Incidental Mutation 'IGL01878:Alox8'
ID 178940
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Alox8
Ensembl Gene ENSMUSG00000020891
Gene Name arachidonate 8-lipoxygenase
Synonyms 8S-LOX, 8S-lipoxygenase, 8-LOX, Alox15b
Accession Numbers
Essential gene? Probably non essential (E-score: 0.114) question?
Stock # IGL01878
Quality Score
Status
Chromosome 11
Chromosomal Location 69074758-69088669 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 69087864 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Lysine at position 147 (Q147K)
Ref Sequence ENSEMBL: ENSMUSP00000091621 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000021262] [ENSMUST00000094078]
AlphaFold O35936
Predicted Effect probably benign
Transcript: ENSMUST00000021262
AA Change: Q147K

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000021262
Gene: ENSMUSG00000020891
AA Change: Q147K

DomainStartEndE-ValueType
LH2 2 122 1.07e-36 SMART
Pfam:Lipoxygenase 163 662 5.5e-70 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000094078
AA Change: Q147K

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
SMART Domains Protein: ENSMUSP00000091621
Gene: ENSMUSG00000020891
AA Change: Q147K

DomainStartEndE-ValueType
LH2 2 122 1.07e-36 SMART
Pfam:Lipoxygenase 205 405 6.9e-44 PFAM
Pfam:Lipoxygenase 402 640 1.9e-60 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000144787
Predicted Effect noncoding transcript
Transcript: ENSMUST00000156157
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: This gene belongs to the lipoxygenase (LOX) gene family whose members encode enzymes that catalyze the addition of molecular oxygen to polyunsaturated fatty acids (PUFAs) to yield fatty acid hydroperoxides. The encoded enzyme preferentially metabolizes arachidonic acid to yield 8-hydroxyeicosatetraenoic acid (8-HETE), while metabolizing linoleic acid less efficiently. The gene may also function as a tumor suppressor. This gene is located in a cluster of related genes that spans approximately 75 kilobases on chromosome 11. [provided by RefSeq, Jan 2013]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ankib1 T A 5: 3,784,152 (GRCm39) M275L possibly damaging Het
Asb2 G A 12: 103,287,922 (GRCm39) P546S possibly damaging Het
B9d1 T C 11: 61,398,449 (GRCm39) probably benign Het
Col12a1 T C 9: 79,557,257 (GRCm39) D1957G possibly damaging Het
Cryzl2 T C 1: 157,299,970 (GRCm39) V44A possibly damaging Het
Fbxw19 A C 9: 109,312,347 (GRCm39) probably benign Het
Gabrb3 T C 7: 57,466,163 (GRCm39) F326L probably damaging Het
Gm10717 C T 9: 3,025,616 (GRCm39) S67L probably benign Het
Gm10718 A T 9: 3,025,118 (GRCm39) Y194F probably benign Het
Gm11168 T C 9: 3,005,204 (GRCm39) C16R probably benign Het
Gm21738 G A 14: 19,416,979 (GRCm38) S144L probably benign Het
Gm7808 T A 9: 19,839,542 (GRCm39) probably benign Het
Gpam T C 19: 55,071,806 (GRCm39) I312V probably benign Het
H2-M10.5 A G 17: 37,084,708 (GRCm39) Y144C probably damaging Het
Hivep3 T C 4: 119,952,424 (GRCm39) S247P possibly damaging Het
Hs3st4 T G 7: 123,996,536 (GRCm39) C401G probably damaging Het
Klhl2 A G 8: 65,212,858 (GRCm39) V227A probably damaging Het
Lct T C 1: 128,222,003 (GRCm39) N1512S probably damaging Het
Lipm T A 19: 34,093,911 (GRCm39) L276Q possibly damaging Het
Lmf2 T A 15: 89,236,621 (GRCm39) H515L probably damaging Het
Mccc1 G A 3: 36,030,041 (GRCm39) S423L probably damaging Het
Mettl21e G A 1: 44,250,193 (GRCm39) S71L probably null Het
Muc16 T A 9: 18,406,839 (GRCm39) H251L possibly damaging Het
Neb T C 2: 52,059,852 (GRCm39) probably benign Het
Ntf5 T C 7: 45,065,450 (GRCm39) I194T probably damaging Het
Or10ag58 T C 2: 87,265,314 (GRCm39) I161T possibly damaging Het
Or1o4 A G 17: 37,590,891 (GRCm39) V140A possibly damaging Het
Or2w6 T C 13: 21,842,953 (GRCm39) D180G possibly damaging Het
Or4x11 T C 2: 89,867,478 (GRCm39) S72P probably damaging Het
