Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01874:Niban2'

178840

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Niban2

Ensembl Gene

ENSMUSG00000026796

Gene Name

niban apoptosis regulator 2

Synonyms

9130404D14Rik, Fam129b

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.200) question?

Stock #

IGL01874

Quality Score

Status

Chromosome

Chromosomal Location

32766146-32815265 bp(+) (GRCm39)

Type of Mutation

critical splice acceptor site

DNA Base Change (assembly)

A to T at 32795779 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000114232 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000028135] [ENSMUST00000028135] [ENSMUST00000028135] [ENSMUST00000138781]

AlphaFold

Q8R1F1

Predicted Effect

probably null
Transcript: ENSMUST00000028135

SMART Domains

Protein: ENSMUSP00000028135
Gene: ENSMUSG00000026796

Domain	Start	End	E-Value	Type
PH	69	194	1.81e-2	SMART
low complexity region	594	607	N/A	INTRINSIC
low complexity region	685	700	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000028135

SMART Domains

Protein: ENSMUSP00000028135
Gene: ENSMUSG00000026796

Domain	Start	End	E-Value	Type
PH	69	194	1.81e-2	SMART
low complexity region	594	607	N/A	INTRINSIC
low complexity region	685	700	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000028135

SMART Domains

Protein: ENSMUSP00000028135
Gene: ENSMUSG00000026796

Domain	Start	End	E-Value	Type
PH	69	194	1.81e-2	SMART
low complexity region	594	607	N/A	INTRINSIC
low complexity region	685	700	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000138781

SMART Domains

Protein: ENSMUSP00000114232
Gene: ENSMUSG00000026796

Domain	Start	End	E-Value	Type
Blast:PH	53	83	2e-15	BLAST

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 48 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adamts16	A	T	13: 70,916,823 (GRCm39)	V723D	possibly damaging	Het
Adgrb1	G	A	15: 74,413,423 (GRCm39)	V536I	possibly damaging	Het
Aox4	T	C	1: 58,291,243 (GRCm39)	L787S	probably damaging	Het
Atp2c1	A	C	9: 105,326,024 (GRCm39)	V293G	probably damaging	Het
Ccnb1	T	C	13: 100,920,001 (GRCm39)	D170G	probably damaging	Het
Cdc42	T	C	4: 137,063,381 (GRCm39)	I4V	probably benign	Het
Clip1	T	C	5: 123,741,729 (GRCm39)	Q1175R	possibly damaging	Het
Cox6a1	A	G	5: 115,483,904 (GRCm39)	*113Q	probably null	Het
Crtc2	C	T	3: 90,165,815 (GRCm39)	P139L	probably damaging	Het
Cyp8b1	A	T	9: 121,744,969 (GRCm39)	M121K	possibly damaging	Het
D630003M21Rik	C	A	2: 158,046,644 (GRCm39)	G778C	probably damaging	Het
Dgat1	A	G	15: 76,387,241 (GRCm39)	F349L	probably damaging	Het
Enox1	A	G	14: 77,816,602 (GRCm39)	Y194C	probably damaging	Het
Fam120b	T	A	17: 15,623,301 (GRCm39)	C426*	probably null	Het
Fxyd3	A	G	7: 30,770,318 (GRCm39)		probably benign	Het
Gin1	A	G	1: 97,710,797 (GRCm39)	Y160C	probably damaging	Het
Gm10718	A	T	9: 3,025,118 (GRCm39)	Y194F	probably benign	Het
Gm11110	T	A	17: 57,399,693 (GRCm39)		probably benign	Het
Gm1818	T	C	12: 48,602,973 (GRCm39)		noncoding transcript	Het
Gucy1a2	T	C	9: 3,797,343 (GRCm39)	S598P	probably damaging	Het
Hook3	T	A	8: 26,529,760 (GRCm39)	N199Y	possibly damaging	Het
Il10ra	A	G	9: 45,178,458 (GRCm39)	L41P	probably damaging	Het
Itgam	C	T	7: 127,714,338 (GRCm39)	T949I	probably damaging	Het
Kctd3	A	G	1: 188,729,188 (GRCm39)	V123A	probably damaging	Het
Krt84	G	A	15: 101,436,239 (GRCm39)	A450V	probably damaging	Het
Lrrc7	G	A	3: 157,946,080 (GRCm39)		probably benign	Het
Nckap1	A	G	2: 80,355,980 (GRCm39)	F608L	probably damaging	Het
Nmbr	A	T	10: 14,642,696 (GRCm39)	Y85F	probably benign	Het
Nol6	A	C	4: 41,115,412 (GRCm39)	L1135R	probably damaging	Het
Ntan1	T	C	16: 13,653,077 (GRCm39)	F278L	probably benign	Het
Or2n1e	T	A	17: 38,586,408 (GRCm39)	S249T	probably benign	Het
Pcsk5	T	A	19: 17,573,041 (GRCm39)	T474S	probably damaging	Het
Pex11b	T	A	3: 96,550,883 (GRCm39)		probably null	Het
Pkhd1	G	T	1: 20,173,459 (GRCm39)	A3786E	probably benign	Het
Prkdc	T	C	16: 15,552,858 (GRCm39)	I2098T	possibly damaging	Het
Prl2c5	T	A	13: 13,365,362 (GRCm39)	S169R	probably benign	Het
Ptbp2	A	G	3: 119,541,449 (GRCm39)	V196A	probably damaging	Het
Rad17	T	C	13: 100,754,192 (GRCm39)		probably benign	Het
Skic2	T	C	17: 35,060,185 (GRCm39)	N114D	probably benign	Het
Slc47a2	T	A	11: 61,203,685 (GRCm39)		probably null	Het
Srcin1	A	T	11: 97,423,924 (GRCm39)	M684K	possibly damaging	Het
Sspo	T	A	6: 48,429,124 (GRCm39)	C298S	probably damaging	Het
Tenm3	G	T	8: 48,689,793 (GRCm39)	Y1915*	probably null	Het
Tnks1bp1	A	G	2: 84,888,791 (GRCm39)	T373A	probably benign	Het
Trp63	A	C	16: 25,701,335 (GRCm39)	N470H	possibly damaging	Het
Ttn	T	C	2: 76,628,907 (GRCm39)	N12703S	probably damaging	Het
Ubr4	T	C	4: 139,120,600 (GRCm39)		probably benign	Het
Vmn2r56	T	A	7: 12,449,602 (GRCm39)	Y212F	probably benign	Het

