Incidental Mutation 'IGL01867:Wtap'
ID 178546
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Wtap
Ensembl Gene ENSMUSG00000060475
Gene Name WT1 associating protein
Synonyms 2810408K05Rik, 9430038B09Rik
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # IGL01867
Quality Score
Status
Chromosome 17
Chromosomal Location 13185686-13211430 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 13188342 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 186 (E186G)
Ref Sequence ENSEMBL: ENSMUSP00000124205 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000007007] [ENSMUST00000159551] [ENSMUST00000159986] [ENSMUST00000160781]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000007007
AA Change: E186G

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
SMART Domains Protein: ENSMUSP00000007007
Gene: ENSMUSG00000060475
AA Change: E186G

DomainStartEndE-ValueType
low complexity region 57 69 N/A INTRINSIC
coiled coil region 121 148 N/A INTRINSIC
coiled coil region 177 248 N/A INTRINSIC
low complexity region 278 291 N/A INTRINSIC
low complexity region 305 327 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000159551
AA Change: E186G

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
SMART Domains Protein: ENSMUSP00000124205
Gene: ENSMUSG00000060475
AA Change: E186G

DomainStartEndE-ValueType
Pfam:Wtap 1 248 2.8e-157 PFAM
low complexity region 278 291 N/A INTRINSIC
low complexity region 305 327 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000159986
SMART Domains Protein: ENSMUSP00000123961
Gene: ENSMUSG00000060475

DomainStartEndE-ValueType
low complexity region 57 69 N/A INTRINSIC
coiled coil region 121 148 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000160781
SMART Domains Protein: ENSMUSP00000124138
Gene: ENSMUSG00000060475

