Incidental Mutation 'IGL01865:Or7a36'
ID 178462
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or7a36
Ensembl Gene ENSMUSG00000046493
Gene Name olfactory receptor family 7 subfamily A member 36
Synonyms GA_x6K02T2QGN0-2828447-2827518, MOR139-1, Olfr1352
Accession Numbers
Essential gene? Probably non essential (E-score: 0.072) question?
Stock # IGL01865
Quality Score
Status
Chromosome 10
Chromosomal Location 78816884-78820555 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 78820512 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Valine at position 296 (D296V)
Ref Sequence ENSEMBL: ENSMUSP00000054355 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000058991] [ENSMUST00000203973]
AlphaFold Q8VGX5
Predicted Effect possibly damaging
Transcript: ENSMUST00000058991
AA Change: D296V

PolyPhen 2 Score 0.938 (Sensitivity: 0.80; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000054355
Gene: ENSMUSG00000046493
AA Change: D296V

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 4.7e-52 PFAM
Pfam:7TM_GPCR_Srsx 35 305 9.1e-6 PFAM
Pfam:7tm_1 41 290 4.7e-28 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000203973
SMART Domains Protein: ENSMUSP00000144895
Gene: ENSMUSG00000046493

DomainStartEndE-ValueType
Pfam:7tm_4 1 122 6.1e-25 PFAM
Pfam:7TM_GPCR_Srx 1 123 7.5e-5 PFAM
Pfam:7TM_GPCR_Srsx 2 123 4.5e-8 PFAM
Pfam:7tm_1 8 123 2.1e-23 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000219714
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9130023H24Rik T C 7: 127,836,107 (GRCm39) H162R probably damaging Het
Adamts10 T A 17: 33,772,140 (GRCm39) M1096K probably damaging Het
Asap3 G T 4: 135,963,715 (GRCm39) C325F probably damaging Het
Atm T C 9: 53,372,302 (GRCm39) E2160G probably damaging Het
Col4a1 G A 8: 11,251,790 (GRCm39) probably benign Het
Ctdp1 C T 18: 80,499,199 (GRCm39) G248S probably damaging Het
Dcaf5 A T 12: 80,386,088 (GRCm39) D679E probably benign Het
Efcab2 C A 1: 178,303,253 (GRCm39) Y91* probably null Het
Eif3d G T 15: 77,851,546 (GRCm39) T88K probably benign Het
Gapvd1 G A 2: 34,585,515 (GRCm39) A1049V probably null Het
Gm10717 C T 9: 3,025,616 (GRCm39) S67L probably benign Het
Gm10717 A T 9: 3,026,287 (GRCm39) Y195F probably damaging Het
Gm10718 A T 9: 3,025,118 (GRCm39) Y194F probably benign Het
Gm18856 T A 13: 14,139,508 (GRCm39) probably benign Het
Gm21738 G A 14: 19,416,979 (GRCm38) S144L probably benign Het
Gm9991 A G 1: 90,606,635 (GRCm39) noncoding transcript Het
Hapln1 T C 13: 89,749,784 (GRCm39) Y110H probably damaging Het
Htr1f A G 16: 64,746,282 (GRCm39) Y337H probably damaging Het
Kirrel1 T A 3: 86,993,731 (GRCm39) S509C probably damaging Het
Limch1 A T 5: 67,131,923 (GRCm39) R138* probably null Het
Lypla1 A C 1: 4,907,259 (GRCm39) I108L probably damaging Het
Mc3r A G 2: 172,090,975 (GRCm39) N66D probably damaging Het
Melk T A 4: 44,344,988 (GRCm39) C373S probably benign Het
Myocd C A 11: 65,091,723 (GRCm39) S73I probably benign Het