Other mutations in Niban2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00543:Niban2	APN	2	32,802,483 (GRCm39)	missense	probably benign	0.04
IGL01072:Niban2	APN	2	32,802,427 (GRCm39)	unclassified	probably benign
IGL02302:Niban2	APN	2	32,811,135 (GRCm39)	missense	probably benign
IGL02681:Niban2	APN	2	32,801,402 (GRCm39)	missense	probably benign	0.05
IGL03126:Niban2	APN	2	32,766,398 (GRCm39)	missense	possibly damaging	0.95
IGL03240:Niban2	APN	2	32,812,109 (GRCm39)	missense	probably benign	0.00
R0125:Niban2	UTSW	2	32,813,833 (GRCm39)	missense	probably benign	0.17
R0948:Niban2	UTSW	2	32,812,872 (GRCm39)	missense	probably damaging	1.00
R1195:Niban2	UTSW	2	32,809,815 (GRCm39)	missense	probably benign
R1195:Niban2	UTSW	2	32,809,815 (GRCm39)	missense	probably benign
R1195:Niban2	UTSW	2	32,809,815 (GRCm39)	missense	probably benign
R2130:Niban2	UTSW	2	32,813,659 (GRCm39)	missense	probably benign	0.34
R2408:Niban2	UTSW	2	32,813,482 (GRCm39)	missense	probably damaging	1.00
R4881:Niban2	UTSW	2	32,812,590 (GRCm39)	nonsense	probably null
R5506:Niban2	UTSW	2	32,810,994 (GRCm39)	missense	probably damaging	0.96
R5748:Niban2	UTSW	2	32,809,581 (GRCm39)	missense	probably damaging	1.00
R5857:Niban2	UTSW	2	32,799,920 (GRCm39)	missense	probably benign	0.28
R6011:Niban2	UTSW	2	32,812,877 (GRCm39)	missense	probably damaging	0.99
R6088:Niban2	UTSW	2	32,813,135 (GRCm39)	missense	probably damaging	1.00
R6720:Niban2	UTSW	2	32,795,838 (GRCm39)	missense	probably damaging	1.00
R6763:Niban2	UTSW	2	32,801,460 (GRCm39)	critical splice donor site	probably null
R6769:Niban2	UTSW	2	32,785,666 (GRCm39)
R7296:Niban2	UTSW	2	32,812,654 (GRCm39)	missense	possibly damaging	0.74
R7769:Niban2	UTSW	2	32,809,844 (GRCm39)	missense	possibly damaging	0.93
R7888:Niban2	UTSW	2	32,812,137 (GRCm39)	nonsense	probably null
R8282:Niban2	UTSW	2	32,809,029 (GRCm39)	missense	probably benign	0.02
R8685:Niban2	UTSW	2	32,809,101 (GRCm39)	missense	probably benign	0.03
R8729:Niban2	UTSW	2	32,799,946 (GRCm39)	missense	probably damaging	1.00
R8878:Niban2	UTSW	2	32,811,105 (GRCm39)	missense	probably benign	0.00
R8916:Niban2	UTSW	2	32,811,106 (GRCm39)	missense	possibly damaging	0.47
R9676:Niban2	UTSW	2	32,802,581 (GRCm39)	missense	probably benign	0.00
R9772:Niban2	UTSW	2	32,795,868 (GRCm39)	missense	probably damaging	1.00

Posted On

2014-05-07