Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01873:Cyp2c69'

178793

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Cyp2c69

Ensembl Gene

ENSMUSG00000092008

Gene Name

cytochrome P450, family 2, subfamily c, polypeptide 69

Synonyms

AI098658

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.067) question?

Stock #

IGL01873

Quality Score

Status

Chromosome

Chromosomal Location

39831258-39875243 bp(-) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

A to G at 39869693 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000132832 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000168838]

AlphaFold

E9PXC3

Predicted Effect

probably benign
Transcript: ENSMUST00000168838

SMART Domains

Protein: ENSMUSP00000132832
Gene: ENSMUSG00000092008

Domain	Start	End	E-Value	Type
signal peptide	1	25	N/A	INTRINSIC
Pfam:p450	30	487	7e-152	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 26 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Chd9	A	G	8: 91,660,395 (GRCm39)	T452A	probably benign	Het
Coq8a	T	A	1: 180,006,542 (GRCm39)	Q115L	probably damaging	Het
Cul9	T	C	17: 46,813,378 (GRCm39)	E2326G	probably damaging	Het
Dennd5b	A	T	6: 148,946,027 (GRCm39)	M528K	probably benign	Het
Gm10717	C	T	9: 3,025,616 (GRCm39)	S67L	probably benign	Het
Gm21738	G	A	14: 19,416,979 (GRCm38)	S144L	probably benign	Het
Gm5862	A	C	5: 26,227,769 (GRCm39)	W41G	probably benign	Het
Gm6665	T	C	18: 31,953,355 (GRCm39)	S38G	probably damaging	Het
Gsg1l	A	G	7: 125,557,615 (GRCm39)	V171A	probably damaging	Het
Ighv5-2	A	T	12: 113,542,350 (GRCm39)	S42T	probably benign	Het
Itch	C	T	2: 155,010,670 (GRCm39)	T46I	possibly damaging	Het
Itsn2	T	G	12: 4,682,366 (GRCm39)		probably benign	Het
Lime1	T	C	2: 181,024,667 (GRCm39)	V107A	probably benign	Het
Mertk	T	C	2: 128,571,195 (GRCm39)	S50P	possibly damaging	Het
Myo5b	T	A	18: 74,713,467 (GRCm39)	V104E	probably damaging	Het
Nckap1	A	T	2: 80,383,729 (GRCm39)	I145K	possibly damaging	Het
Ppp4r3a	A	T	12: 101,008,094 (GRCm39)	I794N	possibly damaging	Het
Psapl1	C	A	5: 36,362,569 (GRCm39)	P387Q	possibly damaging	Het
Ripk1	T	A	13: 34,193,707 (GRCm39)	L23Q	probably damaging	Het
Srrm4	G	T	5: 116,729,527 (GRCm39)		probably benign	Het
St6galnac1	T	A	11: 116,657,437 (GRCm39)	T376S	probably damaging	Het
Tmem74	T	C	15: 43,730,782 (GRCm39)	D87G	probably benign	Het
Trav19	A	G	14: 54,083,173 (GRCm39)	R83G	probably benign	Het
Tubgcp4	T	C	2: 121,018,665 (GRCm39)		probably null	Het
Vmn2r129	C	T	4: 156,690,549 (GRCm39)		noncoding transcript	Het
Zfat	T	C	15: 68,096,744 (GRCm39)	N23S	probably benign	Het

