Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01879:Vmn1r88'

179004

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn1r88

Ensembl Gene

ENSMUSG00000095902

Gene Name

vomeronasal 1 receptor, 88

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.054) question?

Stock #

IGL01879

Quality Score

Status

Chromosome

Chromosomal Location

12911646-12912596 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 12912229 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Lysine at position 195 (M195K)

Ref Sequence

ENSEMBL: ENSMUSP00000128946 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000171783]

AlphaFold

no structure available at present

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000122190

Predicted Effect

probably benign
Transcript: ENSMUST00000171783
AA Change: M195K

PolyPhen 2 Score 0.120 (Sensitivity: 0.93; Specificity: 0.86)

SMART Domains

Protein: ENSMUSP00000128946
Gene: ENSMUSG00000095902
AA Change: M195K

Domain	Start	End	E-Value	Type
Pfam:TAS2R	1	306	2e-14	PFAM
Pfam:V1R	35	301	1.4e-30	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 32 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Cgn	G	A	3: 94,681,674 (GRCm39)	R474*	probably null	Het
Chmp4b	T	C	2: 154,534,601 (GRCm39)		probably benign	Het
Chst15	A	G	7: 131,871,994 (GRCm39)	Y96H	possibly damaging	Het
Clstn3	A	G	6: 124,415,769 (GRCm39)	S638P	probably damaging	Het
Colq	C	T	14: 31,265,952 (GRCm39)	G187E	probably damaging	Het
Cyp2b23	A	G	7: 26,372,279 (GRCm39)	Y389H	probably benign	Het
Cyp3a13	T	C	5: 137,917,265 (GRCm39)	Q54R	probably benign	Het
Dscc1	T	C	15: 54,950,212 (GRCm39)	I178V	probably benign	Het
Fbxo4	G	A	15: 4,005,436 (GRCm39)	T148M	probably damaging	Het
Gm10717	A	T	9: 3,026,287 (GRCm39)	Y195F	probably damaging	Het
Gm10718	A	T	9: 3,025,118 (GRCm39)	Y194F	probably benign	Het
Gm21738	G	A	14: 19,416,979 (GRCm38)	S144L	probably benign	Het
Gpr162	A	G	6: 124,838,204 (GRCm39)	S149P	probably damaging	Het
Grid1	T	A	14: 35,172,327 (GRCm39)	I611N	possibly damaging	Het
Mgat5	T	C	1: 127,325,287 (GRCm39)	F385L	probably damaging	Het
Npepps	T	C	11: 97,149,166 (GRCm39)	T17A	possibly damaging	Het
Or4c125	T	C	2: 89,170,366 (GRCm39)	I93M	probably benign	Het
Or4n4b	A	G	14: 50,535,969 (GRCm39)	S266P	probably benign	Het
Or5p60	A	T	7: 107,724,371 (GRCm39)	I33N	possibly damaging	Het
Or7g29	A	T	9: 19,286,703 (GRCm39)	L158*	probably null	Het
Parg	T	C	14: 31,993,579 (GRCm39)		probably benign	Het
Rad51ap2	A	G	12: 11,508,139 (GRCm39)	D687G	probably benign	Het
Sh3bp1	T	G	15: 78,792,192 (GRCm39)	S450A	probably damaging	Het
Skap2	T	C	6: 51,973,014 (GRCm39)	D90G	possibly damaging	Het
Smc5	C	T	19: 23,205,548 (GRCm39)	R796H	probably damaging	Het
Tdrd12	A	C	7: 35,221,348 (GRCm39)	I146S	probably damaging	Het
Tinf2	T	C	14: 55,918,363 (GRCm39)		probably benign	Het
Trio	G	A	15: 27,741,119 (GRCm39)	T2702I	probably benign	Het
Vmn2r110	T	C	17: 20,794,122 (GRCm39)	H849R	probably benign	Het
Vmn2r129	C	T	4: 156,690,549 (GRCm39)		noncoding transcript	Het
Vmn2r4	C	T	3: 64,298,431 (GRCm39)	G566R	probably damaging	Het
Wdpcp	A	G	11: 21,661,630 (GRCm39)	T301A	probably damaging	Het

Other mutations in Vmn1r88

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01828:Vmn1r88	APN	7	12,911,662 (GRCm39)	missense	probably damaging	1.00
IGL02028:Vmn1r88	APN	7	12,911,719 (GRCm39)	missense	probably benign
IGL02586:Vmn1r88	APN	7	12,911,735 (GRCm39)	nonsense	probably null
IGL03176:Vmn1r88	APN	7	12,911,779 (GRCm39)	missense	probably damaging	1.00
PIT4466001:Vmn1r88	UTSW	7	12,912,403 (GRCm39)	missense	possibly damaging	0.83
R1163:Vmn1r88	UTSW	7	12,912,060 (GRCm39)	missense	probably benign
R1478:Vmn1r88	UTSW	7	12,911,878 (GRCm39)	missense	probably damaging	1.00
R2376:Vmn1r88	UTSW	7	12,911,785 (GRCm39)	missense	probably damaging	0.99
R3624:Vmn1r88	UTSW	7	12,911,790 (GRCm39)	missense	probably benign	0.08
R4543:Vmn1r88	UTSW	7	12,911,907 (GRCm39)	missense	possibly damaging	0.52
R4593:Vmn1r88	UTSW	7	12,911,769 (GRCm39)	missense	probably damaging	0.96
R4721:Vmn1r88	UTSW	7	12,912,451 (GRCm39)	nonsense	probably null
R5927:Vmn1r88	UTSW	7	12,912,440 (GRCm39)	missense	probably benign	0.12
R6411:Vmn1r88	UTSW	7	12,911,970 (GRCm39)	missense	probably damaging	1.00
R6535:Vmn1r88	UTSW	7	12,912,112 (GRCm39)	missense	probably benign	0.03
R6598:Vmn1r88	UTSW	7	12,912,150 (GRCm39)	missense	probably damaging	1.00
R6857:Vmn1r88	UTSW	7	12,912,258 (GRCm39)	missense	possibly damaging	0.87
R9389:Vmn1r88	UTSW	7	12,912,546 (GRCm39)	missense	probably damaging	1.00
R9769:Vmn1r88	UTSW	7	12,912,280 (GRCm39)	missense	probably damaging	0.97

Posted On

2014-05-07