Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01870:Lrrc25'

178684

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Lrrc25

Ensembl Gene

ENSMUSG00000049988

Gene Name

leucine rich repeat containing 25

Synonyms

Mapa

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.082) question?

Stock #

IGL01870

Quality Score

Status

Chromosome

Chromosomal Location

71068810-71073501 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 71070437 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 73 (S73P)

Ref Sequence

ENSEMBL: ENSMUSP00000049686 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000052437] [ENSMUST00000210609]

AlphaFold

Q8K1T1

Predicted Effect

possibly damaging
Transcript: ENSMUST00000052437
AA Change: S73P

PolyPhen 2 Score 0.827 (Sensitivity: 0.84; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000049686
Gene: ENSMUSG00000049988
AA Change: S73P

Domain	Start	End	E-Value	Type
signal peptide	1	25	N/A	INTRINSIC
low complexity region	51	62	N/A	INTRINSIC
Pfam:LRR_8	65	110	9.6e-8	PFAM
transmembrane domain	169	191	N/A	INTRINSIC
low complexity region	192	199	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000210609

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000211053

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 32 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Agtr1a	A	G	13: 30,565,310 (GRCm39)	D125G	probably damaging	Het
Arhgap31	T	C	16: 38,438,604 (GRCm39)	K300E	probably damaging	Het
Cma2	C	A	14: 56,211,194 (GRCm39)	S162Y	probably benign	Het
Cntn4	A	G	6: 106,466,676 (GRCm39)	T193A	possibly damaging	Het
Col22a1	T	A	15: 71,824,377 (GRCm39)	M556L	probably benign	Het
Dld	A	G	12: 31,385,466 (GRCm39)	S292P	possibly damaging	Het
Dnah6	A	T	6: 73,009,552 (GRCm39)	D3746E	probably benign	Het
Eea1	A	G	10: 95,809,848 (GRCm39)	T9A	probably damaging	Het
Eeig1	T	C	2: 32,456,294 (GRCm39)	S319P	probably benign	Het
Gbf1	A	G	19: 46,274,108 (GRCm39)	K1714R	probably benign	Het
Gm10718	A	T	9: 3,025,118 (GRCm39)	Y194F	probably benign	Het
H2-M1	A	T	17: 36,980,955 (GRCm39)	M327K	probably benign	Het
Ifnz	T	A	4: 88,701,548 (GRCm39)	S176T	possibly damaging	Het
Irak4	T	C	15: 94,445,751 (GRCm39)	Y10H	probably benign	Het
Irx5	T	C	8: 93,086,405 (GRCm39)	F163L	probably damaging	Het
Jak3	C	T	8: 72,133,434 (GRCm39)	P376S	probably damaging	Het
Macf1	C	T	4: 123,367,906 (GRCm39)	G2285D	probably damaging	Het
Muc4	A	T	16: 32,574,624 (GRCm39)	T1025S	probably benign	Het
Mylk2	A	G	2: 152,757,134 (GRCm39)	N303S	probably benign	Het
Or5v1b	G	A	17: 37,841,555 (GRCm39)	R229H	probably benign	Het
Pcnx1	T	C	12: 82,022,667 (GRCm39)	V1512A	probably benign	Het
Phlda3	A	G	1: 135,694,376 (GRCm39)	S64G	probably benign	Het
Pptc7	C	A	5: 122,451,665 (GRCm39)	S40R	probably damaging	Het
Pramel19	T	A	4: 101,797,887 (GRCm39)	L95H	probably benign	Het
Ptpn4	A	C	1: 119,603,277 (GRCm39)		probably null	Het
Slc10a1	T	C	12: 81,007,302 (GRCm39)	M160V	probably benign	Het
Stac	T	C	9: 111,401,400 (GRCm39)	I349V	probably benign	Het
Synm	A	G	7: 67,385,866 (GRCm39)	S157P	possibly damaging	Het
Tbc1d9b	T	C	11: 50,052,915 (GRCm39)	L924P	probably damaging	Het
Tcaf2	C	T	6: 42,601,411 (GRCm39)	V883I	possibly damaging	Het
Upp1	T	C	11: 9,075,700 (GRCm39)		probably null	Het
Whamm	C	T	7: 81,245,722 (GRCm39)	T726I	probably damaging	Het

Other mutations in Lrrc25

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02263:Lrrc25	APN	8	71,070,472 (GRCm39)	missense	probably benign	0.27
IGL02354:Lrrc25	APN	8	71,070,477 (GRCm39)	missense	probably benign
IGL02361:Lrrc25	APN	8	71,070,477 (GRCm39)	missense	probably benign
R0320:Lrrc25	UTSW	8	71,070,896 (GRCm39)	missense	probably benign	0.00
R1863:Lrrc25	UTSW	8	71,070,596 (GRCm39)	missense	possibly damaging	0.83
R4816:Lrrc25	UTSW	8	71,070,726 (GRCm39)	missense	probably benign
R6696:Lrrc25	UTSW	8	71,071,015 (GRCm39)	critical splice donor site	probably null
R7169:Lrrc25	UTSW	8	71,070,437 (GRCm39)	missense	probably benign	0.27
R7394:Lrrc25	UTSW	8	71,070,830 (GRCm39)	missense	possibly damaging	0.60
R7958:Lrrc25	UTSW	8	71,070,497 (GRCm39)	missense	possibly damaging	0.66
R8681:Lrrc25	UTSW	8	71,070,314 (GRCm39)	missense	possibly damaging	0.46
R8708:Lrrc25	UTSW	8	71,070,459 (GRCm39)	missense	probably damaging	0.97
R8778:Lrrc25	UTSW	8	71,070,242 (GRCm39)	missense	possibly damaging	0.66
R9281:Lrrc25	UTSW	8	71,073,246 (GRCm39)	missense	probably benign	0.04

Posted On

2014-05-07