Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01868:Vmn2r98'

178585

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r98

Ensembl Gene

ENSMUSG00000096717

Gene Name

vomeronasal 2, receptor 98

Synonyms

EG224552

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.139) question?

Stock #

IGL01868

Quality Score

Status

Chromosome

Chromosomal Location

19053460-19082411 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to T at 19066286 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Valine to Phenylalanine at position 349 (V349F)

Ref Sequence

ENSEMBL: ENSMUSP00000131261 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000170424]

AlphaFold

E9PZ56

Predicted Effect

probably benign
Transcript: ENSMUST00000170424
AA Change: V349F

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000131261
Gene: ENSMUSG00000096717
AA Change: V349F

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	82	460	2.6e-35	PFAM
Pfam:NCD3G	509	562	7.4e-22	PFAM
Pfam:7tm_3	594	830	1.4e-52	PFAM
low complexity region	844	856	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 56 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Afg3l2	G	A	18: 67,414,148	T569M	possibly damaging	Het
Aldh1l1	A	T	6: 90,583,230	K620*	probably null	Het
Amdhd2	G	T	17: 24,157,530	T346K	probably damaging	Het
Arhgap44	T	C	11: 65,012,078	D521G	probably damaging	Het
Ccdc146	C	A	5: 21,333,054	A91S	probably damaging	Het
Ccdc187	C	A	2: 26,280,948	R506L	probably benign	Het
Cd37	T	C	7: 45,236,179	Q128R	probably benign	Het
Cdh22	T	A	2: 165,157,358	M185L	probably damaging	Het
Cib2	A	T	9: 54,548,475	N68K	probably damaging	Het
Ddx46	C	T	13: 55,639,870	R96*	probably null	Het
Dnajc13	A	T	9: 104,162,745	H2050Q	possibly damaging	Het
Duox1	A	G	2: 122,338,407	H1172R	probably benign	Het
Eftud2	C	T	11: 102,869,127	V132I	probably benign	Het
Fcrl5	G	A	3: 87,443,707	D87N	possibly damaging	Het
Gm10718	A	T	9: 3,025,118	Y194F	probably benign	Het
Gm14548	G	A	7: 3,897,175	Q143*	probably null	Het
Gm5862	A	C	5: 26,022,771	W41G	probably benign	Het
Kat6a	T	C	8: 22,926,455	F660L	probably damaging	Het
Lipo2	T	C	19: 33,730,838	M259V	probably benign	Het
Lrrcc1	T	A	3: 14,554,357	L90*	probably null	Het
Lsm1	G	A	8: 25,793,793		probably null	Het
Luzp1	T	C	4: 136,542,737	I757T	probably damaging	Het
Micall1	A	G	15: 79,115,060	I76V	probably benign	Het
Mmp21	A	T	7: 133,675,914	D394E	probably damaging	Het
Mtfr1l	T	C	4: 134,530,707	D68G	probably null	Het
Necab2	A	G	8: 119,462,576	S162G	probably benign	Het
Olfr1186	T	C	2: 88,525,715	V44A	possibly damaging	Het
Olfr429	C	T	1: 174,089,370	T110I	possibly damaging	Het
Olfr64	G	A	7: 103,893,376	R120*	probably null	Het
Olfr96	A	T	17: 37,225,152	Q9L	probably benign	Het
Pde7b	A	T	10: 20,407,165	C376*	probably null	Het
Plcb2	A	G	2: 118,709,590	L1074P	probably damaging	Het
Plcb2	G	T	2: 118,711,387	T914N	probably benign	Het
Prph	C	A	15: 99,056,343	D207E	probably damaging	Het
Prrxl1	C	A	14: 32,608,377	F150L	probably damaging	Het
Rbp4	C	A	19: 38,124,520	R37L	probably damaging	Het
Ryr3	T	C	2: 112,803,158		probably benign	Het
Sardh	T	G	2: 27,227,147	Q496P	probably benign	Het
Serpina1f	T	A	12: 103,693,445	N193Y	probably benign	Het
Slc10a7	G	A	8: 78,697,336		probably null	Het
Spg7	T	C	8: 123,090,236		probably null	Het
Sphkap	T	C	1: 83,280,399		probably null	Het
Tas2r121	T	A	6: 132,700,272	I246L	probably benign	Het
Tbc1d9b	T	C	11: 50,161,633	F889S	probably damaging	Het
Tcp10a	T	C	17: 7,329,864	M140T	possibly damaging	Het
Tctn2	G	A	5: 124,616,528		noncoding transcript	Het
Tfap2b	G	T	1: 19,214,282	R138L	probably damaging	Het
Tnrc18	T	C	5: 142,771,812	T985A	unknown	Het
Treml1	G	A	17: 48,366,007	V211I	probably benign	Het
Ubr4	C	T	4: 139,412,678	Q1191*	probably null	Het
Vim	G	A	2: 13,578,438	R217H	possibly damaging	Het
Vmn2r77	A	G	7: 86,803,016	D468G	probably benign	Het
Vmn2r-ps159	C	T	4: 156,338,254		noncoding transcript	Het
Vwa7	A	T	17: 35,021,259	E401V	probably null	Het
Zfp119b	C	A	17: 55,939,866	V75L	possibly damaging	Het
Zfp287	C	T	11: 62,715,257	E275K	probably benign	Het