Nell2 A G 15: 95,282,962 (GRCm39) V360A possibly damaging Het
Npas4 G A 19: 5,035,819 (GRCm39) Q782* probably null Het
Pdzd8 T C 19: 59,288,077 (GRCm39) K1108E possibly damaging Het
Per2 A G 1: 91,349,239 (GRCm39) I1044T probably benign Het
Pgm3 A G 9: 86,437,371 (GRCm39) F501S possibly damaging Het
Ppp1r3c A G 19: 36,711,578 (GRCm39) V64A probably benign Het
Ptpn6 A T 6: 124,709,428 (GRCm39) I15N probably damaging Het
Pxk T C 14: 8,136,923 (GRCm38) V148A possibly damaging Het
Rngtt T A 4: 33,325,157 (GRCm39) probably benign Het
Rtkn2 T G 10: 67,871,705 (GRCm39) S364R probably benign Het
Rtn1 A C 12: 72,266,074 (GRCm39) L167R probably damaging Het
Sp2 G A 11: 96,851,868 (GRCm39) T352I probably damaging Het
Tbc1d17 A G 7: 44,492,113 (GRCm39) M459T possibly damaging Het
Tbcd T A 11: 121,481,206 (GRCm39) M694K possibly damaging Het
Tln2 G A 9: 67,157,896 (GRCm39) R1148* probably null Het
Trim27 T C 13: 21,376,662 (GRCm39) V294A probably damaging Het
Tspyl5 G T 15: 33,687,858 (GRCm39) A29E unknown Het
Vmn2r129 C T 4: 156,690,549 (GRCm39) noncoding transcript Het
Vrk2 C T 11: 26,485,560 (GRCm39) V143I possibly damaging Het
Zfp952 G A 17: 33,221,791 (GRCm39) R52Q probably benign Het
Zfp979 A T 4: 147,699,774 (GRCm39) D55E probably benign Het
Other mutations in Or7a36
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01468:Or7a36 APN 10 78,819,696 (GRCm39) missense probably damaging 0.96
R0196:Or7a36 UTSW 10 78,820,023 (GRCm39) missense possibly damaging 0.89
R0362:Or7a36 UTSW 10 78,820,220 (GRCm39) missense probably benign 0.00
R1574:Or7a36 UTSW 10 78,819,820 (GRCm39) missense probably damaging 1.00
R1574:Or7a36 UTSW 10 78,819,820 (GRCm39) missense probably damaging 1.00
R2982:Or7a36 UTSW 10 78,820,274 (GRCm39) missense probably damaging 1.00
R4724:Or7a36 UTSW 10 78,820,356 (GRCm39) missense probably damaging 1.00
R5000:Or7a36 UTSW 10 78,820,514 (GRCm39) missense probably benign 0.00
R5085:Or7a36 UTSW 10 78,819,928 (GRCm39) missense probably benign 0.03
R5145:Or7a36 UTSW 10 78,820,143 (GRCm39) missense probably benign 0.35
R5455:Or7a36 UTSW 10 78,820,371 (GRCm39) missense possibly damaging 0.59
R5777:Or7a36 UTSW 10 78,820,512 (GRCm39) missense possibly damaging 0.78
R5822:Or7a36 UTSW 10 78,820,023 (GRCm39) missense possibly damaging 0.89
R6283:Or7a36 UTSW 10 78,820,113 (GRCm39) missense probably benign 0.01
R7242:Or7a36 UTSW 10 78,820,331 (GRCm39) nonsense probably null
R7504:Or7a36 UTSW 10 78,820,494 (GRCm39) missense possibly damaging 0.78
R8198:Or7a36 UTSW 10 78,820,443 (GRCm39) missense probably benign 0.03
R8268:Or7a36 UTSW 10 78,819,831 (GRCm39) missense probably damaging 0.98
R8684:Or7a36 UTSW 10 78,820,212 (GRCm39) missense probably benign 0.06
R8928:Or7a36 UTSW 10 78,820,547 (GRCm39) missense
R9408:Or7a36 UTSW 10 78,820,220 (GRCm39) missense probably benign 0.01
R9626:Or7a36 UTSW 10 78,820,213 (GRCm39) missense probably benign 0.06
Posted On 2014-05-07