DomainStartEndE-ValueType
low complexity region 57 69 N/A INTRINSIC
coiled coil region 121 148 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The Wilms tumor suppressor gene WT1 appears to play a role in both transcriptional and posttranscriptional regulation of certain cellular genes. This gene encodes a WT1-associating protein, which is a ubiquitously expressed nuclear protein. Like WT1 protein, this protein is localized throughout the nucleoplasm as well as in speckles and partially colocalizes with splicing factors. Alternative splicing of this gene results in several transcript variants encoding three different isoforms. [provided by RefSeq, Jul 2012]
PHENOTYPE: Mice homozygous for a mutation display lethality during embryogenesis with abnormalities appearing during gastrulation. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc10 T C 17: 46,635,364 (GRCm39) E213G probably benign Het
Akap6 T C 12: 52,934,791 (GRCm39) L761P probably damaging Het
Bbs7 A C 3: 36,627,696 (GRCm39) L697R probably benign Het
Cd74 G A 18: 60,941,352 (GRCm39) R99H probably benign Het
Cpne6 A G 14: 55,751,137 (GRCm39) N182S probably benign Het
Cyp4f17 A G 17: 32,747,057 (GRCm39) H429R probably benign Het
Dact2 A T 17: 14,415,932 (GRCm39) M756K probably damaging Het
Ets1 A G 9: 32,645,455 (GRCm39) D234G probably damaging Het
Fat3 A C 9: 16,289,197 (GRCm39) S109A probably benign Het
Fras1 G T 5: 96,735,990 (GRCm39) M528I probably benign Het
Gm10718 A T 9: 3,025,118 (GRCm39) Y194F probably benign Het
Gtf3c1 A G 7: 125,261,548 (GRCm39) F1189L probably benign Het
Ift81 A T 5: 122,740,739 (GRCm39) probably benign Het
Insyn2b A G 11: 34,353,065 (GRCm39) E369G probably benign Het
Lag3 A G 6: 124,887,869 (GRCm39) S22P probably benign Het
Mos G T 4: 3,870,845 (GRCm39) Q324K probably benign Het
Mtx2 T A 2: 74,706,733 (GRCm39) V236E probably damaging Het
Naip6 T C 13: 100,436,820 (GRCm39) T568A probably benign Het
Or5k8 A G 16: 58,644,337 (GRCm39) F245S probably damaging Het
Or6c35 T A 10: 129,169,232 (GRCm39) L161M probably damaging Het
Or6c68 T C 10: 129,157,585 (GRCm39) I31T probably benign Het
Or6c88 G A 10: 129,406,696 (GRCm39) M57I possibly damaging Het
Or8b53 A C 9: 38,667,194 (GRCm39) D70A probably damaging Het
Pcid2 A G 8: 13,128,243 (GRCm39) V386A probably benign Het
Pde8b T C 13: 95,237,446 (GRCm39) D116G probably damaging Het
Plxnc1 A G 10: 94,634,008 (GRCm39) V1365A possibly damaging Het
Prex2 G T 1: 11,168,727 (GRCm39) C241F probably benign Het
Prr23a2 A G 9: 98,739,113 (GRCm39) E157G probably benign Het
Ptpn4 A T 1: 119,603,329 (GRCm39) H836Q probably benign Het
Ptprd C T 4: 76,161,884 (GRCm39) R117H probably damaging Het
Rab11fip4 T C 11: 79,574,216 (GRCm39) S102P probably benign Het
Slc44a1 G T 4: 53,536,405 (GRCm39) V194F probably damaging Het
Synm T A 7: 67,383,222 (GRCm39) H1480L probably benign Het
Tmem63a A G 1: 180,783,570 (GRCm39) Y175C possibly damaging Het
Trmt61a C T 12: 111,645,150 (GRCm39) R29C probably benign Het
Ubap1 C T 4: 41,379,236 (GRCm39) T150I probably benign Het
Uimc1 T C 13: 55,223,214 (GRCm39) M353V probably benign Het
Usp34 T C 11: 23,334,411 (GRCm39) M1135T possibly damaging Het
Vmn1r25 A C 6: 57,956,196 (GRCm39) L31R probably damaging Het
Wwc2 T G 8: 48,336,615 (GRCm39) N216H probably benign Het
Zhx1 A T 15: 57,917,841 (GRCm39) M135K probably damaging Het
Other mutations in Wtap
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01305:Wtap APN 17 13,186,782 (GRCm39) missense probably benign 0.08
IGL02379:Wtap APN 17 13,188,336 (GRCm39) missense probably benign
IGL02437:Wtap APN 17 13,186,620 (GRCm39) missense probably benign
IGL02975:Wtap APN 17 13,202,398 (GRCm39) missense possibly damaging 0.85
ANU22:Wtap UTSW 17 13,186,782 (GRCm39) missense probably benign 0.08
R1457:Wtap UTSW 17 13,200,631 (GRCm39) splice site probably null
R1799:Wtap UTSW 17 13,199,771 (GRCm39) missense possibly damaging 0.96
R2240:Wtap UTSW 17 13,194,352 (GRCm39) nonsense probably null
R2328:Wtap UTSW 17 13,186,425 (GRCm39) missense possibly damaging 0.53
R2332:Wtap UTSW 17 13,186,425 (GRCm39) missense possibly damaging 0.53
R3426:Wtap UTSW 17 13,186,425 (GRCm39) missense possibly damaging 0.53
R4382:Wtap UTSW 17 13,194,307 (GRCm39) missense probably damaging 0.99
R4703:Wtap UTSW 17 13,199,711 (GRCm39) missense probably benign 0.23
R4879:Wtap UTSW 17 13,188,322 (GRCm39) missense probably damaging 0.99
R4956:Wtap UTSW 17 13,186,423 (GRCm39) missense probably benign 0.06
R5044:Wtap UTSW 17 13,186,525 (GRCm39) missense possibly damaging 0.47
R6366:Wtap UTSW 17 13,186,945 (GRCm39) splice site probably null
R6813:Wtap UTSW 17 13,186,397 (GRCm39) missense probably damaging 0.96
R7324:Wtap UTSW 17 13,199,833 (GRCm39) missense possibly damaging 0.91
R7443:Wtap UTSW 17 13,199,821 (GRCm39) missense probably benign 0.05
R7810:Wtap UTSW 17 13,199,797 (GRCm39) missense probably damaging 0.99
R7939:Wtap UTSW 17 13,200,683 (GRCm39) nonsense probably null
R8787:Wtap UTSW 17 13,186,488 (GRCm39) missense possibly damaging 0.93
T0970:Wtap UTSW 17 13,188,277 (GRCm39) unclassified probably benign
X0067:Wtap UTSW 17 13,204,816 (GRCm39) missense probably damaging 1.00
Posted On 2014-05-07