Incidental Mutation 'IGL01878:Fbxw19'
ID178974
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Fbxw19
Ensembl Gene ENSMUSG00000074061
Gene NameF-box and WD-40 domain protein 19
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.066) question?
Stock #IGL01878
Quality Score
Status
Chromosome9
Chromosomal Location109476654-109495875 bp(-) (GRCm38)
Type of Mutationsplice site
DNA Base Change (assembly) A to C at 109483279 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000075918 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000076617]
Predicted Effect probably benign
Transcript: ENSMUST00000076617
SMART Domains Protein: ENSMUSP00000075918
Gene: ENSMUSG00000074061

DomainStartEndE-ValueType
FBOX 5 45 1.8e-6 SMART
SCOP:d1gxra_ 87 284 3e-5 SMART
Blast:WD40 137 176 8e-8 BLAST
Predicted Effect noncoding transcript
Transcript: ENSMUST00000197191
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Alox8 G T 11: 69,197,038 Q147K probably benign Het
Ankib1 T A 5: 3,734,152 M275L possibly damaging Het
Asb2 G A 12: 103,321,663 P546S possibly damaging Het
B9d1 T C 11: 61,507,623 probably benign Het
Col12a1 T C 9: 79,649,975 D1957G possibly damaging Het
Cryzl2 T C 1: 157,472,400 V44A possibly damaging Het
Gabrb3 T C 7: 57,816,415 F326L probably damaging Het
Gm10717 C T 9: 3,025,616 S67L probably benign Het
Gm10718 A T 9: 3,025,118 Y194F probably benign Het
Gm11168 T C 9: 3,005,204 C16R probably benign Het
Gm21738 G A 14: 19,416,979 S144L probably benign Het
Gm7808 T A 9: 19,928,246 probably benign Het
Gpam T C 19: 55,083,374 I312V probably benign Het
H2-M10.5 A G 17: 36,773,816 Y144C probably damaging Het
Hivep3 T C 4: 120,095,227 S247P possibly damaging Het
Hs3st4 T G 7: 124,397,313 C401G probably damaging Het
Klhl2 A G 8: 64,759,824 V227A probably damaging Het
Lct T C 1: 128,294,266 N1512S probably damaging Het
Lipm T A 19: 34,116,511 L276Q possibly damaging Het
Lmf2 T A 15: 89,352,418 H515L probably damaging Het
Mccc1 G A 3: 35,975,892 S423L probably damaging Het
Mettl21e G A 1: 44,211,033 S71L probably null Het
Muc16 T A 9: 18,495,543 H251L possibly damaging Het
Neb T C 2: 52,169,840 probably benign Het
Ntf5 T C 7: 45,416,026 I194T probably damaging Het
Olfr1124 T C 2: 87,434,970 I161T possibly damaging Het
Olfr1154 A T 2: 87,903,331 L115* probably null Het
Olfr1265 T C 2: 90,037,134 S72P probably damaging Het
Olfr1361 T C 13: 21,658,783 D180G possibly damaging Het
Olfr99 A G 17: 37,280,000 V140A possibly damaging Het
Pigv T C 4: 133,665,117 I247M probably benign Het
Pik3r5 A G 11: 68,492,530 N392D probably benign Het
Postn A G 3: 54,383,480 probably null Het
Prl2c5 G A 13: 13,185,817 S23N probably benign Het
Prpf40b T C 15: 99,306,532 C220R possibly damaging Het
Pzp A G 6: 128,495,298 S843P probably damaging Het
Rpl23 C A 11: 97,778,351 R85L probably benign Het
Shcbp1 A G 8: 4,749,721 S252P probably damaging Het
Slc26a7 C T 4: 14,519,388 probably null Het
Sptbn4 T C 7: 27,364,146 E2285G probably damaging Het
Telo2 G T 17: 25,101,358 T784K probably benign Het
Tnfrsf19 C T 14: 60,996,644 V136M probably damaging Het
Trpm5 T A 7: 143,074,497 I22F probably damaging Het
Trpv6 G T 6: 41,626,867 probably benign Het
Vmn1r173 T G 7: 23,702,452 H37Q probably damaging Het
Vmn2r-ps159 C T 4: 156,338,254 noncoding transcript Het
Xpo6 T A 7: 126,174,193 H20L probably benign Het
Zfp462 T C 4: 55,010,613 Y860H probably damaging Het
Other mutations in Fbxw19
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01094:Fbxw19 APN 9 109493546 missense probably benign 0.03
IGL02622:Fbxw19 APN 9 109493534 missense probably benign 0.22
IGL02752:Fbxw19 APN 9 109494641 missense probably benign 0.07
IGL02795:Fbxw19 APN 9 109495818 missense possibly damaging 0.52
IGL03401:Fbxw19 APN 9 109494970 critical splice donor site probably null
R0402:Fbxw19 UTSW 9 109484425 missense probably benign 0.00
R0423:Fbxw19 UTSW 9 109486066 missense probably benign 0.22
R0466:Fbxw19 UTSW 9 109478649 missense probably benign 0.32
R0513:Fbxw19 UTSW 9 109481553 splice site probably null
R1538:Fbxw19 UTSW 9 109494988 missense probably damaging 1.00
R1768:Fbxw19 UTSW 9 109494772 nonsense probably null
R1869:Fbxw19 UTSW 9 109482032 missense probably benign 0.11
R1933:Fbxw19 UTSW 9 109481650 missense probably benign 0.20
R1960:Fbxw19 UTSW 9 109485936 missense probably benign
R2288:Fbxw19 UTSW 9 109493568 missense probably damaging 0.99
R2877:Fbxw19 UTSW 9 109485970 missense probably damaging 1.00
R2878:Fbxw19 UTSW 9 109485970 missense probably damaging 1.00
R4778:Fbxw19 UTSW 9 109494646 missense probably damaging 1.00
R5192:Fbxw19 UTSW 9 109484428 missense probably benign 0.01
R5196:Fbxw19 UTSW 9 109484428 missense probably benign 0.01
R5533:Fbxw19 UTSW 9 109486065 missense probably benign 0.00
R6107:Fbxw19 UTSW 9 109495766 missense probably damaging 1.00
R6333:Fbxw19 UTSW 9 109494683 missense probably benign 0.01
R6820:Fbxw19 UTSW 9 109482011 missense probably benign 0.07
R7631:Fbxw19 UTSW 9 109482001 missense probably damaging 1.00
R7651:Fbxw19 UTSW 9 109494646 missense probably damaging 1.00
Z1176:Fbxw19 UTSW 9 109481582 missense probably benign 0.00
Posted On2014-05-07