Or9m1 A T 2: 87,733,675 (GRCm39) L115* probably null Het
Pigv T C 4: 133,392,428 (GRCm39) I247M probably benign Het
Pik3r5 A G 11: 68,383,356 (GRCm39) N392D probably benign Het
Postn A G 3: 54,290,901 (GRCm39) probably null Het
Prl2c5 G A 13: 13,360,402 (GRCm39) S23N probably benign Het
Prpf40b T C 15: 99,204,413 (GRCm39) C220R possibly damaging Het
Pzp A G 6: 128,472,261 (GRCm39) S843P probably damaging Het
Rpl23 C A 11: 97,669,177 (GRCm39) R85L probably benign Het
Shcbp1 A G 8: 4,799,721 (GRCm39) S252P probably damaging Het
Slc26a7 C T 4: 14,519,388 (GRCm39) probably null Het
Sptbn4 T C 7: 27,063,571 (GRCm39) E2285G probably damaging Het
Telo2 G T 17: 25,320,332 (GRCm39) T784K probably benign Het
Tnfrsf19 C T 14: 61,234,093 (GRCm39) V136M probably damaging Het
Trpm5 T A 7: 142,628,234 (GRCm39) I22F probably damaging Het
Trpv6 G T 6: 41,603,801 (GRCm39) probably benign Het
Vmn1r173 T G 7: 23,401,877 (GRCm39) H37Q probably damaging Het
Vmn2r129 C T 4: 156,690,549 (GRCm39) noncoding transcript Het
Xpo6 T A 7: 125,773,365 (GRCm39) H20L probably benign Het
Zfp462 T C 4: 55,010,613 (GRCm39) Y860H probably damaging Het
Other mutations in Alox8
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01411:Alox8 APN 11 69,079,516 (GRCm39) missense probably benign
IGL02342:Alox8 APN 11 69,077,053 (GRCm39) missense probably damaging 1.00
IGL02694:Alox8 APN 11 69,077,455 (GRCm39) missense probably damaging 0.99
IGL03246:Alox8 APN 11 69,076,841 (GRCm39) missense probably damaging 1.00
IGL03373:Alox8 APN 11 69,077,443 (GRCm39) missense probably benign 0.00
R0567:Alox8 UTSW 11 69,082,348 (GRCm39) critical splice donor site probably null
R1575:Alox8 UTSW 11 69,076,067 (GRCm39) missense possibly damaging 0.94
R1688:Alox8 UTSW 11 69,080,732 (GRCm39) missense probably benign 0.01
R2021:Alox8 UTSW 11 69,077,114 (GRCm39) missense probably damaging 0.98
R2041:Alox8 UTSW 11 69,088,517 (GRCm39) missense possibly damaging 0.67
R2175:Alox8 UTSW 11 69,078,592 (GRCm39) missense possibly damaging 0.85
R2237:Alox8 UTSW 11 69,076,597 (GRCm39) missense probably benign 0.00
R3821:Alox8 UTSW 11 69,077,308 (GRCm39) missense probably damaging 0.98
R4870:Alox8 UTSW 11 69,077,394 (GRCm39) missense probably damaging 1.00
R6836:Alox8 UTSW 11 69,080,715 (GRCm39) missense possibly damaging 0.82
R6836:Alox8 UTSW 11 69,077,331 (GRCm39) missense probably damaging 1.00
R7003:Alox8 UTSW 11 69,082,416 (GRCm39) missense possibly damaging 0.70
R7158:Alox8 UTSW 11 69,076,696 (GRCm39) missense probably benign 0.00
R7316:Alox8 UTSW 11 69,077,064 (GRCm39) missense probably benign 0.01
R7513:Alox8 UTSW 11 69,078,670 (GRCm39) missense probably benign 0.34
R9515:Alox8 UTSW 11 69,075,950 (GRCm39) missense probably damaging 1.00
R9721:Alox8 UTSW 11 69,087,911 (GRCm39) missense probably benign 0.19
X0065:Alox8 UTSW 11 69,076,079 (GRCm39) missense probably damaging 1.00
Z1177:Alox8 UTSW 11 69,076,047 (GRCm39) missense probably damaging 1.00
Z1186:Alox8 UTSW 11 69,088,322 (GRCm39) missense probably benign
Z1186:Alox8 UTSW 11 69,076,873 (GRCm39) missense probably benign 0.00
Z1187:Alox8 UTSW 11 69,088,322 (GRCm39) missense probably benign
Z1187:Alox8 UTSW 11 69,076,873 (GRCm39) missense probably benign 0.00
Z1188:Alox8 UTSW 11 69,088,322 (GRCm39) missense probably benign
Z1188:Alox8 UTSW 11 69,076,873 (GRCm39) missense probably benign 0.00
Z1189:Alox8 UTSW 11 69,088,322 (GRCm39) missense probably benign
Z1189:Alox8 UTSW 11 69,076,873 (GRCm39) missense probably benign 0.00
Z1190:Alox8 UTSW 11 69,088,322 (GRCm39) missense probably benign
Z1190:Alox8 UTSW 11 69,076,873 (GRCm39) missense probably benign 0.00
Z1191:Alox8 UTSW 11 69,088,322 (GRCm39) missense probably benign
Z1191:Alox8 UTSW 11 69,076,873 (GRCm39) missense probably benign 0.00
Z1192:Alox8 UTSW 11 69,088,322 (GRCm39) missense probably benign
Z1192:Alox8 UTSW 11 69,076,873 (GRCm39) missense probably benign 0.00
Posted On 2014-05-07