Incidental Mutation 'IGL01870:Ifnz'
ID178694
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ifnz
Ensembl Gene ENSMUSG00000096854
Gene Nameinterferon zeta
Synonyms6030405N23Rik, Lmtn, BGIF
Accession Numbers
Is this an essential gene? Not available question?
Stock #IGL01870
Quality Score
Status
Chromosome4
Chromosomal Location88782131-88783592 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 88783311 bp
ZygosityHeterozygous
Amino Acid Change Serine to Threonine at position 176 (S176T)
Ref Sequence ENSEMBL: ENSMUSP00000100775 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000105144] [ENSMUST00000179372] [ENSMUST00000179425]
Predicted Effect possibly damaging
Transcript: ENSMUST00000105144
AA Change: S176T

PolyPhen 2 Score 0.780 (Sensitivity: 0.85; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000100775
Gene: ENSMUSG00000096854
AA Change: S176T

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
IFabd 58 170 1.18e-12 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000179372
SMART Domains Protein: ENSMUSP00000140435
Gene: ENSMUSG00000099545

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
IFabd 58 170 4.8e-13 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000179425
SMART Domains Protein: ENSMUSP00000135918
Gene: ENSMUSG00000096591

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
IFabd 58 170 2.91e-12 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000180666
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Agtr1a A G 13: 30,381,327 D125G probably damaging Het
Arhgap31 T C 16: 38,618,242 K300E probably damaging Het
Cma2 C A 14: 55,973,737 S162Y probably benign Het
Cntn4 A G 6: 106,489,715 T193A possibly damaging Het
Col22a1 T A 15: 71,952,528 M556L probably benign Het
Dld A G 12: 31,335,467 S292P possibly damaging Het
Dnah6 A T 6: 73,032,569 D3746E probably benign Het
Eea1 A G 10: 95,973,986 T9A probably damaging Het
Fam102a T C 2: 32,566,282 S319P probably benign Het
Gbf1 A G 19: 46,285,669 K1714R probably benign Het
Gm10718 A T 9: 3,025,118 Y194F probably benign Het
Gm12794 T A 4: 101,940,690 L95H probably benign Het
H2-M1 A T 17: 36,670,063 M327K probably benign Het
Irak4 T C 15: 94,547,870 Y10H probably benign Het
Irx5 T C 8: 92,359,777 F163L probably damaging Het
Jak3 C T 8: 71,680,790 P376S probably damaging Het
Lrrc25 T C 8: 70,617,787 S73P possibly damaging Het
Macf1 C T 4: 123,474,113 G2285D probably damaging Het
Muc4 A T 16: 32,753,196 T1025S probably benign Het
Mylk2 A G 2: 152,915,214 N303S probably benign Het
Olfr111 G A 17: 37,530,664 R229H probably benign Het
Pcnx T C 12: 81,975,893 V1512A probably benign Het
Phlda3 A G 1: 135,766,638 S64G probably benign Het
Pptc7 C A 5: 122,313,602 S40R probably damaging Het
Ptpn4 A C 1: 119,675,547 probably null Het
Slc10a1 T C 12: 80,960,528 M160V probably benign Het
Stac T C 9: 111,572,332 I349V probably benign Het
Synm A G 7: 67,736,118 S157P possibly damaging Het
Tbc1d9b T C 11: 50,162,088 L924P probably damaging Het
Tcaf2 C T 6: 42,624,477 V883I possibly damaging Het
Upp1 T C 11: 9,125,700 probably null Het
Whamm C T 7: 81,595,974 T726I probably damaging Het
Other mutations in Ifnz
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01374:Ifnz APN 4 88783341 unclassified probably benign
IGL02705:Ifnz APN 4 88783337 unclassified probably benign
Posted On2014-05-07