Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL01863:Omg'

178423

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Omg

Ensembl Gene

ENSMUSG00000049612

Gene Name

oligodendrocyte myelin glycoprotein

Synonyms

Accession Numbers

Is this an essential gene?

Essential (E-score: 1.000) question?

Stock #

IGL01863

Quality Score

Status

Chromosome

Chromosomal Location

79500982-79504084 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 79502224 bp

Zygosity

Heterozygous

Amino Acid Change

Methionine to Isoleucine at position 269 (M269I)

Ref Sequence

ENSEMBL: ENSMUSP00000132918 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000071325] [ENSMUST00000108251] [ENSMUST00000164465]

Predicted Effect

probably benign
Transcript: ENSMUST00000071325

SMART Domains

Protein: ENSMUSP00000071289
Gene: ENSMUSG00000020716

Domain	Start	End	E-Value	Type
RasGAP	1189	1559	2.56e-151	SMART
SEC14	1585	1737	2.36e-11	SMART
low complexity region	2619	2629	N/A	INTRINSIC
low complexity region	2750	2763	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000108251

SMART Domains

Protein: ENSMUSP00000103886
Gene: ENSMUSG00000020716

Domain	Start	End	E-Value	Type
RasGAP	1189	1538	1.23e-153	SMART
SEC14	1564	1716	2.36e-11	SMART
low complexity region	2598	2608	N/A	INTRINSIC
low complexity region	2729	2742	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000164465
AA Change: M269I

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000132918
Gene: ENSMUSG00000049612
AA Change: M269I

Domain	Start	End	E-Value	Type
signal peptide	1	27	N/A	INTRINSIC
LRRNT	28	62	5.02e-10	SMART
LRR	80	103	1.07e0	SMART
LRR_TYP	148	171	1.18e-2	SMART
LRR	172	192	2.33e2	SMART
LRR_TYP	193	216	4.01e-5	SMART
low complexity region	427	442	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Mice homozygous for a null allele exhibit improved recovery from spinal cord injuries when on a mixed 129S4/SvJae C57BL/6 background. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 31 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Afg1l	T	A	10: 42,339,911	I326F	possibly damaging	Het
Aimp1	T	C	3: 132,672,092	T171A	probably benign	Het
Armc4	T	C	18: 7,222,617	T551A	probably damaging	Het
Ash1l	T	A	3: 88,985,506	L1564*	probably null	Het
Atp1a1	G	T	3: 101,591,889	Y131*	probably null	Het
Celsr2	T	C	3: 108,394,022	E2686G	probably benign	Het
Cyp4f18	A	G	8: 71,989,926	V395A	possibly damaging	Het
Ephb2	T	C	4: 136,659,777	Q713R	probably benign	Het
Esf1	A	T	2: 140,120,679	M824K	probably benign	Het
Fam46c	C	T	3: 100,472,664	D259N	probably benign	Het
Fat4	T	C	3: 38,970,619		probably benign	Het
Gem	A	G	4: 11,705,980	I23V	probably benign	Het
Gm10718	A	T	9: 3,025,118	Y194F	probably benign	Het
Gm5862	A	C	5: 26,022,771	W41G	probably benign	Het
Il6st	A	G	13: 112,504,210	E779G	possibly damaging	Het
Lama3	T	A	18: 12,419,936		probably benign	Het
Lipi	A	C	16: 75,550,226	I435R	probably damaging	Het
Lrrc6	A	T	15: 66,396,974		probably benign	Het
Olfr291	T	C	7: 84,856,411	L14P	probably damaging	Het
Optn	A	T	2: 5,021,487		probably benign	Het
Pex1	A	G	5: 3,606,066	T298A	probably benign	Het
Rab27b	T	A	18: 69,989,554	R111S	probably damaging	Het
Rhbdf1	T	G	11: 32,213,484	E329D	probably benign	Het
Slc2a13	T	C	15: 91,516,492	I176V	probably benign	Het
Slc30a1	T	A	1: 191,909,084	C281S	probably damaging	Het
Slc4a7	T	A	14: 14,762,430	C509S	probably damaging	Het
Slfn9	T	C	11: 82,981,325	R862G	probably benign	Het
Tbc1d2	A	G	4: 46,607,064	I782T	possibly damaging	Het
Vmn2r-ps159	C	T	4: 156,338,254		noncoding transcript	Het
Vps33b	T	C	7: 80,274,311		probably null	Het
Wrap73	A	G	4: 154,145,333	I54V	probably benign	Het

Other mutations in Omg

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00742:Omg	APN	11	79503913	utr 5 prime	probably benign
IGL00850:Omg	APN	11	79502714	missense	possibly damaging	0.71
IGL03034:Omg	APN	11	79502121	missense	possibly damaging	0.53
E0374:Omg	UTSW	11	79502949	missense	probably benign	0.16
R0125:Omg	UTSW	11	79502853	missense	possibly damaging	0.53
R0413:Omg	UTSW	11	79502835	missense	possibly damaging	0.73
R1636:Omg	UTSW	11	79502340	missense	probably benign	0.21
R1659:Omg	UTSW	11	79502900	missense	possibly damaging	0.86
R1713:Omg	UTSW	11	79502853	missense	probably benign	0.03
R1882:Omg	UTSW	11	79501719	intron	probably benign
R3974:Omg	UTSW	11	79502398	missense	probably benign
R4668:Omg	UTSW	11	79502423	missense	probably damaging	0.98
R5560:Omg	UTSW	11	79501758	missense	possibly damaging	0.96
R6230:Omg	UTSW	11	79502958	missense	probably benign	0.03
R6803:Omg	UTSW	11	79502268	missense	possibly damaging	0.53
R6983:Omg	UTSW	11	79501938	missense	probably benign	0.00
R7557:Omg	UTSW	11	79502853	missense	possibly damaging	0.53
R7719:Omg	UTSW	11	79502233	missense	probably benign	0.33
R8014:Omg	UTSW	11	79502903	missense	possibly damaging	0.92
R8389:Omg	UTSW	11	79502175	missense	probably benign	0.01
R8425:Omg	UTSW	11	79502000	missense	possibly damaging	0.72
Z1088:Omg	UTSW	11	79502320	missense	possibly damaging	0.72

Posted On

2014-05-07