Incidental Mutation 'IGL01867:Mos'
ID178563
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Mos
Ensembl Gene ENSMUSG00000078365
Gene NameMoloney sarcoma oncogene
Synonymsc-mos
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL01867
Quality Score
Status
Chromosome4
Chromosomal Location3870657-3872105 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to T at 3870845 bp
ZygosityHeterozygous
Amino Acid Change Glutamine to Lysine at position 324 (Q324K)
Ref Sequence ENSEMBL: ENSMUSP00000100789 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000105158]
Predicted Effect probably benign
Transcript: ENSMUST00000105158
AA Change: Q324K

PolyPhen 2 Score 0.329 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000100789
Gene: ENSMUSG00000078365
AA Change: Q324K

DomainStartEndE-ValueType
low complexity region 39 54 N/A INTRINSIC
Pfam:Pkinase_Tyr 63 335 9e-41 PFAM
Pfam:Pkinase 64 334 6.3e-43 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] MOS is a serine/threonine kinase that activates the MAP kinase cascade through direct phosphorylation of the MAP kinase activator MEK (MAP2K1; MIM 176872) (Prasad et al., 2008 [PubMed 18246541]).[supplied by OMIM, Jul 2009]
PHENOTYPE: Mutations that inactivate the gene result in female infertility and an increased susceptibility to tumors. Oocytes progress through meiosis II without arrest and undergo spontaneous parthenogenetic activation. Male mice are fertile and show no spermatogenic defects. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc10 T C 17: 46,324,438 E213G probably benign Het
Akap6 T C 12: 52,888,008 L761P probably damaging Het
Bbs7 A C 3: 36,573,547 L697R probably benign Het
Cd74 G A 18: 60,808,280 R99H probably benign Het
Cpne6 A G 14: 55,513,680 N182S probably benign Het
Cyp4f17 A G 17: 32,528,083 H429R probably benign Het
Dact2 A T 17: 14,195,670 M756K probably damaging Het
Ets1 A G 9: 32,734,159 D234G probably damaging Het
Fam196b A G 11: 34,403,065 E369G probably benign Het
Fat3 A C 9: 16,377,901 S109A probably benign Het
Fras1 G T 5: 96,588,131 M528I probably benign Het
Gm10718 A T 9: 3,025,118 Y194F probably benign Het
Gtf3c1 A G 7: 125,662,376 F1189L probably benign Het
Ift81 A T 5: 122,602,676 probably benign Het
Lag3 A G 6: 124,910,906 S22P probably benign Het
Mtx2 T A 2: 74,876,389 V236E probably damaging Het
Naip6 T C 13: 100,300,312 T568A probably benign Het
Olfr175-ps1 A G 16: 58,823,974 F245S probably damaging Het
Olfr780 T C 10: 129,321,716 I31T probably benign Het
Olfr781 T A 10: 129,333,363 L161M probably damaging Het
Olfr794 G A 10: 129,570,827 M57I possibly damaging Het
Olfr920 A C 9: 38,755,898 D70A probably damaging Het
Pcid2 A G 8: 13,078,243 V386A probably benign Het
Pde8b T C 13: 95,100,938 D116G probably damaging Het
Plxnc1 A G 10: 94,798,146 V1365A possibly damaging Het
Prex2 G T 1: 11,098,503 C241F probably benign Het
Prr23a2 A G 9: 98,857,060 E157G probably benign Het
Ptpn4 A T 1: 119,675,599 H836Q probably benign Het
Ptprd C T 4: 76,243,647 R117H probably damaging Het
Rab11fip4 T C 11: 79,683,390 S102P probably benign Het
Slc44a1 G T 4: 53,536,405 V194F probably damaging Het
Synm T A 7: 67,733,474 H1480L probably benign Het
Tmem63a A G 1: 180,956,005 Y175C possibly damaging Het
Trmt61a C T 12: 111,678,716 R29C probably benign Het
Ubap1 C T 4: 41,379,236 T150I probably benign Het
Uimc1 T C 13: 55,075,401 M353V probably benign Het
Usp34 T C 11: 23,384,411 M1135T possibly damaging Het
Vmn1r25 A C 6: 57,979,211 L31R probably damaging Het
Wtap T C 17: 12,969,455 E186G probably benign Het
Wwc2 T G 8: 47,883,580 N216H probably benign Het
Zhx1 A T 15: 58,054,445 M135K probably damaging Het
Other mutations in Mos
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00848:Mos APN 4 3871459 missense probably damaging 1.00
IGL01302:Mos APN 4 3871815 utr 5 prime probably benign
IGL01739:Mos APN 4 3871816 utr 5 prime probably benign
IGL02647:Mos APN 4 3870961 missense probably damaging 1.00
PIT4418001:Mos UTSW 4 3870814 missense possibly damaging 0.86
R0967:Mos UTSW 4 3870932 missense probably benign
R4927:Mos UTSW 4 3871093 missense probably damaging 1.00
R5729:Mos UTSW 4 3870971 missense probably benign 0.01
R6947:Mos UTSW 4 3871585 missense probably damaging 1.00
R8359:Mos UTSW 4 3871097 missense probably damaging 1.00
Posted On2014-05-07