Other mutations in Vmn2r98

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00897:Vmn2r98	APN	17	19065745	splice site	probably benign
IGL01296:Vmn2r98	APN	17	19065185	missense	probably damaging	1.00
IGL01363:Vmn2r98	APN	17	19065758	missense	probably benign	0.01
IGL01618:Vmn2r98	APN	17	19065259	missense	possibly damaging	0.93
IGL01746:Vmn2r98	APN	17	19066451	missense	probably damaging	1.00
IGL01747:Vmn2r98	APN	17	19066440	missense	probably damaging	1.00
IGL01770:Vmn2r98	APN	17	19066440	missense	probably damaging	1.00
IGL02123:Vmn2r98	APN	17	19080679	missense	probably damaging	1.00
IGL02323:Vmn2r98	APN	17	19065851	missense	probably damaging	0.99
IGL02543:Vmn2r98	APN	17	19065821	missense	probably benign
IGL02650:Vmn2r98	APN	17	19080961	missense	probably benign	0.00
IGL02676:Vmn2r98	APN	17	19065259	missense	probably benign	0.00
IGL02803:Vmn2r98	APN	17	19066013	missense	probably benign
IGL02807:Vmn2r98	APN	17	19081021	missense	probably damaging	1.00
IGL03307:Vmn2r98	APN	17	19065980	missense	possibly damaging	0.62
IGL03396:Vmn2r98	APN	17	19069845	missense	possibly damaging	0.92
PIT4131001:Vmn2r98	UTSW	17	19080961	missense	probably benign	0.00
R0122:Vmn2r98	UTSW	17	19066400	missense	probably benign	0.06
R0329:Vmn2r98	UTSW	17	19066347	missense	probably benign	0.21
R0330:Vmn2r98	UTSW	17	19066347	missense	probably benign	0.21
R0368:Vmn2r98	UTSW	17	19065827	nonsense	probably null
R0545:Vmn2r98	UTSW	17	19053613	missense	probably benign	0.15
R0635:Vmn2r98	UTSW	17	19080497	missense	probably benign	0.00
R0689:Vmn2r98	UTSW	17	19080520	missense	possibly damaging	0.83
R1035:Vmn2r98	UTSW	17	19080749	missense	possibly damaging	0.90
R1243:Vmn2r98	UTSW	17	19065948	missense	possibly damaging	0.52
R1421:Vmn2r98	UTSW	17	19065178	missense	probably damaging	1.00
R1629:Vmn2r98	UTSW	17	19067383	missense	possibly damaging	0.94
R1643:Vmn2r98	UTSW	17	19080908	missense	probably damaging	1.00
R1795:Vmn2r98	UTSW	17	19066440	missense	probably damaging	1.00
R1958:Vmn2r98	UTSW	17	19066418	missense	possibly damaging	0.70
R1962:Vmn2r98	UTSW	17	19065333	nonsense	probably null
R2165:Vmn2r98	UTSW	17	19081291	missense	unknown
R2238:Vmn2r98	UTSW	17	19065951	missense	probably damaging	1.00
R2252:Vmn2r98	UTSW	17	19080436	missense	probably benign	0.00
R2323:Vmn2r98	UTSW	17	19065819	missense	probably benign	0.18
R2887:Vmn2r98	UTSW	17	19081177	missense	possibly damaging	0.83
R2909:Vmn2r98	UTSW	17	19067402	missense	probably damaging	1.00
R3001:Vmn2r98	UTSW	17	19065863	missense	probably benign	0.01
