Incidental Mutation 'IGL01867:Lag3'
ID178570
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Lag3
Ensembl Gene ENSMUSG00000030124
Gene Namelymphocyte-activation gene 3
SynonymsCD223, Ly66, LAG-3
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.076) question?
Stock #IGL01867
Quality Score
Status
Chromosome6
Chromosomal Location124904361-124911705 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 124910906 bp
ZygosityHeterozygous
Amino Acid Change Serine to Proline at position 22 (S22P)
Ref Sequence ENSEMBL: ENSMUSP00000032217 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000032216] [ENSMUST00000032217]
Predicted Effect probably benign
Transcript: ENSMUST00000032216
SMART Domains Protein: ENSMUSP00000032216
Gene: ENSMUSG00000030122

DomainStartEndE-ValueType
Pfam:Prothymosin 2 98 1e-17 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000032217
AA Change: S22P

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000032217
Gene: ENSMUSG00000030124
AA Change: S22P

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
IG 29 163 1.3e-2 SMART
IG 170 254 6.51e-3 SMART
IG 261 345 4.96e-8 SMART
Blast:IG_like 348 421 2e-28 BLAST
transmembrane domain 443 465 N/A INTRINSIC
low complexity region 492 521 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000134916
Predicted Effect noncoding transcript
Transcript: ENSMUST00000139571
Predicted Effect noncoding transcript
Transcript: ENSMUST00000181150
Predicted Effect noncoding transcript
Transcript: ENSMUST00000203422
Predicted Effect noncoding transcript
Transcript: ENSMUST00000204671
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Lymphocyte-activation protein 3 belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for disruptions in this gene have a generally normal phenotype but do display reduced natural killer cell activity and increased T cell response to infection. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc10 T C 17: 46,324,438 E213G probably benign Het
Akap6 T C 12: 52,888,008 L761P probably damaging Het
Bbs7 A C 3: 36,573,547 L697R probably benign Het
Cd74 G A 18: 60,808,280 R99H probably benign Het
Cpne6 A G 14: 55,513,680 N182S probably benign Het
Cyp4f17 A G 17: 32,528,083 H429R probably benign Het
Dact2 A T 17: 14,195,670 M756K probably damaging Het
Ets1 A G 9: 32,734,159 D234G probably damaging Het
Fam196b A G 11: 34,403,065 E369G probably benign Het
Fat3 A C 9: 16,377,901 S109A probably benign Het
Fras1 G T 5: 96,588,131 M528I probably benign Het
Gm10718 A T 9: 3,025,118 Y194F probably benign Het
Gtf3c1 A G 7: 125,662,376 F1189L probably benign Het
Ift81 A T 5: 122,602,676 probably benign Het
Mos G T 4: 3,870,845 Q324K probably benign Het
Mtx2 T A 2: 74,876,389 V236E probably damaging Het
Naip6 T C 13: 100,300,312 T568A probably benign Het
Olfr175-ps1 A G 16: 58,823,974 F245S probably damaging Het
Olfr780 T C 10: 129,321,716 I31T probably benign Het
Olfr781 T A 10: 129,333,363 L161M probably damaging Het
Olfr794 G A 10: 129,570,827 M57I possibly damaging Het
Olfr920 A C 9: 38,755,898 D70A probably damaging Het
Pcid2 A G 8: 13,078,243 V386A probably benign Het
Pde8b T C 13: 95,100,938 D116G probably damaging Het
Plxnc1 A G 10: 94,798,146 V1365A possibly damaging Het
Prex2 G T 1: 11,098,503 C241F probably benign Het
Prr23a2 A G 9: 98,857,060 E157G probably benign Het
Ptpn4 A T 1: 119,675,599 H836Q probably benign Het
Ptprd C T 4: 76,243,647 R117H probably damaging Het
Rab11fip4 T C 11: 79,683,390 S102P probably benign Het
Slc44a1 G T 4: 53,536,405 V194F probably damaging Het
Synm T A 7: 67,733,474 H1480L probably benign Het
Tmem63a A G 1: 180,956,005 Y175C possibly damaging Het
Trmt61a C T 12: 111,678,716 R29C probably benign Het
Ubap1 C T 4: 41,379,236 T150I probably benign Het
Uimc1 T C 13: 55,075,401 M353V probably benign Het
Usp34 T C 11: 23,384,411 M1135T possibly damaging Het
Vmn1r25 A C 6: 57,979,211 L31R probably damaging Het
Wtap T C 17: 12,969,455 E186G probably benign Het
Wwc2 T G 8: 47,883,580 N216H probably benign Het
Zhx1 A T 15: 58,054,445 M135K probably damaging Het
Other mutations in Lag3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01128:Lag3 APN 6 124909417 missense probably damaging 1.00
IGL02880:Lag3 APN 6 124905471 missense probably benign 0.01
R1502:Lag3 UTSW 6 124909243 missense probably damaging 1.00
R1573:Lag3 UTSW 6 124909247 missense possibly damaging 0.65
R1886:Lag3 UTSW 6 124909439 missense probably damaging 0.99
R1907:Lag3 UTSW 6 124909487 missense possibly damaging 0.52
R2508:Lag3 UTSW 6 124911309 missense possibly damaging 0.91
R3016:Lag3 UTSW 6 124908466 missense probably damaging 1.00
R3732:Lag3 UTSW 6 124910140 missense probably benign 0.05
R3732:Lag3 UTSW 6 124910140 missense probably benign 0.05
R3733:Lag3 UTSW 6 124910140 missense probably benign 0.05
R3734:Lag3 UTSW 6 124910140 missense probably benign 0.05
R4679:Lag3 UTSW 6 124904545 missense possibly damaging 0.92
R4994:Lag3 UTSW 6 124904453 missense unknown
R5057:Lag3 UTSW 6 124905355 missense possibly damaging 0.58
R5527:Lag3 UTSW 6 124908629 missense probably damaging 0.99
R7227:Lag3 UTSW 6 124908494 missense possibly damaging 0.79
R7255:Lag3 UTSW 6 124910235 missense probably benign 0.04
R8081:Lag3 UTSW 6 124905447 nonsense probably null
R8138:Lag3 UTSW 6 124905492 missense probably damaging 0.99
X0009:Lag3 UTSW 6 124905352 missense possibly damaging 0.62
Posted On2014-05-07