Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL01865:Zfp952'

178476

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp952

Ensembl Gene

ENSMUSG00000053390

Gene Name

zinc finger protein 952

Synonyms

C920016K16Rik

Accession Numbers

Genbank: NM_001045559; MGI: 2441928

Is this an essential gene?

Probably non essential (E-score: 0.082) question?

Stock #

IGL01865

Quality Score

Status

Chromosome

Chromosomal Location

32993129-33005457 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 33002817 bp

Zygosity

Heterozygous

Amino Acid Change

Arginine to Glutamine at position 52 (R52Q)

Ref Sequence

ENSEMBL: ENSMUSP00000123066 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000087666] [ENSMUST00000157017]

Predicted Effect

probably benign
Transcript: ENSMUST00000087666
AA Change: R90Q

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000084949
Gene: ENSMUSG00000053390
AA Change: R90Q

Domain	Start	End	E-Value	Type
KRAB	10	73	4.6e-14	SMART
ZnF_C2H2	251	273	3.44e-4	SMART
ZnF_C2H2	279	301	1.28e-3	SMART
ZnF_C2H2	307	329	1.36e-2	SMART
ZnF_C2H2	335	357	2.75e-3	SMART
ZnF_C2H2	363	385	9.44e-2	SMART
ZnF_C2H2	391	413	1.47e-3	SMART
ZnF_C2H2	419	441	2.91e-2	SMART
ZnF_C2H2	447	469	2.57e-3	SMART
ZnF_C2H2	475	497	1.43e-1	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000141815

Predicted Effect

probably benign
Transcript: ENSMUST00000157017
AA Change: R52Q

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)

SMART Domains

Protein: ENSMUSP00000123066
Gene: ENSMUSG00000053390
AA Change: R52Q

Domain	Start	End	E-Value	Type
Blast:KRAB	1	35	4e-17	BLAST

Coding Region Coverage

Validation Efficiency

Allele List at MGI

All alleles(2) : Gene trapped(2)

Other mutations in this stock

Total: 45 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
9130023H24Rik	T	C	7: 128,236,935	H162R	probably damaging	Het
Adamts10	T	A	17: 33,553,166	M1096K	probably damaging	Het
Asap3	G	T	4: 136,236,404	C325F	probably damaging	Het
Atm	T	C	9: 53,461,002	E2160G	probably damaging	Het
Col4a1	G	A	8: 11,201,790		probably benign	Het
Ctdp1	C	T	18: 80,455,984	G248S	probably damaging	Het
Dcaf5	A	T	12: 80,339,314	D679E	probably benign	Het
Efcab2	C	A	1: 178,475,688	Y91*	probably null	Het
Eif3d	G	T	15: 77,967,346	T88K	probably benign	Het
Gapvd1	G	A	2: 34,695,503	A1049V	probably null	Het
Gm10717	C	T	9: 3,025,616	S67L	probably benign	Het
Gm10717	A	T	9: 3,026,287	Y195F	probably damaging	Het
Gm10718	A	T	9: 3,025,118	Y194F	probably benign	Het
Gm18856	T	A	13: 13,964,923		probably benign	Het
Gm21738	G	A	14: 19,416,979	S144L	probably benign	Het
Gm9991	A	G	1: 90,678,913		noncoding transcript	Het
Hapln1	T	C	13: 89,601,665	Y110H	probably damaging	Het
Htr1f	A	G	16: 64,925,919	Y337H	probably damaging	Het
Kirrel	T	A	3: 87,086,424	S509C	probably damaging	Het
Limch1	A	T	5: 66,974,580	R138*	probably null	Het
Lypla1	A	C	1: 4,837,036	I108L	probably damaging	Het
Mc3r	A	G	2: 172,249,055	N66D	probably damaging	Het
Melk	T	A	4: 44,344,988	C373S	probably benign	Het
Myocd	C	A	11: 65,200,897	S73I	probably benign	Het
Nell2	A	G	15: 95,385,081	V360A	possibly damaging	Het
Npas4	G	A	19: 4,985,791	Q782*	probably null	Het
Olfr1352	A	T	10: 78,984,678	D296V	possibly damaging	Het
Pdzd8	T	C	19: 59,299,645	K1108E	possibly damaging	Het
Per2	A	G	1: 91,421,517	I1044T	probably benign	Het
Pgm3	A	G	9: 86,555,318	F501S	possibly damaging	Het
Ppp1r3c	A	G	19: 36,734,178	V64A	probably benign	Het
Ptpn6	A	T	6: 124,732,465	I15N	probably damaging	Het
Pxk	T	C	14: 8,136,923	V148A	possibly damaging	Het
Rngtt	T	A	4: 33,325,157		probably benign	Het
Rtkn2	T	G	10: 68,035,875	S364R	probably benign	Het
Rtn1	A	C	12: 72,219,300	L167R	probably damaging	Het
Sp2	G	A	11: 96,961,042	T352I	probably damaging	Het
Tbc1d17	A	G	7: 44,842,689	M459T	possibly damaging	Het
Tbcd	T	A	11: 121,590,380	M694K	possibly damaging	Het
Tln2	G	A	9: 67,250,614	R1148*	probably null	Het
Trim27	T	C	13: 21,192,492	V294A	probably damaging	Het
Tspyl5	G	T	15: 33,687,712	A29E	unknown	Het
Vmn2r-ps159	C	T	4: 156,338,254		noncoding transcript	Het
Vrk2	C	T	11: 26,535,560	V143I	possibly damaging	Het
Zfp979	A	T	4: 147,615,317	D55E	probably benign	Het

Other mutations in Zfp952

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02560:Zfp952	APN	17	33002819	nonsense	probably null
IGL03056:Zfp952	APN	17	33002766	missense	probably damaging	0.98
IGL03151:Zfp952	APN	17	33003008	missense	probably benign	0.01
0152:Zfp952	UTSW	17	33003221	unclassified	probably null
R0508:Zfp952	UTSW	17	33003005	missense	possibly damaging	0.90
R1936:Zfp952	UTSW	17	33003669	missense	possibly damaging	0.71
R3882:Zfp952	UTSW	17	33001975	nonsense	probably null
R4560:Zfp952	UTSW	17	33003954	missense	probably benign	0.33
R4649:Zfp952	UTSW	17	33002925	missense	probably damaging	0.99
R7103:Zfp952	UTSW	17	33003632	missense	possibly damaging	0.94
R7207:Zfp952	UTSW	17	33003515	missense	possibly damaging	0.93
R7209:Zfp952	UTSW	17	33003470	missense	possibly damaging	0.71
R7508:Zfp952	UTSW	17	33003782	missense	probably benign	0.06
Z1177:Zfp952	UTSW	17	33003104	nonsense	probably null

Posted On

2014-05-07