Incidental Mutation 'IGL01879:Olfr847'
ID 178997
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr847
Ensembl Gene ENSMUSG00000059821
Gene Name olfactory receptor 847
Synonyms MOR149-2, GA_x6K02T2PVTD-13113073-13112135
Accession Numbers
Essential gene? Probably non essential (E-score: 0.144) question?
Stock # IGL01879
Quality Score
Chromosome 9
Chromosomal Location 19373668-19378669 bp(-) (GRCm38)
Type of Mutation nonsense
DNA Base Change (assembly) A to T at 19375407 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Leucine to Stop codon at position 158 (L158*)
Ref Sequence ENSEMBL: ENSMUSP00000151112 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079620] [ENSMUST00000216839]
AlphaFold Q8VFF4
Predicted Effect probably null
Transcript: ENSMUST00000079620
AA Change: L158*
SMART Domains Protein: ENSMUSP00000078568
Gene: ENSMUSG00000059821
AA Change: L158*

Pfam:7tm_4 31 308 1.9e-56 PFAM
Pfam:7tm_1 41 290 2.1e-22 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000212306
AA Change: L158*
Predicted Effect probably null
Transcript: ENSMUST00000216839
AA Change: L158*
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Cgn G A 3: 94,774,364 (GRCm38) R474* probably null Het
Chmp4b T C 2: 154,692,681 (GRCm38) probably benign Het
Chst15 A G 7: 132,270,265 (GRCm38) Y96H possibly damaging Het
Clstn3 A G 6: 124,438,810 (GRCm38) S638P probably damaging Het
Colq C T 14: 31,543,995 (GRCm38) G187E probably damaging Het
Cyp2b23 A G 7: 26,672,854 (GRCm38) Y389H probably benign Het
Cyp3a13 T C 5: 137,919,003 (GRCm38) Q54R probably benign Het
Dscc1 T C 15: 55,086,816 (GRCm38) I178V probably benign Het
Fbxo4 G A 15: 3,975,954 (GRCm38) T148M probably damaging Het
Gm10717 A T 9: 3,026,287 (GRCm38) Y195F probably damaging Het
Gm10718 A T 9: 3,025,118 (GRCm38) Y194F probably benign Het
Gm21738 G A 14: 19,416,979 (GRCm38) S144L probably benign Het
Gpr162 A G 6: 124,861,241 (GRCm38) S149P probably damaging Het
Grid1 T A 14: 35,450,370 (GRCm38) I611N possibly damaging Het
Mgat5 T C 1: 127,397,550 (GRCm38) F385L probably damaging Het
Npepps T C 11: 97,258,340 (GRCm38) T17A possibly damaging Het
Olfr1233 T C 2: 89,340,022 (GRCm38) I93M probably benign Het
Olfr484 A T 7: 108,125,164 (GRCm38) I33N possibly damaging Het
Olfr733 A G 14: 50,298,512 (GRCm38) S266P probably benign Het
Parg T C 14: 32,271,622 (GRCm38) probably benign Het
Rad51ap2 A G 12: 11,458,138 (GRCm38) D687G probably benign Het
Sh3bp1 T G 15: 78,907,992 (GRCm38) S450A probably damaging Het
Skap2 T C 6: 51,996,034 (GRCm38) D90G possibly damaging Het
Smc5 C T 19: 23,228,184 (GRCm38) R796H probably damaging Het
Tdrd12 A C 7: 35,521,923 (GRCm38) I146S probably damaging Het
Tinf2 T C 14: 55,680,906 (GRCm38) probably benign Het
Trio G A 15: 27,741,033 (GRCm38) T2702I probably benign Het
Vmn1r88 T A 7: 13,178,302 (GRCm38) M195K probably benign Het
Vmn2r110 T C 17: 20,573,860 (GRCm38) H849R probably benign Het
Vmn2r4 C T 3: 64,391,010 (GRCm38) G566R probably damaging Het
Vmn2r-ps159 C T 4: 156,338,254 (GRCm38) noncoding transcript Het
Wdpcp A G 11: 21,711,630 (GRCm38) T301A probably damaging Het
Other mutations in Olfr847
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01150:Olfr847 APN 9 19,375,239 (GRCm38) missense probably damaging 1.00
IGL01293:Olfr847 APN 9 19,375,336 (GRCm38) missense probably benign 0.23
IGL03298:Olfr847 APN 9 19,375,062 (GRCm38) missense probably damaging 1.00
R1350:Olfr847 UTSW 9 19,375,414 (GRCm38) missense possibly damaging 0.94
R1400:Olfr847 UTSW 9 19,375,062 (GRCm38) missense probably damaging 0.98
R2894:Olfr847 UTSW 9 19,375,292 (GRCm38) nonsense probably null
R4468:Olfr847 UTSW 9 19,375,648 (GRCm38) missense probably benign 0.00
R4694:Olfr847 UTSW 9 19,375,398 (GRCm38) missense probably damaging 1.00
R4791:Olfr847 UTSW 9 19,375,809 (GRCm38) missense probably benign 0.28
R4794:Olfr847 UTSW 9 19,375,545 (GRCm38) missense probably benign 0.00
R5517:Olfr847 UTSW 9 19,375,767 (GRCm38) missense probably damaging 1.00
R5599:Olfr847 UTSW 9 19,375,629 (GRCm38) missense possibly damaging 0.77
R5777:Olfr847 UTSW 9 19,375,718 (GRCm38) missense probably benign 0.29
R6505:Olfr847 UTSW 9 19,374,941 (GRCm38) makesense probably null
R6509:Olfr847 UTSW 9 19,375,143 (GRCm38) missense probably benign
R7246:Olfr847 UTSW 9 19,375,465 (GRCm38) nonsense probably null
R7659:Olfr847 UTSW 9 19,375,558 (GRCm38) missense probably benign 0.03
R7789:Olfr847 UTSW 9 19,375,065 (GRCm38) missense probably benign 0.33
R7886:Olfr847 UTSW 9 19,375,906 (GRCm38) splice site probably null
R8948:Olfr847 UTSW 9 19,374,966 (GRCm38) missense probably benign 0.03
R9326:Olfr847 UTSW 9 19,375,050 (GRCm38) missense probably damaging 1.00
R9612:Olfr847 UTSW 9 19,375,381 (GRCm38) missense possibly damaging 0.69
R9784:Olfr847 UTSW 9 19,375,820 (GRCm38) missense probably damaging 0.99
R9798:Olfr847 UTSW 9 19,375,281 (GRCm38) missense probably benign 0.30
Z1088:Olfr847 UTSW 9 19,375,684 (GRCm38) missense probably damaging 1.00
Posted On 2014-05-07