Other mutations in Cyp2c69

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02127:Cyp2c69	APN	19	39,839,501 (GRCm39)	missense	probably damaging	0.99
IGL02945:Cyp2c69	APN	19	39,875,091 (GRCm39)	missense	possibly damaging	0.81
IGL03067:Cyp2c69	APN	19	39,869,537 (GRCm39)	missense	probably benign	0.29
IGL03069:Cyp2c69	APN	19	39,869,537 (GRCm39)	missense	probably benign	0.29
BB007:Cyp2c69	UTSW	19	39,831,434 (GRCm39)	missense	possibly damaging	0.47
BB017:Cyp2c69	UTSW	19	39,831,434 (GRCm39)	missense	possibly damaging	0.47
R0545:Cyp2c69	UTSW	19	39,875,105 (GRCm39)	missense	probably damaging	1.00
R1276:Cyp2c69	UTSW	19	39,864,668 (GRCm39)	missense	possibly damaging	0.47
R1468:Cyp2c69	UTSW	19	39,837,839 (GRCm39)	missense	probably damaging	1.00
R1468:Cyp2c69	UTSW	19	39,837,839 (GRCm39)	missense	probably damaging	1.00
R1534:Cyp2c69	UTSW	19	39,839,593 (GRCm39)	missense	probably benign
R1549:Cyp2c69	UTSW	19	39,831,430 (GRCm39)	missense	probably benign	0.11
R1703:Cyp2c69	UTSW	19	39,864,810 (GRCm39)	missense	probably benign	0.10
R1752:Cyp2c69	UTSW	19	39,869,597 (GRCm39)	missense	probably damaging	1.00
R1769:Cyp2c69	UTSW	19	39,864,815 (GRCm39)	missense	probably benign	0.00
R1843:Cyp2c69	UTSW	19	39,865,972 (GRCm39)	missense	probably benign	0.27
R1938:Cyp2c69	UTSW	19	39,837,810 (GRCm39)	missense	probably damaging	0.97
R2100:Cyp2c69	UTSW	19	39,875,130 (GRCm39)	missense	probably benign	0.11
R2366:Cyp2c69	UTSW	19	39,866,038 (GRCm39)	missense	probably benign	0.12
R2367:Cyp2c69	UTSW	19	39,866,038 (GRCm39)	missense	probably benign	0.12
R2440:Cyp2c69	UTSW	19	39,864,738 (GRCm39)	missense	probably benign	0.17
R2931:Cyp2c69	UTSW	19	39,837,927 (GRCm39)	missense	probably damaging	1.00
R3709:Cyp2c69	UTSW	19	39,839,667 (GRCm39)	splice site	probably benign
R3793:Cyp2c69	UTSW	19	39,869,600 (GRCm39)	missense	probably benign	0.44
R3898:Cyp2c69	UTSW	19	39,864,834 (GRCm39)	missense	probably benign	0.00
R4579:Cyp2c69	UTSW	19	39,869,630 (GRCm39)	missense	possibly damaging	0.89
R4707:Cyp2c69	UTSW	19	39,837,852 (GRCm39)	missense	probably benign	0.39
R4778:Cyp2c69	UTSW	19	39,866,038 (GRCm39)	missense	probably benign	0.12
R4779:Cyp2c69	UTSW	19	39,866,038 (GRCm39)	missense	probably benign	0.12
R4780:Cyp2c69	UTSW	19	39,866,038 (GRCm39)	missense	probably benign	0.12
R4838:Cyp2c69	UTSW	19	39,866,038 (GRCm39)	missense	probably benign	0.12
R4877:Cyp2c69	UTSW	19	39,866,056 (GRCm39)	missense	probably damaging	1.00
R5488:Cyp2c69	UTSW	19	39,839,603 (GRCm39)	missense	probably null	0.94
R5489:Cyp2c69	UTSW	19	39,839,603 (GRCm39)	missense	probably null	0.94
R6083:Cyp2c69	UTSW	19	39,837,900 (GRCm39)	missense	probably damaging	1.00
R6278:Cyp2c69	UTSW	19	39,831,507 (GRCm39)	nonsense	probably null
R6415:Cyp2c69	UTSW	19	39,831,365 (GRCm39)	missense	probably benign	0.44
R6732:Cyp2c69	UTSW	19	39,869,943 (GRCm39)	missense	probably benign
R6858:Cyp2c69	UTSW	19	39,866,009 (GRCm39)	missense	probably benign	0.19
R7023:Cyp2c69	UTSW	19	39,865,986 (GRCm39)	missense	probably benign	0.43
R7227:Cyp2c69	UTSW	19	39,869,610 (GRCm39)	missense	possibly damaging	0.77
R7228:Cyp2c69	UTSW	19	39,869,610 (GRCm39)	missense	possibly damaging	0.77
R7260:Cyp2c69	UTSW	19	39,831,344 (GRCm39)	missense	probably benign	0.00
R7262:Cyp2c69	UTSW	19	39,875,176 (GRCm39)	start gained	probably benign
R7479:Cyp2c69	UTSW	19	39,870,001 (GRCm39)	missense	probably benign	0.00
R7570:Cyp2c69	UTSW	19	39,848,342 (GRCm39)	missense	probably damaging	1.00
R7663:Cyp2c69	UTSW	19	39,865,953 (GRCm39)	nonsense	probably null
R7785:Cyp2c69	UTSW	19	39,839,610 (GRCm39)	missense	probably damaging	1.00
R7795:Cyp2c69	UTSW	19	39,864,663 (GRCm39)	missense	probably benign
R7920:Cyp2c69	UTSW	19	39,866,247 (GRCm39)	splice site	probably null
R7930:Cyp2c69	UTSW	19	39,831,434 (GRCm39)	missense	possibly damaging	0.47
R8203:Cyp2c69	UTSW	19	39,869,584 (GRCm39)	missense	probably damaging	1.00
R8888:Cyp2c69	UTSW	19	39,869,910 (GRCm39)	missense	possibly damaging	0.65
R8895:Cyp2c69	UTSW	19	39,869,910 (GRCm39)	missense	possibly damaging	0.65
R9530:Cyp2c69	UTSW	19	39,848,311 (GRCm39)	missense	possibly damaging	0.82
R9645:Cyp2c69	UTSW	19	39,869,593 (GRCm39)	missense	probably damaging	1.00
R9665:Cyp2c69	UTSW	19	39,839,504 (GRCm39)	missense	possibly damaging	0.73
R9753:Cyp2c69	UTSW	19	39,865,991 (GRCm39)	missense	probably benign	0.44

Posted On

2014-05-07