2 A G 4: 46,607,064 (GRCm39) I782T possibly damaging Het
Tent5c C T 3: 100,379,980 (GRCm39) D259N probably benign Het
Vmn2r129 C T 4: 156,690,549 (GRCm39) noncoding transcript Het
Vps33b T C 7: 79,924,059 (GRCm39) probably null Het
Wrap73 A G 4: 154,229,790 (GRCm39) I54V probably benign Het
Other mutations in Omg
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00742:Omg APN 11 79,394,739 (GRCm39) utr 5 prime probably benign
IGL00850:Omg APN 11 79,393,540 (GRCm39) missense possibly damaging 0.71
IGL03034:Omg APN 11 79,392,947 (GRCm39) missense possibly damaging 0.53
E0374:Omg UTSW 11 79,393,775 (GRCm39) missense probably benign 0.16
R0125:Omg UTSW 11 79,393,679 (GRCm39) missense possibly damaging 0.53
R0413:Omg UTSW 11 79,393,661 (GRCm39) missense possibly damaging 0.73
R1636:Omg UTSW 11 79,393,166 (GRCm39) missense probably benign 0.21
R1659:Omg UTSW 11 79,393,726 (GRCm39) missense possibly damaging 0.86
R1713:Omg UTSW 11 79,393,679 (GRCm39) missense probably benign 0.03
R1882:Omg UTSW 11 79,392,545 (GRCm39) intron probably benign
R3974:Omg UTSW 11 79,393,224 (GRCm39) missense probably benign
R4668:Omg UTSW 11 79,393,249 (GRCm39) missense probably damaging 0.98
R5560:Omg UTSW 11 79,392,584 (GRCm39) missense possibly damaging 0.96
R6230:Omg UTSW 11 79,393,784 (GRCm39) missense probably benign 0.03
R6803:Omg UTSW 11 79,393,094 (GRCm39) missense possibly damaging 0.53
R6983:Omg UTSW 11 79,392,764 (GRCm39) missense probably benign 0.00
R7557:Omg UTSW 11 79,393,679 (GRCm39) missense possibly damaging 0.53
R7719:Omg UTSW 11 79,393,059 (GRCm39) missense probably benign 0.33
R8014:Omg UTSW 11 79,393,729 (GRCm39) missense possibly damaging 0.92
R8389:Omg UTSW 11 79,393,001 (GRCm39) missense probably benign 0.01
R8425:Omg UTSW 11 79,392,826 (GRCm39) missense possibly damaging 0.72
R8891:Omg UTSW 11 79,393,829 (GRCm39) nonsense probably null
R9203:Omg UTSW 11 79,393,051 (GRCm39) missense probably benign 0.00
Z1088:Omg UTSW 11 79,393,146 (GRCm39) missense possibly damaging 0.72
Posted On 2014-05-07