Incidental Mutation 'IGL01867:Trmt61a'
ID178571
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Trmt61a
Ensembl Gene ENSMUSG00000060950
Gene NametRNA methyltransferase 61A
Synonyms
Accession Numbers
Is this an essential gene? Probably essential (E-score: 0.949) question?
Stock #IGL01867
Quality Score
Status
Chromosome12
Chromosomal Location111678105-111683902 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to T at 111678716 bp
ZygosityHeterozygous
Amino Acid Change Arginine to Cysteine at position 29 (R29C)
Ref Sequence ENSEMBL: ENSMUSP00000152280 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000084947] [ENSMUST00000168338] [ENSMUST00000221089] [ENSMUST00000222737]
Predicted Effect probably benign
Transcript: ENSMUST00000084947
AA Change: R29C

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000082011
Gene: ENSMUSG00000060950
AA Change: R29C

DomainStartEndE-ValueType
Pfam:GCD14 64 287 3.2e-113 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000168338
AA Change: R29C

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000133128
Gene: ENSMUSG00000060950
AA Change: R29C

DomainStartEndE-ValueType
Pfam:GCD14 64 287 6.2e-110 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000221089
AA Change: R29C

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Predicted Effect probably benign
Transcript: ENSMUST00000222737
AA Change: R29C

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc10 T C 17: 46,324,438 E213G probably benign Het
Akap6 T C 12: 52,888,008 L761P probably damaging Het
Bbs7 A C 3: 36,573,547 L697R probably benign Het
Cd74 G A 18: 60,808,280 R99H probably benign Het
Cpne6 A G 14: 55,513,680 N182S probably benign Het
Cyp4f17 A G 17: 32,528,083 H429R probably benign Het
Dact2 A T 17: 14,195,670 M756K probably damaging Het
Ets1 A G 9: 32,734,159 D234G probably damaging Het
Fam196b A G 11: 34,403,065 E369G probably benign Het
Fat3 A C 9: 16,377,901 S109A probably benign Het
Fras1 G T 5: 96,588,131 M528I probably benign Het
Gm10718 A T 9: 3,025,118 Y194F probably benign Het
Gtf3c1 A G 7: 125,662,376 F1189L probably benign Het
Ift81 A T 5: 122,602,676 probably benign Het
Lag3 A G 6: 124,910,906 S22P probably benign Het
Mos G T 4: 3,870,845 Q324K probably benign Het
Mtx2 T A 2: 74,876,389 V236E probably damaging Het
Naip6 T C 13: 100,300,312 T568A probably benign Het
Olfr175-ps1 A G 16: 58,823,974 F245S probably damaging Het
Olfr780 T C 10: 129,321,716 I31T probably benign Het
Olfr781 T A 10: 129,333,363 L161M probably damaging Het
Olfr794 G A 10: 129,570,827 M57I possibly damaging Het
Olfr920 A C 9: 38,755,898 D70A probably damaging Het
Pcid2 A G 8: 13,078,243 V386A probably benign Het
Pde8b T C 13: 95,100,938 D116G probably damaging Het
Plxnc1 A G 10: 94,798,146 V1365A possibly damaging Het
Prex2 G T 1: 11,098,503 C241F probably benign Het
Prr23a2 A G 9: 98,857,060 E157G probably benign Het
Ptpn4 A T 1: 119,675,599 H836Q probably benign Het
Ptprd C T 4: 76,243,647 R117H probably damaging Het
Rab11fip4 T C 11: 79,683,390 S102P probably benign Het
Slc44a1 G T 4: 53,536,405 V194F probably damaging Het
Synm T A 7: 67,733,474 H1480L probably benign Het
Tmem63a A G 1: 180,956,005 Y175C possibly damaging Het
Ubap1 C T 4: 41,379,236 T150I probably benign Het
Uimc1 T C 13: 55,075,401 M353V probably benign Het
Usp34 T C 11: 23,384,411 M1135T possibly damaging Het
Vmn1r25 A C 6: 57,979,211 L31R probably damaging Het
Wtap T C 17: 12,969,455 E186G probably benign Het
Wwc2 T G 8: 47,883,580 N216H probably benign Het
Zhx1 A T 15: 58,054,445 M135K probably damaging Het
Other mutations in Trmt61a
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0538:Trmt61a UTSW 12 111678927 missense probably damaging 1.00
R4798:Trmt61a UTSW 12 111678713 missense possibly damaging 0.47
R5909:Trmt61a UTSW 12 111680858 missense probably damaging 1.00
R6021:Trmt61a UTSW 12 111680977 missense probably damaging 1.00
R7388:Trmt61a UTSW 12 111678887 missense possibly damaging 0.79
Posted On2014-05-07