Incidental Mutation 'IGL01869:Vmn1r60'
| ID |
178651 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Vmn1r60
|
| Ensembl Gene |
ENSMUSG00000090794 |
| Gene Name |
vomeronasal 1 receptor 60 |
| Synonyms |
Gm7184 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.055)
|
| Stock # |
IGL01869
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
7 |
| Chromosomal Location |
5547196-5548098 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 5547228 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Methionine
at position 291
(V291M)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000173782]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000172111
AA Change: V291M
PolyPhen 2
Score 0.055 (Sensitivity: 0.94; Specificity: 0.84)
|
| SMART Domains |
Protein: ENSMUSP00000133113
Gene: ENSMUSG00000090794
AA Change: V291M
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TAS2R
|
1 |
294 |
1.1e-10 |
PFAM |
|
Pfam:7tm_1
|
20 |
280 |
7.3e-12 |
PFAM |
|
Pfam:V1R
|
31 |
299 |
1.3e-18 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000173782
AA Change: V291M
PolyPhen 2
Score 0.047 (Sensitivity: 0.94; Specificity: 0.83)
|
| SMART Domains |
Protein: ENSMUSP00000133943
Gene: ENSMUSG00000090794
AA Change: V291M
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TAS2R
|
8 |
304 |
4.7e-10 |
PFAM |
|
Pfam:7tm_1
|
30 |
289 |
7.2e-6 |
PFAM |
|
Pfam:V1R
|
41 |
309 |
1.8e-17 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 33 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700026F02Rik |
A |
G |
8: 71,495,689 (GRCm39) |
|
noncoding transcript |
Het |
| Adam29 |
T |
C |
8: 56,324,732 (GRCm39) |
H574R |
probably damaging |
Het |
| Arap1 |
C |
A |
7: 101,049,490 (GRCm39) |
T984K |
probably damaging |
Het |
| Ccdc146 |
A |
T |
5: 21,521,837 (GRCm39) |
S396T |
probably benign |
Het |
| Col6a3 |
T |
C |
1: 90,700,770 (GRCm39) |
K2587E |
unknown |
Het |
| Cyp3a44 |
A |
G |
5: 145,727,496 (GRCm39) |
S278P |
probably damaging |
Het |
| Daw1 |
T |
G |
1: 83,159,965 (GRCm39) |
|
probably benign |
Het |
| Dnah17 |
T |
C |
11: 117,943,502 (GRCm39) |
K3200R |
probably benign |
Het |
| Efhd2 |
A |
G |
4: 141,601,913 (GRCm39) |
F89S |
probably damaging |
Het |
| Fras1 |
A |
G |
5: 96,856,642 (GRCm39) |
|
probably benign |
Het |
| Ggps1 |
T |
C |
13: 14,228,979 (GRCm39) |
D68G |
probably damaging |
Het |
| Gm10718 |
A |
T |
9: 3,025,118 (GRCm39) |
Y194F |
probably benign |
Het |
| Gm21738 |
G |
A |
14: 19,416,979 (GRCm38) |
S144L |
probably benign |
Het |
| Gm3604 |
A |
T |
13: 62,517,954 (GRCm39) |
C134S |
probably damaging |
Het |
| Gpaa1 |
A |
G |
15: 76,217,198 (GRCm39) |
T178A |
probably benign |
Het |
| Lama3 |
A |
G |
18: 12,657,820 (GRCm39) |
N312S |
possibly damaging |
Het |
| Npepps |
T |
C |
11: 97,126,948 (GRCm39) |
I437M |
probably damaging |
Het |
| Or10q12 |
A |
G |
19: 13,746,534 (GRCm39) |
D276G |
probably benign |
Het |
| Or11i1 |
C |
T |
3: 106,729,342 (GRCm39) |
D178N |
probably benign |
Het |
| Rcor1 |
C |
A |
12: 111,070,193 (GRCm39) |
T330K |
possibly damaging |
Het |
| Sbno2 |
A |
G |
10: 79,896,226 (GRCm39) |
|
probably null |
Het |
| Sema3g |
A |
G |
14: 30,945,624 (GRCm39) |
E478G |
probably damaging |
Het |
| Smg9 |
A |
G |
7: 24,115,949 (GRCm39) |
D280G |
probably damaging |
Het |
| Smtnl1 |
A |
T |
2: 84,641,741 (GRCm39) |
*460R |
probably null |
Het |
| Syde1 |
A |
G |
10: 78,424,753 (GRCm39) |
C360R |
possibly damaging |
Het |
| Szt2 |
A |
G |
4: 118,256,268 (GRCm39) |
V197A |