R3002:Vmn2r98	UTSW	17	19065863	missense	probably benign	0.01
R3003:Vmn2r98	UTSW	17	19065863	missense	probably benign	0.01
R3788:Vmn2r98	UTSW	17	19080625	missense	probably benign	0.31
R4570:Vmn2r98	UTSW	17	19066092	missense	probably benign	0.11
R4706:Vmn2r98	UTSW	17	19069745	missense	probably damaging	1.00
R4723:Vmn2r98	UTSW	17	19066340	missense	probably benign	0.01
R5036:Vmn2r98	UTSW	17	19066157	missense	probably benign	0.00
R5072:Vmn2r98	UTSW	17	19066044	missense	probably benign	0.07
R5121:Vmn2r98	UTSW	17	19053553	missense	probably benign	0.13
R5283:Vmn2r98	UTSW	17	19080719	missense	probably benign	0.05
R5294:Vmn2r98	UTSW	17	19069754	nonsense	probably null
R5371:Vmn2r98	UTSW	17	19069753	missense	probably damaging	1.00
R5532:Vmn2r98	UTSW	17	19067383	missense	possibly damaging	0.94
R5598:Vmn2r98	UTSW	17	19080899	missense	probably benign	0.37
R5800:Vmn2r98	UTSW	17	19065998	missense	probably benign	0.17
R6089:Vmn2r98	UTSW	17	19066074	missense	probably benign	0.29
R6155:Vmn2r98	UTSW	17	19065881	missense	possibly damaging	0.87
R6853:Vmn2r98	UTSW	17	19065801	missense	probably benign	0.00
R6920:Vmn2r98	UTSW	17	19065248	missense	probably damaging	0.98
R7012:Vmn2r98	UTSW	17	19066268	missense	probably benign	0.06
R7042:Vmn2r98	UTSW	17	19080922	missense	probably benign
R7068:Vmn2r98	UTSW	17	19065313	missense	probably benign
R7607:Vmn2r98	UTSW	17	19067308	missense	possibly damaging	0.95
R7763:Vmn2r98	UTSW	17	19080535	missense	probably benign	0.00
R7771:Vmn2r98	UTSW	17	19067198	splice site	probably null
R7915:Vmn2r98	UTSW	17	19067231	missense	probably benign	0.10
R8028:Vmn2r98	UTSW	17	19053650	missense	probably benign	0.00
R8205:Vmn2r98	UTSW	17	19081163	missense	probably damaging	0.99
R8241:Vmn2r98	UTSW	17	19080769	missense	probably damaging	0.99
R8906:Vmn2r98	UTSW	17	19066270	missense	probably benign
R8952:Vmn2r98	UTSW	17	19065269	missense	possibly damaging	0.76
R9147:Vmn2r98	UTSW	17	19066121	missense	probably benign	0.04
R9148:Vmn2r98	UTSW	17	19066121	missense	probably benign	0.04
R9187:Vmn2r98	UTSW	17	19081219	missense	probably damaging	1.00
R9344:Vmn2r98	UTSW	17	19066515	missense	probably benign	0.14
R9467:Vmn2r98	UTSW	17	19067255	missense	probably benign	0.01
R9487:Vmn2r98	UTSW	17	19081234	missense	possibly damaging	0.78
R9753:Vmn2r98	UTSW	17	19065403	missense	probably benign	0.27
Z1177:Vmn2r98	UTSW	17	19065136	critical splice acceptor site	probably null
Z1177:Vmn2r98	UTSW	17	19067423	nonsense	probably null

Posted On

2014-05-07