Incidental Mutation 'IGL01876:Olfr1222'
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ID178911
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr1222
Ensembl Gene ENSMUSG00000075101
Gene Nameolfactory receptor 1222
SynonymsMOR233-14, GA_x6K02T2Q125-50604368-50603433
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.076) question?
Stock #IGL01876
Quality Score
Status
Chromosome2
Chromosomal Location89122885-89133054 bp(-) (GRCm38)
Type of Mutationsplice site
DNA Base Change (assembly) A to T at 89125737 bp
ZygosityHeterozygous
Amino Acid Change
Gene Model predicted gene model for transcript(s): [ENSMUST00000099794] [ENSMUST00000214027] [ENSMUST00000215816]
Predicted Effect probably null
Transcript: ENSMUST00000099794
SMART Domains Protein: ENSMUSP00000097382
Gene: ENSMUSG00000075101

DomainStartEndE-ValueType
Pfam:7tm_4 29 303 1.3e-44 PFAM
Pfam:7tm_1 39 286 4.8e-16 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000137595
SMART Domains Protein: ENSMUSP00000120074
Gene: ENSMUSG00000075101

DomainStartEndE-ValueType
Pfam:7tm_1 39 217 1.9e-22 PFAM
Pfam:7tm_4 138 217 1.4e-17 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000214027
Predicted Effect probably benign
Transcript: ENSMUST00000215816
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 24 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2010111I01Rik T C 13: 63,190,522 S570P probably damaging Het
Ap3b2 T A 7: 81,473,854 probably null Het
Api5 A G 2: 94,418,954 probably benign Het
Arhgap1 A G 2: 91,650,219 probably null Het
BC003331 G T 1: 150,382,338 T182N probably benign Het
C130026I21Rik A G 1: 85,254,186 probably benign Het
C330027C09Rik T C 16: 49,001,678 V223A probably damaging Het
Cldn6 G T 17: 23,681,184 V41F probably damaging Het
Dctn1 G T 6: 83,197,921 V1032L probably damaging Het
Eef2 T A 10: 81,180,270 F488L probably benign Het
Fars2 A G 13: 36,537,311 T410A probably benign Het
Hnrnpc T C 14: 52,081,873 N91S probably null Het
Magel2 T C 7: 62,378,827 V493A possibly damaging Het
Olfr199 A G 16: 59,216,019 V198A possibly damaging Het
Pcnx2 G T 8: 125,866,031 S731R probably benign Het
Plekhm1 A G 11: 103,376,751 L798P probably damaging Het
Prkd1 T C 12: 50,366,348 E680G probably damaging Het
Rabggta T C 14: 55,718,671 T140A probably damaging Het
Slc2a1 G A 4: 119,133,378 D236N probably benign Het
Sptlc1 C A 13: 53,374,012 V39F probably benign Het
Svs1 A T 6: 48,990,036 R639S possibly damaging Het
Vmn1r6 A G 6: 57,002,461 K36R probably benign Het
Vmn2r-ps159 C T 4: 156,338,254 noncoding transcript Het
Wdpcp T A 11: 21,813,383 D581E possibly damaging Het
Other mutations in Olfr1222
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01160:Olfr1222 APN 2 89125728 start codon destroyed probably null 1.00
IGL02090:Olfr1222 APN 2 89125677 missense probably benign 0.20
IGL03230:Olfr1222 APN 2 89125548 missense probably damaging 1.00
R3907:Olfr1222 UTSW 2 89125583 nonsense probably null
R4272:Olfr1222 UTSW 2 89125362 missense probably damaging 1.00
R4975:Olfr1222 UTSW 2 89125338 missense probably damaging 1.00
R4981:Olfr1222 UTSW 2 89125501 missense probably benign 0.02
R5466:Olfr1222 UTSW 2 89125133 missense probably benign 0.25
R5768:Olfr1222 UTSW 2 89125449 missense probably benign 0.01
R7296:Olfr1222 UTSW 2 89124836 missense probably benign 0.03
R7757:Olfr1222 UTSW 2 89124989 missense possibly damaging 0.80
R8414:Olfr1222 UTSW 2 89125714 missense probably benign 0.00
Posted On2014-05-07