possibly damaging |
Het |
| Tnrc6c |
T |
C |
11: 117,646,274 (GRCm39) |
V1405A |
possibly damaging |
Het |
| Ttbk1 |
A |
G |
17: 46,757,989 (GRCm39) |
S882P |
probably damaging |
Het |
| Tubgcp4 |
T |
A |
2: 121,006,269 (GRCm39) |
H116Q |
possibly damaging |
Het |
| Vmn1r192 |
T |
A |
13: 22,371,750 (GRCm39) |
N157Y |
probably damaging |
Het |
| Vmn2r129 |
C |
T |
4: 156,690,549 (GRCm39) |
|
noncoding transcript |
Het |
| Xpo5 |
C |
T |
17: 46,553,133 (GRCm39) |
P1184L |
possibly damaging |
Het |
| Zfp946 |
T |
G |
17: 22,673,684 (GRCm39) |
I146S |
probably benign |
Het |
|
| Other mutations in Vmn1r60 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01892:Vmn1r60
|
APN |
7 |
5,547,309 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL02427:Vmn1r60
|
APN |
7 |
5,547,780 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03071:Vmn1r60
|
APN |
7 |
5,547,368 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R0200:Vmn1r60
|
UTSW |
7 |
5,547,379 (GRCm39) |
missense |
probably benign |
|
|
R0457:Vmn1r60
|
UTSW |
7 |
5,548,118 (GRCm39) |
start gained |
probably benign |
|
|
R1175:Vmn1r60
|
UTSW |
7 |
5,547,621 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1199:Vmn1r60
|
UTSW |
7 |
5,547,971 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1529:Vmn1r60
|
UTSW |
7 |
5,547,902 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1859:Vmn1r60
|
UTSW |
7 |
5,547,549 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R2033:Vmn1r60
|
UTSW |
7 |
5,547,819 (GRCm39) |
missense |
probably benign |
|
|
R2405:Vmn1r60
|
UTSW |
7 |
5,547,912 (GRCm39) |
missense |
probably benign |
|
|
R3408:Vmn1r60
|
UTSW |
7 |
5,548,148 (GRCm39) |
splice site |
probably null |
|
|
R3771:Vmn1r60
|
UTSW |
7 |
5,547,710 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R3773:Vmn1r60
|
UTSW |
7 |
5,547,710 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R3852:Vmn1r60
|
UTSW |
7 |
5,548,026 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R4236:Vmn1r60
|
UTSW |
7 |
5,547,803 (GRCm39) |
missense |
probably benign |
0.06 |
|
R4331:Vmn1r60
|
UTSW |
7 |
5,547,364 (GRCm39) |
nonsense |
probably null |
|
|
R4439:Vmn1r60
|
UTSW |
7 |
5,547,488 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5099:Vmn1r60
|
UTSW |
7 |
5,547,816 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5325:Vmn1r60
|
UTSW |
7 |
5,547,201 (GRCm39) |
missense |
probably benign |
|
|
R5415:Vmn1r60
|
UTSW |
7 |
5,547,416 (GRCm39) |
missense |
probably benign |
0.38 |
|
R5818:Vmn1r60
|
UTSW |
7 |
5,548,098 (GRCm39) |
start codon destroyed |
probably benign |
0.04 |
|
R6375:Vmn1r60
|
UTSW |
7 |
5,548,017 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6378:Vmn1r60
|
UTSW |
7 |
5,547,782 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6478:Vmn1r60
|
UTSW |
7 |
5,547,864 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6572:Vmn1r60
|
UTSW |
7 |
5,547,599 (GRCm39) |
missense |
probably benign |
0.40 |
|
R6586:Vmn1r60
|
UTSW |
7 |
5,547,446 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7061:Vmn1r60
|
UTSW |
7 |
5,547,310 (GRCm39) |
nonsense |
probably null |
|
|
R7506:Vmn1r60
|
UTSW |
7 |
5,547,861 (GRCm39) |
missense |
|
|
|
R7589:Vmn1r60
|
UTSW |
7 |
5,547,688 (GRCm39) |
missense |
|
|
|
R8182:Vmn1r60
|
UTSW |
7 |
5,547,876 (GRCm39) |
missense |
|
|
|
R9295:Vmn1r60
|
UTSW |
7 |
5,547,218 (GRCm39) |
missense |
probably null |
|
|
R9408:Vmn1r60
|
UTSW |
7 |
5,547,918 (GRCm39) |
missense |
|
|
|
| Posted On |
2014-05-07 |
Incidental Mutation